| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simone V Bigi-Botterill, Anthony Ivetac, Erica L Bradshaw, Derek Cole, Douglas R Dougan, Jacques Ermolieff, Petro Halkowycz, Ben Johnson, Christopher McBride, Jason Pickens, Mark Sabat, Steven Swan. Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp Bioorganic & medicinal chemistry letters. vol 30. issue 17. 2021-06-08. PMID:32738982. |
structure-guided optimization of a novel class of ask1 inhibitors with increased sp apoptosis signal-regulating kinase-1 (ask1) is a known member of the mitogen-activated protein kinase kinase kinase (map3k) family and upon stimulation will activate the p38- and jnk-pathways leading to cardiac apoptosis, fibrosis, and hypertrophy. |
2021-06-08 |
2023-08-13 |
Not clear |
| Yang Yang, Ming Zhao, Xi He, Qing Wu, Dong-Ling Li, Wei-Jin Zan. Pyridostigmine Protects Against Diabetic Cardiomyopathy by Regulating Vagal Activity, Gut Microbiota, and Branched-Chain Amino Acid Catabolism in Diabetic Mice. Frontiers in pharmacology. vol 12. 2021-06-05. PMID:34084135. |
moreover, pyridostigmine alleviated abnormal mitochondrial structure; increased atp production; decreased reactive oxygen species and mitochondria-related apoptosis; and attenuated cardiac dysfunction, hypertrophy, and fibrosis in diabetic cardiomyopathy mice. |
2021-06-05 |
2023-08-13 |
mouse |
| Grace A Chappell, Chad M Thompson, Jeffrey C Wolf, John M Cullen, James E Klaunig, Laurie C Haw. Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks. Toxicologic pathology. vol 48. issue 3. 2021-06-04. PMID:32138627. |
these findings were phenotypically anchored to histopathological changes in the same tissue blocks: hypertrophy, mitoses, and apoptosis. |
2021-06-04 |
2023-08-13 |
mouse |
| Christoph Haller, Mark K Friedberg, Michael A Laflamm. The role of regenerative therapy in the treatment of right ventricular failure: a literature review. Stem cell research & therapy. vol 11. issue 1. 2021-05-27. PMID:33239066. |
in this review, we provide a comprehensive overview of the molecular mechanisms involved in rv failure such as hypertrophy, fibrosis, inflammation, changes in energy metabolism, calcium handling, decreasing rv contractility, and apoptosis. |
2021-05-27 |
2023-08-13 |
human |
| Yan Gao, Di Zhao, Wen-Zhi Xie, Tingting Meng, Chunxiao Xu, Yutong Liu, Pengfei Zhang, Xiuping Bi, Zhuo Zha. Rap1GAP Mediates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Inhibiting Autophagy and Increasing Oxidative Stress. Oxidative medicine and cellular longevity. vol 2021. 2021-05-19. PMID:33936386. |
overexpression of rap1gap in cultured cardiomyocytes exacerbated ang ii-induced cardiomyocyte hypertrophy, reactive oxygen species (ros) generation, and cell apoptosis and inhibited autophagy. |
2021-05-19 |
2023-08-13 |
rat |
| Júlia Chaumel, Merlind Schotte, Joseph J Bizzarro, Paul Zaslansky, Peter Fratzl, Daniel Baum, Mason N Dea. Co-aligned chondrocytes: Zonal morphological variation and structured arrangement of cell lacunae in tessellated cartilage. Bone. vol 134. 2021-05-17. PMID:32058019. |
our findings support previous hypotheses that elasmobranch chondrocytes, unlike those of other taxa, do not proliferate, hypertrophy or undergo apoptosis during mineralization. |
2021-05-17 |
2023-08-13 |
Not clear |
| Alicia Jurado Acosta, Jaana Rysä, Zoltan Szabo, Anne-Mari Moilanen, Raisa Serpi, Heikki Ruskoah. Phosphorylation of GATA4 at serine 105 is required for left ventricular remodelling process in angiotensin II-induced hypertension in rats. Basic & clinical pharmacology & toxicology. vol 127. issue 3. 2021-05-17. PMID:32060996. |
