| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lishan Huang, Ruiyu Chen, Libin Liu, Yu Zhou, Zhou Che. Lactoferrin ameliorates pathological cardiac hypertrophy related to mitochondrial quality control in aged mice. Food & function. vol 12. issue 16. 2021-08-17. PMID:34223567. |
upon the administration of lactoferrin, aged hearts showed amelioration of pathological cardiac hypertrophy, which was associated with decreased apoptosis, improved morphology, rearrangement of mitochondrial dynamics, increased lysosome-dependent autophagy, and inhibition of factors detrimental to the mitochondrial-lysosomal axis. |
2021-08-17 |
2023-08-13 |
mouse |
| Lishan Huang, Ruiyu Chen, Libin Liu, Yu Zhou, Zhou Che. Lactoferrin ameliorates pathological cardiac hypertrophy related to mitochondrial quality control in aged mice. Food & function. vol 12. issue 16. 2021-08-17. PMID:34223567. |
in conclusion, lactoferrin ameliorated pathological cardiac hypertrophy, potentially by improving the mitochondrial quality related to mitochondrial dynamics and the mitochondrial-lysosomal axis, thus reducing mitochondria-dependent apoptosis, which is the pivotal factor for cardiac hypertrophy in aged mice. |
2021-08-17 |
2023-08-13 |
mouse |
| Feng Wang, Yuying Dai, Meng Huang, Chenchen Zhang, Liping Huang, Hui Wang, Liangping Ye, Qifeng Wu, Xuejun Zhang, Qixing Zh. Glomerular Damage in Trichloroethylene-Sensitized Mice: Targeting Cathepsin L-Induced Hyperactive mTOR Signaling. Frontiers in pharmacology. vol 12. 2021-08-17. PMID:34393767. |
our results showed that tce sensitization caused damage to glomerular structural integrity and also increased the activation of mtorc1 signaling, which was accompanied by podocyte loss, hypertrophy, and glomerular apoptosis. |
2021-08-17 |
2023-08-13 |
mouse |
| Tian Liang, Feng Gao, Jinghai Che. Role of PTEN-less in cardiac injury, hypertrophy and regeneration. Cell regeneration (London, England). vol 10. issue 1. 2021-08-13. PMID:34337686. |
when cardiac stress occurs, cardiomyocytes undergo transition from physiological homeostasis to hypertrophic growth, proliferation, or apoptosis. |
2021-08-13 |
2023-08-13 |
Not clear |
| Lei Qi, Huimei Zang, Weiwei Wu, Prakash Nagarkatti, Mitzi Nagarkatti, Qinghang Liu, Jeffrey Robbins, Xuejun Wang, Taixing Cu. CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes. Journal of molecular and cellular cardiology. vol 145. 2021-08-12. PMID:32553594. |
however, cr-cyld overexpression exacerbated pressure overload (po)-induced cardiac dysfunction associated with suppressed cardiac hypertrophy and increased myocardial apoptosis in mice independent of the gender. |
2021-08-12 |
2023-08-13 |
mouse |
| Chung-Jen Chiang, Bruce Chi-Kang Tsai, Tzu-Li Lu, Yun-Peng Chao, Cecilia Hsuan Day, Tsung-Jung Ho, Pin-Ning Wang, Sheng-Chuan Lin, V Vijaya Padma, Wei-Wen Kuo, Chih-Yang Huan. Diabetes-induced cardiomyopathy is ameliorated by heat-killed Lactobacillus reuteri GMNL-263 in diabetic rats via the repression of the toll-like receptor 4 pathway. European journal of nutrition. vol 60. issue 6. 2021-08-12. PMID:33555373. |
diabetes mellitus (dm) leads to disorders such as cardiac hypertrophy, cardiac myocyte apoptosis, and cardiac fibrosis. |
2021-08-12 |
2023-08-13 |
rat |
| Wenhua Su, Qian Huo, Hao Wu, Lulin Wang, Xiaoxue Ding, Liwen Liang, Liang Zhou, Yan Zhao, Juhua Dan, Hong Zhan. The function of LncRNA-H19 in cardiac hypertrophy. Cell & bioscience. vol 11. issue 1. 2021-08-07. PMID:34344446. |
