| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weiwei Li, Jiancheng Yang, Qiufeng Lyu, Gaofeng Wu, Shumei Lin, Qunhui Yang, Jianmin H. Taurine attenuates isoproterenol-induced H9c2 cardiomyocytes hypertrophy by improving antioxidative ability and inhibiting calpain-1-mediated apoptosis. Molecular and cellular biochemistry. vol 469. issue 1-2. 2021-01-12. PMID:32304004. |
pathological cardiac hypertrophy is ultimately accompanied by cardiomyocyte apoptosis. |
2021-01-12 |
2023-08-13 |
Not clear |
| Xiaojian Gao, Zeyu Zhang, Xin Li, Qingxia Wei, Hanlu Li, Chen Li, Haixu Chen, Chunlei Liu, Kunlun H. Ursolic Acid Improves Monocrotaline-Induced Right Ventricular Remodeling by Regulating Metabolism. Journal of cardiovascular pharmacology. vol 75. issue 6. 2021-01-11. PMID:32141989. |
rv hypertrophy, fibrosis, increased apoptosis, and abnormal metabolism were induced by mct and suppressed by ua via a mechanism that changed the expression of key markers. |
2021-01-11 |
2023-08-13 |
rat |
| Behzad Javaheri, Soraia P Caetano-Silva, Ioannis Kanakis, George Bou-Gharios, Andrew A Pitsillide. The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within? Frontiers in bioengineering and biotechnology. vol 6. 2021-01-09. PMID:29619368. |
the long-held accepted dogma states that hypertrophic chondrocytes are terminally differentiated and will eventually undergo apoptosis. |
2021-01-09 |
2023-08-13 |
Not clear |
| Xin Qin, Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Toshihiro Miyazaki, Hisato Komori, Kosei Ito, Klaus von der Mark, Chiharu Sakane, Hitomi Kaneko, Toshihisa Komor. Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLoS genetics. vol 16. issue 11. 2021-01-06. PMID:33253203. |
vascular invasion into the cartilage occurs in the terminal hypertrophic chondrocyte layer, and terminal hypertrophic chondrocytes die by apoptosis or transdifferentiate into osteoblasts. |
2021-01-06 |
2023-08-13 |
mouse |
| Xin Qin, Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Toshihiro Miyazaki, Hisato Komori, Kosei Ito, Klaus von der Mark, Chiharu Sakane, Hitomi Kaneko, Toshihisa Komor. Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLoS genetics. vol 16. issue 11. 2021-01-06. PMID:33253203. |
the apoptosis of terminal hypertrophic chondrocytes was increased and their transdifferentiation was interrupted in runx2fl/flcre mice, leading to lack of primary spongiosa and osteoblasts in the region at e16.5. |
2021-01-06 |
2023-08-13 |
mouse |
| Yong Huang, Yuting Wang, Xueming Wang, Lixin Lin, Peng Wang, Junjun Sun, Lei Jian. The Effects of the Transforming Growth Factor-β1 (TGF-β1) Signaling Pathway on Cell Proliferation and Cell Migration are Mediated by Ubiquitin Specific Protease 4 (USP4) in Hypertrophic Scar Tissue and Primary Fibroblast Cultures. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-05. PMID:32308208. |
conclusions usp4 regulated the proliferation, migration, and apoptosis of hypertrophic scar fibroblasts by regulating the tgf-ß1 signaling pathway. |
2021-01-05 |
2023-08-13 |
human |
| Tsai-Chun Lai, Tzu-Lin Lee, Yu-Chun Chang, Yu-Chen Chen, Shu-Rung Lin, Shu-Wha Lin, Chi-Ming Pu, Jaw-Shiun Tsai, Yuh-Lien Che. MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-1. Frontiers in cell and developmental biology. vol 8. 2020-12-22. PMID:33344446. |
