| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huilin Qu, Yue Zhang, Wei Zhang, Yaxin Zhu, Ruixia X. Knockout of Cardiac Troponin I-Interacting Kinase leads to cardiac dysfunction and remodeling. Clinical and experimental pharmacology & physiology. 2022-07-05. PMID:35781726. |
tnni3k-cko mice exhibited cardiac hypertrophy, cardiac fibrosis, and cardiomyocyte apoptosis. |
2022-07-05 |
2023-08-14 |
mouse |
| Yueh-Min Lin, Jiro Hasegawa Situmorang, Jia-Zun Guan, Dennis Jine-Yuan Hsieh, Jaw-Ji Yang, Michael Yu-Chih Chen, Ching-Hui Loh, Chia-Hua Kuo, Shang-Yeh Lu, Ying-Ming Liou, Chih-Yang Huan. ZAKβ Alleviates Oxidized Low-density Lipoprotein (ox-LDL)-Induced Apoptosis and B-type Natriuretic Peptide (BNP) Upregulation in Cardiomyoblast. Cell biochemistry and biophysics. 2022-07-01. PMID:35776316. |
our previous study serendipitously found opposite effects of zakα and zakβ in which zakβ antagonizes zakα-induced apoptosis and hypertrophy of the heart. |
2022-07-01 |
2023-08-14 |
Not clear |
| Yueh-Min Lin, Jiro Hasegawa Situmorang, Jia-Zun Guan, Dennis Jine-Yuan Hsieh, Jaw-Ji Yang, Michael Yu-Chih Chen, Ching-Hui Loh, Chia-Hua Kuo, Shang-Yeh Lu, Ying-Ming Liou, Chih-Yang Huan. ZAKβ Alleviates Oxidized Low-density Lipoprotein (ox-LDL)-Induced Apoptosis and B-type Natriuretic Peptide (BNP) Upregulation in Cardiomyoblast. Cell biochemistry and biophysics. 2022-07-01. PMID:35776316. |
western blot was used to detect apoptosis, hypertrophy, and pro-survival signaling proteins. |
2022-07-01 |
2023-08-14 |
Not clear |
| Yueh-Min Lin, Jiro Hasegawa Situmorang, Jia-Zun Guan, Dennis Jine-Yuan Hsieh, Jaw-Ji Yang, Michael Yu-Chih Chen, Ching-Hui Loh, Chia-Hua Kuo, Shang-Yeh Lu, Ying-Ming Liou, Chih-Yang Huan. ZAKβ Alleviates Oxidized Low-density Lipoprotein (ox-LDL)-Induced Apoptosis and B-type Natriuretic Peptide (BNP) Upregulation in Cardiomyoblast. Cell biochemistry and biophysics. 2022-07-01. PMID:35776316. |
furthermore, ox-ldl increases cleaved caspase-3, cleaved caspase-9 as indicators of apoptosis and increases b-type natriuretic peptide (bnp) as an indicator of hypertrophy. |
2022-07-01 |
2023-08-14 |
Not clear |
| Qiang Liu, Chenjun Han, Xiaoyun Wu, Jian Zhou, Wangfu Zan. F-box and WD repeat-containing protein 7 ameliorates angiotensin II-induced myocardial hypertrophic injury via the mTOR-mediated autophagy pathway. Experimental and therapeutic medicine. vol 24. issue 1. 2022-06-24. PMID:35747152. |
fbw7 overexpression promoted the cell viability, inhibited ang ii-induced apoptosis, cellular hypertrophy and fibrosis in h9c2 cells via the autophagic pathway, as well as inflammation and oxidative stress. |
2022-06-24 |
2023-08-14 |
Not clear |
| João Antonio Celestino Dos Santos, Allice Santos Cruz Veras, Victor Rogério Garcia Batista, Maria Eduarda Almeida Tavares, Rafael Ribeiro Correia, Cara Beth Suggett, Giovana Rampazzo Teixeir. Physical exercise and the functions of microRNAs. Life sciences. 2022-06-19. PMID:35718233. |
it is well established that physical exercise promotes various benefits in the human body such as muscle hypertrophy, mental health improvement, cellular apoptosis, weight loss, and inhibition of cell proliferation. |
2022-06-19 |
2023-08-14 |
human |
| Fei-Fei Yang, Jin-Zhu Zhou, Xue-Li Xu, Ting Hu, Jian-Quan Liu, Ya-Xi Wu, Bo Wei, Li-Ying M. Discovery of 1,3,4-oxadiazole derivatives containing a bisamide moiety as a novel class of potential cardioprotective agents. European journal of medicinal chemistry. vol 239. 2022-06-18. PMID:35716515. |