for the first time, this review summarizes the current studies about the role of lncrna-h19 in cardiac hypertrophy, including its pathophysiological processes and underlying pathological mechanism, including calcium regulation, fibrosis, apoptosis, angiogenesis, inflammation, and methylation. |
2021-08-07 |
2023-08-13 |
Not clear |
| Mark Lafranconi, Robert Budinsky, Lisa Corey, Joanna Klapacz, James Crissman, Matthew LeBaron, Rachel Golden, Richard Pleu. A 90-day drinking water study in mice to characterize early events in the cancer mode of action of 1,4-dioxane. Regulatory toxicology and pharmacology : RTP. vol 119. 2021-08-05. PMID:33189748. |
early events identified in this study include glycogen-like vacuolization, centrilobular hypertrophy, centrilobular gst-p staining, apoptosis, and pan-lobular increase in cell proliferation observed after 90-days of exposure to 6000 ppm 1,4-dx. |
2021-08-05 |
2023-08-13 |
mouse |
| Lechu Yu, Yuanyuan Liu, Yichun Jin, Tinghao Liu, Wenhan Wang, Xuemian Lu, Chi Zhan. Zinc Supplementation Prevented Type 2 Diabetes-Induced Liver Injury Mediated by the Nrf2-MT Antioxidative Pathway. Journal of diabetes research. vol 2021. 2021-07-27. PMID:34307690. |
this induced preventive effects on conditions caused by type 2 diabetes like oxidative stress, apoptosis, the subsequent hepatic inflammatory response, fibrosis, hypertrophy, and hepatic dysfunction. |
2021-07-27 |
2023-08-13 |
mouse |
| Tim Snijders, Thorben Aussieker, Andy Holwerda, Gianni Parise, Luc J C van Loon, Lex B Verdij. The concept of skeletal muscle memory: Evidence from animal and human studies. Acta physiologica (Oxford, England). vol 229. issue 3. 2021-07-26. PMID:32175681. |
the myonuclear domain is kept (relatively) constant by adding additional nuclei (supplied by muscle satellite cells) during muscle fibre hypertrophy and nuclear loss (by apoptosis) during muscle fibre atrophy. |
2021-07-26 |
2023-08-13 |
human |
| Ilenia Martinelli, Daniele Tomassoni, Proshanta Roy, Lorenzo Di Cesare Mannelli, Francesco Amenta, Seyed Khosrow Tayebat. Antioxidant Properties of Alpha-Lipoic (Thioctic) Acid Treatment on Renal and Heart Parenchyma in a Rat Model of Hypertension. Antioxidants (Basel, Switzerland). vol 10. issue 7. 2021-07-25. PMID:34201726. |
the results confirmed that the oxidative mechanisms of organ alterations, due to hypertension, and characterized by glomerular and tubular lesions, left ventricular hypertrophy, and fibrosis but not by apoptosis were accompanied by proteins' and nucleic acids' oxidation. |
2021-07-25 |
2023-08-13 |
rat |
| Qing Liu, Hulin Piao, Yong Wang, Dongdong Zheng, Weitie Wan. Circulating exosomes in cardiovascular disease: Novel carriers of biological information. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 135. 2021-07-22. PMID:33412387. |
intercellular communication is a universal phenomenon mediated by exosomes and their contents during several pathological processes in cardiovascular diseases, such as cardiomyocyte hypertrophy, apoptosis, and angiogenesis. |
2021-07-22 |
2023-08-13 |
Not clear |
| Sureshbabu Mangali, Audesh Bhat, Deepika Dasari, Dharmarajan Sriram, Arti Dha. Inhibition of double stranded RNA dependent protein kinase (PKR) abrogates isoproterenol induced myocardial ischemia in vitro in cultured cardiomyocytes and in vivo in wistar rats. European journal of pharmacology. vol 906. 2021-07-16. PMID:34081906. |
our findings report that inhibition of pkr improves the ischemic mediated inflammation, apoptosis, cardiac hypertrophy and fibrosis in mi induced rats. |
2021-07-16 |
2023-08-13 |
rat |
