| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong-Fang Gong, Xiao-Ming Zhang, Jian Yu, Tian-Yu Huang, Zhen-Zhen Wang, Fei Liu, Xue-Ying Huan. Effect of recombinant human endostatin on hypertrophic scar fibroblast apoptosis in a rabbit ear model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 91. 2018-03-26. PMID:28499239. |
hypertrophic scar (hs) is a dermal fibroproliferative disorder characterized by the excessive proliferation of fibroblasts and is thought to result from a cellular imbalance caused by the increased growth and reduced apoptosis of hypertrophic scar fibroblasts (hsfs). |
2018-03-26 |
2023-08-13 |
human |
| Yue Guo, Xiaodong Zhuang, Zena Huang, Jing Zou, Daya Yang, Xun Hu, Zhimin Du, Lichun Wang, Xinxue Lia. Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 1. 2018-03-26. PMID:28982613. |
klotho pretreatment effectively inhibited high glucose-induced inflammation, ros generation, apoptosis, mitochondrial dysfunction, fibrosis and hypertrophy in both h9c2 cells and neonatal cardiomyocytes. |
2018-03-26 |
2023-08-13 |
mouse |
| André Viveiros Monteiro, António Fiarresga, Duarte Cacela, Lídia de Sousa, Ruben Ramos, Ana Galrinho, Luísa Branco, Rui Cruz Ferreir. Alcohol septal ablation in obstructive acromegalic hypertrophic cardiomyopathy - a first case report. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. vol 35. issue 9. 2018-03-19. PMID:27503591. |
cardiovascular complications are common and are associated with cardiomyocyte apoptosis and concentric cardiac hypertrophy. |
2018-03-19 |
2023-08-13 |
Not clear |
| Bisher Abuyassin, Mohammad Badran, Najib T Ayas, Ismail Lahe. Intermittent hypoxia causes histological kidney damage and increases growth factor expression in a mouse model of obstructive sleep apnea. PloS one. vol 13. issue 2. 2018-03-13. PMID:29389945. |
we conclude that ih causes kidney injury that is accompanied by glomerular hypertrophy, mesangial matrix expansion, increased expression of glomerular growth factors and an increased cellular apoptosis. |
2018-03-13 |
2023-08-13 |
mouse |
| Azadeh Mofid, Nadav S Newman, Paul J H Lee, Cynthia Abbasi, Pratiek N Matkar, Dmitriy Rudenko, Michael A Kuliszewski, Hao H Chen, Kolsoom Afrasiabi, James N Tsoporis, Anthony O Gramolini, Kim A Connelly, Thomas G Parker, Howard Leong-Po. Cardiac Overexpression of S100A6 Attenuates Cardiomyocyte Apoptosis and Reduces Infarct Size After Myocardial Ischemia-Reperfusion. Journal of the American Heart Association. vol 6. issue 2. 2018-02-28. PMID:28174168. |
cardiomyocyte-specific transgenic mice overexpressing s100a6, a member of the family of ef-hand calcium-binding proteins, develop less cardiac hypertrophy, interstitial fibrosis, and myocyte apoptosis after permanent coronary ligation, findings that support s100a6 as a potential therapeutic target after acute myocardial infarction. |
2018-02-28 |
2023-08-13 |
mouse |
| Hedyieh Karbasforooshan, Gholamreza Karim. The role of SIRT1 in diabetic cardiomyopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 90. 2018-02-21. PMID:28380414. |
they increase advanced glycation end products (ages) following a series of events leading to myocardial damage and cardiomyopathy which include oxidative stress, increased inflammation, fibrosis, hypertrophy and apoptosis. |
2018-02-21 |
2023-08-13 |
Not clear |
