| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dafeng Yang, Ya Wang, Minna Jiang, Xu Deng, Zhifang Pei, Fei Li, Ke Xia, Lingyan Zhu, Tianlun Yang, Meifang Che. Downregulation of Profilin-1 Expression Attenuates Cardiomyocytes Hypertrophy and Apoptosis Induced by Advanced Glycation End Products in H9c2 Cells. BioMed research international. vol 2017. 2018-07-20. PMID:29238726. |
pfn-1 was upregulated in ages-treated h9c2 cells, which was associated with increased cardiomyocytes hypertrophy and apoptosis. |
2018-07-20 |
2023-08-13 |
Not clear |
| Dafeng Yang, Ya Wang, Minna Jiang, Xu Deng, Zhifang Pei, Fei Li, Ke Xia, Lingyan Zhu, Tianlun Yang, Meifang Che. Downregulation of Profilin-1 Expression Attenuates Cardiomyocytes Hypertrophy and Apoptosis Induced by Advanced Glycation End Products in H9c2 Cells. BioMed research international. vol 2017. 2018-07-20. PMID:29238726. |
silencing pfn-1 expression remarkably attenuated ages-induced h9c2 cell hypertrophy and apoptosis. |
2018-07-20 |
2023-08-13 |
Not clear |
| Dafeng Yang, Ya Wang, Minna Jiang, Xu Deng, Zhifang Pei, Fei Li, Ke Xia, Lingyan Zhu, Tianlun Yang, Meifang Che. Downregulation of Profilin-1 Expression Attenuates Cardiomyocytes Hypertrophy and Apoptosis Induced by Advanced Glycation End Products in H9c2 Cells. BioMed research international. vol 2017. 2018-07-20. PMID:29238726. |
collectively, these data suggest that pfn-1 may play an important role in ages-induced hypertrophy and apoptosis in h9c2 cells. |
2018-07-20 |
2023-08-13 |
Not clear |
| Jun-Biao Wu, Yuan Zhou, Chun-Ling Liang, Xiao-Jun Zhang, Jie-Mei Lai, Shu-Fang Ye, Hui Ouyang, Jin Lin, Jiu-Yao Zho. Cyclovirobuxinum D alleviates cardiac hypertrophy in hyperthyroid rats by preventing apoptosis of cardiac cells and inhibiting the p38 mitogen-activated protein kinase signaling pathway. Chinese journal of integrative medicine. vol 23. issue 10. 2018-07-12. PMID:27048408. |
cyclovirobuxinum d alleviates cardiac hypertrophy in hyperthyroid rats by preventing apoptosis of cardiac cells and inhibiting the p38 mitogen-activated protein kinase signaling pathway. |
2018-07-12 |
2023-08-13 |
rat |
| Yang Xiao, Qing Qing Wu, Ming Xia Duan, Chen Liu, Yuan Yuan, Zheng Yang, Hai Han Liao, Di Fan, Qi Zhu Tan. TAX1BP1 overexpression attenuates cardiac dysfunction and remodeling in STZ-induced diabetic cardiomyopathy in mice by regulating autophagy. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 5 Pt A. 2018-07-09. PMID:29476905. |
tax1bp1 overexpression in the heart alleviated cardiac hypertrophy and fibrosis, attenuated inflammation, oxidative stress, and apoptosis, and improved cardiac function in stz-induced diabetic mice. |
2018-07-09 |
2023-08-13 |
mouse |
| Yihua Bei, Saumya Das, Rodosthenis S Rodosthenous, Paul Holvoet, Maarten Vanhaverbeke, Marta Chagas Monteiro, Valter Vinicius Silva Monteiro, Jana Radosinska, Monika Bartekova, Felix Jansen, Qian Li, Johnson Rajasingh, Junjie Xia. Extracellular Vesicles in Cardiovascular Theranostics. Theranostics. vol 7. issue 17. 2018-07-02. PMID:29158817. |
evs secreted by cardiomyocytes, endothelial cells, fibroblasts, and stem cells play essential roles in pathophysiological processes such as cardiac hypertrophy, cardiomyocyte survival and apoptosis, cardiac fibrosis, and angiogenesis in relation to cvds. |
2018-07-02 |
2023-08-13 |
Not clear |
| Ya-Fang Chen, Cecilia Hsuan Day, Nien-Hung Lee, Yu-Feng Chen, Jaw-Ji Yang, Chih-Hsueh Lin, Ray-Jade Chen, Peramaiyan Rajendran, Vijaya Padma Viswanadha, Chih-Yang Huan. Tanshinone IIA Inhibits β-Catenin Nuclear Translocation and IGF-2R Activation via Estrogen Receptors to Suppress Angiotensin II-Induced H9c2 Cardiomyoblast Cell Apoptosis. International journal of medical sciences. vol 14. issue 12. 2018-06-21. PMID:29104486. |
