| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S W Tobin, S Hashemi, K Dadson, S Turdi, K Ebrahimian, J Zhao, G Sweeney, J Grigull, J C McDermot. Heart Failure and MEF2 Transcriptome Dynamics in Response to β-Blockers. Scientific reports. vol 7. issue 1. 2019-01-10. PMID:28667250. |
rarres2 was identified as a novel mef2 target gene that is upregulated with tac in vivo and isoproterenol treatment in vitro which may have implications in cardiomyocyte apoptosis and hypertrophy. |
2019-01-10 |
2023-08-13 |
mouse |
| Jieyun You, Jian Wu, Qi Zhang, Yong Ye, Shijun Wang, Jiayuan Huang, Haibo Liu, Xiaoyan Wang, Weijing Zhang, Liping Bu, Jiming Li, Li Lin, Junbo Ge, Yunzeng Zo. Differential cardiac hypertrophy and signaling pathways in pressure versus volume overload. American journal of physiology. Heart and circulatory physiology. vol 314. issue 3. 2019-01-07. PMID:29196344. |
signaling pathways related to hypertrophy, fibrosis, angiogenesis, and apoptosis were studied by histological analysis, rt-pcr, and western blot analysis. |
2019-01-07 |
2023-08-13 |
mouse |
| Aleksandra Dziubak, Grażyna Wójcicka, Andrzej Wojtak, Jerzy Bełtowsk. Metabolic Effects of Metformin in the Failing Heart. International journal of molecular sciences. vol 19. issue 10. 2019-01-07. PMID:30248910. |
by increasing nitric oxide (no) bioavailability, limiting interstitial fibrosis, reducing the deposition of advanced glycation end-products (ages), and inhibiting myocardial cell apoptosis metformin reduces cardiac remodeling and hypertrophy, and thereby preserves left ventricular systolic and diastolic functions. |
2019-01-07 |
2023-08-13 |
Not clear |
| Ying Xu, Qin Gu, Jian Tang, Yajun Qian, Xiao Tan, Zhuxi Yu, Chen Q. Substance P Attenuates Hypoxia/Reoxygenation-Induced Apoptosis via the Akt Signalling Pathway and the NK1-Receptor in H9C2Cells. Heart, lung & circulation. vol 27. issue 12. 2019-01-02. PMID:29107510. |
during i/r injury, cardiomyocytes undergo cell death including apoptosis and necrosis with increased frequency, and this leads to compensatory cardiac hypertrophy, dysfunction, ventricular remodelling, and ultimately, heart failure. |
2019-01-02 |
2023-08-13 |
Not clear |
| Ji Hoon Yang, Ji Young Yoon, Jungyoon Moon, Seonguk Min, Hyuck Hoon Kwon, Dae Hun Su. Expression of inflammatory and fibrogenetic markers in acne hypertrophic scar formation: focusing on role of TGF-β and IGF-1R. Archives of dermatological research. vol 310. issue 8. 2018-12-17. PMID:30167815. |
increased apoptosis was observed in immature stages of hypertrophic scars but not in mature stages. |
2018-12-17 |
2023-08-13 |
Not clear |
| Guangcai Li, Meng Jin, Yuan He, Jie Ren, Minghua Zhang, Yilin Chen, Xiong Lan, Jianhua Zhong, Huiguo Li. Fork Head Box Class O1 (FOXO1) Activates Bim Expression to Mediate Cardiac Apoptosis in Chronic Intermittent Hypoxia-Induced Cardiac Hypertrophy. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-12-12. PMID:28738025. |
fork head box class o1 (foxo1) activates bim expression to mediate cardiac apoptosis in chronic intermittent hypoxia-induced cardiac hypertrophy. |
2018-12-12 |
2023-08-13 |
Not clear |
| Xiaotong Wang, Chunyan Yang, Xueyan Liu, Ping Yan. Ghrelin Alleviates Angiotensin II-Induced H9c2 Apoptosis: Impact of the miR-208 Family. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-12. PMID:30244257. |
the mir-208 family, consisting of cardiac-specifically expressed micrornas, are not only involved in hypertrophy and fibrosis, but are also closely related with myocyte apoptosis. |
2018-12-12 |
2023-08-13 |
Not clear |
| Tharni Vasavan, Elisa Ferraro, Effendi Ibrahim, Peter Dixon, Julia Gorelik, Catherine Williamso. Heart and bile acids - Clinical consequences of altered bile acid metabolism. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 4 Pt B. 2018-12-11. PMID:29317337. |
bile acids are directly implicated in this, causing qt interval prolongation, cardiac hypertrophy, cardiomyocyte apoptosis and abnormal haemodynamics of the heart. |
2018-12-11 |
2023-08-13 |
Not clear |
| Ying He, Ying Zhang, Dan Zhang, Meng Zhang, Mengying Wang, Zhuocheng Jiang, Miguel Otero, Jinghong Che. 3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-11. PMID:30119244. |
sin-1 induced necrosis in hypertrophic chondrocytes, whereas triggered apoptosis in non-hypertrophic cells of non-differentiated atdc5 cells and c28/i2 cells. |
2018-12-11 |
2023-08-13 |
Not clear |
| Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong L. [Over-expression of BDNF inhibits angiotensin II-induced apoptosis of cardiomyocytes in SD rats]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 3. 2018-11-27. PMID:29773102. |
objective to investigate the role and molecular mechanism of brain-derived neurotrophic factor (bdnf) against the process of cardiomyocyte hypertrophy and apoptosis. |
2018-11-27 |
2023-08-13 |
rat |
| Hongjiang Wang, Jun Ca. The role of microRNAs in heart failure. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 8. 2018-11-20. PMID:27916680. |
