| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoyu Liu, Bingyan Guo, Wei Zhang, Bocong Ma, Yongjun L. MiR-20a-5p overexpression prevented diabetic cardiomyopathy via inhibition of cardiomyocyte apoptosis, hypertrophy, fibrosis and JNK/NF-κB signalling pathway. Journal of biochemistry. vol 170. issue 3. 2021-11-23. PMID:33837411. |
overall, mir-20a-5p may effectively ameliorate dcm through improving cardiac metabolism, and subsequently inhibiting inflammation, apoptosis, hypertrophy, fibrosis and jnk/nf-κb pathway via modulating rock2. |
2021-11-23 |
2023-08-13 |
mouse |
| Bo Liu, Lijuan Lin, Shengjin Yu, Rongjun Xia, Linlin Zhen. Long non-coding RNA H19 acts as a microRNA-194 sponge to inhibit the apoptosis and promote the proliferation of hypertrophic scar fibroblasts. Canadian journal of physiology and pharmacology. vol 99. issue 12. 2021-11-22. PMID:34310900. |
long non-coding rna h19 acts as a microrna-194 sponge to inhibit the apoptosis and promote the proliferation of hypertrophic scar fibroblasts. |
2021-11-22 |
2023-08-13 |
Not clear |
| Bo Liu, Lijuan Lin, Shengjin Yu, Rongjun Xia, Linlin Zhen. Long non-coding RNA H19 acts as a microRNA-194 sponge to inhibit the apoptosis and promote the proliferation of hypertrophic scar fibroblasts. Canadian journal of physiology and pharmacology. vol 99. issue 12. 2021-11-22. PMID:34310900. |
the effects of the lncrna h19 on the proliferation and apoptosis of hypertrophic scar fibroblasts (hsfs) were analyzed using 5'-ethynyl-2'-deoxyuridine staining, flow cytometry, and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2 |
2021-11-22 |
2023-08-13 |
Not clear |
| Kaizu Xu, Chungui Chen, Ying Wu, Meifang Wu, Liming Li. Advances in miR-132-Based Biomarker and Therapeutic Potential in the Cardiovascular System. Frontiers in pharmacology. vol 12. 2021-11-20. PMID:34795586. |
more importantly, mir-132 in the myocardium has been demonstrated to be a master regulator in many pathological processes of ischemic or nonischemic heart failure in the past decade, such as myocardial hypertrophy, fibrosis, apoptosis, angiogenesis, calcium handling, neuroendocrine activation, and oxidative stress, through downregulating target mrna expression. |
2021-11-20 |
2023-08-13 |
Not clear |
| Chen Lin, Yongzhen Guo, Yunlong Xia, Congye Li, Xiaoming Xu, Tingting Qi, Fuyang Zhang, Miaomiao Fan, Guangyu Hu, Hang Zhao, Huishou Zhao, Rui Liu, Erhe Gao, Wenjun Yan, Ling Ta. FNDC5/Irisin attenuates diabetic cardiomyopathy in a type 2 diabetes mouse model by activation of integrin αV/β5-AKT signaling and reduction of oxidative/nitrosative stress. Journal of molecular and cellular cardiology. vol 160. 2021-11-16. PMID:34224725. |
adverse structural remodeling, including cardiomyocyte apoptosis, myocardial fibrosis, and cardiac hypertrophy were observed in the hearts of db/db mice. |
2021-11-16 |
2023-08-13 |
mouse |
| Thatiany de Souza Marinho, Fabiane Ferreira Martins, Luiz Eduardo de Macedo Cardoso, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerd. Pancreatic islet cells disarray, apoptosis, and proliferation in obese mice. The role of Semaglutide treatment. Biochimie. 2021-11-12. PMID:34742857. |
pancreatic islet hypertrophy was observed with alpha- and beta-cell remodeling, cell disarray, and apoptosis. |
2021-11-12 |
2023-08-13 |
mouse |
| Mengjing Xiao, Xiaofang Zou, Bin Li, Bo Zhan. Long non-coding RNA H19 promotes the proliferation, migration and invasion while inhibits apoptosis of hypertrophic scarring fibroblasts by targeting miR-3187-3p/GAB1 axis. Burns : journal of the International Society for Burn Injuries. vol 47. issue 3. 2021-11-09. PMID:32888745. |
