| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomás R Guilarte, Neal C Burton, Tatyana Verina, Vinaykumar V Prabhu, Kevin G Becker, Tore Syversen, Jay S Schneide. Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates. Journal of neurochemistry. vol 105. issue 5. 2008-06-12. PMID:18284614. |
cortical neurons also exhibited nuclear hypertrophy, intracytoplasmic vacuoles, and apoptosis stigmata. |
2008-06-12 |
2023-08-12 |
Not clear |
| Iram Murtaza, Hong-Xia Wang, Xue Feng, Natalia Alenina, Michael Bader, Bellur S Prabhakar, Pei-Feng L. Down-regulation of catalase and oxidative modification of protein kinase CK2 lead to the failure of apoptosis repressor with caspase recruitment domain to inhibit cardiomyocyte hypertrophy. The Journal of biological chemistry. vol 283. issue 10. 2008-05-30. PMID:18171680. |
down-regulation of catalase and oxidative modification of protein kinase ck2 lead to the failure of apoptosis repressor with caspase recruitment domain to inhibit cardiomyocyte hypertrophy. |
2008-05-30 |
2023-08-12 |
mouse |
| Rajarajan A Thandavarayan, Kenichi Watanabe, Meilei Ma, Punniyakoti T Veeraveedu, Narasimman Gurusamy, Suresh S Palaniyandi, Shaosong Zhang, Anthony J Muslin, Makoto Kodama, Yoshifusa Aizaw. 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. Biochemical pharmacology. vol 75. issue 9. 2008-05-27. PMID:18342293. |
marked increases in myocardial apoptosis, cardiac hypertrophy, and fibrosis were observed with a corresponding up-regulation of atrial natriuretic peptide and galectin-3, as well as a downregulation of sarcoendoplasmic reticulum ca2+ atpase2 expression. |
2008-05-27 |
2023-08-12 |
mouse |
| Anton A Shemetov, Alim S Seit-Nebi, Nikolai B Guse. Structure, properties, and functions of the human small heat-shock protein HSP22 (HspB8, H11, E2IG1): a critical review. Journal of neuroscience research. vol 86. issue 2. 2008-05-13. PMID:17722063. |
hsp22 seems to be involved in regulation of cell proliferation, cardiac hypertrophy, apoptosis, and carcinogenesis, and expression of point mutants of hsp22 correlates with development of different neuromuscular diseases. |
2008-05-13 |
2023-08-12 |
human |
| Xiao-Jun D. Distinct role of adrenoceptor subtypes in cardiac adaptation to chronic pressure overload. Clinical and experimental pharmacology & physiology. vol 35. issue 3. 2008-04-29. PMID:18290877. |
although subjecting alpha(1b)-ko mice to transverse aortic constriction (tac) did not reveal significant phenotype differences compared with controls, mice deficient in both alpha(1a)- and alpha(1b)-ar responded to tac with poor survival, increased cardiomyocyte apoptosis, more severe fibrosis and dysfunction, but a similar degree of lv hypertrophy, compared with wild-type littermates. |
2008-04-29 |
2023-08-12 |
mouse |
| Premal Trivedi, Ronghua Yang, Lili A Barouc. Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. Cell cycle (Georgetown, Tex.). vol 7. issue 5. 2008-04-24. PMID:18239469. |
decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. |
2008-04-24 |
2023-08-12 |
mouse |
| Premal Trivedi, Ronghua Yang, Lili A Barouc. Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. Cell cycle (Georgetown, Tex.). vol 7. issue 5. 2008-04-24. PMID:18239469. |
we recently demonstrated that leptin deficiency in ob/ob mice and leptin insensitivity in db/db mice leads to increased myocyte apoptosis and left ventricular (lv) hypertrophy. |
2008-04-24 |
2023-08-12 |
mouse |
| Premal Trivedi, Ronghua Yang, Lili A Barouc. Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. Cell cycle (Georgetown, Tex.). vol 7. issue 5. 2008-04-24. PMID:18239469. |
an intriguing candidate for the study of obesity-associated cardiac hypertrophy and apoptosis is pi3k, which functions to not only regulate cell size but also maintain cell integrity through protection from apoptosis. |
2008-04-24 |
2023-08-12 |
mouse |
| Premal Trivedi, Ronghua Yang, Lili A Barouc. Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. Cell cycle (Georgetown, Tex.). vol 7. issue 5. 2008-04-24. PMID:18239469. |
leptin repletion in ob/ob mice also reduced both myocyte apoptosis and lv hypertrophy to wt levels. |
2008-04-24 |
2023-08-12 |
mouse |
| Premal Trivedi, Ronghua Yang, Lili A Barouc. Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. Cell cycle (Georgetown, Tex.). vol 7. issue 5. 2008-04-24. PMID:18239469. |
we have therefore concluded that normal leptin signaling is necessary to prevent age-related myocyte apoptosis and lv hypertrophy and that pi3k is a critical component of the leptin signaling axis. |
2008-04-24 |
2023-08-12 |
mouse |
