| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yebei Li, Gaosi X. Sodium Glucose Cotransporter 1 (SGLT1) Inhibitors in Cardiovascular Protection: Mechanism Progresses and Challenges. Pharmacological research. 2021-12-31. PMID:34971725. |
to explain the cardiovascular protective effects of sglt1 inhibitors, several potential arguments have been proposed, including decreasing oxidative stress, regulating cardiac glucose uptake, preventing ischemia/reperfusion injury, alleviating the activation of cardiac fibroblasts, attenuating apoptosis, reducing intermittent high glucose-induced pyroptosis, ameliorating cardiac hypertrophy, attenuating arrhythmic vulnerabilities, and improving left ventricular systolic disorder. |
2021-12-31 |
2023-08-13 |
Not clear |
| Chrishan S Samuel, Robert G Bennet. Relaxin as an anti-fibrotic treatment: perspectives, challenges and future directions. Biochemical pharmacology. 2021-12-30. PMID:34968489. |
this review outlines the broad anti-fibrotic and related organ-protective roles of relaxin, mainly from studies conducted in preclinical models of ageing and fibrotic disease, including its ability to ameliorate several aspects of fibrosis progression and maturation, from immune cell infiltration, pro-inflammatory and pro-fibrotic cytokine secretion, oxidative stress, organ hypertrophy, cell apoptosis, myofibroblast differentiation and ecm production, to its ability to facilitate established ecm degradation. |
2021-12-30 |
2023-08-13 |
human |
| Hongxia Jiang, Yang Niu, Yuanzhou He, Xiaochen Li, Yongjian Xu, Xiansheng Li. Proteomic analysis reveals that Xbp1s promotes hypoxic pulmonary hypertension through the p-JNK MAPK pathway. Journal of cellular physiology. 2021-12-29. PMID:34964131. |
adeno-associated virus (aav) serotype 1-mediated xbp1s knockdown in the prevention and therapy groups significantly reduced right ventricular systolic pressure, total pulmonary resistance, right ventricular hypertrophy, and the medial wall thickness of muscularized distal pulmonary arterioles; aav-xbp1s also decreased proliferating cell nuclear antigen expression and increased apoptosis in pulmonary arterioles. |
2021-12-29 |
2023-08-13 |
rat |
| Jiabing Zhan, Chen Chen, Dao Wen Wang, Huaping L. Hyperglycemic memory in diabetic cardiomyopathy. Frontiers of medicine. 2021-12-18. PMID:34921674. |
hyperglycemia is a symptom that abnormally activates multiple downstream pathways and contributes to cardiac hypertrophy, fibrosis, apoptosis, and other pathophysiological changes. |
2021-12-18 |
2023-08-13 |
Not clear |
| Dan Li, Ying-Ying Guo, Xian-Feng Cen, Hong-Liang Qiu, Si Chen, Xiao-Feng Zeng, Qian Zeng, Man Xu, Qi-Zhu Tan. Lupeol protects against cardiac hypertrophy via TLR4-PI3K-Akt-NF-κB pathways. Acta pharmacologica Sinica. 2021-12-17. PMID:34916609. |
inflammation and apoptosis are main pathological processes that lead to the development of cardiac hypertrophy. |
2021-12-17 |
2023-08-13 |
mouse |
| Jiten Patel, Jose Torrealba, Emilio Poggio, Jack Bebiak, Charles Alpers, Stephanie Grewenow, Robert Toto, Michael Eado. Molecular Signatures of Diabetic Kidney Disease Hiding in a Patient with Hypertension-Related Kidney Disease. Clinical journal of the American Society of Nephrology : CJASN. 2021-12-16. PMID:34911732. |
the molecular signatures uncovered revealed evidence of early dkd adaptation and ongoing active tubular injury with enriched pathways related to mesangial cell hypertrophy, glycosaminoglycan biosynthesis, and apoptosis. |
