| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaochen Wang, Yifan Zhang, Kun Chi, Yuwei Ji, Keying Zhang, Ping Li, Zhangning Fu, Xu Wang, Shaoyuan Cui, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Hanyu Zhu, Quan Hon. IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin α5/FAK in diabetic kidney disease. Apoptosis : an international journal on programmed cell death. 2024-05-25. PMID:38796567. |
deficiency of igfbp2 attenuated the urine protein, renal pathological injury and glomeruli hypertrophy of dkd mice induced by stz, and knockdown or deletion of igfbp2 alleviated podocytes apoptosis induced by high concentration of glucose or in dkd mouse. |
2024-05-25 |
2024-05-31 |
mouse |
| Man Xu, Li-Peng Li, Xi He, Xing-Zhu Lu, Xue-Yuan Bi, Qi Li, Xiao-Rong Xu. Metformin induction of heat shock factor 1 activation and the mitochondrial unfolded protein response alleviate cardiac remodeling in spontaneously hypertensive rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 9. 2024-05-08. PMID:38717442. |
moreover, hsf1 small-interfering rna reduced the metformin-mediated improvements in mitochondrial morphology and the uprmt by suppressing hypertrophic signals and cardiomyocyte apoptosis. |
2024-05-08 |
2024-05-27 |
rat |
| Alireza Mousavian, Mohammad Abdollahi, Negin Haddada. Talus Avascular Necrosis as a Rare Complication of Cushing's Disease: A Case Report. Cureus. vol 16. issue 4. 2024-05-06. PMID:38707157. |
mechanisms behind avn in hypercortisolism involve fat cell hypertrophy, fat embolization, osteocyte apoptosis, and glucocorticoid-induced hypertension. |
2024-05-06 |
2024-05-08 |
Not clear |
| Jianan Wang, Shiying Liu, Lihong Sun, Zhanping Kong, Jiamin Chai, Jigang Wen, Xuan Tian, Nan Chen, Chengli X. Association of attenuated leptin signaling pathways with impaired cardiac function under prolonged high-altitude hypoxia. Scientific reports. vol 14. issue 1. 2024-05-03. PMID:38702334. |
chronic hypoxia for 14 days led to increased myocyte hypertrophy, fibrosis, apoptosis, and mitochondrial dysfunction, coupled with reduced protein levels of leptin signaling pathways in myocardial tissues. |
2024-05-03 |
2024-05-06 |
rat |
| Mengyang Song, He Wang, Caixia Liu, Sijie Jin, Bin Liu, Wei Su. Non-coding RNAs as regulators of the Hippo pathway in cardiac development and cardiovascular disease. Frontiers in pharmacology. vol 15. 2024-05-03. PMID:38698813. |
recent studies have found that ncrnas interact with hippo pathway components to regulate myocardial fibrosis, cardiomyocyte proliferation, apoptosis, and hypertrophy and play an important role in cardiovascular disease. |
2024-05-03 |
2024-05-05 |
human |
| A Khalilimeybodi, Jeffrey J Saucerman, P Rangaman. Modeling cardiomyocyte signaling and metabolism predicts genotype-to-phenotype mechanisms in hypertrophic cardiomyopathy. Computers in biology and medicine. vol 175. 2024-04-27. PMID:38677172. |
we predicted that the transcription factors stat, srf, gata4, tp53, and foxo are the key regulators of cardiomyocyte hypertrophy and apoptosis in hcm in alignment with experiments. |
2024-04-27 |
2024-04-30 |
mouse |
| A Khalilimeybodi, Jeffrey J Saucerman, P Rangaman. Modeling cardiomyocyte signaling and metabolism predicts genotype-to-phenotype mechanisms in hypertrophic cardiomyopathy. Computers in biology and medicine. vol 175. 2024-04-27. PMID:38677172. |
