| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Cheng, Aling Shen, Xiangyan Wu, Zhiqing Shen, Xiaoping Chen, Jiapeng Li, Liya Liu, Xiaoying Lin, Meizhu Wu, Youqin Chen, Jianfeng Chu, Jun Pen. Qingda granule attenuates angiotensin II-induced cardiac hypertrophy and apoptosis and modulates the PI3K/AKT pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 133. 2021-02-24. PMID:33378940. |
these results suggest that qdg can significantly attenuate ang ii-induced hypertension, cardiac hypertrophy and apoptosis, and it may exert these effects in part by suppressing ros production and activating the pi3k/akt signaling pathway. |
2021-02-24 |
2023-08-13 |
mouse |
| Hsin-Chaio Chou, Chung-Hwan Chen, Liang-Yin Chou, Tsung-Lin Cheng, Lin Kang, Shu-Chun Chuang, Yi-Shan Lin, Mei-Ling Ho, Yan-Hsiung Wang, Sung-Yen Lin, Chau-Zen Wan. Discoidin Domain Receptors 1 Inhibition Alleviates Osteoarthritis via Enhancing Autophagy. International journal of molecular sciences. vol 21. issue 19. 2021-02-23. PMID:32977456. |
we recently reported that the chondrocyte-specific knockout of discoidin domain receptors 1 (ddr1) delayed endochondral ossification (eo) in the growth plate by reducing the chondrocyte hypertrophic terminal differentiation, and apoptosis. |
2021-02-23 |
2023-08-13 |
mouse |
| Meng Xie, Pavel Gol'din, Anna Nele Herdina, Jordi Estefa, Ekaterina V Medvedeva, Lei Li, Phillip T Newton, Svetlana Kotova, Boris Shavkuta, Aditya Saxena, Lauren T Shumate, Brian D Metscher, Karl Großschmidt, Shigeki Nishimori, Anastasia Akovantseva, Anna P Usanova, Anastasiia D Kurenkova, Anoop Kumar, Irene Linares Arregui, Paul Tafforeau, Kaj Fried, Mattias Carlström, András Simon, Christian Gasser, Henry M Kronenberg, Murat Bastepe, Kimberly L Cooper, Peter Timashev, Sophie Sanchez, Igor Adameyko, Anders Eriksson, Andrei S Chagi. Secondary ossification center induces and protects growth plate structure. eLife. vol 9. 2021-02-23. PMID:33063669. |
functional experiments revealed the high vulnerability of hypertrophic chondrocytes to mechanical stress and showed that soc protects these cells from apoptosis caused by extensive loading. |
2021-02-23 |
2023-08-13 |
Not clear |
| Silvia Cetrullo, Stefania D'Adamo, Veronica Panichi, Rosa Maria Borzì, Carla Pignatti, Flavio Flamign. Modulation of Fatty Acid-Related Genes in the Response of H9c2 Cardiac Cells to Palmitate and n-3 Polyunsaturated Fatty Acids. Cells. vol 9. issue 3. 2021-02-19. PMID:32110930. |
treatment with a high dose of palmitate provoked mitochondrial depolarization, apoptosis, and hypertrophy of cardiomyoblasts. |
2021-02-19 |
2023-08-13 |
rat |
| Tomohiro Yokota, Jin Li, Jijun Huang, Zhaojun Xiong, Qing Zhang, Tracey Chan, Yichen Ding, Christoph Rau, Kevin Sung, Shuxun Ren, Rajan Kulkarni, Tzung Hsiai, Xinshu Xiao, Marlin Touma, Susumu Minamisawa, Yibin Wan. p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart. The Journal of clinical investigation. vol 130. issue 10. 2021-02-16. PMID:32573492. |
inactivation of p38 activity led to a marked increase in cardiomyocyte proliferation and hypertrophy but diminished cardiomyocyte apoptosis, specifically in the rv. |
2021-02-16 |
2023-08-13 |
mouse |
| John Twomey-Kozak, Salomi Desai, Wenguang Liu, Neill Y Li, Nicholas Lemme, Qian Chen, Brett D Owens, Chathuraka T Jayasuriy. Distal-Less Homeobox 5 Is a Therapeutic Target for Attenuating Hypertrophy and Apoptosis of Mesenchymal Progenitor Cells. International journal of molecular sciences. vol 21. issue 14. 2021-02-16. PMID:32650430. |