preliminary mechanistic studies showed compound 12d could decrease the expression of cardiac hypertrophy and oxidative stress-related proteins/genes and reduce mitochondria-mediated cell apoptosis, thereby enhancing the cell vitality of injured cardiomyocytes. |
2022-06-18 |
2023-08-14 |
Not clear |
| Yunxian Dong, Dongming Lv, Zirui Zhao, Zhongye Xu, Zhicheng Hu, Bing Tan. Lycorine Inhibits Hypertrophic Scar Formation by Inducing ROS-Mediated Apoptosis. Frontiers in bioengineering and biotechnology. vol 10. 2022-06-10. PMID:35685086. |
lycorine inhibits hypertrophic scar formation by inducing ros-mediated apoptosis. |
2022-06-10 |
2023-08-14 |
Not clear |
| Prasad Chunduri, Shrey A Patel, Scott P Levic. Relaxin/serelaxin for cardiac dysfunction and heart failure in hypertension. Advances in pharmacology (San Diego, Calif.). vol 94. 2022-06-06. PMID:35659372. |
many pre-clinical animal studies have demonstrated a beneficial effect of exogenous relaxin on adverse cardiac remodeling including inflammation, fibrosis, cardiomyocyte hypertrophy and apoptosis, as well as effects on cardiac contractile function. |
2022-06-06 |
2023-08-14 |
Not clear |
| Toshihisa Komor. Whole Aspect of Runx2 Functions in Skeletal Development. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628587. |
runx2 inhibits the apoptosis of the terminal hypertrophic chondrocytes and induces their transdifferentiation into osteoblasts and osteoblast progenitors. |
2022-05-28 |
2023-08-13 |
mouse |
| R E Kostiv, N Yu Matveeva, S G Kalinichenk. Localization of VEGF, TGF-β1, BMP-2, and Apoptosis Factors in Hypertrophic Nonunion of Human Tubular Bones. Bulletin of experimental biology and medicine. 2022-05-27. PMID:35624354. |
localization of vegf, tgf-β1, bmp-2, and apoptosis factors in hypertrophic nonunion of human tubular bones. |
2022-05-27 |
2023-08-13 |
human |
| C Wang, W Chen, B J Wan. [Regulatory effects and signaling mechanism of sodium ferulate on the proliferation and apoptosis of human skin hypertrophic scar fibroblasts]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 38. issue 5. 2022-05-23. PMID:35599423. |
[regulatory effects and signaling mechanism of sodium ferulate on the proliferation and apoptosis of human skin hypertrophic scar fibroblasts]. |
2022-05-23 |
2023-08-13 |
human |
| Yong Zeng, Hong-Xia Wang, Shu-Bin Guo, Hui Yang, Xiang-Jun Zeng, Quan Fang, Chao-Shu Tang, Jie Du, Hui-Hua L. Correction: Transcriptional Effects of E3 Ligase Atrogin-1/MAFbx on Apoptosis, Hypertrophy and Inflammation in Neonatal Rat Cardiomyocytes. PloS one. vol 17. issue 4. 2022-04-27. PMID:35476811. |
correction: transcriptional effects of e3 ligase atrogin-1/mafbx on apoptosis, hypertrophy and inflammation in neonatal rat cardiomyocytes. |
2022-04-27 |
2023-08-13 |
rat |
| Jingci Xing, Wei Ji. Methyltransferase SET domain family and its relationship with cardiovascular development and diseases. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 50. issue 7. 2022-04-24. PMID:35462466. |
the setd family has the following regulatory effects on cardiovascular development and diseases: regulating coronary artery formation and cardiac development; protecting cardiac tissue from ischemia reperfusion injury; regulating inflammation, oxidative stress and apoptosis in cardiovascular complications of diabetes; participating in the formation of pulmonary hypertension; regulating thrombosis, cardiac hypertrophy and arrhythmia. |
2022-04-24 |
2023-08-13 |
Not clear |