we also predicted potential combination drug targets for hcm (e.g., mavacamten plus ros inhibitors) preventing or reversing hcm phenotype (i.e., hypertrophic growth, apoptosis, and metabolic remodeling) in cardiomyocytes. |
2024-04-27 |
2024-04-30 |
mouse |
| Lijun Zhang, Fang Xie, Fengmei Zhang, Beiyao L. The potential roles of exosomes in pathological cardiomyocyte hypertrophy mechanisms and therapy: A review. Medicine. vol 103. issue 17. 2024-04-26. PMID:38669371. |
exosomes from cardiomyocytes, endothelial cells, fibroblasts, and stem cells are key in regulating processes like cardiac hypertrophy, cardiomyocyte survival, apoptosis, fibrosis, and angiogenesis within the context of cardiovascular diseases. |
2024-04-26 |
2024-04-29 |
Not clear |
| Xiaoxu Li, Zhijun Pu, Gang Xu, Yidong Yang, Yu Cui, Xiaoying Zhou, Chenyuan Wang, Zhifeng Zhong, Simin Zhou, Jun Yin, Fabo Shan, Chengzhong Yang, Li Jiao, Dewei Chen, Jian Huan. Hypoxia-Induced Myocardial Hypertrophy Companies with Apoptosis Enhancement and p38-MAPK Pathway Activation. High altitude medicine & biology. 2024-04-22. PMID:38647652. |
hypoxia-induced myocardial hypertrophy companies with apoptosis enhancement and p38-mapk pathway activation. |
2024-04-22 |
2024-04-26 |
Not clear |
| Xiaoxu Li, Zhijun Pu, Gang Xu, Yidong Yang, Yu Cui, Xiaoying Zhou, Chenyuan Wang, Zhifeng Zhong, Simin Zhou, Jun Yin, Fabo Shan, Chengzhong Yang, Li Jiao, Dewei Chen, Jian Huan. Hypoxia-Induced Myocardial Hypertrophy Companies with Apoptosis Enhancement and p38-MAPK Pathway Activation. High altitude medicine & biology. 2024-04-22. PMID:38647652. |
hypoxia-induced myocardial hypertrophy companies with apoptosis enhancement and p38-mapk pathway activation. |
2024-04-22 |
2024-04-26 |
Not clear |
| Dimyana Neufeldt, Arne Schmidt, Elisa Mohr, Dongchao Lu, Shambhabi Chatterjee, Maximilian Fuchs, Ke Xiao, Wen Pan, Sarah Cushman, Christopher Jahn, Malte Juchem, Hannah Jill Hunkler, Giuseppe Cipriano, Bjarne Jürgens, Kevin Schmidt, Sonja Groß, Mira Jung, Jeannine Hoepfner, Natalie Weber, Roger Foo, Andreas Pich, Robert Zweigerdt, Theresia Kraft, Thomas Thum, Christian Bä. Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival. Basic research in cardiology. 2024-04-19. PMID:38639887. |
a knockdown of circzfpm2 was found to induce cardiomyocyte hypertrophy and compromise mitochondrial respiration, leading to an increased production of reactive oxygen species and apoptosis. |
2024-04-19 |
2024-04-21 |
human |
| Mohammad Rami, Amirhossein Ahmadi Hekmatikar, Samaneh Rahdar, Sayed Shafa Marashi, D Maryama Awang Dau. Highlighting the effects of high-intensity interval training on the changes associated with hypertrophy, apoptosis, and histological proteins of the heart of old rats with type 2 diabetes. Scientific reports. vol 14. issue 1. 2024-03-27. PMID:38531890. |
highlighting the effects of high-intensity interval training on the changes associated with hypertrophy, apoptosis, and histological proteins of the heart of old rats with type 2 diabetes. |
2024-03-27 |
2024-03-29 |
rat |
| Le-Kun Gui, Huang-Jun Liu, Li-Jun Jin, Xiao-Chun Pen. Krüpple-like factors in cardiomyopathy: emerging player and therapeutic opportunities. Frontiers in cardiovascular medicine. vol 11. 2024-03-22. PMID:38516000. |
as pleiotropic transcription factors (tfs), the krüppel-like factors (klfs), a family of zinc finger proteins, are involved in regulating the setting and development of cardiomyopathies, and play critical roles in associated biological processes, including oxidative stress (os), inflammatory reactions, myocardial hypertrophy and fibrosis, and cellular autophagy and apoptosis, particularly in diabetic cardiomyopathy. |