myocardial ischemia/reperfusion (i/r) causes cardiomyocyte damage such as apoptosis and hypertrophy. |
2020-12-22 |
2023-08-13 |
mouse |
| Tsai-Chun Lai, Tzu-Lin Lee, Yu-Chun Chang, Yu-Chen Chen, Shu-Rung Lin, Shu-Wha Lin, Chi-Ming Pu, Jaw-Shiun Tsai, Yuh-Lien Che. MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-1. Frontiers in cell and developmental biology. vol 8. 2020-12-22. PMID:33344446. |
adsc-exo significantly decreased i/r-induced cardiomyocyte apoptosis and hypertrophy, as detected by tdt-mediated dutp nick end-labeling (tunel) and wheat germ agglutinin (wga) staining, respectively. |
2020-12-22 |
2023-08-13 |
mouse |
| Tsai-Chun Lai, Tzu-Lin Lee, Yu-Chun Chang, Yu-Chen Chen, Shu-Rung Lin, Shu-Wha Lin, Chi-Ming Pu, Jaw-Shiun Tsai, Yuh-Lien Che. MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-1. Frontiers in cell and developmental biology. vol 8. 2020-12-22. PMID:33344446. |
we also observed that cardiac i/r operation markedly increased cell apoptosis and hypertrophy in mir-221/222 knockout (ko) mice, while adsc-exo reduced the effects of i/r operation. |
2020-12-22 |
2023-08-13 |
mouse |
| Beibei Dai, Feng Wang, Xiang Nie, Hengzhi Du, Yanru Zhao, Zhongwei Yin, Huaping Li, Jiahui Fan, Zheng Wen, Dao Wen Wang, Chen Che. The Cell Type-Specific Functions of miR-21 in Cardiovascular Diseases. Frontiers in genetics. vol 11. 2020-12-18. PMID:33329700. |
diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia, might initiate cardiac remodeling and dysfunction by inducing hypertrophy or apoptosis in cardiomyocytes and by promoting proliferation in cardiac fibroblasts. |
2020-12-18 |
2023-08-13 |
Not clear |
| b' Joaquim Fern\\xc3\\xa1ndez-Sol\\xc3\\xa. The Effects of Ethanol on the Heart: Alcoholic Cardiomyopathy. Nutrients. vol 12. issue 2. 2020-12-07. PMID:32098364.' |
pathologically, ethanol induces myocytolysis, apoptosis, and necrosis of myocytes, with repair mechanisms causing hypertrophy and interstitial fibrosis. |
2020-12-07 |
2023-08-13 |
Not clear |
| Fernando Santos Rodrígue. X-Linked Hypophosphataemic Rickets and Growth. Advances in therapy. vol 37. issue Suppl 2. 2020-12-07. PMID:32236870. |
some of the findings in the growth plate of patients with xlh include atypical organization of chondrocytes due to low rates of proliferation and apoptosis and disturbance of chondrocyte hypertrophy, overactivation of the mitogen-activated protein kinase (mapk) signalling pathway and upregulation of phosphorylated extracellular signal-regulated kinase (perk). |
2020-12-07 |
2023-08-13 |
Not clear |
| Jian Zhang, Chen Yan, Weidong He, Min Wang, Jian Li. Inhibition against p38/MEF2C pathway by Pamapimod protects osteoarthritis chondrocytes hypertrophy. Panminerva medica. 2020-12-02. PMID:33263251. |
the p38 mitogen-activated protein kinase pathway plays an important role in the pathogenesis of osteoarthritis (oa) involving in hypertrophy, calcification, and apoptosis of chondrocytes (chs). |
2020-12-02 |
2023-08-13 |
Not clear |
| Si-Min Yan, Hu Li, Qing Shu, Wei-Jun Wu, Xue-Mei Luo, Lei L. LncRNA SNHG1 exerts a protective role in cardiomyocytes hypertrophy via targeting miR-15a-5p/HMGA1 axis. Cell biology international. vol 44. issue 4. 2020-11-19. PMID:31889385. |
