| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Khalilimeybodi, Jeffrey J Saucerman, P Rangaman. Modeling cardiomyocyte signaling and metabolism predicts genotype-to-phenotype mechanisms in hypertrophic cardiomyopathy. Computers in biology and medicine. vol 175. 2024-04-27. PMID:38677172. |
we also predicted potential combination drug targets for hcm (e.g., mavacamten plus ros inhibitors) preventing or reversing hcm phenotype (i.e., hypertrophic growth, apoptosis, and metabolic remodeling) in cardiomyocytes. |
2024-04-27 |
2024-04-30 |
mouse |
| Lijun Zhang, Fang Xie, Fengmei Zhang, Beiyao L. The potential roles of exosomes in pathological cardiomyocyte hypertrophy mechanisms and therapy: A review. Medicine. vol 103. issue 17. 2024-04-26. PMID:38669371. |
exosomes from cardiomyocytes, endothelial cells, fibroblasts, and stem cells are key in regulating processes like cardiac hypertrophy, cardiomyocyte survival, apoptosis, fibrosis, and angiogenesis within the context of cardiovascular diseases. |
2024-04-26 |
2024-04-29 |
Not clear |
| Xiaoxu Li, Zhijun Pu, Gang Xu, Yidong Yang, Yu Cui, Xiaoying Zhou, Chenyuan Wang, Zhifeng Zhong, Simin Zhou, Jun Yin, Fabo Shan, Chengzhong Yang, Li Jiao, Dewei Chen, Jian Huan. Hypoxia-Induced Myocardial Hypertrophy Companies with Apoptosis Enhancement and p38-MAPK Pathway Activation. High altitude medicine & biology. 2024-04-22. PMID:38647652. |
hypoxia-induced myocardial hypertrophy companies with apoptosis enhancement and p38-mapk pathway activation. |
2024-04-22 |
2024-04-26 |
Not clear |
| Xiaoxu Li, Zhijun Pu, Gang Xu, Yidong Yang, Yu Cui, Xiaoying Zhou, Chenyuan Wang, Zhifeng Zhong, Simin Zhou, Jun Yin, Fabo Shan, Chengzhong Yang, Li Jiao, Dewei Chen, Jian Huan. Hypoxia-Induced Myocardial Hypertrophy Companies with Apoptosis Enhancement and p38-MAPK Pathway Activation. High altitude medicine & biology. 2024-04-22. PMID:38647652. |
hypoxia-induced myocardial hypertrophy companies with apoptosis enhancement and p38-mapk pathway activation. |
2024-04-22 |
2024-04-26 |
Not clear |
| Dimyana Neufeldt, Arne Schmidt, Elisa Mohr, Dongchao Lu, Shambhabi Chatterjee, Maximilian Fuchs, Ke Xiao, Wen Pan, Sarah Cushman, Christopher Jahn, Malte Juchem, Hannah Jill Hunkler, Giuseppe Cipriano, Bjarne Jürgens, Kevin Schmidt, Sonja Groß, Mira Jung, Jeannine Hoepfner, Natalie Weber, Roger Foo, Andreas Pich, Robert Zweigerdt, Theresia Kraft, Thomas Thum, Christian Bä. Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival. Basic research in cardiology. 2024-04-19. PMID:38639887. |
a knockdown of circzfpm2 was found to induce cardiomyocyte hypertrophy and compromise mitochondrial respiration, leading to an increased production of reactive oxygen species and apoptosis. |
2024-04-19 |
2024-04-21 |
human |
| Mohammad Rami, Amirhossein Ahmadi Hekmatikar, Samaneh Rahdar, Sayed Shafa Marashi, D Maryama Awang Dau. Highlighting the effects of high-intensity interval training on the changes associated with hypertrophy, apoptosis, and histological proteins of the heart of old rats with type 2 diabetes. Scientific reports. vol 14. issue 1. 2024-03-27. PMID:38531890. |
highlighting the effects of high-intensity interval training on the changes associated with hypertrophy, apoptosis, and histological proteins of the heart of old rats with type 2 diabetes. |
2024-03-27 |
2024-03-29 |
rat |
