| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ye Lu, Chengyuan Zhang, Shilin Jiang, Feng Yua. Anti-Dlx5 Retards the Progression of Osteoarthritis through Inhibiting Chondrocyte Hypertrophy and Apoptosis. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-03-14. PMID:35280506. |
anti-dlx5 retards the progression of osteoarthritis through inhibiting chondrocyte hypertrophy and apoptosis. |
2022-03-14 |
2023-08-13 |
Not clear |
| Sarita Nehra, Varun Bhardwaj, Namita Kalra, Lilly Ganju, Anju Bansal, Shweta Saxena, Deepika Saraswa. Correction to: Nanocurcumin protects cardiomyoblasts H9c2 from hypoxia-induced hypertrophy and apoptosis by improving oxidative balance. Journal of physiology and biochemistry. 2022-03-12. PMID:35278197. |
correction to: nanocurcumin protects cardiomyoblasts h9c2 from hypoxia-induced hypertrophy and apoptosis by improving oxidative balance. |
2022-03-12 |
2023-08-13 |
Not clear |
| Mengli Chen, Hongyan Zhu, Qingqing Zhu, Xiaodong Wu, Yufei Zhou, Rongrong Gao, Mengsha Shi, Ting Zhang, Ting Yin, Haifeng Zhang, Hongcai Shang, Xinli L. Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression. Clinical and experimental pharmacology & physiology. 2022-03-12. PMID:35278230. |
our findings revealed that crp attenuated cardiac hypertrophy, fibrosis and apoptosis and alleviated heart failure after mi in vivo. |
2022-03-12 |
2023-08-13 |
mouse |
| Mengli Chen, Hongyan Zhu, Qingqing Zhu, Xiaodong Wu, Yufei Zhou, Rongrong Gao, Mengsha Shi, Ting Zhang, Ting Yin, Haifeng Zhang, Hongcai Shang, Xinli L. Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression. Clinical and experimental pharmacology & physiology. 2022-03-12. PMID:35278230. |
crp alleviates cardiac hypertrophy, fibrosis, and apoptosis and can ameliorate heart failure after mi via activation of pparγ. |
2022-03-12 |
2023-08-13 |
mouse |
| Yu-Kai Cui, Yi-Xiang Hong, Wei-Yin Wu, Wei-Min Han, Yao Wu, Chan Wu, Gui-Rong Li, Yan Wan. Acacetin ameliorates cardiac hypertrophy by activating Sirt1/AMPK/PGC-1α pathway. European journal of pharmacology. 2022-02-27. PMID:35219729. |
our results demonstrate the novel pharmacological effect that acacetin ameliorates cardiac hypertrophy via sirt1-mediated activation of ampk/pgc-1α signal molecules followed by reducing oxidation, inflammation and apoptosis. |
2022-02-27 |
2023-08-13 |
rat |
| Ke Lin, Na Yang, Wu Luo, Jin-Fu Qian, Wei-Wei Zhu, Shi-Ju Ye, Chen-Xin Yuan, Di-Yun Xu, Guang Liang, Wei-Jian Huang, Pei-Ren Sha. Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1/MAPK signaling. Acta pharmacologica Sinica. 2022-02-26. PMID:35217813. |
we showed that dapa pretreatment concentration-dependently attenuated pa-induced cell hypertrophy, fibrosis and apoptosis. |
2022-02-26 |
2023-08-13 |
mouse |
| Xiao Han, Yun-Long Zhang, Qiu-Yue Lin, Hui-Hua Li, Shu-Bin Gu. ATGL deficiency aggravates pressure overload-triggered myocardial hypertrophic remodeling associated with the proteasome-PTEN-mTOR-autophagy pathway. Cell biology and toxicology. 2022-02-26. PMID:35218467. |
tac in wt mice significantly reduced cardiac function and autophagy while enhancing left ventricular hypertrophy, interstitial fibrosis, inflammatory response, superoxide generation, and cardiomyocyte apoptosis, accompanied with upregulation of the proteasome activity, reduction of pten level and activation of akt-mtor signaling, and these effects were further aggravated in atgl ko mice. |
2022-02-26 |
2023-08-13 |
mouse |
| Ling Wang, Yue-Qin Zeng, Juan-Hua Gu, Rui Song, Peng-Hui Cang, Yong-Xuan Xu, Xiao-Xia Shao, Li-Jin Pu, Hai-Yun Luo, Xin-Fu Zho. Novel oral edaravone attenuates diastolic dysfunction of diabetic cardiomyopathy by activating the Nrf2 signaling pathway. European journal of pharmacology. 2022-02-24. PMID:35202676. |