2024-03-22 |
2024-03-24 |
Not clear |
| Misty M Owens, Suman Dalal, Aleksandra Radovic, Luciano Fernandes, Hassan Syed, Mary-Katherine Herndon, Coty Cooper, Krishna Singh, Eric Beaumon. Vagus nerve stimulation alleviates cardiac dysfunction and inflammatory markers during heart failure in rats. Autonomic neuroscience : basic & clinical. vol 253. 2024-03-21. PMID:38513382. |
additionally, po rats exhibited significant increases in myocyte cross sectional areas indicating hypertrophy, along with significant increases in myocardial fibrosis and apoptosis, all of which were reversed by vns therapy (p < 0.05). |
2024-03-21 |
2024-03-24 |
rat |
| Xiaoxiang Xu, Jun Liu, Zixuan Xiao, Shuang Li, Ya Zhang, Peng Song, Kun Lin, Lei Zhang, Haoquan Zheng, Yuye Zhou, Xiong Che. Zeolitic imidazolate framework-90 loaded with methylprednisolone sodium succinate effectively reduces hypertrophic scar Nanoscale. 2024-03-15. PMID:38488127. |
mpss@zif-90 enhanced the apoptosis of human hypertrophic scar fibroblasts and downregulated the overexpression of tgf-β1, vegf, α-sma, and collagen i/iii both |
2024-03-15 |
2024-03-17 |
human |
| Bin-Bin Du, Hui-Ting Shi, Li-Li Xiao, Ya-Peng Li, Rui Yao, Cui Liang, Xiao-Xu Tian, Lu-Lu Yang, Ling-Yao Kong, Jia-Qi Du, Zhao-Zhi Zhang, Yan-Zhou Zhang, Huang Zhe. Melanoma differentiation-associated protein 5 prevents cardiac hypertrophy via apoptosis signal-regulating kinase 1-c-Jun N-terminal kinase/p38 signaling. International journal of biological macromolecules. 2024-03-03. PMID:38432272. |
melanoma differentiation-associated protein 5 prevents cardiac hypertrophy via apoptosis signal-regulating kinase 1-c-jun n-terminal kinase/p38 signaling. |
2024-03-03 |
2024-03-06 |
mouse |
| Waruna Thotamune, Sithurandi Ubeysinghe, Kendra K Shrestha, Mahmoud Elhusseiny Mostafa, Michael C Young, Ajith Karunarathn. Optical Control of Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling. bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405895. |
in addition to plasma membrane βar, emerging evidence indicates potential pathological implications of deeper endomembrane βars, such as inducing cardiomyocyte hypertrophy and apoptosis, underlying heart failure. |
2024-02-26 |
2024-02-28 |
Not clear |
| Jun Zuo, Shaolin M. Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts. Heliyon. vol 10. issue 4. 2024-02-19. PMID:38370262. |
resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ros-mediated p38-mapk/hif-1a /p53 signaling in hypertrophic scar fibroblasts. |
2024-02-19 |
2024-02-21 |
Not clear |
| Jun Zuo, Shaolin M. Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts. Heliyon. vol 10. issue 4. 2024-02-19. PMID:38370262. |
during the regression of hypertrophic scars, autophagy and apoptosis are the main ways of cell death. |
2024-02-19 |
2024-02-21 |
Not clear |
| Karthikeyan Bose, Radhika Agrawal, Thiagarajan Sairam, Jessenya Mil, Matthew P Butler, Perundurai S Dhandapan. Sleep fragmentation induces heart failure in a hypertrophic cardiomyopathy mouse model by altering redox metabolism. iScience. vol 27. issue 3. 2024-02-16. PMID:38361607. |
sf induces mitochondrial damage, sarcomere disarray, and apoptosis in hcm mice; these changes result in a transition of hypertrophy to an hf phenotype by chiefly targeting redox metabolic pathways. |
2024-02-16 |
2024-02-18 |
mouse |