| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Branislav Kura, Barbara Szeiffova Bacova, Barbora Kalocayova, Matus Sykora, Jan Sleza. Oxidative Stress-Responsive MicroRNAs in Heart Injury. International journal of molecular sciences. vol 21. issue 1. 2020-10-23. PMID:31948131. |
as a result of oxidative stress action, apoptosis, hypertrophy, and fibrosis may occur. |
2020-10-23 |
2023-08-13 |
Not clear |
| Belal A Mohamed, Manar Elkenani, Joanna Jakubiczka-Smorag, Eric Buchholz, Sabrina Koszewa, Dawid Lbik, Moritz Schnelle, Gerd Hasenfuss, Karl Toische. Genetic deletion of calcium/calmodulin-dependent protein kinase type II delta does not mitigate adverse myocardial remodeling in volume-overloaded hearts. Scientific reports. vol 9. issue 1. 2020-10-22. PMID:31285482. |
additionally, cardiomyocytes hypertrophy, augmented myocyte apoptosis, and up-regulation of hypertrophic genes were also not significantly different in δ-ko versus wt hearts after shunt. |
2020-10-22 |
2023-08-13 |
mouse |
| Kyle I Mentkowski, Jennifer K Lan. Exosomes Engineered to Express a Cardiomyocyte Binding Peptide Demonstrate Improved Cardiac Retention in Vivo. Scientific reports. vol 9. issue 1. 2020-10-21. PMID:31296886. |
exosomes derived from cardiosphere-derived cells (cdcs) have been shown to stimulate angiogenesis, induce endogenous cardiomyocyte proliferation and modulate cardiomyocyte apoptosis and hypertrophy. |
2020-10-21 |
2023-08-13 |
Not clear |
| Zhichao Ma, Jie Qi, Li Gao, Jun Zhan. Role of Exercise on Alleviating Pressure Overload-Induced Left Ventricular Dysfunction and Remodeling via AMPK-Dependent Autophagy Activation. International heart journal. vol 61. issue 5. 2020-10-19. PMID:32999189. |
impaired cardiac function, interstitial fibrosis, enhanced apoptosis, and er stress were observed in the tac-induced left ventricular hypertrophy. |
2020-10-19 |
2023-08-13 |
rat |
| X U Deng, K E Xia, P O Chen, Md Sayed Ali Sheikh, DA-Feng Yang, Si-Min Li, Tian-Lun Yan. Reversion of left ventricle remodeling in spontaneously hypertensive rats by valsartan is associated with the inhibition of caspase-3, -8 and -9 activities. Biomedical reports. vol 3. issue 4. 2020-10-01. PMID:26171161. |
the development of hypertension is closely associated with cardiac hypertrophy and apoptosis, and caspase-3, -8 and -9 are key enzymes of apoptosis. |
2020-10-01 |
2023-08-13 |
rat |
| X U Deng, K E Xia, P O Chen, Md Sayed Ali Sheikh, DA-Feng Yang, Si-Min Li, Tian-Lun Yan. Reversion of left ventricle remodeling in spontaneously hypertensive rats by valsartan is associated with the inhibition of caspase-3, -8 and -9 activities. Biomedical reports. vol 3. issue 4. 2020-10-01. PMID:26171161. |
the aim of the present study was to evaluate the effects of valsartan on left ventricle hypertrophy and myocardial apoptosis in spontaneously hypertensive rats (shrs) and to explore the mechanisms for valsartan against apoptosis. |
2020-10-01 |
2023-08-13 |
rat |
| X U Deng, K E Xia, P O Chen, Md Sayed Ali Sheikh, DA-Feng Yang, Si-Min Li, Tian-Lun Yan. Reversion of left ventricle remodeling in spontaneously hypertensive rats by valsartan is associated with the inhibition of caspase-3, -8 and -9 activities. Biomedical reports. vol 3. issue 4. 2020-10-01. PMID:26171161. |
at the end of the experiments, blood pressure, parameters regarding hypertrophy, apoptosis and activities of caspase-3, -8 and -9 were measured. |
2020-10-01 |
2023-08-13 |
rat |
| X U Deng, K E Xia, P O Chen, Md Sayed Ali Sheikh, DA-Feng Yang, Si-Min Li, Tian-Lun Yan. Reversion of left ventricle remodeling in spontaneously hypertensive rats by valsartan is associated with the inhibition of caspase-3, -8 and -9 activities. Biomedical reports. vol 3. issue 4. 2020-10-01. PMID:26171161. |
the results showed that valsartan significantly reduced systolic blood pressure and left ventricular hypertrophy, improved left ventricular remodeling, attenuated the myocardial damage and apoptosis, and decreased the activities of caspase-3, -8 and -9 in shrs. |
2020-10-01 |
2023-08-13 |
rat |
| Xinyu Liu, Shixue Li. Role of microRNAs in the pathogenesis of diabetic cardiomyopathy. Biomedical reports. vol 6. issue 2. 2020-10-01. PMID:28357065. |
it was concluded that mirs contribute to the regulation of cardiomyocyte hypertrophy, myocardial fibrosis, cardiomyocyte apoptosis, mitochondrial dysfunction, myocardial electrical remodeling, epigenetic modification and various other pathophysiological processes of dcm. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shihua Dong, Yanfeng Su. MicroRNA-22 may promote apoptosis and inhibit the proliferation of hypertrophic scar fibroblasts by regulating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p21 pathway. Experimental and therapeutic medicine. vol 14. issue 4. 2020-10-01. PMID:29042989. |
microrna-22 may promote apoptosis and inhibit the proliferation of hypertrophic scar fibroblasts by regulating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p21 pathway. |
2020-10-01 |
2023-08-13 |
human |
| Shihua Dong, Yanfeng Su. MicroRNA-22 may promote apoptosis and inhibit the proliferation of hypertrophic scar fibroblasts by regulating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p21 pathway. Experimental and therapeutic medicine. vol 14. issue 4. 2020-10-01. PMID:29042989. |