distal-less homeobox 5 is a therapeutic target for attenuating hypertrophy and apoptosis of mesenchymal progenitor cells. |
2021-02-16 |
2023-08-13 |
human |
| John Twomey-Kozak, Salomi Desai, Wenguang Liu, Neill Y Li, Nicholas Lemme, Qian Chen, Brett D Owens, Chathuraka T Jayasuriy. Distal-Less Homeobox 5 Is a Therapeutic Target for Attenuating Hypertrophy and Apoptosis of Mesenchymal Progenitor Cells. International journal of molecular sciences. vol 21. issue 14. 2021-02-16. PMID:32650430. |
modulating dlx5 activity regulates cell hypertrophy and apoptosis in bm-mscs and c-pcs. |
2021-02-16 |
2023-08-13 |
human |
| John Twomey-Kozak, Salomi Desai, Wenguang Liu, Neill Y Li, Nicholas Lemme, Qian Chen, Brett D Owens, Chathuraka T Jayasuriy. Distal-Less Homeobox 5 Is a Therapeutic Target for Attenuating Hypertrophy and Apoptosis of Mesenchymal Progenitor Cells. International journal of molecular sciences. vol 21. issue 14. 2021-02-16. PMID:32650430. |
these findings suggest that dlx5 is a biomarker of oa changes in human knee joint tissues and confirms the dlx5 mechanism contributes to hypertrophy and apoptosis in bm-mscs. |
2021-02-16 |
2023-08-13 |
human |
| Meng-Wan Zhang, Yun-Jie Shen, Jing Shi, Jian-Guang Y. MiR-223-3p in Cardiovascular Diseases: A Biomarker and Potential Therapeutic Target. Frontiers in cardiovascular medicine. vol 7. 2021-02-10. PMID:33553260. |
it participates in regulation of several crucial signaling pathways such as phosphatidylinositol 3-kinase/protein kinase b, insulin-like growth factor 1, nuclear factor kappa b, mitogen-activated protein kinase, nod-like receptor family pyrin domain containing 3 inflammasome, and ribosomal protein s6 kinase b1/hypoxia inducible factor 1 α pathways to affect cell proliferation, migration, apoptosis, hypertrophy, and polarization, as well as electrophysiology, resulting in dysfunction of cardiovascular system. |
2021-02-10 |
2023-08-13 |
Not clear |
| Xiaolan Yang, Yongqiang Xiao, Chenjian Zhong, Futing Shu, Shichu Xiao, Yongjun Zheng, Zhaofan Xi. ABT-263 Reduces Hypertrophic Scars by Targeting Apoptosis of Myofibroblasts. Frontiers in pharmacology. vol 11. 2021-02-02. PMID:33519480. |
abt-263 reduces hypertrophic scars by targeting apoptosis of myofibroblasts. |
2021-02-02 |
2023-08-13 |
Not clear |
| Anbo Gao, Jinyong Jiang, Feng Xie, Linxi Che. Bnip3 in mitophagy: Novel insights and potential therapeutic target for diseases of secondary mitochondrial dysfunction. Clinica chimica acta; international journal of clinical chemistry. vol 506. 2021-01-25. PMID:32092316. |
in addition, bnip3 promotes the development of cardiac hypertrophy by mediating inflammatory response or the related signaling pathways of cardiomyocytes and is also responsible for raising abnormal mitophagy and apoptosis progression through multiple molecular signaling pathways, inducing the pathogenesis and progress of hepatocellular carcinoma (hcc). |
2021-01-25 |
2023-08-13 |
Not clear |
| Yi Feng, Jun-Jie Wu, Zi-Li Sun, Si-Yu Liu, Ming-Li Zou, Zheng-Dong Yuan, Shun Yu, Guo-Zhong Lv, Feng-Lai Yua. Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation. EBioMedicine. vol 54. 2021-01-25. PMID:32251998. |
targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation. |
2021-01-25 |
2023-08-13 |
Not clear |
| Yi Feng, Jun-Jie Wu, Zi-Li Sun, Si-Yu Liu, Ming-Li Zou, Zheng-Dong Yuan, Shun Yu, Guo-Zhong Lv, Feng-Lai Yua. Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation. EBioMedicine. vol 54. 2021-01-25. PMID:32251998. |
hypertrophic scar (hs) is characterized by the increased proliferation and decreased apoptosis of myofibroblasts. |
2021-01-25 |
2023-08-13 |
