| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emily Shih, John J Squiers, Jacob Turner, Michael DiMaio, William T Brinkman, Robert L Smit. Differential gene expression in patients with primary mitral valve disease: identifying potential therapeutic targets in the era of precision medicine. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 68. issue 7. 2021-09-29. PMID:32895229. |
these five networks have been previously implicated in pathophysiological cardiac abnormalities, including inhibited contractility of the heart and fatty acid oxidation as well as activation of apoptosis of smooth muscle cells, cardiac degeneration, and hypertrophy of cardiac cells. |
2021-09-29 |
2023-08-13 |
Not clear |
| Elizabeth Allmon, Jennifer Serafin, Shuai Chen, Danielle Simning, Robert Griffitt, Thijs Bosker, Sylvain De Guise, Maria S Sepúlved. The influence of hypoxia on the cardiac transcriptomes of two estuarine species - C. variegatus and F. grandis. Comparative biochemistry and physiology. Part D, Genomics & proteomics. vol 39. 2021-09-24. PMID:33892309. |
results suggest that while differential gene expression is largely distinct between the two species, downstream impacts on pathways and functional responses such as reduced cardiac hypertrophy, modulation of blood pressure, and increased incidence of apoptosis appear to be conserved. |
2021-09-24 |
2023-08-13 |
Not clear |
| Li Jiang, Xiaoyan Wang, Xiaopeng Zhan, Sheng Kang, Haibo Liu, Yu Luo, Li Li. Advance in circular RNA modulation effects of heart failure. Gene. vol 763S. 2021-09-24. PMID:34493370. |
recently, circrnas have been demonstrated to play crucial roles in cardiomyocyte hypertrophy, fibrosis, autophagy and apoptosis, participating in the development of heart failure. |
2021-09-24 |
2023-08-13 |
Not clear |
| Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D Upton, Sonja Loges, Nicholas W Morrell, Werner Seeger, Ralph T Schermul. Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2. Communications biology. vol 4. issue 1. 2021-09-23. PMID:34429509. |
in vivo r428 aggravated right ventricular hypertrophy and dysfunction, abrogated bmpr2 signaling, elevated pulmonary endothelial cell apoptosis and loss. |
2021-09-23 |
2023-08-13 |
rat |
| Tianqi Zhang, Yingying Tian, Qinghui Wang, Meng Fu, Changhu Xue, Jingfeng Wan. Comparative Study of DHA with Different Molecular Forms for Ameliorating Osteoporosis by Promoting Chondrocyte-to-Osteoblast Transdifferentiation in the Growth Plate of Ovariectomized Mice. Journal of agricultural and food chemistry. vol 69. issue 36. 2021-09-16. PMID:34464107. |
apoptosis was not the only fate of hypertrophic chondrocytes. |
2021-09-16 |
2023-08-13 |
mouse |
| Donato Cappetta, Antonella De Angelis, Sara Flamini, Anna Cozzolino, Oxana Bereshchenko, Simona Ronchetti, Eleonora Cianflone, Andrea Gagliardi, Erika Ricci, Concetta Rafaniello, Francesco Rossi, Carlo Riccardi, Liberato Berrino, Stefano Bruscoli, Konrad Urbane. Deficit of glucocorticoid-induced leucine zipper amplifies angiotensin-induced cardiomyocyte hypertrophy and diastolic dysfunction. Journal of cellular and molecular medicine. vol 25. issue 1. 2021-09-15. PMID:33247627. |
infusion of angiotensin ii (ang ii) resulted in myocardial dysfunction, inflammation, apoptosis, fibrosis, capillary rarefaction and hypertrophy. |
2021-09-15 |
2023-08-13 |
mouse |
| Yajuan Ni, Jie Deng, Xin Liu, Qing Li, Juanli Zhang, Hongyuan Bai, Jingwen Zhan. Echinacoside reverses myocardial remodeling and improves heart function via regulating SIRT1/FOXO3a/MnSOD axis in HF rats induced by isoproterenol. Journal of cellular and molecular medicine. vol 25. issue 1. 2021-09-15. PMID:33314649. |
