| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heng Kong, Qingsheng Yu, Liu Zh. [Experimental study on artesunate inducing apoptosis of hypertrophic scar fibroblasts]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery. vol 21. issue 9. 2009-09-30. PMID:17933233. |
to study the effect and mechanism of the apoptosis of hypertrophic scar fibroblasts (hsf) induced by artesunate (art). |
2009-09-30 |
2023-08-12 |
Not clear |
| Qizhu Tang, Jun Cai, Difei Shen, Zhouyan Bian, Ling Yan, You-Xin Wang, Jie Lan, Guo-Qing Zhuang, Wen-Zhan Ma, Wei Wan. Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling. Journal of molecular medicine (Berlin, Germany). vol 87. issue 3. 2009-09-25. PMID:19096818. |
constitutive overexpression of human ctsl in the murine heart attenuated the hypertrophic response, markedly reduced apoptosis, and fibrosis. |
2009-09-25 |
2023-08-12 |
mouse |
| Guo-You Zhang, Xuan Li, Xing-Long Chen, Zhi-Jie Li, Qing Yu, Liang-Fu Jiang, Jian Ding, Wei-Yang Ga. Contribution of epidermal stem cells to hypertrophic scars pathogenesis. Medical hypotheses. vol 73. issue 3. 2009-09-22. PMID:19427134. |
current therapies are only partially effective and safe because they couldn't inhibit the cell and extracellular matrix proliferation and eliminate other relative factors of hypertrophic scars formation at all, such as: absence of epidermal-mesenchymal interaction, and at the same time inducing death (apoptosis and necrosis) of other normal cells. |
2009-09-22 |
2023-08-12 |
Not clear |
| Bruna De Felice, Corrado Garbi, Margherita Santoriello, Alessandra Santillo, Robert R Wilso. Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts. Molecular and cellular biochemistry. vol 327. issue 1-2. 2009-09-21. PMID:19224335. |
differential apoptosis markers in human keloids and hypertrophic scars fibroblasts. |
2009-09-21 |
2023-08-12 |
human |
| Bruna De Felice, Corrado Garbi, Margherita Santoriello, Alessandra Santillo, Robert R Wilso. Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts. Molecular and cellular biochemistry. vol 327. issue 1-2. 2009-09-21. PMID:19224335. |
since p53 plays a central role in the dna damage response by inducing cell cycle arrest and/or apoptotic cell death, we also set up time course experiments making cell cultures at different times to investigate the phenomenon of apoptosis and its involvement in the process of pathological scarring in both hypertrophic scars and keloids. |
2009-09-21 |
2023-08-12 |
human |
| Bruna De Felice, Corrado Garbi, Margherita Santoriello, Alessandra Santillo, Robert R Wilso. Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts. Molecular and cellular biochemistry. vol 327. issue 1-2. 2009-09-21. PMID:19224335. |
moreover, the correlation of apoptosis and ros levels in keloid and hypertrophic scars fibroblasts was assessed. |
2009-09-21 |
2023-08-12 |
human |
| Bruna De Felice, Corrado Garbi, Margherita Santoriello, Alessandra Santillo, Robert R Wilso. Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts. Molecular and cellular biochemistry. vol 327. issue 1-2. 2009-09-21. PMID:19224335. |
understanding the molecular mechanisms that determine the regulation of apoptosis during wound healing might allow us to therapeutically modulate these pathways so that apoptotic cell death is reactivated in dysregulated and hypertrophic cells. |
2009-09-21 |
2023-08-12 |
human |
| Dov Tiosano, Ze'ev Hochber. Hypophosphatemia: the common denominator of all rickets. Journal of bone and mineral metabolism. vol 27. issue 4. 2009-09-02. PMID:19504043. |
rickets is a disease of the hypertrophic chondrocytes in the growth plate and is caused by hypophosphatemia-a derived defect in terminal chondrocyte apoptosis. |
2009-09-02 |
2023-08-12 |
Not clear |
| Willem M van der Veer, Monica C T Bloemen, Magda M W Ulrich, Grietje Molema, Paul P van Zuijlen, Esther Middelkoop, Frank B Niesse. Potential cellular and molecular causes of hypertrophic scar formation. Burns : journal of the International Society for Burn Injuries. vol 35. issue 1. 2009-08-03. PMID:18952381. |
it seems that a wide array of subsequent processes are involved in hypertrophic scar formation, like an affected haemostasis, exaggerated inflammation, prolonged reepithelialization, overabundant extracellular matrix production, augmented neovascularization, atypical extracellular matrix remodeling and reduced apoptosis. |
2009-08-03 |
2023-08-12 |
Not clear |
| Mimi S Kim, Ke Ying Wu, Valerie Auyeung, Qian Chen, Philip A Gruppuso, Chanika Phornphutku. Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling. American journal of physiology. Endocrinology and metabolism. vol 296. issue 6. 2009-07-16. PMID:19401455. |
this was accounted by reduced cell proliferation and hypertrophy but not apoptosis. |
2009-07-16 |
2023-08-12 |
rat |