| Yaeni Kim, Ji Hee Lim, Eun Nim Kim, Yu Ah Hong, Hun-Jun Park, Sungjin Chung, Bum Soon Choi, Yong-Soo Kim, Ji Yong Park, Hye Won Kim, Cheol Whee Par. Adiponectin receptor agonist ameliorates cardiac lipotoxicity via enhancing ceramide metabolism in type 2 diabetic mice. Cell death & disease. vol 13. issue 3. 2022-03-30. PMID:35351872. |
adiporon might control oxidative stress, inflammation, and apoptosis in the heart through increased adipor expression, acid ceramidase activity, and activation of ampk-pparα/pgc-1α and related downstream pathways, collectively improving cardiac lipid metabolism, hypertrophy, and functional parameters. |
2022-03-30 |
2023-08-13 |
mouse |
| Nancy P Gómez-Crisóstomo, Selva Rivas-Arancibia, Erika Rodríguez-Martínez, Erick N De la Cruz-Hernández, Corazón de María Márquez Álvarez, Pablo Alexis Estrada Caraveo, Noemí Gelista Herrera, Marlen Valdés-Fuentes, Eduardo Martínez-Abundi. Chronic exposition to ozone induces cardiac antioxidant response and overexpression of either mitochondrial fision protein DRP1 and hipertrophyc-related proteins. Journal of bioenergetics and biomembranes. 2022-03-29. PMID:35347511. |
our study aimed to evaluate the effect of chronic exposition of rats to controlled low doses of ozone on oxidative stress, apoptosis, mitochondrial dynamics, and cardiac hypertrophy. |
2022-03-29 |
2023-08-13 |
rat |
| Nancy P Gómez-Crisóstomo, Selva Rivas-Arancibia, Erika Rodríguez-Martínez, Erick N De la Cruz-Hernández, Corazón de María Márquez Álvarez, Pablo Alexis Estrada Caraveo, Noemí Gelista Herrera, Marlen Valdés-Fuentes, Eduardo Martínez-Abundi. Chronic exposition to ozone induces cardiac antioxidant response and overexpression of either mitochondrial fision protein DRP1 and hipertrophyc-related proteins. Journal of bioenergetics and biomembranes. 2022-03-29. PMID:35347511. |
oxidative stress was evaluated by tbars and protein nitrosylation in addition to superoxide dismutase 1 (sod1) and catalase levels; the apoptosis related-proteins caspase 3, caspase 9, bax, bcl-2, and the mitochondrial dynamic-associated proteins fis1, drp1, opa1, and mfn1 were quantified by western blot among the cardiac hypertrophy indicator alpha-actin (cardiac actin). |
2022-03-29 |
2023-08-13 |
rat |
| Bharathi Priya Lohanathan, Baskaran Rathinasamy, Chih-Yang Huang, Vijaya Padma Viswanadh. Neferine attenuates doxorubicin-induced fibrosis and hypertrophy in H9c2 cells. Journal of biochemical and molecular toxicology. 2022-03-29. PMID:35347819. |
pretreatment with neferine markedly activated sirt1 expression and modulated the expression levels of tgf-β1 and p53, thereby significantly reducing dox-induced fibrosis, hypertrophy, and apoptosis in h9c2 cardiomyoblasts. |
2022-03-29 |
2023-08-13 |
Not clear |
| Pranav Ramesh, Jian L Yeo, Emer M Brady, Gerry P McCan. Role of inflammation in diabetic cardiomyopathy. Therapeutic advances in endocrinology and metabolism. vol 13. 2022-03-21. PMID:35308180. |
chronic myocardial inflammation in t2d mediates structural and metabolic changes, including cardiomyocyte apoptosis, impaired calcium handling, myocardial hypertrophy and fibrosis, all of which contribute to the diabetic hf phenotype. |
2022-03-21 |
2023-08-13 |
Not clear |
| Qin Guo, Yujia Li, Yuan Chen, Jin Ji, Shizhong Zheng, Xuefen Xu, Biyun Zhang, Jianzhou Y. β-Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts. IUBMB life. 2022-03-16. PMID:35294085. |
β-elemene induces apoptosis by activating the p53 pathway in human hypertrophic scar fibroblasts. |
2022-03-16 |
2023-08-13 |
human |