| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Harry Pavlopoulos, Petros Nihoyannopoulo. The constellation of hypertensive heart disease. Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese. vol 49. issue 2. 2008-07-29. PMID:18459466. |
future assessment of hypertensive patients' global risk should probably incorporate not only evaluation of the known traditional risk factors, such as hypercholesterolaemia, smoking, glucose levels and left ventricular hypertrophy, but also myocardial fibrosis, microvascular ischaemia, arterial stiffness, systemic inflammation, endothelial dysfunction and level of apoptosis. |
2008-07-29 |
2023-08-12 |
Not clear |
| Katashi Okoshi, Julliano F Campos Guimarães, Bruno Paulino Di Muzio, Ana Angélica H Fernandes, Marina Politi Okosh. [Diabetic cardiomyopathy]. Arquivos brasileiros de endocrinologia e metabologia. vol 51. issue 2. 2008-07-22. PMID:17505622. |
clinical and experimental studies have shown that diabetes mellitus causes myocardial hypertrophy, necrosis, and apoptosis, and increases interstitial tissue. |
2008-07-22 |
2023-08-12 |
Not clear |
| Rekha Bassi, Richard Heads, Michael S Marber, James E Clar. Targeting p38-MAPK in the ischaemic heart: kill or cure? Current opinion in pharmacology. vol 8. issue 2. 2008-07-22. PMID:18289939. |
the p38-mapk pathway plays an important role in myocardial ischaemia/reperfusion injury and has been implicated in the regulation of cardiac gene expression, myocyte hypertrophy, inflammation, energetic metabolism, contractility, proliferation and apoptosis. |
2008-07-22 |
2023-08-12 |
Not clear |
| Kristian Gundersen, Jo C Bruusgaar. Nuclear domains during muscle atrophy: nuclei lost or paradigm lost? The Journal of physiology. vol 586. issue 11. 2008-07-21. PMID:18440990. |
to preserve the domain size, it is believed that nuclei are injected from satellite cells fusing to fibres undergoing hypertrophy, and lost by apoptosis during atrophy. |
2008-07-21 |
2023-08-12 |
Not clear |
| B Stratmann, I Stork, D Tschoep. [Diabetic cardiomyopathy--a type of coronary artery disease?]. Der Internist. vol 49. issue 4. 2008-07-15. PMID:18301873. |
clinical and experimental studies have shown that diabetes mellitus causes myocardial hypertrophy, apoptosis and necrosis, and increases interstitial tissue. |
2008-07-15 |
2023-08-12 |
Not clear |
| Coimbatore S Sreevidya, Noor M Khaskhely, Atsushi Fukunaga, Polina Khaskina, Stephen E Ullric. Inhibition of photocarcinogenesis by platelet-activating factor or serotonin receptor antagonists. Cancer research. vol 68. issue 10. 2008-06-24. PMID:18483284. |
we noted a significant decrease in uv-induced hypertrophy, sunburn cell formation, and apoptosis when the mice were injected with paf and/or 5-ht(2a) receptor antagonists. |
2008-06-24 |
2023-08-12 |
mouse |
| Michael B Mueller, Rocky S Tua. Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells. Arthritis and rheumatism. vol 58. issue 5. 2008-06-23. PMID:18438858. |
expression of cartilage hypertrophy markers (e.g., type x collagen) by mscs undergoing chondrogenesis raises concern for a tissue engineering application for mscs, because hypertrophy would result in apoptosis and ossification. |
2008-06-23 |
2023-08-12 |
human |
| Tomás R Guilarte, Neal C Burton, Tatyana Verina, Vinaykumar V Prabhu, Kevin G Becker, Tore Syversen, Jay S Schneide. Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates. Journal of neurochemistry. vol 105. issue 5. 2008-06-12. PMID:18284614. |
cortical neurons also exhibited nuclear hypertrophy, intracytoplasmic vacuoles, and apoptosis stigmata. |
2008-06-12 |
2023-08-12 |
Not clear |
| Iram Murtaza, Hong-Xia Wang, Xue Feng, Natalia Alenina, Michael Bader, Bellur S Prabhakar, Pei-Feng L. Down-regulation of catalase and oxidative modification of protein kinase CK2 lead to the failure of apoptosis repressor with caspase recruitment domain to inhibit cardiomyocyte hypertrophy. The Journal of biological chemistry. vol 283. issue 10. 2008-05-30. PMID:18171680. |
down-regulation of catalase and oxidative modification of protein kinase ck2 lead to the failure of apoptosis repressor with caspase recruitment domain to inhibit cardiomyocyte hypertrophy. |
2008-05-30 |
2023-08-12 |
mouse |
| Rajarajan A Thandavarayan, Kenichi Watanabe, Meilei Ma, Punniyakoti T Veeraveedu, Narasimman Gurusamy, Suresh S Palaniyandi, Shaosong Zhang, Anthony J Muslin, Makoto Kodama, Yoshifusa Aizaw. 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. Biochemical pharmacology. vol 75. issue 9. 2008-05-27. PMID:18342293. |