| Le-Kun Gui, Huang-Jun Liu, Li-Jun Jin, Xiao-Chun Pen. Krüpple-like factors in cardiomyopathy: emerging player and therapeutic opportunities. Frontiers in cardiovascular medicine. vol 11. 2024-03-22. PMID:38516000. |
as pleiotropic transcription factors (tfs), the krüppel-like factors (klfs), a family of zinc finger proteins, are involved in regulating the setting and development of cardiomyopathies, and play critical roles in associated biological processes, including oxidative stress (os), inflammatory reactions, myocardial hypertrophy and fibrosis, and cellular autophagy and apoptosis, particularly in diabetic cardiomyopathy. |
2024-03-22 |
2024-03-24 |
Not clear |
| Misty M Owens, Suman Dalal, Aleksandra Radovic, Luciano Fernandes, Hassan Syed, Mary-Katherine Herndon, Coty Cooper, Krishna Singh, Eric Beaumon. Vagus nerve stimulation alleviates cardiac dysfunction and inflammatory markers during heart failure in rats. Autonomic neuroscience : basic & clinical. vol 253. 2024-03-21. PMID:38513382. |
additionally, po rats exhibited significant increases in myocyte cross sectional areas indicating hypertrophy, along with significant increases in myocardial fibrosis and apoptosis, all of which were reversed by vns therapy (p < 0.05). |
2024-03-21 |
2024-03-24 |
rat |
| Xiaoxiang Xu, Jun Liu, Zixuan Xiao, Shuang Li, Ya Zhang, Peng Song, Kun Lin, Lei Zhang, Haoquan Zheng, Yuye Zhou, Xiong Che. Zeolitic imidazolate framework-90 loaded with methylprednisolone sodium succinate effectively reduces hypertrophic scar Nanoscale. 2024-03-15. PMID:38488127. |
mpss@zif-90 enhanced the apoptosis of human hypertrophic scar fibroblasts and downregulated the overexpression of tgf-β1, vegf, α-sma, and collagen i/iii both |
2024-03-15 |
2024-03-17 |
human |
| Bin-Bin Du, Hui-Ting Shi, Li-Li Xiao, Ya-Peng Li, Rui Yao, Cui Liang, Xiao-Xu Tian, Lu-Lu Yang, Ling-Yao Kong, Jia-Qi Du, Zhao-Zhi Zhang, Yan-Zhou Zhang, Huang Zhe. Melanoma differentiation-associated protein 5 prevents cardiac hypertrophy via apoptosis signal-regulating kinase 1-c-Jun N-terminal kinase/p38 signaling. International journal of biological macromolecules. 2024-03-03. PMID:38432272. |
melanoma differentiation-associated protein 5 prevents cardiac hypertrophy via apoptosis signal-regulating kinase 1-c-jun n-terminal kinase/p38 signaling. |
2024-03-03 |
2024-03-06 |
mouse |
| Waruna Thotamune, Sithurandi Ubeysinghe, Kendra K Shrestha, Mahmoud Elhusseiny Mostafa, Michael C Young, Ajith Karunarathn. Optical Control of Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling. bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405895. |
in addition to plasma membrane βar, emerging evidence indicates potential pathological implications of deeper endomembrane βars, such as inducing cardiomyocyte hypertrophy and apoptosis, underlying heart failure. |
2024-02-26 |
2024-02-28 |
Not clear |
| Jun Zuo, Shaolin M. Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts. Heliyon. vol 10. issue 4. 2024-02-19. PMID:38370262. |
resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ros-mediated p38-mapk/hif-1a /p53 signaling in hypertrophic scar fibroblasts. |
2024-02-19 |
2024-02-21 |
Not clear |
| Jun Zuo, Shaolin M. Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts. Heliyon. vol 10. issue 4. 2024-02-19. PMID:38370262. |
during the regression of hypertrophic scars, autophagy and apoptosis are the main ways of cell death. |
2024-02-19 |
2024-02-21 |
Not clear |