long non-coding rna h19 promotes the proliferation, migration and invasion while inhibits apoptosis of hypertrophic scarring fibroblasts by targeting mir-3187-3p/gab1 axis. |
2021-11-09 |
2023-08-13 |
Not clear |
| Hui Song Cui, So Young Joo, Yoon Soo Cho, Ji Heon Park, Yu Mi Ro, June-Bum Kim, Cheong Hoon Se. Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34453089. |
keratinocytes derived from hypertrophic scar tissue were cultured and expression of proliferation markers (keratin 5 and 14), activation markers (keratin 6 and 17), differentiation markers (keratin 1, 10, and involucrin), apoptosis factors (bax, bcl2, and caspase 14), and proliferation/differentiation regulators (p21 and p27) was investigated to compared with that of those in keratinocytes derived from normal skin tissue. |
2021-11-08 |
2023-08-13 |
human |
| Xingwang Deng, Fang Zhao, Dan Zhao, Qing Zhang, Yongzhao Zhu, Qian Chen, Lijuan Qiang, Nan Xie, Jiaxiang Ma, Xiaoliang Pan, Yinsheng Wu, Lifeng Guan, Yan Xi. Oxymatrine promotes hypertrophic scar repair through reduced human scar fibroblast viability, collagen and induced apoptosis via autophagy inhibition. International wound journal. 2021-11-08. PMID:34749441. |
oxymatrine promotes hypertrophic scar repair through reduced human scar fibroblast viability, collagen and induced apoptosis via autophagy inhibition. |
2021-11-08 |
2023-08-13 |
human |
| Xingwang Deng, Fang Zhao, Dan Zhao, Qing Zhang, Yongzhao Zhu, Qian Chen, Lijuan Qiang, Nan Xie, Jiaxiang Ma, Xiaoliang Pan, Yinsheng Wu, Lifeng Guan, Yan Xi. Oxymatrine promotes hypertrophic scar repair through reduced human scar fibroblast viability, collagen and induced apoptosis via autophagy inhibition. International wound journal. 2021-11-08. PMID:34749441. |
in summary, oxymatrine promoted hypertrophic scar repair by decreasing hsf viability and collagen, and inducing apoptosis via autophagy inhibition. |
2021-11-08 |
2023-08-13 |
human |
| Ziguang Song, Xiao Zhong, Mingyang Li, Pingping Gao, Zhongping Ning, Zhiqi Sun, Xiang Son. 1-MNA Ameliorates High Fat Diet-Induced Heart Injury by Upregulating Nrf2 Expression and Inhibiting NF-κB Frontiers in cardiovascular medicine. vol 8. 2021-10-30. PMID:34712707. |
we found a significantly higher level of reactive oxygen species, inflammation, apoptosis, and cell hypertrophy in pa-treated h9c2 cells and this effect was inhibited by 1-mna treatment. |
2021-10-30 |
2023-08-13 |
mouse |
| Takeshi Tsud. Clinical Assessment of Ventricular Wall Stress in Understanding Compensatory Hypertrophic Response and Maladaptive Ventricular Remodeling. Journal of cardiovascular development and disease. vol 8. issue 10. 2021-10-26. PMID:34677191. |
although hypertrophy is an adaptive response to increased biomechanical stress, persistent hypertrophic stimulation forces the stressed myocardium into a progressive maladaptive process called ventricular remodeling, consisting of ventricular dilatation and dysfunction in conjunction with the development of myocyte hypertrophy, apoptosis, and fibrosis. |
2021-10-26 |
2023-08-13 |
Not clear |
| Mitchel Tate, Nimna Perera, Darnel Prakoso, Andrew M Willis, Minh Deo, Osezua Oseghale, Hongwei Qian, Daniel G Donner, Helen Kiriazis, Miles J De Blasio, Paul Gregorevic, Rebecca H Ritchi. Bone Morphogenetic Protein 7 Gene Delivery Improves Cardiac Structure and Function in a Murine Model of Diabetic Cardiomyopathy. Frontiers in pharmacology. vol 12. 2021-10-26. PMID:34690762. |
