| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carola Doerries, Karsten Grote, Denise Hilfiker-Kleiner, Maren Luchtefeld, Arnd Schaefer, Steven M Holland, Sajoscha Sorrentino, Costantina Manes, Bernhard Schieffer, Helmut Drexler, Ulf Landmesse. Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction. Circulation research. vol 100. issue 6. 2007-04-12. PMID:17332431. |
furthermore, cardiomyocyte hypertrophy, apoptosis, and interstitial fibrosis were substantially reduced in p47(phox)-/- mice as compared with wt mice. |
2007-04-12 |
2023-08-12 |
mouse |
| Mei Sun, Manyin Chen, Fayez Dawood, Urszula Zurawska, Jeff Y Li, Thomas Parker, Zamaneh Kassiri, Lorrie A Kirshenbaum, Malcolm Arnold, Rama Khokha, Peter P Li. Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state. Circulation. vol 115. issue 11. 2007-04-12. PMID:17353445. |
pressure overload is accompanied by cardiac myocyte apoptosis, hypertrophy, and inflammatory/fibrogenic responses that lead to ventricular remodeling and heart failure. |
2007-04-12 |
2023-08-12 |
Not clear |
| Michael J Mihm, Deborah M Amann, Brandon L Schanbacher, Ruth A Altschuld, John Anthony Bauer, Kari R Hoy. Cardiac dysfunction in the R6/2 mouse model of Huntington's disease. Neurobiology of disease. vol 25. issue 2. 2007-04-11. PMID:17126554. |
hypertrophy, fibrosis, apoptosis, beta(1) adrenergic receptor downregulation) was observed. |
2007-04-11 |
2023-08-12 |
mouse |
| William G Couser, Masaomi Nangak. Cellular and molecular biology of membranous nephropathy. Journal of nephrology. vol 19. issue 6. 2007-04-05. PMID:17173240. |
other podocyte changes including detachment, apoptosis and alterations in cell cycle regulatory proteins favoring hypertrophy over proliferation also contribute to proteinuria and to development of glomerular sclerosis. |
2007-04-05 |
2023-08-12 |
human |
| Prasanna Krishnamurthy, Venkateswaran Subramanian, Mahipal Singh, Krishna Sing. Beta1 integrins modulate beta-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling. Hypertension (Dallas, Tex. : 1979). vol 49. issue 4. 2007-04-05. PMID:17283249. |
thus, beta1 integrins play a crucial role in beta-adrenergic receptor-stimulated myocardial remodeling with effects on cardiac myocyte hypertrophy, apoptosis, and left ventricular function. |
2007-04-05 |
2023-08-12 |
mouse |
| Dimitris Tousoulis, Marietta Charakida, Elli Stefanadi, Gerasimimos Siasos, George Latsios, Christodoulos Stefanadi. Statins in heart failure. Beyond the lipid lowering effect. International journal of cardiology. vol 115. issue 2. 2007-04-04. PMID:17175040. |
experimental evidence suggests that statins may be beneficial in heart failure as they can inhibit myocardial hypertrophy, reduce cardiomyocyte loss by apoptosis, reduce oxidative stress and restore neurohormonal imbalance. |
2007-04-04 |
2023-08-12 |
Not clear |
| Oliver Zolk, Carolus Schenke, Antonio Sarika. The ubiquitin-proteasome system: focus on the heart. Cardiovascular research. vol 70. issue 3. 2007-04-02. PMID:16497285. |
recent studies demonstrated that the ups regulates receptor internalization, hypertrophic response, apoptosis, and tolerance to ischemia and reperfusion in cardiomyocytes. |
2007-04-02 |
2023-08-12 |
Not clear |
| Alison C Cave, Alison C Brewer, Anilkumar Narayanapanicker, Robin Ray, David J Grieve, Simon Walker, Ajay M Sha. NADPH oxidases in cardiovascular health and disease. Antioxidants & redox signaling. vol 8. issue 5-6. 2007-03-27. PMID:16771662. |
this article reviews the potential roles of nadph oxidases in both cardiovascular physiological processes (such as the regulation of vascular tone and oxygen sensing) and pathophysiological processes such as endothelial dysfunction, inflammation, hypertrophy, apoptosis, migration, angiogenesis, and vascular and cardiac remodeling. |
2007-03-27 |
2023-08-12 |
human |
| Manveen K Gupta, T V Neelakantan, Mishra Sanghamitra, Rakesh K Tyagi, Amit Dinda, Subir Maulik, Chinmay K Mukhopadhyay, Shyamal K Goswam. An assessment of the role of reactive oxygen species and redox signaling in norepinephrine-induced apoptosis and hypertrophy of H9c2 cardiac myoblasts. Antioxidants & redox signaling. vol 8. issue 5-6. 2007-03-27. PMID:16771697. |
an assessment of the role of reactive oxygen species and redox signaling in norepinephrine-induced apoptosis and hypertrophy of h9c2 cardiac myoblasts. |
2007-03-27 |
2023-08-12 |
rat |
| Manveen K Gupta, T V Neelakantan, Mishra Sanghamitra, Rakesh K Tyagi, Amit Dinda, Subir Maulik, Chinmay K Mukhopadhyay, Shyamal K Goswam. An assessment of the role of reactive oxygen species and redox signaling in norepinephrine-induced apoptosis and hypertrophy of H9c2 cardiac myoblasts. Antioxidants & redox signaling. vol 8. issue 5-6. 2007-03-27. PMID:16771697. |
therefore, ne induces hypertrophy and apoptosis in cardiac myocytes by distinct redox-signaling rather than a general surge of ros. |
2007-03-27 |
2023-08-12 |
rat |