| Helene Tronchere, Mathieu Cinato, Andrei Timotin, Laurie Guitou, Camille Villedieu, Helene Thibault, Delphine Baetz, Bernard Payrastre, Philippe Valet, Angelo Parini, Oksana Kunduzova, Frederic Boa. Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice. EMBO molecular medicine. vol 9. issue 6. 2018-02-19. PMID:28396567. |
inhibition of pikfyve prevents myocardial apoptosis and hypertrophy through activation of sirt3 in obese mice. |
2018-02-19 |
2023-08-13 |
mouse |
| Xiurong Li, Yuhuai Lan, Yan Wang, Minghao Nie, Yanhong Lu, Eryang Zha. Telmisartan suppresses cardiac hypertrophy by inhibiting cardiomyocyte apoptosis via the NFAT/ANP/BNP signaling pathway. Molecular medicine reports. vol 15. issue 5. 2018-02-16. PMID:28447738. |
telmisartan suppresses cardiac hypertrophy by inhibiting cardiomyocyte apoptosis via the nfat/anp/bnp signaling pathway. |
2018-02-16 |
2023-08-13 |
mouse |
| Xiurong Li, Yuhuai Lan, Yan Wang, Minghao Nie, Yanhong Lu, Eryang Zha. Telmisartan suppresses cardiac hypertrophy by inhibiting cardiomyocyte apoptosis via the NFAT/ANP/BNP signaling pathway. Molecular medicine reports. vol 15. issue 5. 2018-02-16. PMID:28447738. |
nuclear factor of activated t‑cells (nfat) contributes to cardiac hypertrophy via nuclear translocation, which induces a cascade of atrial natriuretic peptide (anp) and brain/b‑type natriuretic peptide (bnp) expression and cardiomyocyte apoptosis. |
2018-02-16 |
2023-08-13 |
mouse |
| Xiurong Li, Yuhuai Lan, Yan Wang, Minghao Nie, Yanhong Lu, Eryang Zha. Telmisartan suppresses cardiac hypertrophy by inhibiting cardiomyocyte apoptosis via the NFAT/ANP/BNP signaling pathway. Molecular medicine reports. vol 15. issue 5. 2018-02-16. PMID:28447738. |
the present study demonstrated that telmisartan suppressed cardiomyocyte hypertrophy in a mouse model of cardiac afterload and in cultured cardiomyocytes by inhibiting nfat nuclear translocation, as well as by inhibiting anp and bnp expression and cardiomyocyte apoptosis, in a dose‑dependent manner. |
2018-02-16 |
2023-08-13 |
mouse |
| Cynthia Kankeu, Kylie Clarke, Egle Passante, Heinrich J Hube. Doxorubicin-induced chronic dilated cardiomyopathy-the apoptosis hypothesis revisited. Journal of molecular medicine (Berlin, Germany). vol 95. issue 3. 2018-02-13. PMID:27933370. |
this lack of momp induction is proposed to alter the metabolic phenotype, induce hypertrophic remodeling, and lead to functional cardiac impairment even in the absence of cardiomyocyte apoptosis. |
2018-02-13 |
2023-08-13 |
Not clear |
| Cynthia Kankeu, Kylie Clarke, Egle Passante, Heinrich J Hube. Doxorubicin-induced chronic dilated cardiomyopathy-the apoptosis hypothesis revisited. Journal of molecular medicine (Berlin, Germany). vol 95. issue 3. 2018-02-13. PMID:27933370. |
we discuss findings that dox exposure can lead to increased sensitivity to further cardiomyocyte apoptosis, which may cause a gradual loss in cardiomyocytes over time and a compensatory hypertrophic remodeling after treatment, potentially explaining the long lag time in disease onset. |
2018-02-13 |
2023-08-13 |
Not clear |
| Esam S B Salem, Guo-Chang Fa. Pathological Effects of Exosomes in Mediating Diabetic Cardiomyopathy. Advances in experimental medicine and biology. vol 998. 2018-02-13. PMID:28936736. |
pathologically, this cardiac dysfunction is manifested by inflammation, apoptosis, fibrosis, hypertrophy and altered cardiomyocytes metabolism. |
2018-02-13 |
2023-08-13 |
human |
| Yihua Bei, Ting Chen, Daniel Dumitru Banciu, Dragos Cretoiu, Junjie Xia. Circulating Exosomes in Cardiovascular Diseases. Advances in experimental medicine and biology. vol 998. 2018-02-13. PMID:28936745. |