Not clear |
| Grażyna Sygitowicz, Agata Maciejak-Jastrzębska, Dariusz Sitkiewic. MicroRNAs in the development of left ventricular remodeling and postmyocardial infarction heart failure. Polish archives of internal medicine. vol 130. issue 1. 2021-01-22. PMID:31933487. |
in this review, we summarize the current knowledge on the role of mirnas in the regulation of basic processes, such as excessive myocardial fibrosis, pathological cardiomyocyte hypertrophy, and myocardial cell apoptosis. |
2021-01-22 |
2023-08-13 |
Not clear |
| Angela Ruscitto, Mallory M Morel, Carrie J Shawber, Gwendolyn Reeve, Michael K Lecholop, Daniel Bonthius, Hai Yao, Mildred C Embre. Evidence of vasculature and chondrocyte to osteoblast transdifferentiation in craniofacial synovial joints: Implications for osteoarthritis diagnosis and therapy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 3. 2021-01-21. PMID:32030828. |
the established dogma of endochondral bone ossification is that hypertrophic chondrocytes undergo apoptosis, while invading vasculature with osteoprogenitors replace cartilage with bone. |
2021-01-21 |
2023-08-13 |
Not clear |
| Lisa K Mullany, Aarti D Rohira, John P Leach, Jong H Kim, Tanner O Monroe, Andrea R Ortiz, Brittany Stork, M Waleed Gaber, Poonam Sarkar, Andrew G Sikora, Todd K Rosengart, Brian York, Yongcheng Song, Clifford C Dacso, David M Lonard, James F Martin, Bert W O'Malle. A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 49. 2021-01-21. PMID:33229578. |
mcb-613 decreases infarct size, apoptosis, hypertrophy, and fibrosis while maintaining significant cardiac function. |
2021-01-21 |
2023-08-13 |
Not clear |
| Huaping Li, Jiahui Fan, Chen Chen, Dao Wen Wan. Subcellular microRNAs in diabetic cardiomyopathy. Annals of translational medicine. vol 8. issue 23. 2021-01-14. PMID:33437801. |
the high incidence and poor prognosis of heart failure in diabetic patients have been associated, in part, to the presence of an underlying cardiomyopathy characterized by cardiac hypertrophy, cardiomyocytes apoptosis, and fibrosis. |
2021-01-14 |
2023-08-13 |
Not clear |
| Mao Xu, Meng Feng, Hang Peng, Zhuang Qian, Liting Zhao, Shufang W. Epigenetic regulation of chondrocyte hypertrophy and apoptosis through Sirt1/P53/P21 pathway in surgery-induced osteoarthritis. Biochemical and biophysical research communications. vol 528. issue 1. 2021-01-13. PMID:32499111. |
epigenetic regulation of chondrocyte hypertrophy and apoptosis through sirt1/p53/p21 pathway in surgery-induced osteoarthritis. |
2021-01-13 |
2023-08-13 |
mouse |
| Mao Xu, Meng Feng, Hang Peng, Zhuang Qian, Liting Zhao, Shufang W. Epigenetic regulation of chondrocyte hypertrophy and apoptosis through Sirt1/P53/P21 pathway in surgery-induced osteoarthritis. Biochemical and biophysical research communications. vol 528. issue 1. 2021-01-13. PMID:32499111. |
loss of sirt1 in cartilage led to accelerated oa pathogenesis via aberrant activation of p53/p21 mediated senescence associated secretory phenotype, hypertrophy and apoptosis. |
2021-01-13 |
2023-08-13 |
mouse |
| Weiwei Li, Jiancheng Yang, Qiufeng Lyu, Gaofeng Wu, Shumei Lin, Qunhui Yang, Jianmin H. Taurine attenuates isoproterenol-induced H9c2 cardiomyocytes hypertrophy by improving antioxidative ability and inhibiting calpain-1-mediated apoptosis. Molecular and cellular biochemistry. vol 469. issue 1-2. 2021-01-12. PMID:32304004. |
taurine attenuates isoproterenol-induced h9c2 cardiomyocytes hypertrophy by improving antioxidative ability and inhibiting calpain-1-mediated apoptosis. |
2021-01-12 |
2023-08-13 |
Not clear |