long noncoding rna small nucleolar rna host gene 1 (snhg1) was reported to inhibit cardiomyocytes apoptosis, but the role and underlying mechanism of snhg1 in pathological cardiac hypertrophy have not yet been understood. |
2020-11-19 |
2023-08-13 |
Not clear |
| Kanika Singh, Ankit Gupta, Ashish Sarkar, Ishita Gupta, Santanu Rana, Sagartirtha Sarkar, Sameena Kha. Arginyltransferase knockdown attenuates cardiac hypertrophy and fibrosis through TAK1-JNK1/2 pathway. Scientific reports. vol 10. issue 1. 2020-11-19. PMID:31953451. |
here we found that in adult rat model, downregulation of ate1 mitigates cardiac hypertrophic, cardiac fibrosis as well as apoptosis responses in the presence of cardiac stress i.e. |
2020-11-19 |
2023-08-13 |
mouse |
| Ludmila Soledad Peres Diaz, Mariano Luis Schuman, Maia Aisicovich, Jorge Eduardo Toblli, Carlos José Pirola, María Silvina Landa, Silvia Inés Garcí. Short-term doxorubicin cardiotoxic effects: involvement of cardiac Thyrotropin Releasing Hormone system. Life sciences. vol 261. 2020-11-18. PMID:32853656. |
further, ctrh overexpression induces cardiac apoptosis, hypertrophy and fibrosis. |
2020-11-18 |
2023-08-13 |
Not clear |
| Magdalena Dudek, Marta Kałużna-Oleksy, Jacek Migaj, Ewa Straburzyńska-Miga. Clinical value of soluble ST2 in cardiology. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. vol 29. issue 10. 2020-11-04. PMID:33049127. |
the interaction of interleukin 33 (il-33) and st2l is part of a cardioprotective pathway that prevents fibrosis and inhibits inflammatory response, hypertrophy and apoptosis of cardiomyocytes. |
2020-11-04 |
2023-08-13 |
Not clear |
| Michael E J Preedy, Reshma S Baliga, Adrian J Hobb. Multiplicity of Nitric Oxide and Natriuretic Peptide Signaling in Heart Failure. Journal of cardiovascular pharmacology. vol 75. issue 5. 2020-11-02. PMID:31498237. |
cyclic guanosine-3',5'-monophosphate (cgmp), synthesized by nitric oxide (no)- and natriuretic peptide (np)-responsive guanylyl cyclase (gc) enzymes, exerts numerous protective effects on cardiac contractility, hypertrophy, fibrosis, and apoptosis. |
2020-11-02 |
2023-08-13 |
Not clear |
| Miyesaier Abudureyimu, Wenjun Yu, Richard Yang Cao, Yingmei Zhang, Haibo Liu, Hongchao Zhen. Berberine Promotes Cardiac Function by Upregulating PINK1/Parkin-Mediated Mitophagy in Heart Failure. Frontiers in physiology. vol 11. 2020-10-28. PMID:33101051. |
our findings showed that tac-induced pressure overload (po) prompted cardiac dysfunction, cardiac hypertrophy, interstitial fibrosis, cardiomyocyte apoptosis and mitochondrial injury, accompanied with suppressed mitophagy, the effects of which were attenuated by berberine. |
2020-10-28 |
2023-08-13 |
mouse |
| Kelsie E Oatmen, Elizabeth Cull, Francis G Spinal. Heart failure as interstitial cancer: emergence of a malignant fibroblast phenotype. Nature reviews. Cardiology. vol 17. issue 8. 2020-10-26. PMID:31686012. |
in animal models, a major factor driving progression from pressure-overload hypertrophy (poh) to hfpef is the activation and proliferation of an abnormal fibroblast phenotype that is resistant to apoptosis, degrades normal stromal matrix and is replaced with a fibrotic matrix structure. |
2020-10-26 |
2023-08-13 |
Not clear |