2021-12-16 |
2023-08-13 |
Not clear |
| Dieter Haffner, Maren Leifheit-Nestler, Andrea Grund, Dirk Schnabe. Rickets guidance: part I-diagnostic workup. Pediatric nephrology (Berlin, Germany). 2021-12-15. PMID:34910242. |
rickets is a disease of the growing child arising from alterations in calcium and phosphate homeostasis resulting in impaired apoptosis of hypertrophic chondrocytes in the growth plate. |
2021-12-15 |
2023-08-13 |
Not clear |
| Dan Shao, Peiyong Zhai, Chengchen Hu, Risa Mukai, Sebastiano Sciarretta, Dominic Del Re, Junichi Sadoshim. Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload. Scientific reports. vol 11. issue 1. 2021-12-12. PMID:34873220. |
lats2 stimulates apoptosis and negatively affects hypertrophy in cardiomyocytes. |
2021-12-12 |
2023-08-13 |
mouse |
| Dan Shao, Peiyong Zhai, Chengchen Hu, Risa Mukai, Sebastiano Sciarretta, Dominic Del Re, Junichi Sadoshim. Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload. Scientific reports. vol 11. issue 1. 2021-12-12. PMID:34873220. |
cardiac hypertrophy and dysfunction induced by 4 weeks of tac were attenuated in lats2 +/- mice, and interstitial fibrosis and apoptosis were suppressed. |
2021-12-12 |
2023-08-13 |
mouse |
| Jarmon G Lees, Marek Napierala, Alice Pébay, Mirella Dottori, Shiang Y Li. Cellular pathophysiology of Friedreich's ataxia cardiomyopathy. International journal of cardiology. vol 346. 2021-12-08. PMID:34798207. |
at the cellular level, cardiomyocyte hypertrophy, apoptosis and fibrosis contribute to the cardiac pathology. |
2021-12-08 |
2023-08-13 |
Not clear |
| Amrita Sarkar, Sanket K Shukla, Aseel Alqatawni, Anil Kumar, Sankar Addya, Alexander Y Tsygankov, Khadija Rafi. The Role of Allograft Inflammatory Factor-1 in the Effects of Experimental Diabetes on B Cell Functions in the Heart. Frontiers in cardiovascular medicine. vol 5. 2021-12-06. PMID:30258845. |
diabetes mellitus (dm) often causes chronic inflammation, hypertrophy, apoptosis and fibrosis in the heart and subsequently leads to myocardial remodeling, deteriorated cardiac function and heart failure. |
2021-12-06 |
2023-08-13 |
mouse |
| Arun K Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Mukesh Nandave, Hanan Haga. Crosstalk between GSK-3β-actuated molecular cascades and myocardial physiology. Heart failure reviews. vol 26. issue 6. 2021-12-02. PMID:32314086. |
the current study focuses on its expanding therapeutic action in myocardial tissue, concentrating primarily on its role in diabetes-associated cardiac complication, apoptosis and metabolism, heart failure, cardiac hypertrophy, and myocardial infarction. |
2021-12-02 |
2023-08-13 |
Not clear |
| He Cai, Yunxia Liu, Hongbo Men, Yang Zhen. Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases. Frontiers in endocrinology. vol 12. 2021-12-01. PMID:34177809. |
oxidative stress is involved in the pathogenesis of aging-related cardiovascular diseases (acvd), such as atherosclerosis, myocardial infarction, and heart failure, by contributing to apoptosis, hypertrophy, and fibrosis. |
2021-12-01 |
2023-08-13 |
Not clear |
| Magali Samia El Hayek, Laura Ernande, Jean-Pierre Benitah, Ana-Maria Gomez, Laetitia Pereir. The role of hyperglycaemia in the development of diabetic cardiomyopathy. Archives of cardiovascular diseases. vol 114. issue 11. 2021-12-01. PMID:34627704. |