| Fuhai Li, Wei Xia, Aiwu Li, Cuifen Zhao, Ruopeng Su. Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats. Pharmacological research. vol 55. issue 1. 2007-03-20. PMID:17127075. |
compared with the shunt groups, fasudil treatment significantly suppressed rho-kinase activity at both weeks 4 and 8, improved pulmonary hypertension at week 8, attenuated right ventricular hypertrophy at week 8, and enhanced pulmonary vascular remodeling both at weeks 4 and 8, which were associated with suppressed pulmonary artery smooth muscle cells proliferation at week 4 and apoptosis both at weeks 4 and 8. |
2007-03-20 |
2023-08-12 |
rat |
| Serge Grégoire, Lin Xiao, Jianyun Nie, Xiaohong Zhang, Minghong Xu, Jiarong Li, Jiemin Wong, Edward Seto, Xiang-Jiao Yan. Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Molecular and cellular biology. vol 27. issue 4. 2007-03-16. PMID:17158926. |
the myocyte enhancer factor 2 (mef2) family of transcription factors is not only important for controlling gene expression in normal cellular programs, like muscle differentiation, t-cell apoptosis, neuronal survival, and synaptic differentiation, but has also been linked to cardiac hypertrophy and other pathological conditions. |
2007-03-16 |
2023-08-12 |
Not clear |
| Michael Arad, Christine E Seidman, J G Seidma. AMP-activated protein kinase in the heart: role during health and disease. Circulation research. vol 100. issue 4. 2007-03-16. PMID:17332438. |
these kinases have a fundamental role in cell-cycle regulation and protein synthesis, suggesting involvement in a number of human disorders including cardiac hypertrophy, apoptosis, cancer, and atherosclerosis. |
2007-03-16 |
2023-08-12 |
human |
| Bruna Pucci, Christopher S Adams, Jolanta Fertala, Bradley C Snyder, Kyle D Mansfield, Marco Tafani, Theresa Freeman, Irving M Shapir. Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation. Journal of cellular physiology. vol 210. issue 3. 2007-03-08. PMID:17133357. |
it is concluded that during hypertrophy, the change in membrane potential, the increased binding of a pro-apoptotic protein to mitochondria, and the activation of caspase-3 serve to prime cells for apoptosis. |
2007-03-08 |
2023-08-12 |
Not clear |
| Guo-Chang Fan, Qunying Yuan, Guojie Song, Yigang Wang, Guoli Chen, Jiang Qian, Xiaoyang Zhou, Yong J Lee, Muhammad Ashraf, Evangelia G Krania. Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Circulation research. vol 99. issue 11. 2007-03-06. PMID:17068291. |
hsp20 attenuated the cardiac hypertrophic response, markedly reduced interstitial fibrosis, and decreased apoptosis. |
2007-03-06 |
2023-08-12 |
human |
| Venkateswaran Subramanian, Prasanna Krishnamurthy, Krishna Singh, Mahipal Sing. Lack of osteopontin improves cardiac function in streptozotocin-induced diabetic mice. American journal of physiology. Heart and circulatory physiology. vol 292. issue 1. 2007-02-20. PMID:16980342. |
thus increased expression of opn may play a deleterious role during streptozotocin-induced diabetic cardiomyopathy with effects on cardiac fibrosis, hypertrophy, and myocyte apoptosis. |
2007-02-20 |
2023-08-12 |
mouse |
| Ralph McWhinnie, Dmitri V Pechkovsky, Danyi Zhou, David Lane, Andrew J Halayko, Darryl A Knight, Tony R Ba. Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. vol 292. issue 1. 2007-02-09. PMID:16920889. |
endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells. |
2007-02-09 |
2023-08-12 |
human |
| Ralph McWhinnie, Dmitri V Pechkovsky, Danyi Zhou, David Lane, Andrew J Halayko, Darryl A Knight, Tony R Ba. Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. vol 292. issue 1. 2007-02-09. PMID:16920889. |
we hypothesized that et-1 may contribute to the increased airway smooth muscle mass found in severe asthma by inducing hypertrophy and inhibiting apoptosis of smooth muscle cells. |
2007-02-09 |
2023-08-12 |
human |
| Eleonora Olivotto, Roberta Vitellozzi, Patricia Fernandez, Elisabetta Falcieri, Michela Battistelli, Sabrina Burattini, Annalisa Facchini, Flavio Flamigni, Spartaco Santi, Andrea Facchini, Rosa Maria Borzi\. Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. Journal of cellular physiology. vol 210. issue 2. 2007-02-09. PMID:17096385. |
chondrocyte hypertrophy and apoptosis induced by groalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin b. cxcr2 ligands contribute to chondrocyte hypertrophy and apoptosis, important determinants in cartilage pathophysiology. |
2007-02-09 |
2023-08-12 |
human |
| David R Buvat de Virgin. Novel and potential future biomarkers for assessment of the severity and prognosis of chronic heart failure : a clinical review. Heart failure reviews. vol 11. issue 4. 2007-01-30. PMID:17131079. |
this knowledge has allowed expert researchers and clinicians to explore an entirely new spectrum of potential biochemical markers derived from different cellular and signaling pathways that lead to myocardial hypertrophy, chronic damage of the myocyte, apoptosis, and, ultimately, myocardial remodeling. |
2007-01-30 |
2023-08-12 |
Not clear |