the selected mirnas are categorized according to the biological relevance of their target genes in relation to four cardiovascular pathologies, namely angiogenesis, cardiac hypertrophy, fibrosis and apoptosis. |
2018-11-20 |
2023-08-13 |
Not clear |
| Adam J Wilson, Eleanor K Gill, Rawan A Abudalo, Kevin S Edgar, Chris J Watson, David J Griev. Reactive oxygen species signalling in the diabetic heart: emerging prospect for therapeutic targeting. Heart (British Cardiac Society). vol 104. issue 4. 2018-11-14. PMID:28954833. |
indeed, experimental and clinical diabetes are linked with oxidative stress which plays a key role in cardiomyopathy, while key processes underlying diabetic cardiac remodelling, such as inflammation, angiogenesis, cardiomyocyte hypertrophy and apoptosis, fibrosis and contractile dysfunction, are redox sensitive. |
2018-11-14 |
2023-08-13 |
Not clear |
| Bin Zhang, Qiang Shen, Yaping Chen, Ruile Pan, Shihuan Kuang, Guiyan Liu, Guibo Sun, Xiaobo Su. Myricitrin Alleviates Oxidative Stress-induced Inflammation and Apoptosis and Protects Mice against Diabetic Cardiomyopathy. Scientific reports. vol 7. 2018-11-07. PMID:28287141. |
in vitro experiments revealed that pretreatment with myr significantly decreased ages-induced inflammatory cytokine expression, limited an increase in ros levels, and reduced cell apoptosis, fibrosis, and hypertrophy in h9c2 cells. |
2018-11-07 |
2023-08-13 |
mouse |
| Jiming Li, Jingjing Zeng, Lianpin Wu, Luyuan Tao, Zhiyong Liao, Maoping Chu, Lei L. Loss of P53 regresses cardiac remodeling induced by pressure overload partially through inhibiting HIF1α signaling in mice. Biochemical and biophysical research communications. vol 501. issue 2. 2018-11-05. PMID:29729274. |
global knockout of p53 in the mice reduced the hypertrophic response and markedly reduced cardiac apoptosis, and fibrosis. |
2018-11-05 |
2023-08-13 |
mouse |
| Jiming Li, Jingjing Zeng, Lianpin Wu, Luyuan Tao, Zhiyong Liao, Maoping Chu, Lei L. Loss of P53 regresses cardiac remodeling induced by pressure overload partially through inhibiting HIF1α signaling in mice. Biochemical and biophysical research communications. vol 501. issue 2. 2018-11-05. PMID:29729274. |
the study indicated p53 deteriorated cardiac functions and cardiac hypertrophy, apoptosis, and fibrosis by partially inhibition of hif1α and vegf. |
2018-11-05 |
2023-08-13 |
mouse |
| Chih-Yang Huang, Chia-Hua Kuo, Pei-Ying Pai, Tsung-Jung Ho, Yueh-Min Lin, Ray-Jade Chen, Fuu-Jen Tsai, V Vijaya Padma, Wei-Wen Kuo, Chih-Yang Huan. Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy. International journal of cardiology. vol 257. 2018-10-23. PMID:29180262. |
we have found that the insulin-like growth factor receptor ii (igf-iir) signaling was critical for hypertensive angiotensin ii-induced cardiomyocyte hypertrophy and apoptosis. |
2018-10-23 |
2023-08-13 |
rat |
| Wenliang Zhong, Wen Jin, Shanghua Xu, Yanqing Wu, Shunxiang Luo, Minlie Liang, Lianglong Che. Pioglitazone Induces Cardiomyocyte Apoptosis and Inhibits Cardiomyocyte Hypertrophy Via VEGFR-2 Signaling Pathway. Arquivos brasileiros de cardiologia. vol 111. issue 2. 2018-10-18. PMID:29972411. |
pioglitazone induces cardiomyocyte apoptosis and inhibits cardiomyocyte hypertrophy via vegfr-2 signaling pathway. |
2018-10-18 |
2023-08-13 |
Not clear |
| April R Foster, Carina Nicu, Marlon R Schneider, Eleanor Hinde, Ralf Pau. Dermal white adipose tissue undergoes major morphological changes during the spontaneous and induced murine hair follicle cycling: a reappraisal. Archives of dermatological research. vol 310. issue 5. 2018-10-11. PMID:29704126. |
we sought to elucidate whether increased dwat thickness during anagen is mediated by adipocyte hypertrophy or adipogenesis, and whether lipolysis or apoptosis can explain the decreased dwat thickness during catagen. |
2018-10-11 |
2023-08-13 |
Not clear |
| April R Foster, Carina Nicu, Marlon R Schneider, Eleanor Hinde, Ralf Pau. Dermal white adipose tissue undergoes major morphological changes during the spontaneous and induced murine hair follicle cycling: a reappraisal. Archives of dermatological research. vol 310. issue 5. 2018-10-11. PMID:29704126. |
we show that hc-dependent dwat remodelling is not an artefact caused by fluctuations in hf down-growth, and that dermal adipocyte (da) proliferation and hypertrophy are hc-dependent, while classical da apoptosis is absent. |
2018-10-11 |
2023-08-13 |
Not clear |
| April R Foster, Carina Nicu, Marlon R Schneider, Eleanor Hinde, Ralf Pau. Dermal white adipose tissue undergoes major morphological changes during the spontaneous and induced murine hair follicle cycling: a reappraisal. Archives of dermatological research. vol 310. issue 5. 2018-10-11. PMID:29704126. |
hence, we postulate that progressive, lipogenesis-driven da hypertrophy followed by dynamic switches between lipogenesis and lipolysis underlie dwat fluctuations in the spontaneous hc, and dismiss apoptosis as a mechanism of dwat reduction. |
2018-10-11 |
2023-08-13 |
Not clear |