these mechanisms are responsible for the activation of hypertrophic pathways, epigenetic modifications, mitochondrial dysfunction, cell apoptosis, fibrosis and calcium mishandling, leading to cardiac stiffness, as well as contractile and relaxation dysfunction. |
2021-12-01 |
2023-08-13 |
Not clear |
| Jun-Xiu Lu, Yue Qiu, Li-Juan Guo, Ping Song, Jian Xu, Guang-Rui Wan, Shuang-Xi Wang, Ya-Ling Yin, Peng L. Potential Therapeutic Effect of Citronellal on Diabetic Cardiomyopathy in Experimental Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-11-30. PMID:34840590. |
the dcm rats in the nontreatment group experienced diastolic and systolic dysfunctions, associated with myocardial hypertrophy, fibrosis, and cardiomyocyte apoptosis. |
2021-11-30 |
2023-08-13 |
rat |
| Jun-Xiu Lu, Yue Qiu, Li-Juan Guo, Ping Song, Jian Xu, Guang-Rui Wan, Shuang-Xi Wang, Ya-Ling Yin, Peng L. Potential Therapeutic Effect of Citronellal on Diabetic Cardiomyopathy in Experimental Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-11-30. PMID:34840590. |
myocardial hypertrophy, fibrosis, oxidative stress, and cell apoptosis were obviously inhibited after treatment with ct (150 mg/kg/day). |
2021-11-30 |
2023-08-13 |
rat |
| Dylan O'Toole, Ali Abdullah I Zaeri, Stuart A Nicklin, Anne T French, Christopher M Loughrey, Tamara P Marti. Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling. Cellular signalling. vol 76. 2021-11-29. PMID:32891693. |
cysteine cathepsins contribute to key signalling pathways involved in adverse cardiac remodelling including synthesis and degradation of the cardiac extracellular matrix (ecm), cardiomyocyte hypertrophy, impaired cardiomyocyte contractility and apoptosis. |
2021-11-29 |
2023-08-13 |
Not clear |
| Donato Cappetta, Oxana Bereshchenko, Eleonora Cianflone, Francesco Rossi, Carlo Riccardi, Daniele Torella, Liberato Berrino, Konrad Urbanek, Antonella De Angelis, Stefano Bruscol. Glucocorticoid-Induced Leucine Zipper (GILZ) in Cardiovascular Health and Disease. Cells. vol 10. issue 8. 2021-11-29. PMID:34440924. |
gilz also has the capacity to protect myocardial cells, as its deletion makes the heart, after a deleterious stimulus, more susceptible to apoptosis, immune cell infiltration, hypertrophy, and impaired function. |
2021-11-29 |
2023-08-13 |
Not clear |
| Meixu Wan, Kunkun Yin, Jing Yuan, Shiyan Ma, Qing Xu, Dekun Li, Hui Gao, Xiangbo Go. YQFM alleviated cardiac hypertrophy by apoptosis inhibition and autophagy regulation via PI Journal of ethnopharmacology. 2021-11-24. PMID:34798161. |
yqfm alleviated cardiac hypertrophy by apoptosis inhibition and autophagy regulation via pi as a traditional compound preparation of chinese medicine, yiqi fumai lyophilized injection (yqfm) has protective effects on various cardiac diseases including cardiac hypertrophy, which is the primary cause of arrhythmia. |
2021-11-24 |
2023-08-13 |
Not clear |
| Xiaoyu Liu, Bingyan Guo, Wei Zhang, Bocong Ma, Yongjun L. MiR-20a-5p overexpression prevented diabetic cardiomyopathy via inhibition of cardiomyocyte apoptosis, hypertrophy, fibrosis and JNK/NF-κB signalling pathway. Journal of biochemistry. vol 170. issue 3. 2021-11-23. PMID:33837411. |
mir-20a-5p overexpression prevented diabetic cardiomyopathy via inhibition of cardiomyocyte apoptosis, hypertrophy, fibrosis and jnk/nf-κb signalling pathway. |
2021-11-23 |
2023-08-13 |
mouse |