in angii-induced hypertension, gata4 overexpression repressed fibrotic gene expression, reversed the hypertrophic adult-to-foetal isoform switch of myofibrillar genes and prevented apoptosis, whereas histological fibrosis was not affected. |
2021-05-17 |
2023-08-13 |
rat |
| Abdul Haye, Mohd Asif Ansari, Syed Obaidur Rahman, Yasmeen Shamsi, Danish Ahmed, Manju Sharm. Role of AMP-activated protein kinase on cardio-metabolic abnormalities in the development of diabetic cardiomyopathy: A molecular landscape. European journal of pharmacology. vol 888. 2021-05-17. PMID:32810493. |
during the development and progression of diabetic cardiomyopathy, a plethora of evidence demonstrate the beneficial role of ampk on cardio-metabolic abnormalities including altered substrate utilization, impaired cardiac insulin metabolic signaling, mitochondrial dysfunction and oxidative stress, myocardial inflammation, increased accumulation of advanced glycation end-products, impaired cardiac calcium handling, maladaptive activation of the renin-angiotensin-aldosterone system, endoplasmic reticulum stress, myocardial fibrosis, ventricular hypertrophy, cardiac apoptosis, and impaired autophagy. |
2021-05-17 |
2023-08-13 |
Not clear |
| Feby Savira, Bing H Wang, Amanda J Edgley, Beat M Jucker, Robert N Willette, Henry Krum, Darren J Kelly, Andrew R Komp. Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome. International journal of cardiology. vol 310. 2021-05-14. PMID:32305147. |
inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome. |
2021-05-14 |
2023-08-13 |
rat |
| Fangyuan Sun, Gang Chen, Yingyao Yang, Ming Le. Fatty acid-binding protein 4 silencing protects against lipopolysaccharide-induced cardiomyocyte hypertrophy and apoptosis by inhibiting the Toll-like receptor 4-nuclear factor-κB pathway. The Journal of international medical research. vol 49. issue 3. 2021-05-14. PMID:33719658. |
fatty acid-binding protein 4 silencing protects against lipopolysaccharide-induced cardiomyocyte hypertrophy and apoptosis by inhibiting the toll-like receptor 4-nuclear factor-κb pathway. |
2021-05-14 |
2023-08-13 |
Not clear |
| Yanpeng Zhou, Xun Shi, Shengfei Li, Quan Gan, Zhengjun Cu. microRNA-181a promotes the proliferation of hypertrophic scar fibroblasts and inhibits their apoptosis via targeting phosphatase and tensin homolog. Annals of palliative medicine. vol 10. issue 4. 2021-05-14. PMID:33966404. |
microrna-181a promotes the proliferation of hypertrophic scar fibroblasts and inhibits their apoptosis via targeting phosphatase and tensin homolog. |
2021-05-14 |
2023-08-13 |
human |
| Yanpeng Zhou, Xun Shi, Shengfei Li, Quan Gan, Zhengjun Cu. microRNA-181a promotes the proliferation of hypertrophic scar fibroblasts and inhibits their apoptosis via targeting phosphatase and tensin homolog. Annals of palliative medicine. vol 10. issue 4. 2021-05-14. PMID:33966404. |
this study aimed to compare the expression of microrna (mir)-181a and phosphatase and tensin homolog (pten) in hypertrophic scar tissue and cells and to explore the effects of mir-181a and pten on the proliferation and apoptosis of the human scar fibroblast cell line hsfb. |
2021-05-14 |
2023-08-13 |
human |
| Wenshuai Ma, Wangang Guo, Fujun Shang, Yan Li, Wei Li, Jing Liu, Chao Ma, Jiwei Ten. Bakuchiol Alleviates Hyperglycemia-Induced Diabetic Cardiomyopathy by Reducing Myocardial Oxidative Stress via Activating the SIRT1/Nrf2 Signaling Pathway. Oxidative medicine and cellular longevity. vol 2020. 2021-05-12. PMID:33062139. |
our data demonstrated for the first time that bak could significantly abate diabetic cardiomyopathy by alleviating the cardiac dysfunction, ameliorating the myocardial fibrosis, mitigating the cardiac hypertrophy, and reducing the cardiomyocyte apoptosis. |