cardiomyopathy involves changes in the myocardial ultra-structure, hypertrophy, apoptosis, fibrosis and inflammation. |
2018-06-21 |
2023-08-13 |
Not clear |
| George Georgiopoulos, Christina Chrysohoou, Georgia Vogiatzi, Nikolaos Magkas, Ippokratis Bournelis, Sofia Bampali, Damien Gruson, Dimitris Tousouli. Vitamins in Heart Failure: Friend or Enemy? Current pharmaceutical design. vol 23. issue 25. 2018-06-04. PMID:28325140. |
the failing heart is characterized by a depleted metabolic energy reserve and the upregulation of several molecular mechanisms leading to cardiac hypertrophy, inflammation, fibrosis, angiogenesis, and apoptosis. |
2018-06-04 |
2023-08-13 |
Not clear |
| Bingju Yan, Yingxian Sun, Jun Wan. Depletion of ubiA prenyltransferase domain containing 1 expression promotes angiotensin II‑induced hypertrophic response in AC16 human myocardial cells via modulating the expression levels of coenzyme Q10 and endothelial nitric oxide synthase. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901410. |
ang ii induced hypertrophy and apoptosis in ac16 cells, accompanied by increased expression of anf and caspase-3, and decreased expression of ubiad1. |
2018-06-04 |
2023-08-13 |
human |
| R Purroy, E Britti, F Delaspre, J Tamarit, J Ro. Mitochondrial pore opening and loss of Ca Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 2. 2018-05-22. PMID:29223733. |
also, the transcription factor nfat3, involved in cardiac hypertrophy and apoptosis, becomes activated by dephosphorylation in both cardiomyocytes and drg neurons. |
2018-05-22 |
2023-08-13 |
rat |
| Xiaohong Yang, Rui Yang, Xianli Li, Xiaohui Zhen. Danshensu attenuates aldosterone-induced cardiomyocytes injury through interfering p53 pathway. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28765913. |
previous studies have indicated that excessive aldosterone (ald) serves an essential role in the process of heart failure, and the heart is also one of the direct targets of ald, which can provoke hypertrophy and the apoptosis of cardiomyocytes. |
2018-05-21 |
2023-08-13 |
Not clear |
| Ge Shi, Zhi-Min Mao, Yi-Gang Wan, Shan-Mei Shen, Wei Wu, Jing-Jing Yang, Jian Ya. [Pathomechanisms of podocyte injury in diabetic nephropathy and interventional effects of Chinese herbal medicine]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 13. 2018-05-21. PMID:28905562. |
the pathological characters of podocyte injury mainly refer to the change of podocyte form and function, including foot process effacement, reduction of podocyte number and density, podocyte apoptosis, podocyte epithelial-mesenchymal transdifferentiation(emt)and podocyte hypertrophy. |
2018-05-21 |
2023-08-13 |
rat |
| Daigang Lu, Jining Qu, Liang Sun, Qiang Li, Hua Ling, Na Yang, Teng Ma, Qian Wang, Ming Li, Kun Zhang, Zhong L. Ca2+/Mg2+ homeostasis‑related TRPM7 channel mediates chondrocyte hypertrophy via regulation of the PI3K‑Akt signaling pathway. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849029. |
chondrocytes are specialized cells that form cartilage tissue, and are able to respond to their osmotic environment and exercise important roles in endochondral ossification via undergoing proliferation, hypertrophy and apoptosis. |
2018-05-11 |
2023-08-13 |
mouse |
| Balázs Tamás Németh, Csaba Mátyás, Attila Oláh, Árpád Lux, László Hidi, Mihály Ruppert, Dalma Kellermayer, Gábor Kökény, Gábor Szabó, Béla Merkely, Tamás Radovit. Cinaciguat prevents the development of pathologic hypertrophy in a rat model of left ventricular pressure overload. Scientific reports. vol 6. 2018-05-10. PMID:27853261. |