marked increases in myocardial apoptosis, cardiac hypertrophy, and fibrosis were observed with a corresponding up-regulation of atrial natriuretic peptide and galectin-3, as well as a downregulation of sarcoendoplasmic reticulum ca2+ atpase2 expression. |
2008-05-27 |
2023-08-12 |
mouse |
| Anton A Shemetov, Alim S Seit-Nebi, Nikolai B Guse. Structure, properties, and functions of the human small heat-shock protein HSP22 (HspB8, H11, E2IG1): a critical review. Journal of neuroscience research. vol 86. issue 2. 2008-05-13. PMID:17722063. |
hsp22 seems to be involved in regulation of cell proliferation, cardiac hypertrophy, apoptosis, and carcinogenesis, and expression of point mutants of hsp22 correlates with development of different neuromuscular diseases. |
2008-05-13 |
2023-08-12 |
human |
| Xiao-Jun D. Distinct role of adrenoceptor subtypes in cardiac adaptation to chronic pressure overload. Clinical and experimental pharmacology & physiology. vol 35. issue 3. 2008-04-29. PMID:18290877. |
although subjecting alpha(1b)-ko mice to transverse aortic constriction (tac) did not reveal significant phenotype differences compared with controls, mice deficient in both alpha(1a)- and alpha(1b)-ar responded to tac with poor survival, increased cardiomyocyte apoptosis, more severe fibrosis and dysfunction, but a similar degree of lv hypertrophy, compared with wild-type littermates. |
2008-04-29 |
2023-08-12 |
mouse |
| Premal Trivedi, Ronghua Yang, Lili A Barouc. Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. Cell cycle (Georgetown, Tex.). vol 7. issue 5. 2008-04-24. PMID:18239469. |
decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. |
2008-04-24 |
2023-08-12 |
mouse |
| Premal Trivedi, Ronghua Yang, Lili A Barouc. Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. Cell cycle (Georgetown, Tex.). vol 7. issue 5. 2008-04-24. PMID:18239469. |
we recently demonstrated that leptin deficiency in ob/ob mice and leptin insensitivity in db/db mice leads to increased myocyte apoptosis and left ventricular (lv) hypertrophy. |
2008-04-24 |
2023-08-12 |
mouse |
| Premal Trivedi, Ronghua Yang, Lili A Barouc. Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. Cell cycle (Georgetown, Tex.). vol 7. issue 5. 2008-04-24. PMID:18239469. |
an intriguing candidate for the study of obesity-associated cardiac hypertrophy and apoptosis is pi3k, which functions to not only regulate cell size but also maintain cell integrity through protection from apoptosis. |
2008-04-24 |
2023-08-12 |
mouse |
| Premal Trivedi, Ronghua Yang, Lili A Barouc. Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. Cell cycle (Georgetown, Tex.). vol 7. issue 5. 2008-04-24. PMID:18239469. |
leptin repletion in ob/ob mice also reduced both myocyte apoptosis and lv hypertrophy to wt levels. |
2008-04-24 |
2023-08-12 |
mouse |
| Premal Trivedi, Ronghua Yang, Lili A Barouc. Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. Cell cycle (Georgetown, Tex.). vol 7. issue 5. 2008-04-24. PMID:18239469. |
we have therefore concluded that normal leptin signaling is necessary to prevent age-related myocyte apoptosis and lv hypertrophy and that pi3k is a critical component of the leptin signaling axis. |
2008-04-24 |
2023-08-12 |
mouse |
| Premal Trivedi, Ronghua Yang, Lili A Barouc. Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. Cell cycle (Georgetown, Tex.). vol 7. issue 5. 2008-04-24. PMID:18239469. |
the decrease in p110alpha catalytic activity could explain the development of increased myocyte apoptosis and cardiac hypertrophy in these obese mouse models. |
2008-04-24 |
2023-08-12 |
mouse |
| Agata Bielecka-Dabrowa, Magdalena Wierzbicka, Jan H Goc. [Proinflammatory cytokines in cardiovascular diseases as potential therapeutic target]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 60. issue 9-10. 2008-04-22. PMID:18350717. |
several lines of evidence suggest that inflammation plays a pathogenic role in the development and progression of congestive heart failure, influencing heart contractility and hypertrophy, promoting apoptosis, and contributing to the myocardial remodeling process. |
2008-04-22 |
2023-08-12 |
Not clear |
| Tamara M Paravicini, Rhian M Touy. NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes care. vol 31 Suppl 2. 2008-03-28. PMID:18227481. |
nad(p)h oxidase-derived ros plays a physiological role in the regulation of endothelial function and vascular tone and a pathophysiological role in endothelial dysfunction, inflammation, hypertrophy, apoptosis, migration, fibrosis, angiogenesis, and rarefaction, important processes underlying cardiovascular and renal remodeling in hypertension and diabetes. |
2008-03-28 |
2023-08-12 |
Not clear |