in addition, human hypertrophic scar fibroblasts (hsfbs) were cultured and transfected with mir-22 mimics, and mtt and annexin v apoptosis assays were performed to investigate the role of mir-22 in the proliferation and apoptosis of the human hsfbs. |
2020-10-01 |
2023-08-13 |
human |
| Qing Q Wu, Jian Ni, Ning Zhang, Hai H Liao, Qi Z Tang, Wei Den. Andrographolide Protects against Aortic Banding-Induced Experimental Cardiac Hypertrophy by Inhibiting MAPKs Signaling. Frontiers in pharmacology. vol 8. 2020-10-01. PMID:29184496. |
andr has also been shown to inhibit inflammation and apoptosis, which are factors related to cardiac hypertrophy. |
2020-10-01 |
2023-08-13 |
mouse |
| Zheng Zhang, Yunsheng Chen, Jiayue Ding, Chunlei Zhang, Amin Zhang, Dannong He, Yixin Zhan. Biocompatible 5-Aminolevulinic Acid/Au Nanoparticle-Loaded Ethosomal Vesicles for In Vitro Transdermal Synergistic Photodynamic/Photothermal Therapy of Hypertrophic Scars. Nanoscale research letters. vol 12. issue 1. 2020-10-01. PMID:29247361. |
taking human hypertrophic scar fibroblasts (hsf) as therapeutic targets, synergistic pdt/ptt of hs indicates that a/a-es could enhance quantum yields of ros by photothermal effect and localized surface plasmon resonance (lspr) of aunps, resulting in a high level of apoptosis or necrosis. |
2020-10-01 |
2023-08-13 |
human |
| Anantha Harijith, Viswanathan Natarajan, Panfeng F. The Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Lung Architecture Remodeling. Antioxidants (Basel, Switzerland). vol 6. issue 4. 2020-10-01. PMID:29257052. |
nicotinamide adenine dinucleotide phosphate (nadph) oxidases (nox) appear to play a pivotal role in lung signaling, leading to marked changes in pulmonary airway and vascular cell phenotypes, including proliferation, hypertrophy and apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yuan Dai, Weijia Luo, Jiang Chan. Rho kinase signaling and cardiac physiology. Current opinion in physiology. vol 1. 2020-10-01. PMID:29527586. |
abnormal activation of rocks participate in multiple cardiovascular pathological processes, including cardiac hypertrophy, apoptosis, fibrosis, systemic hypertension, and pulmonary hypertension. |
2020-10-01 |
2023-08-13 |
Not clear |
| Guihua Tian, Yang Sun, Shuo Liu, Chengyu Li, Shiqi Chen, Ruijin Qiu, Xiaoyu Zhang, Youping Li, Min Li, Hongcai Shan. Therapeutic Effects of Wenxin Keli in Cardiovascular Diseases: An Experimental and Mechanism Overview. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30233380. |
wxkl exhibited its cardioprotective roles by inhibiting inflammatory reaction, decreasing oxidative stress, regulating vasomotor disorders, lowering cell apoptosis, and protection against endothelial injure, myocardial ischemia, cardiac fibrosis, and cardiac hypertrophy. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zizheng Kee, Xenia Kodji, Susan D Brai. The Role of Calcitonin Gene Related Peptide (CGRP) in Neurogenic Vasodilation and Its Cardioprotective Effects. Frontiers in physiology. vol 9. 2020-10-01. PMID:30283343. |
with regards to its cardioprotective effects in conditions such as heart failure and ischaemia, cgrp-containing nerves innervate throughout cardiac tissue and the vasculature, where evidence shows this peptide alleviates various aspects of their pathophysiology, including cardiac hypertrophy, reperfusion injury, cardiac inflammation, and apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Meili Lu, Bin Leng, Xin He, Zhen Zhang, Hongxin Wang, Futian Tan. Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30364197. |
the aim of the present study was to investigate the underlying mechanism of casr in cardiac hypertrophy and apoptosis and to evaluate whether the protective effect of asiv against myocardial injury is associated with casr and its related signaling pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| Alfredo Walker, Dina El Demellawy, Jorge Davil. Rickets: Historical, Epidemiological, Pathophysiological, and Pathological Perspectives. Academic forensic pathology. vol 7. issue 2. 2020-10-01. PMID:31239976. |
this results in 1) disordered proliferation of chondrocytes in the hypertrophic zone secondary to a lack of apoptosis, 2) loss of the columnar arrangement of chondrocytes that results in thickening and disorganization of the hypertrophic zone, 3) tongue-like projections of cartilage that extend into the spongiosa, 4) irregularity of the limit between the proliferative and hypertrophic zones, and 5) penetration of blood vessels into the hypertrophic zone. |
2020-10-01 |
2023-08-13 |
Not clear |
| Kailash Prasa. AGE-RAGE Stress in the Pathophysiology of Pulmonary Hypertension and its Treatment. The International journal of angiology : official publication of the International College of Angiology, Inc. vol 28. issue 2. 2020-10-01. PMID:31384104. |
age and its interaction with rage induce vascular hypertrophy through proliferation of vascular smc, accumulation of ecm, and suppression of apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |