| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arne Yndestad, Jan Kristian Damås, Erik Øie, Thor Ueland, Lars Gullestad, Pål Aukrus. Role of inflammation in the progression of heart failure. Current cardiology reports. vol 9. issue 3. 2007-06-19. PMID:17470337. |
importantly, experimental studies have shown that inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1b, and monocyte chemoattractant peptide-1 may contribute to the development and progression of hf by promoting myocardial hypertrophy, activating matrix metalloproteinases, provoking contractile dysfunction, and inducing apoptosis. |
2007-06-19 |
2023-08-12 |
Not clear |
| S Simsa, E Monsonego Orna. Endochondral ossification process of the turkey (Meleagris gallopavo) during embryonic and juvenile development. Poultry science. vol 86. issue 3. 2007-06-18. PMID:17297170. |
this process includes commitment of cells to the chondrocytic lineage and further differentiation into hypertrophic chondrocytes, which subsequently undergo apoptosis and are replaced by osteoblasts laying down the trabecular bone. |
2007-06-18 |
2023-08-12 |
Not clear |
| Pallavi S Peter, Jennifer E Brady, Lin Yan, Wei Chen, Stefan Engelhardt, Yibin Wang, Junichi Sadoshima, Stephen F Vatner, Dorothy E Vatne. Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor. The Journal of clinical investigation. vol 117. issue 5. 2007-06-13. PMID:17446930. |
both beta(1)-ar and beta(2)-ar tg mice had enhanced lv ejection fraction (lvef) as young adults and developed similar cardiomyopathy at 11-15 months, characterized by reduced lvef, myocyte hypertrophy, fibrosis, and apoptosis. |
2007-06-13 |
2023-08-12 |
mouse |
| Pallavi S Peter, Jennifer E Brady, Lin Yan, Wei Chen, Stefan Engelhardt, Yibin Wang, Junichi Sadoshima, Stephen F Vatner, Dorothy E Vatne. Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor. The Journal of clinical investigation. vol 117. issue 5. 2007-06-13. PMID:17446930. |
we inhibited p38alpha mapk by mating beta(1)-ar tg and beta(2)-ar tg mice with dnp38alpha mapk mice, which rescued the depressed lvef and reduced apoptosis and fibrosis in bigenic beta(2)-ar x dnp38alpha mapk mice, but not bigenic beta(1)-ar x dnp38alpha mapk mice, and failed to reduce myocyte hypertrophy in either group. |
2007-06-13 |
2023-08-12 |
mouse |
| Kevyn E Merten, Youchun Jiang, Y James Kan. Zinc inhibits doxorubicin-activated calcineurin signal transduction pathway in H9c2 embryonic rat cardiac cells. Experimental biology and medicine (Maywood, N.J.). vol 232. issue 5. 2007-06-11. PMID:17463165. |
elevation of the zinc-binding protein metallothionein (mt) in the heart inhibits doxorubicin (dox)-induced myocardial apoptosis and heart hypertrophy. |
2007-06-11 |
2023-08-12 |
rat |
| Kevyn E Merten, Youchun Jiang, Y James Kan. Zinc inhibits doxorubicin-activated calcineurin signal transduction pathway in H9c2 embryonic rat cardiac cells. Experimental biology and medicine (Maywood, N.J.). vol 232. issue 5. 2007-06-11. PMID:17463165. |
zinc release from mt in response to oxidative stress has been suggested as a mechanism of action of mt protection from dox toxicity, and calcineurin is involved in the signaling pathways leading to myocardial apoptosis and heart hypertrophy. |
2007-06-11 |
2023-08-12 |
rat |
| Ralph R Alcendor, Shumin Gao, Peiyong Zhai, Daniela Zablocki, Eric Holle, Xianzhong Yu, Bin Tian, Thomas Wagner, Stephen F Vatner, Junichi Sadoshim. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circulation research. vol 100. issue 10. 2007-06-07. PMID:17446436. |
in contrast, a high level (12.5-fold) of sirt1 increased apoptosis and hypertrophy and decreased cardiac function, thereby stimulating the development of cardiomyopathy. |
2007-06-07 |
2023-08-12 |
mouse |
| Roberto M Saraiva, Khalid M Minhas, Meizi Zheng, Eleanor Pitz, Adriana Treuer, Daniel Gonzalez, Karl H Schuleri, Koenraad M Vandegaer, Lili A Barouch, Joshua M Har. Reduced neuronal nitric oxide synthase expression contributes to cardiac oxidative stress and nitroso-redox imbalance in ob/ob mice. Nitric oxide : biology and chemistry. vol 16. issue 3. 2007-06-05. PMID:17307368. |
disruption of leptin signaling in the heart may contribute to obesity-related cardiac disease, as leptin deficient (oblob) mice display cardiac hypertrophy, increased cardiac apoptosis and reduced survival. |
2007-06-05 |
2023-08-12 |
mouse |
| Matthias Meier, Jan Menne, Joon-Keun Park, Marcel Holtz, Faikah Gueler, Thorsten Kirsch, Mario Schiffer, Michael Mengel, Carsten Lindschau, Michael Leitges, Hermann Halle. Deletion of protein kinase C-epsilon signaling pathway induces glomerulosclerosis and tubulointerstitial fibrosis in vivo. Journal of the American Society of Nephrology : JASN. vol 18. issue 4. 2007-05-31. PMID:17360953. |
protein kinase c (pkc), a family of 12 distinct serine-threonine kinases, is an important intracellular signaling pathway involved in various cellular functions, such as proliferation, hypertrophy, apoptosis, and adhesion. |
2007-05-31 |
2023-08-12 |
mouse |
| Mari Odashima, Soichiro Usui, Hiromitsu Takagi, Chull Hong, Jing Liu, Mitsuhiro Yokota, Junichi Sadoshim. Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circulation research. vol 100. issue 9. 2007-05-29. PMID:17395874. |
inhibition of endogenous mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. |
2007-05-29 |
2023-08-12 |
mouse |
| Mari Odashima, Soichiro Usui, Hiromitsu Takagi, Chull Hong, Jing Liu, Mitsuhiro Yokota, Junichi Sadoshim. Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circulation research. vol 100. issue 9. 2007-05-29. PMID:17395874. |
these results indicate that endogenous mst1 plays an important role in mediating cardiac dilation, apoptosis, fibrosis, and cardiac dysfunction, but not cardiac hypertrophy, after mi. |
2007-05-29 |
2023-08-12 |
mouse |
| Maria Cecília M Coelho, Uenis Tannuri, Ana Cristina A Tannuri, Evandro S Mello, Neide Aparecida S R dos Santo. Expression of interleukin 6 and apoptosis-related genes in suckling and weaning rat models of hepatectomy and liver regeneration. Journal of pediatric surgery. vol 42. issue 4. 2007-05-21. PMID:17448755. |
the process of liver regeneration includes both the hypertrophy and hyperplasia of cells (processes regulated by growth factors and cytokines, mainly interleukin 6 [il-6]) as well as apoptosis, or programmed cell death (a process regulated mainly by the bcl-2 family of proteins). |
2007-05-21 |
2023-08-12 |
rat |
| Hong-Liang Li, Ming-Lei Zhuo, Dong Wang, Ai-Bing Wang, Hua Cai, Li-Hong Sun, Qinglin Yang, Yue Huang, Yu-Sheng Wei, Peter P Liu, De-Pei Liu, Chih-Chuan Lian. Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circulation. vol 115. issue 14. 2007-05-07. PMID:17389268. |
as an inhibitor of nuclear factor-kappab signaling, a20 protects against apoptosis, inflammation, and cardiac hypertrophy. |
2007-05-07 |
2023-08-12 |
human |
| Ken-ichi Watanabe, Meilei Ma, Ken-ichi Hirabayashi, Narasimman Gurusamy, Punniyakoti T Veeraveedu, Paras Prakash, Shaosong Zhang, Anthony J Muslin, Makoto Kodama, Yoshifusa Aizaw. Swimming stress in DN 14-3-3 mice triggers maladaptive cardiac remodeling: role of p38 MAPK. American journal of physiology. Heart and circulatory physiology. vol 292. issue 3. 2007-04-26. PMID:17040971. |
cardiomyocyte apoptosis, cardiac hypertrophy, and fibrosis were greatly increased in the tg group compared with those in the ntg group. |
2007-04-26 |
2023-08-12 |
mouse |
| Xiao-lei Moore, Su-ling Tan, Chen-yi Lo, Lu Fang, Yi-Dan Su, Xiao-Ming Gao, Elizabeth A Woodcock, Roger J Summers, Geoffrey W Tregear, Ross A D Bathgate, Xiao-Jun D. Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes. Endocrinology. vol 148. issue 4. 2007-04-24. PMID:17204550. |
relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes. |
2007-04-24 |
2023-08-12 |
human |
| Xiao-lei Moore, Su-ling Tan, Chen-yi Lo, Lu Fang, Yi-Dan Su, Xiao-Ming Gao, Elizabeth A Woodcock, Roger J Summers, Geoffrey W Tregear, Ross A D Bathgate, Xiao-Jun D. Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes. Endocrinology. vol 148. issue 4. 2007-04-24. PMID:17204550. |
we investigated effects of isoform 2 of the human relaxin (h2-relaxin) on cm hypertrophy and apoptosis. |
2007-04-24 |
2023-08-12 |
human |
| Xiao-lei Moore, Su-ling Tan, Chen-yi Lo, Lu Fang, Yi-Dan Su, Xiao-Ming Gao, Elizabeth A Woodcock, Roger J Summers, Geoffrey W Tregear, Ross A D Bathgate, Xiao-Jun D. Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes. Endocrinology. vol 148. issue 4. 2007-04-24. PMID:17204550. |
in conclusion, these results extend our current knowledge of the cardiac actions of relaxin by demonstrating that h2-relaxin indirectly inhibits cm hypertrophy and directly protects cm from apoptosis. |
2007-04-24 |
2023-08-12 |
human |
| Dominic P Del Re, Shigeki Miyamoto, Joan Heller Brow. RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis. The Journal of biological chemistry. vol 282. issue 11. 2007-04-24. PMID:17234627. |
we demonstrate here that adenoviral overexpression of activated rhoa in cardiomyocytes induces hypertrophy, which transitions over time to apoptosis, as evidenced by caspase activation and nucleosomal dna fragmentation. |
2007-04-24 |
2023-08-12 |
Not clear |
| Minsun Park, Yeryoung Yong, Seung-Won Choi, Jae Hwan Kim, Jong Eun Lee, Dae-Won Ki. Constitutive RelA activation mediated by Nkx3.2 controls chondrocyte viability. Nature cell biology. vol 9. issue 3. 2007-04-24. PMID:17310243. |
during endochondral ossification, a process that accounts for the majority of bone formation in vertebrates, hypertrophic chondrocytes display a greater susceptibility to apoptosis when compared to proliferating chondrocytes. |
2007-04-24 |
2023-08-12 |
Not clear |
| Hiroshi Miyazaki, Naoki Oka, Akimasa Koga, Haruya Ohmura, Tamenobu Ueda, Tsutomu Imaizum. Comparison of gene expression profiling in pressure and volume overload-induced myocardial hypertrophies in rats. Hypertension research : official journal of the Japanese Society of Hypertension. vol 29. issue 12. 2007-04-24. PMID:17378376. |
the over-expression of mt in h9c2 cells inhibited norepinephrine-induced apoptosis, suggesting that mt may act as an anti-apoptotic molecule in cardiac hypertrophy. |
2007-04-24 |
2023-08-12 |
rat |