its effect was mainly achieved by attenuating hyperglycemia and hyperlipidemia-induced cardiomyocyte hypertrophy, apoptosis, and fibrosis by activating the nrf2 signaling pathway. |
2022-02-24 |
2023-08-13 |
rat |
| Yu-Qing Tan, Jun Li, Heng-Wen Che. Epac, a positive or negative signaling molecule in cardiovascular diseases. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 148. 2022-02-20. PMID:35183995. |
epac acts on a variety of pathways, including ion level regulation, cardiac hypertrophy, cardiac fibrosis, cardiomyocyte apoptosis, and angiogenesis. |
2022-02-20 |
2023-08-13 |
Not clear |
| An-Liang Huang, Fan Yang, Ping Cheng, Dian-Ying Liao, Li Zhou, Xing-Li Ji, Dou-Dou Peng, Li Zhang, Ting-Ting Cheng, Li Ma, Xian-Gen Xi. Honokiol attenuate the arsenic trioxide-induced cardiotoxicity by reducing the myocardial apoptosis. Pharmacology research & perspectives. vol 10. issue 2. 2022-02-16. PMID:35171536. |
for the in vitro study, we evaluated the effects of ato and/or honokiol on reactive oxygen species (ros) production and apoptosis induction in primary cultured cardiomyocytes; for the in vivo study, balb/c mice were administrated with ato and/or hkl for a period of 4 weeks, myocardial apoptosis, cardiac function, and cardiac remodeling (cardiac hypertrophy and cardiac fibrosis) were assessed at the end of administration. |
2022-02-16 |
2023-08-13 |
mouse |
| Wei-Ting Chang, Chia-Chun Wu, Yu-Wen Lin, Jhih-Yuan Shih, Zhih-Cherng Chen, Sheng-Nan Wu, Chia-Ching Wu, Chih-Hsin Hs. Dynamic Changes in miR-21 Regulate Right Ventricular Dysfunction in Congenital Heart Disease-Related Pulmonary Arterial Hypertension. Cells. vol 11. issue 3. 2022-02-15. PMID:35159373. |
collectively, our study revealed that the upregulation of mir-21 in the early phase (rv hypertrophy) and downregulation in the late phase (rv dysfunction) under pah triggered a biphasic regulation of cardiac remodeling and cardiomyocyte apoptosis. |
2022-02-15 |
2023-08-13 |
rat |
| Xueqi Wang, Yiming Guan, Shiyu Xiang, Karen L Clark, Peter G Alexander, Lauren E Simonian, Yuhao Deng, Hang Li. Role of Canonical Wnt/β-Catenin Pathway in Regulating Chondrocytic Hypertrophy in Mesenchymal Stem Cell-Based Cartilage Tissue Engineering. Frontiers in cell and developmental biology. vol 10. 2022-02-10. PMID:35141220. |
given that hypertrophic chondrocytes potentially undergo apoptosis or convert into osteoblasts, this undesired phenotype needs to be prevented or minimized before mscs can be used to repair cartilage injuries in the clinic. |
2022-02-10 |
2023-08-13 |
Not clear |
| Jhansi Magisetty, Vijay Kumar Reddy Kondreddy, Shiva Keshava, Kaushik Das, Charles Esmon, Usha R Pendurthi, L Vijaya Mohan Ra. Selective inhibition of activated protein C anticoagulant activity protects against hemophilic arthropathy. Blood. 2022-02-10. PMID:35143636. |
ha was evaluated by monitoring joint bleeding, change in joint diameter, and histopathological analysis of joint tissue sections for synovial hypertrophy, macrophage infiltration, neoangiogenesis, cartilage degeneration, and chondrocyte apoptosis. |
2022-02-10 |
2023-08-13 |
mouse |
| Chengyun Hu, Feibiao Dai, Jiawu Wang, Lai Jiang, Di Wang, Jie Gao, Jun Huang, Jianfeng Luo, Fei Tang, Zhetao Zhang, Chaoliang Tan. Peroxiredoxin-5 Knockdown Accelerates Pressure Overload-Induced Cardiac Hypertrophy in Mice. Oxidative medicine and cellular longevity. vol 2022. 2022-02-08. PMID:35132351. |
in addition, prx5 knockdown accelerated pressure overload-induced cardiac hypertrophy and dysfunction in mice by activating oxidative stress and cardiomyocyte apoptosis. |