myocardial remodelling is important pathological basis of hf, mitochondrial oxidative stress is a promoter to myocardial hypertrophy, fibrosis and apoptosis. |
2021-09-15 |
2023-08-13 |
rat |
| Yajuan Ni, Jie Deng, Xin Liu, Qing Li, Juanli Zhang, Hongyuan Bai, Jingwen Zhan. Echinacoside reverses myocardial remodeling and improves heart function via regulating SIRT1/FOXO3a/MnSOD axis in HF rats induced by isoproterenol. Journal of cellular and molecular medicine. vol 25. issue 1. 2021-09-15. PMID:33314649. |
indexes of heart function, myocardial remodelling, mitochondrial oxidative stress and function, expression of sirt1/foxo3a/mnsod signalling axis are measured, the data indicate that ech improves heart function, inhibits myocardial hypertrophy, fibrosis and apoptosis, increases the expression of sirt1/foxo3a/mnsod signalling axis, reduces the mitochondrial oxidative damages, protects mitochondrial function. |
2021-09-15 |
2023-08-13 |
rat |
| Takahisa Kawaguchi, Kazuhiro Hasegawa, Itaru Yasuda, Hirokazu Muraoka, Hiroyuki Umino, Hirobumi Tokuyama, Akinori Hashiguchi, Shu Wakino, Hiroshi Ito. Diabetic condition induces hypertrophy and vacuolization in glomerular parietal epithelial cells. Scientific reports. vol 11. issue 1. 2021-09-15. PMID:33452384. |
in cultured pecs, a high glucose condition, compared with normal glucose condition, induced cellular hypertrophy and apoptosis. |
2021-09-15 |
2023-08-13 |
mouse |
| Man Xu, Xue-Yuan Bi, Xiao-Rong Xue, Xing-Zhu Lu, Qiong-Ge Li, Qiang Jian, Jian-Yong Su. Activation of the M3AChR and Notch1/HSF1 Signaling Pathway by Choline Alleviates Angiotensin II-Induced Cardiomyocyte Apoptosis. Oxidative medicine and cellular longevity. vol 2021. 2021-09-11. PMID:34504645. |
angiotensin ii- (ang ii-) induced cardiac hypertrophy and apoptosis are major characteristics of early-stage heart failure. |
2021-09-11 |
2023-08-13 |
rat |
| Jung Joo Yoon, Chan Ok Son, Hye Yoom Kim, Byung Hyuk Han, Yun Jung Lee, Ho Sub Lee, Dae Gill Kan. Betulinic Acid Protects DOX-Triggered Cardiomyocyte Hypertrophy Response through the GATA-4/Calcineurin/NFAT Pathway. Molecules (Basel, Switzerland). vol 26. issue 1. 2021-09-08. PMID:33374365. |
however, there is no study about its direct effect on dox induced cardiac hypertrophy and apoptosis. |
2021-09-08 |
2023-08-13 |
Not clear |
| Jung Joo Yoon, Chan Ok Son, Hye Yoom Kim, Byung Hyuk Han, Yun Jung Lee, Ho Sub Lee, Dae Gill Kan. Betulinic Acid Protects DOX-Triggered Cardiomyocyte Hypertrophy Response through the GATA-4/Calcineurin/NFAT Pathway. Molecules (Basel, Switzerland). vol 26. issue 1. 2021-09-08. PMID:33374365. |
the present study aims to investigate the effect of ba on dox-induced cardiomyocyte hypertrophy and apoptosis in vitro in h9c2 cells. |
2021-09-08 |
2023-08-13 |
Not clear |
| Jung Joo Yoon, Chan Ok Son, Hye Yoom Kim, Byung Hyuk Han, Yun Jung Lee, Ho Sub Lee, Dae Gill Kan. Betulinic Acid Protects DOX-Triggered Cardiomyocyte Hypertrophy Response through the GATA-4/Calcineurin/NFAT Pathway. Molecules (Basel, Switzerland). vol 26. issue 1. 2021-09-08. PMID:33374365. |
therefore, ba can be a potential treatment for cardiomyocyte hypertrophy and apoptosis that lead to sudden heart failure. |
2021-09-08 |
2023-08-13 |
Not clear |
| Xi He, Si Yang, Juan Deng, Qing Wu, Wei-Jin Zan. Amelioration of circadian disruption and calcium-handling protein defects by choline alleviates cardiac remodeling in abdominal aorta coarctation rats. Laboratory investigation; a journal of technical methods and pathology. vol 101. issue 7. 2021-09-06. PMID:33649466. |