this was associated with a reduction in cardiac fibrosis, cardiomyocyte hypertrophy and cardiomyocyte apoptosis. |
2021-10-26 |
2023-08-13 |
mouse |
| Ali H Zahalka, N Patrik Brodin, Maria Maryanovich, Xizhe Wang, Kara L Watts, Sandra Pinho, Chandan Guha, Paul S Frenett. Using CT-guided stereotactic prostate radiation therapy (CT-SPRT) to assess sustained murine prostate ablation. Scientific reports. vol 11. issue 1. 2021-10-25. PMID:33753857. |
androgen deprivation therapy leads to apoptosis of prostatic cells and organ regression, and is a cornerstone of prostate cancer and benign prostatic hypertrophy treatment. |
2021-10-25 |
2023-08-13 |
mouse |
| Dongqi An, Qingchun Zeng, Peijian Zhang, Zhuang Ma, Hao Zhang, Zuheng Liu, Jiaying Li, Hao Ren, Dingli X. Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice. Redox biology. vol 46. 2021-10-25. PMID:34364218. |
akg supplementation inhibited pressure overload-induced myocardial hypertrophy and fibrosis and improved cardiac systolic dysfunction; in vitro, akg decreased the ang ii-induced upregulation of β-mhc and anp, reduced ros production and cardiomyocyte apoptosis, and repaired ang ii-mediated injury to the mitochondrial membrane potential (mmp). |
2021-10-25 |
2023-08-13 |
mouse |
| Lei Han, Minggao Li, Xin Li. Effects of long-term atorvastatin treatment on cardiac aging. Experimental and therapeutic medicine. vol 6. issue 3. 2021-10-21. PMID:24137254. |
in general, long-term avt treatment reduces blood lipids, inhibits cardiac hypertrophy, suppresses cardiomyocyte apoptosis and lowers the level of oxidative stress to protect the heart from aging. |
2021-10-21 |
2023-08-12 |
rat |
| F L Jiang, S Leo, X G Wang, H Li, L Y Gong, Y Kuang, X F X. Effect of tanshinone IIA on cardiomyocyte hypertrophy and apoptosis in spontaneously hypertensive rats. Experimental and therapeutic medicine. vol 6. issue 6. 2021-10-21. PMID:24255684. |
effect of tanshinone iia on cardiomyocyte hypertrophy and apoptosis in spontaneously hypertensive rats. |
2021-10-21 |
2023-08-12 |
rat |
| Heng Zhou, Yuan Yuan, Yuan Liu, Wei Deng, Jing Zong, Zhou-Yan Bian, Jia Dai, Qi-Zhu Tan. Icariin attenuates angiotensin II-induced hypertrophy and apoptosis in H9c2 cardiomyocytes by inhibiting reactive oxygen species-dependent JNK and p38 pathways. Experimental and therapeutic medicine. vol 7. issue 5. 2021-10-21. PMID:24940396. |
icariin attenuates angiotensin ii-induced hypertrophy and apoptosis in h9c2 cardiomyocytes by inhibiting reactive oxygen species-dependent jnk and p38 pathways. |
2021-10-21 |
2023-08-13 |
rat |
| Heng Zhou, Yuan Yuan, Yuan Liu, Wei Deng, Jing Zong, Zhou-Yan Bian, Jia Dai, Qi-Zhu Tan. Icariin attenuates angiotensin II-induced hypertrophy and apoptosis in H9c2 cardiomyocytes by inhibiting reactive oxygen species-dependent JNK and p38 pathways. Experimental and therapeutic medicine. vol 7. issue 5. 2021-10-21. PMID:24940396. |
therefore, the results of the present study indicated that icariin protected h9c2 cardiomyocytes from ang ii-induced hypertrophy and apoptosis by inhibiting the ros-dependent jnk and p38 pathways. |
2021-10-21 |
2023-08-13 |
rat |
| Qun Lu, Shaohong Luo, Yongfang We. Effect of ligustilide on Ang II-induced hypertrophy in cardiomyocytes and the potential mechanisms. Experimental and therapeutic medicine. vol 8. issue 1. 2021-10-21. PMID:24944617. |
therefore, lig can prevent the hypertrophy of cardiomyocytes induced by ang ii, which may be associated with the inhibitory effect that lig exhibits on cardiomyocyte apoptosis. |
2021-10-21 |
2023-08-13 |
rat |