| Xiao-Jie Bai, Jun-Tao Hao, Rong-Hua Zheng, Cai-Ping Yan, Jin Wang, Cai-Hong Yang, Wei-Fang Zhang, Zhi-Qing Zha. Glucagon-Like Peptide-1 Analog Liraglutide Attenuates Pressure-Overload Induced Cardiac Hypertrophy and Apoptosis through Activating ATP Sensitive Potassium Channels. Cardiovascular drugs and therapy. vol 35. issue 1. 2021-07-15. PMID:33057968. |
glucagon-like peptide-1 analog liraglutide attenuates pressure-overload induced cardiac hypertrophy and apoptosis through activating atp sensitive potassium channels. |
2021-07-15 |
2023-08-13 |
Not clear |
| Xiao-Jie Bai, Jun-Tao Hao, Rong-Hua Zheng, Cai-Ping Yan, Jin Wang, Cai-Hong Yang, Wei-Fang Zhang, Zhi-Qing Zha. Glucagon-Like Peptide-1 Analog Liraglutide Attenuates Pressure-Overload Induced Cardiac Hypertrophy and Apoptosis through Activating ATP Sensitive Potassium Channels. Cardiovascular drugs and therapy. vol 35. issue 1. 2021-07-15. PMID:33057968. |
this study aimed to investigate whether inhibition of glucagon-like peptide-1 (glp-1) on pressure overload induced cardiac hypertrophy and apoptosis is related to activation of atp sensitive potassium (katp) channels. |
2021-07-15 |
2023-08-13 |
Not clear |
| Qinshuo Zhao, Wei Song, Jingqiu Huang, Dong Wang, Changwu X. Metformin decreased myocardial fibrosis and apoptosis in hyperhomocysteinemia -induced cardiac hypertrophy. Current research in translational medicine. vol 69. issue 1. 2021-07-15. PMID:33268288. |
metformin decreased myocardial fibrosis and apoptosis in hyperhomocysteinemia -induced cardiac hypertrophy. |
2021-07-15 |
2023-08-13 |
Not clear |
| Qian Li, Xin Chen, Ling Chen, Hui Yan, Jun L. LINC00173 promotes the apoptosis of hypertrophic scar fibroblasts through increasing β-catenin expression. Molecular and cellular biochemistry. vol 476. issue 2. 2021-07-13. PMID:33141309. |
linc00173 promotes the apoptosis of hypertrophic scar fibroblasts through increasing β-catenin expression. |
2021-07-13 |
2023-08-13 |
Not clear |
| Qian Li, Xin Chen, Ling Chen, Hui Yan, Jun L. LINC00173 promotes the apoptosis of hypertrophic scar fibroblasts through increasing β-catenin expression. Molecular and cellular biochemistry. vol 476. issue 2. 2021-07-13. PMID:33141309. |
overall, the study demonstrated that linc00173 promoted the apoptosis of fibroblasts through increasing β-catenin expression, suggesting that linc00173 might be a new target for hypertrophic scar treatment. |
2021-07-13 |
2023-08-13 |
Not clear |
| b' Petra Grubi\\xc4\\x87 Rotkvi\\xc4\\x87, Zrinka Planini\\xc4\\x87, Ana-Marija Liberati Pr\\xc5\\xa1o, Jozica \\xc5\\xa0iki\\xc4\\x87, Edvard Gali\\xc4\\x87, Luka Rotkvi\\xc4\\x8. The Mystery of Diabetic Cardiomyopathy: From Early Concepts and Underlying Mechanisms to Novel Therapeutic Possibilities. International journal of molecular sciences. vol 22. issue 11. 2021-07-13. PMID:34205870.' |
diabetic patients are predisposed to diabetic cardiomyopathy, a specific form of cardiomyopathy which is characterized by the development of myocardial fibrosis, cardiomyocyte hypertrophy, and apoptosis that develops independently of concomitant macrovascular and microvascular diabetic complications. |
2021-07-13 |
2023-08-13 |
Not clear |
| Tiqun Yang, Tianxin Long, Tailai Du, Yili Chen, Yugang Dong, Zhan-Peng Huan. Circle the Cardiac Remodeling With circRNAs. Frontiers in cardiovascular medicine. vol 8. 2021-07-13. PMID:34250050. |
cardiac remodeling occurs after the heart is exposed to stress, which is manifested by pathological processes such as cardiomyocyte hypertrophy and apoptosis, dendritic cells activation and cytokine secretion, proliferation and activation of fibroblasts, and finally leads to heart failure. |
2021-07-13 |
2023-08-13 |
Not clear |