the key pathophysiological process leading to heart failure is cardiac remodeling, a term referring to cardiac hypertrophy, fibrosis, and apoptosis. |
2021-09-06 |
2023-08-13 |
rat |
| Jie Zhou, Jie Yang, Yu-Meng Wang, Hong Ding, Tu-Shuai Li, Zhi-Hong Liu, Li Chen, Rui-Qing Jiao, Dong-Mei Zhang, Ling-Dong Kon. IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation. Cellular signalling. vol 86. 2021-08-30. PMID:34252535. |
exogenous il-6 stimulation up-regulated il-6/stat3 signaling and mir-92a-3p, reduced p57 expression and promoted podocyte proliferation, apoptosis and hypertrophy in vitro. |
2021-08-30 |
2023-08-13 |
human |
| Jie Zhou, Jie Yang, Yu-Meng Wang, Hong Ding, Tu-Shuai Li, Zhi-Hong Liu, Li Chen, Rui-Qing Jiao, Dong-Mei Zhang, Ling-Dong Kon. IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation. Cellular signalling. vol 86. 2021-08-30. PMID:34252535. |
the data from anti-inflammatory agent maslinic acid treatment or ttp sirna transfection showed that high fructose may decrease ttp to activate il-6/stat3 signaling in podocyte overproliferation and apoptosis, causing podocyte hypertrophy. |
2021-08-30 |
2023-08-13 |
human |
| Jie Zhou, Jie Yang, Yu-Meng Wang, Hong Ding, Tu-Shuai Li, Zhi-Hong Liu, Li Chen, Rui-Qing Jiao, Dong-Mei Zhang, Ling-Dong Kon. IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation. Cellular signalling. vol 86. 2021-08-30. PMID:34252535. |
whereas, khk-a sirna transfection remarkably restored high fructose-induced ttp down-regulation, il-6/stat3 signaling activation, podocyte overproliferation, apoptosis and hypertrophy in differentiated hpcs. |
2021-08-30 |
2023-08-13 |
human |
| Jie Zhou, Jie Yang, Yu-Meng Wang, Hong Ding, Tu-Shuai Li, Zhi-Hong Liu, Li Chen, Rui-Qing Jiao, Dong-Mei Zhang, Ling-Dong Kon. IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation. Cellular signalling. vol 86. 2021-08-30. PMID:34252535. |
taken together, these results suggested that high fructose possibly increased khk-a expression to down-regulate ttp, subsequently activated il-6/stat3 signaling to interfere with podocyte proliferation and apoptosis by up-regulating mir-92a-3p to suppress p57 expression, causing podocyte hypertrophy. |
2021-08-30 |
2023-08-13 |
human |
| Xingxu Wang, Wei Wei, Jian Wu, Le Kang, Shuangquan Wu, Jiming Li, Yunli Shen, Jieyun You, Yong Ye, Qi Zhang, Yunzeng Zo. Involvement of Endoplasmic Reticulum Stress-Mediated Activation of C/EBP Homologous Protein in Aortic Regurgitation-Induced Cardiac Remodeling in Mice. Journal of cardiovascular translational research. 2021-08-24. PMID:34426929. |
with a unique murine model of ar which induced eccentric cardiac hypertrophy and heart failure, we also found aggravation of cardiac er stress and apoptosis, as evidenced by a reduction of bcl-2/bax ratio and an increase of caspase-3 cleavage. |
2021-08-24 |
2023-08-13 |
mouse |
| Xingxu Wang, Wei Wei, Jian Wu, Le Kang, Shuangquan Wu, Jiming Li, Yunli Shen, Jieyun You, Yong Ye, Qi Zhang, Yunzeng Zo. Involvement of Endoplasmic Reticulum Stress-Mediated Activation of C/EBP Homologous Protein in Aortic Regurgitation-Induced Cardiac Remodeling in Mice. Journal of cardiovascular translational research. 2021-08-24. PMID:34426929. |
in summary, our findings suggest that er stress-chop signaling is involved in the development of volume overload cardiac hypertrophy induced by ar through promoting cardiomyocytes apoptosis and provide a previously unrecognized target in heart failure induced by volume overload. |
2021-08-24 |
2023-08-13 |
mouse |