pathologic myocardial hypertrophy was present in the aabco group following 6 weeks of pressure overload of the heart, evidenced by increased relative heart weight, average cardiomyocyte diameter, collagen content and apoptosis. |
2018-05-10 |
2023-08-13 |
rat |
| Ulises Novoa, Diego Arauna, Marisol Moran, Madelaine Nuñez, Sebastián Zagmutt, Sergio Saldivia, Cristian Valdes, Jorge Villaseñor, Carmen Gloria Zambrano, Daniel R Gonzale. High-Intensity Exercise Reduces Cardiac Fibrosis and Hypertrophy but Does Not Restore the Nitroso-Redox Imbalance in Diabetic Cardiomyopathy. Oxidative medicine and cellular longevity. vol 2017. 2018-05-07. PMID:28698769. |
diabetic cardiomyopathy refers to the manifestations in the heart as a result of altered glucose homeostasis, reflected as fibrosis, cellular hypertrophy, increased oxidative stress, and apoptosis, leading to ventricular dysfunction. |
2018-05-07 |
2023-08-13 |
rat |
| Haoran Dai, Qingquan Liu, Baoli Li. Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy. Journal of diabetes research. vol 2017. 2018-05-01. PMID:28791309. |
increased amounts of urinary protein in dn may be associated with functional and morphological alterations of podocyte, mainly including podocyte hypertrophy, epithelial-mesenchymal transdifferentiation (emt), podocyte detachment, and podocyte apoptosis. |
2018-05-01 |
2023-08-13 |
Not clear |
| Tung-Sheng Chen, Chia-Hua Kuo, Sarnai Battsengel, Lung-Fa Pan, Cecilia Hsuan Day, Chia-Yao Shen, Li-Chin Chung, V Vijaya Padma, Chen-Kai Yao, Yueh-Min Lin, Chih-Yang Huan. Adipose-derived stem cells decrease cardiomyocyte damage induced by porphyromonas gingivalis endotoxin through suppressing hypertrophy, apoptosis, fibrosis, and MAPK markers. Environmental toxicology. vol 33. issue 4. 2018-04-17. PMID:29383833. |
adipose-derived stem cells decrease cardiomyocyte damage induced by porphyromonas gingivalis endotoxin through suppressing hypertrophy, apoptosis, fibrosis, and mapk markers. |
2018-04-17 |
2023-08-13 |
Not clear |
| Tung-Sheng Chen, Chia-Hua Kuo, Sarnai Battsengel, Lung-Fa Pan, Cecilia Hsuan Day, Chia-Yao Shen, Li-Chin Chung, V Vijaya Padma, Chen-Kai Yao, Yueh-Min Lin, Chih-Yang Huan. Adipose-derived stem cells decrease cardiomyocyte damage induced by porphyromonas gingivalis endotoxin through suppressing hypertrophy, apoptosis, fibrosis, and MAPK markers. Environmental toxicology. vol 33. issue 4. 2018-04-17. PMID:29383833. |
from the experimental results we find that pg-lps reduce cardiomyocyte viability via the activation of apoptosis, hypertrophy, fibrosis and mapk signaling. |
2018-04-17 |
2023-08-13 |
Not clear |
| Kasper Kyhl, Jacob Lønborg, Bolette Hartmann, Hannelouise Kissow, Steen Seier Poulsen, Henrik El Ali, Andreas Kjær, Flemming Dela, Thomas Engstrøm, Marek Treima. Lack of effect of prolonged treatment with liraglutide on cardiac remodeling in rats after acute myocardial infarction. Peptides. vol 93. 2018-03-26. PMID:28460895. |
this complex set of processes, including interstitial fibrosis, inflammation, myocyte hypertrophy and apoptosis may progress to heart failure. |
2018-03-26 |
2023-08-13 |
rat |
| Yong-Fang Gong, Xiao-Ming Zhang, Jian Yu, Tian-Yu Huang, Zhen-Zhen Wang, Fei Liu, Xue-Ying Huan. Effect of recombinant human endostatin on hypertrophic scar fibroblast apoptosis in a rabbit ear model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 91. 2018-03-26. PMID:28499239. |
effect of recombinant human endostatin on hypertrophic scar fibroblast apoptosis in a rabbit ear model. |
2018-03-26 |
2023-08-13 |
human |