| Karthikeyan Bose, Radhika Agrawal, Thiagarajan Sairam, Jessenya Mil, Matthew P Butler, Perundurai S Dhandapan. Sleep fragmentation induces heart failure in a hypertrophic cardiomyopathy mouse model by altering redox metabolism. iScience. vol 27. issue 3. 2024-02-16. PMID:38361607. |
sf induces mitochondrial damage, sarcomere disarray, and apoptosis in hcm mice; these changes result in a transition of hypertrophy to an hf phenotype by chiefly targeting redox metabolic pathways. |
2024-02-16 |
2024-02-18 |
mouse |
| Shaohui Li, Yunwei Wang, Yang Chen, Hao Zhang, Peng Cao, Kuo Shen, Hao Gua. PTEN hinders the formation of scars by regulating the levels of proteins in the extracellular matrix and promoting the apoptosis of dermal fibroblasts through Bcl-xL. Archives of biochemistry and biophysics. 2024-02-07. PMID:38325773. |
the findings of our study provide validation for the role of pten in inhibiting the development of hypertrophic scars (hs) by modulating the expression of extracellular matrix (ecm) proteins and promoting apoptosis in hypertrophic scar fibroblasts (hsfs) via bcl-xl. |
2024-02-07 |
2024-02-10 |
Not clear |
| Alice Ruth Lapthorn, Marcus Maximillian Ilg, Peter Dziewulski, Selim Celle. Hydroxypyridone anti-fungals selectively induce myofibroblast apoptosis in an in vitro model of hypertrophic scars. European journal of pharmacology. 2024-02-07. PMID:38325796. |
hydroxypyridone anti-fungals selectively induce myofibroblast apoptosis in an in vitro model of hypertrophic scars. |
2024-02-07 |
2024-02-10 |
human |
| Xidong Zhang, Yanhua Nie, Rui Zhang, Jiquan Yu, Jianjun G. Reduced DNMT1 levels induce cell apoptosis via upregulation of METTL3 in cardiac hypertrophy. Heliyon. vol 10. issue 3. 2024-02-05. PMID:38314261. |
reduced dnmt1 levels induce cell apoptosis via upregulation of mettl3 in cardiac hypertrophy. |
2024-02-05 |
2024-02-07 |
mouse |
| Qiu-Yue Lin, Wei-Jia Yu, Jie Bai, Wen-Xi Jiang, Hui-Hua L. Mac-1 deficiency ameliorates pressure overloaded heart failure through inhibiting macrophage polarization and activation. Biochimica et biophysica acta. Molecular basis of disease. vol 1870. issue 3. 2024-02-01. PMID:38296117. |
moreover, compared with wt mice, mac-1-ko mice exhibited dramatically ameliorated tac-induced cardiac dysfunction, hypertrophy, fibrosis, oxidative stress and apoptosis. |
2024-02-01 |
2024-02-04 |
mouse |
| Min Jia, Wenxue Liu, Keyin Zhang, Zhigang Wang, Ruisha Li, Jun Pan, Jianjun Yang, Dongjin Wan. Larixyl acetate, a TRPC6 inhibitor, attenuates pressure overload‑induced heart failure in mice. Molecular medicine reports. vol 29. issue 3. 2024-01-26. PMID:38275127. |
cardiac and cellular structure, function and the expression levels of hypertrophy, endoplasmic reticulum (er) stress, apoptosis, autophagy and pmtor/mtor related mrnas or proteins were assessed to explore the underlying molecular mechanisms. |
2024-01-26 |
2024-01-28 |
mouse |
| Min Jia, Wenxue Liu, Keyin Zhang, Zhigang Wang, Ruisha Li, Jun Pan, Jianjun Yang, Dongjin Wan. Larixyl acetate, a TRPC6 inhibitor, attenuates pressure overload‑induced heart failure in mice. Molecular medicine reports. vol 29. issue 3. 2024-01-26. PMID:38275127. |
the results indicated that treatment with tac or ang ii leads to significant hypertrophy and dysfunction of the heart or h9c2 cells, accompanied by an increase in er stress, apoptosis and activation of the mtor signaling pathway, and a decrease in autophagy. |
2024-01-26 |
2024-01-28 |
mouse |