2022-02-08 |
2023-08-13 |
mouse |
| Yu Zhang, Xiaowei Wang, Jian Chen, Dingfei Qian, Peng Gao, Tao Qin, Tao Jiang, Jiang Yi, Tao Xu, Yifan Huang, Qian Wang, Zheng Zhou, Tianyi Bao, Xuan Zhao, Hao Liu, Ziyang Zheng, Jin Fan, Shujie Zhao, Qingqing Li, Guoyong Yi. Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis. Journal of nanobiotechnology. vol 20. issue 1. 2022-01-30. PMID:35093078. |
in vivo experiments confirmed that exo-gel increased the local retention of exo, inhibited the apoptosis and hypertrophy of chondrocytes, enhanced their proliferation, and potentially played the role in stem cell recruitment to delay the development of stoa. |
2022-01-30 |
2023-08-13 |
mouse |
| Lin Hu, Ziyuan Wang, Huan Li, Jiarui Wei, Fengyue Tang, Qing Wang, Jing Wang, Xiaoqiao Zhang, Qiufang Zhan. Icariin inhibits isoproterenol-induced cardiomyocyte hypertropic injury through activating autophagy via the AMPK/mTOR signaling pathway. Biochemical and biophysical research communications. vol 593. 2022-01-22. PMID:35063771. |
but the effects of ica on iso-induced cardiomyocytes hypertrophy were attenuated by selective ampk inhibitor compound c. in conclusion, these findings indicated that ica attenuated cardiomyocyte hypertrophy induced by iso and prevented cell injury, and the specific mechanism was mediated by ampk/mtor pathway to enhance autophagy and reduce autophagy-related cardiomyocyte apoptosis. |
2022-01-22 |
2023-08-13 |
Not clear |
| Kai Jiang, Di Zhao, Rui Ye, Xinlong Liu, Chao Gao, Yuanyuan Guo, Chuan Zhang, Jian Zeng, Shi Wang, Jie Son. Transdermal delivery of poly-hyaluronic acid-based spherical nucleic acids for chemogene therapy. Nanoscale. 2022-01-18. PMID:35040454. |
moreover, phaad nanoparticles facilitated the apoptosis of hypertrophic scar cells, and reduced the burden and progression of hypertrophic scars in a xenografted mouse model without adverse side effects. |
2022-01-18 |
2023-08-13 |
mouse |
| Shiqi Chen, Jingwei Ma, Jiangyang Chi, Bingxia Zhang, Xiaojuan Zheng, Jie Chen, Junwei Li. Roles and potential clinical implications of tissue transglutaminase in cardiovascular diseases. Pharmacological research. 2022-01-16. PMID:35033646. |
tissue transglutaminase (tg2) is pivotal to the pathological development of cvds, including participating in the cross-linking of extracellular proteins, activation of fibroblasts, hypertrophy and apoptosis of cardiomyocytes, proliferation and migration of smooth muscle cells (smcs), and inflammatory reactions. |
2022-01-16 |
2023-08-13 |
Not clear |
| Ram B Singh, Fabiola B Sozzi, Jan Fedacko, Krasimira Hristova, Ghizal Fatima, Daniel Pella, Germaine Cornelissen, Adrian Isaza, Dominik Pella, Jaipaul Singh, Stefano Carugo, Navin C Nanda, Galal E Nagib Elkilan. Pre-heart failure at 2D- and 3D-speckle tracking echocardiography: A comprehensive review. Echocardiography (Mount Kisco, N.Y.). 2022-01-13. PMID:35026047. |
these risk factors damage the myocytes leading to fibrosis, apoptosis, cardiac hypertrophy, along with alterations in cardiomyocyte' size and shape. |
2022-01-13 |
2023-08-13 |
Not clear |
| Shengnan Li, Yalin Yu, Boyang Wang, Shiyuan Qiao, Maomao Hu, Han Wang, Changning Fu, Bo Don. Overexpression of G protein-coupled receptor 40 protects obesity-induced cardiomyopathy through the SIRT1/LKB1/AMPK pathway. Human gene therapy. 2022-01-12. PMID:35018806. |
obesity-induced cardiac injury models exhibit cardiac dysfunction, myocardial hypertrophy and collagen accumulation, accompanied by increased inflammation, oxidative stress and apoptosis. |
2022-01-12 |
2023-08-13 |
rat |