circulating exosomes and exosomal cargos are critically involved in cardiovascular pathophysiology, such as cardiomyocyte hypertrophy, apoptosis, and angiogenesis. |
2018-02-13 |
2023-08-13 |
Not clear |
| Hiroyuki Tsutsu. Role of Natural Killer T Cells in Cardiac Remodeling and Failure and the Development of Novel Therapeutic Strategy. Fukuoka igaku zasshi = Hukuoka acta medica. vol 107. issue 10. 2018-02-02. PMID:29227067. |
lvcavity dilatation and dysfunction were significantly attenuated inmi +agc, despite comparable infarctsize, accompanied by a decrease in myocyte hypertrophy, interstitial fibrosis, and apoptosis. |
2018-02-02 |
2023-08-13 |
mouse |
| Daniël C Koppenol, Fred J Vermolen, Frank B Niessen, Paul P M van Zuijlen, Kees Vui. A mathematical model for the simulation of the formation and the subsequent regression of hypertrophic scar tissue after dermal wounding. Biomechanics and modeling in mechanobiology. vol 16. issue 1. 2018-01-26. PMID:27229739. |
interestingly, the comparison between the outcomes of the simulations and the clinical measurements demonstrates that a relatively high apoptosis rate of myofibroblasts results in scar tissue that behaves more like normal scar tissue with respect to the evolution of the thickness of the tissue over time, while a relatively low apoptosis rate results in scar tissue that behaves like hypertrophic scar tissue with respect to the evolution of the thickness of the tissue over time. |
2018-01-26 |
2023-08-13 |
human |
| Wei-Jen Ting, Jaw-Ji Yang, Chia-Hua Kuo, Zi-Jun Xiao, Xin-Ze Lu, Yu-Lan Yeh, Cecilia-Hsuan Day, Su-Ying Wen, Vijaya PadmaViswanadha, Chong-He Jiang, Wei-Wen Kuo, Chih-Yang Huan. Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts. Oncotarget. vol 7. issue 26. 2018-01-22. PMID:27167200. |
furthermore, the igf2r cardiac hypertrophy signaling pathway was also triggered, although cardiac apoptosis and hypertrophy were not induced. |
2018-01-22 |
2023-08-13 |
mouse |
| Kuan-Ho Lin, Wei-Wen Kuo, Marthandam Asokan Shibu, Cecilia-Hsuan Day, You-Liang Hsieh, Li-Chin Chung, Ray-Jade Chen, Su-Ying Wen, Vijaya Padma Viswanadha, Chih-Yang Huan. E2/ER β Enhances Calcineurin Protein Degradation and PI3K/Akt/MDM2 Signal Transduction to Inhibit ISO-Induced Myocardial Cell Apoptosis. International journal of molecular sciences. vol 18. issue 4. 2018-01-19. PMID:28441761. |
in addition, protein phosphatase such as protein phosphatase 1 (pp1) and calcineurin (pp2b) are also involved in cardiac hypertrophy and cell apoptosis signaling. |
2018-01-19 |
2023-08-13 |
Not clear |
| Silpa Arkat, Prachi Umbarkar, Sarojini Singh, Sandhya L Sitasawa. Mitochondrial Peroxiredoxin-3 protects against hyperglycemia induced myocardial damage in Diabetic cardiomyopathy. Free radical biology & medicine. vol 97. 2018-01-04. PMID:27393003. |
it was also successful in reducing cardiac cell apoptosis, hypertrophy and fibrosis leading to amelioration of cardiac contractility defects. |
2018-01-04 |
2023-08-13 |
rat |
| Bao Li, Rui-Fang Chi, Fu-Zhong Qin, Xiao-Fei Gu. Distinct changes of myocyte autophagy during myocardial hypertrophy and heart failure: association with oxidative stress. Experimental physiology. vol 101. issue 8. 2018-01-01. PMID:27219474. |
reduced autophagy is correlated with myocyte hypertrophy, and increased autophagy is correlated with myocyte apoptosis. |
2018-01-01 |
2023-08-13 |
mouse |