| Premal Trivedi, Ronghua Yang, Lili A Barouc. Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob/ob mice. Cell cycle (Georgetown, Tex.). vol 7. issue 5. 2008-04-24. PMID:18239469. |
the decrease in p110alpha catalytic activity could explain the development of increased myocyte apoptosis and cardiac hypertrophy in these obese mouse models. |
2008-04-24 |
2023-08-12 |
mouse |
| Agata Bielecka-Dabrowa, Magdalena Wierzbicka, Jan H Goc. [Proinflammatory cytokines in cardiovascular diseases as potential therapeutic target]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 60. issue 9-10. 2008-04-22. PMID:18350717. |
several lines of evidence suggest that inflammation plays a pathogenic role in the development and progression of congestive heart failure, influencing heart contractility and hypertrophy, promoting apoptosis, and contributing to the myocardial remodeling process. |
2008-04-22 |
2023-08-12 |
Not clear |
| Tamara M Paravicini, Rhian M Touy. NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes care. vol 31 Suppl 2. 2008-03-28. PMID:18227481. |
nad(p)h oxidase-derived ros plays a physiological role in the regulation of endothelial function and vascular tone and a pathophysiological role in endothelial dysfunction, inflammation, hypertrophy, apoptosis, migration, fibrosis, angiogenesis, and rarefaction, important processes underlying cardiovascular and renal remodeling in hypertension and diabetes. |
2008-03-28 |
2023-08-12 |
Not clear |
| Masayuki Taniike, Osamu Yamaguchi, Ikuko Tsujimoto, Shungo Hikoso, Toshihiro Takeda, Atsuko Nakai, Shigemiki Omiya, Isamu Mizote, Yuko Nakano, Yoshiharu Higuchi, Yasushi Matsumura, Kazuhiko Nishida, Hidenori Ichijo, Masatsugu Hori, Kinya Ots. Apoptosis signal-regulating kinase 1/p38 signaling pathway negatively regulates physiological hypertrophy. Circulation. vol 117. issue 4. 2008-03-26. PMID:18195174. |
apoptosis signal-regulating kinase 1/p38 signaling pathway negatively regulates physiological hypertrophy. |
2008-03-26 |
2023-08-12 |
Not clear |
| M Zhong, L J Wike, J T Ryaby, D H Carney, B D Boyan, Z Schwart. Thrombin peptide TP508 prevents nitric oxide mediated apoptosis in chondrocytes in the endochondral developmental pathway. Biochimica et biophysica acta. vol 1783. issue 1. 2008-03-19. PMID:18023291. |
this study tested the hypothesis that tp508 acts by blocking the onset of apoptosis associated with hypertrophy. |
2008-03-19 |
2023-08-12 |
human |
| Lars Gullestad, Erik Oie, Thor Ueland, Arne Yndestad, Pål Aukrus. The role of statins in heart failure. Fundamental & clinical pharmacology. vol 21 Suppl 2. 2008-03-06. PMID:18001320. |
beneficial effects include attenuation of cardiac hypertrophy, improvement in endothelial function, anti-inflammatory effects, reduction in the activity of matrix metalloproteinases, reduction in apoptosis, interference with neurohormones, and improved homeostasis. |
2008-03-06 |
2023-08-12 |
human |
| Ling Chen, Jin Zhang, Tracey X Gan, Ye Chen-Izu, Jeffrey D Hasday, Morris Karmazyn, C William Balke, Steven M Schar. Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia. Journal of applied physiology (Bethesda, Md. : 1985). vol 104. issue 1. 2008-02-28. PMID:18006871. |
in conclusion, cih-mediated lv global dysfunction is associated with myocyte hypertrophy and apoptosis at the cellular level. |
2008-02-28 |
2023-08-12 |
rat |
| Yee H Looi, David J Grieve, Anjana Siva, Simon J Walker, Narayana Anilkumar, Alison C Cave, Michael Marber, Mark J Monaghan, Ajay M Sha. Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction. Hypertension (Dallas, Tex. : 1979). vol 51. issue 2. 2008-02-26. PMID:18180403. |
nox2(-/-) mice exhibited less cardiomyocyte hypertrophy, apoptosis, and interstitial fibrosis; reduced increases in expression of connective tissue growth factor and procollagen 1 mrna; and smaller increases in myocardial matrix metalloproteinase-2 activity than wt mice. |
2008-02-26 |
2023-08-12 |
mouse |
| Abhinav Diwan, Janaka Wansapura, Faisal M Syed, Scot J Matkovich, John N Lorenz, Gerald W Dor. Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation. Circulation. vol 117. issue 3. 2008-02-25. PMID:18178777. |
nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation. |
2008-02-25 |
2023-08-12 |
Not clear |
| Tao Hang, Shisen Jiang, Chunhui Wang, Dujiang Xie, Hailing Ren, Haihong Zhug. Apoptosis and expression of uncoupling protein-2 in pressure overload-induced left ventricular hypertrophy. Acta cardiologica. vol 62. issue 5. 2008-02-08. PMID:17982966. |
apoptosis and expression of uncoupling protein-2 in pressure overload-induced left ventricular hypertrophy. |
2008-02-08 |
2023-08-12 |
Not clear |