| Tetsushi Dodo, Yoshikazu Taketa, Mayumi Sugiyama, Akira Inomata, Jiro Sonoda, Yasuyuki Okuda, Hiroshi Mineshima, Satoru Hosokawa, Toyohiko Aok. Collaborative work on evaluation of ovarian toxicity. 11) Two- or four-week repeated-dose studies and fertility study of ethylene glycol monomethyl ether in female rats. The Journal of toxicological sciences. vol 34 Suppl 1. 2009-06-30. PMID:19265278. |
the alterations of ovarian morphology observed at > or = 100 mg/kg after 2 or 4 weeks of administration were characterized by hypertrophy of the corpora lutea with decreased cellular debris indicating apoptosis, and increased proliferating cell nuclear antigen (pcna)-negative large atretic follicles. |
2009-06-30 |
2023-08-12 |
rat |
| Jacqueline Heger, Saskia C Peters, Hans-Michael Piper, Gerhild Eule. SMAD-proteins as a molecular switch from hypertrophy to apoptosis induction in adult ventricular cardiomyocytes. Journal of cellular physiology. vol 220. issue 2. 2009-06-29. PMID:19415695. |
smad-proteins as a molecular switch from hypertrophy to apoptosis induction in adult ventricular cardiomyocytes. |
2009-06-29 |
2023-08-12 |
rat |
| Jacqueline Heger, Saskia C Peters, Hans-Michael Piper, Gerhild Eule. SMAD-proteins as a molecular switch from hypertrophy to apoptosis induction in adult ventricular cardiomyocytes. Journal of cellular physiology. vol 220. issue 2. 2009-06-29. PMID:19415695. |
heart failure development goes along with a transition from hypertrophic growth to apoptosis induction. |
2009-06-29 |
2023-08-12 |
rat |
| Jacqueline Heger, Saskia C Peters, Hans-Michael Piper, Gerhild Eule. SMAD-proteins as a molecular switch from hypertrophy to apoptosis induction in adult ventricular cardiomyocytes. Journal of cellular physiology. vol 220. issue 2. 2009-06-29. PMID:19415695. |
therefore, smads could be candidates that turn the balance from hypertrophic growth to apoptosis resulting in heart failure development. |
2009-06-29 |
2023-08-12 |
rat |
| Jacqueline Heger, Saskia C Peters, Hans-Michael Piper, Gerhild Eule. SMAD-proteins as a molecular switch from hypertrophy to apoptosis induction in adult ventricular cardiomyocytes. Journal of cellular physiology. vol 220. issue 2. 2009-06-29. PMID:19415695. |
to test this hypothesis we infected isolated rat ventricular cardiomyocytes with adenovirus encoding smad4 (adsmad4) and investigated the impact of smad4 overexpression on the development of apoptosis and hypertrophy under stimulation with phenylephrine (pe). |
2009-06-29 |
2023-08-12 |
rat |
| Jacqueline Heger, Saskia C Peters, Hans-Michael Piper, Gerhild Eule. SMAD-proteins as a molecular switch from hypertrophy to apoptosis induction in adult ventricular cardiomyocytes. Journal of cellular physiology. vol 220. issue 2. 2009-06-29. PMID:19415695. |
smad4 triggers the transition from hypertrophy to apoptosis in ventricular cardiomyocytes. |
2009-06-29 |
2023-08-12 |
rat |
| Julien Bruban, Anne-Lise Glotin, Virginie Dinet, Naïma Chalour, Florian Sennlaub, Laurent Jonet, Na An, Anne Marie Faussat, Frédéric Mascarell. Amyloid-beta(1-42) alters structure and function of retinal pigmented epithelial cells. Aging cell. vol 8. issue 2. 2009-06-26. PMID:19239420. |
subretinally injected oabeta(1-42) induced pigmentation loss and rpe hypertrophy but not rpe cell apoptosis in c57bl/6 j mice. |
2009-06-26 |
2023-08-12 |
mouse |
| Craig Steven McLachlan, Shamima Lasker, Shah M Keramat Ali, Lexin Wang, Herbert Jeline. The absence of pathological myofibre disarray in the diabetic heart: is it a paradox? Acta cardiologica. vol 64. issue 2. 2009-06-23. PMID:19476122. |
this is surprising given that many of the pathological, remodelling and mechanical changes that present in the diabetic ventricle are also present in hcm, for example, myocardial stiffness, myocardial hypertrophy, apoptosis, cell slippage, extensive collagen expression and fibrosis. |
2009-06-23 |
2023-08-12 |
Not clear |
| Chun-Hsien Chu, Bor-Show Tzang, Li-Mien Chen, Chung-Jung Liu, Fuu-Jen Tsai, Chang-Hai Tsai, James A Lin, Wei-Wen Kuo, Da-Tian Bau, Chun-Hsu Yao, Chih-Yang Huan. Activation of insulin-like growth factor II receptor induces mitochondrial-dependent apoptosis through G(alpha)q and downstream calcineurin signaling in myocardial cells. Endocrinology. vol 150. issue 6. 2009-06-18. PMID:19095737. |
in previous studies, we have found that igf-ii and igf-ii receptor (igf-iir) dose dependently correlated with the progression of pathological hypertrophy after complete abdominal aorta ligation, which may play a critical role in angiotensin ii-induced cardiomyocyte apoptosis. |
2009-06-18 |
2023-08-12 |
rat |
| M R Richardson, X Lai, S B Mason, S J Miller, F A Witzman. Differential protein expression during aging in ventricular myocardium of Fischer 344 x Brown Norway hybrid rats. Experimental gerontology. vol 43. issue 10. 2009-06-16. PMID:18682286. |
of 46 differentially expressed proteins identified, seventeen have roles in apoptosis, ten in hypertrophy, seven in fibrosis, and three in diastolic dysfunction, aging-associated processes previously reported in both human and fbn rat heart. |
2009-06-16 |
2023-08-12 |
human |