2021-05-12 |
2023-08-13 |
mouse |
| Jie Ding, Yu X Chen, Yan Chen, Yun Mou, Xiao T Sun, Dong P Dai, Chen Z Zhao, Jian Yang, Shen J Hu, Xiaogang Gu. Overexpression of FNTB and the activation of Ras induce hypertrophy and promote apoptosis and autophagic cell death in cardiomyocytes. Journal of cellular and molecular medicine. vol 24. issue 16. 2021-05-06. PMID:32579303. |
overexpression of fntb and the activation of ras induce hypertrophy and promote apoptosis and autophagic cell death in cardiomyocytes. |
2021-05-06 |
2023-08-13 |
rat |
| Jie Ding, Yu X Chen, Yan Chen, Yun Mou, Xiao T Sun, Dong P Dai, Chen Z Zhao, Jian Yang, Shen J Hu, Xiaogang Gu. Overexpression of FNTB and the activation of Ras induce hypertrophy and promote apoptosis and autophagic cell death in cardiomyocytes. Journal of cellular and molecular medicine. vol 24. issue 16. 2021-05-06. PMID:32579303. |
in addition, salirasib (a ras farnesylcysteine mimetic) can alleviate the hypertrophic phenotype of cardiomyocytes and inhibit the up-regulation of apoptosis and autophagy flux induced by fntb overexpression. |
2021-05-06 |
2023-08-13 |
rat |
| Kirti Parwani, Palash Manda. Role of advanced glycation end products and insulin resistance in diabetic nephropathy. Archives of physiology and biochemistry. 2021-05-06. PMID:32730131. |
accumulation of ages, enhanced reactive oxygen species (ros) generation and activation of protein kinase c (pkc), are considered to induce glomerular hypertrophy, podocyte apoptosis, therefore contributing to the development and progression of dn. |
2021-05-06 |
2023-08-13 |
Not clear |
| Anju Zuo, Xiaoyu Zhao, Tingting Li, Jun Li, Shengyun Lei, Jiying Chen, Dan Xu, Chengxiang Song, Tianjiao Liu, Cuigang Li, Yuan Gu. CTRP9 knockout exaggerates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy through inhibiting the LKB1/AMPK pathway. Journal of cellular and molecular medicine. vol 24. issue 4. 2021-04-27. PMID:31930700. |
our results demonstrated that the hfd-fed ctrp9-ko mice accentuated cardiac hypertrophy, fibrosis, endoplasmic reticulum (er) stress-initiated apoptosis and oxidative stress compared with the hfd-fed wt mice. |
2021-04-27 |
2023-08-13 |
mouse |
| H B Luo, Y Cao, M C Tao, X H Yang, J Che. Long non-coding RNA GAS5 inhibits the proliferation and induces the apoptosis of hypertrophic scar fibroblasts by sponging miR-21. Journal of biological regulators and homeostatic agents. vol 35. issue 1. 2021-04-27. PMID:33594853. |
long non-coding rna gas5 inhibits the proliferation and induces the apoptosis of hypertrophic scar fibroblasts by sponging mir-21. |
2021-04-27 |
2023-08-13 |
Not clear |
| Hao-Chun Chuang, Kun-Ling Tsai, Kuen-Jer Tsai, Ting-Yuan Tu, Yan-Jye Shyong, I-Ming Jou, Che-Chia Hsu, Shu-Shien Shih, Yuan-Fu Liu, Cheng-Li Li. Oxidative stress mediates age-related hypertrophy of ligamentum flavum by inducing inflammation, fibrosis, and apoptosis through activating Akt and MAPK pathways. Aging. vol 12. issue 23. 2021-04-26. PMID:33223505. |
oxidative stress mediates age-related hypertrophy of ligamentum flavum by inducing inflammation, fibrosis, and apoptosis through activating akt and mapk pathways. |
2021-04-26 |
2023-08-13 |
Not clear |
| Dongwen Jiang, Bingyu Guo, Feng Lin, Shixiu Lin, Kai Ta. miR-205 inhibits the development of hypertrophic scars by targeting THBS1. Aging. vol 12. issue 21. 2021-04-23. PMID:33186919. |
here, we investigated the relationship between mir-205, thrombospondin 1 (thbs1) expression, and hypertrophic scars, and showed that mir-205 inhibits cell proliferation and migration and induces apoptosis. |
2021-04-23 |
2023-08-13 |
Not clear |