| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Le-Xun Wang, Xiao Yang, Yuan Yue, Tian Fan, Jian Hou, Guang-Xian Chen, Meng-Ya Liang, Zhong-Kai W. Imatinib attenuates cardiac fibrosis by inhibiting platelet-derived growth factor receptors activation in isoproterenol induced model. PloS one. vol 12. issue 6. 2017-09-26. PMID:28570599. |
we found that the ventricular wall thickness, cardiac hypertrophy, and apoptosis were enhanced following iso treatment. |
2017-09-26 |
2023-08-13 |
mouse |
| Le-Xun Wang, Xiao Yang, Yuan Yue, Tian Fan, Jian Hou, Guang-Xian Chen, Meng-Ya Liang, Zhong-Kai W. Imatinib attenuates cardiac fibrosis by inhibiting platelet-derived growth factor receptors activation in isoproterenol induced model. PloS one. vol 12. issue 6. 2017-09-26. PMID:28570599. |
ima decreased the left ventricular wall thickness, prevented hypertrophy, and inhibited apoptosis induced by iso. |
2017-09-26 |
2023-08-13 |
mouse |
| Francielle Graus-Nunes, Thatiany de Souza Marinho, Sandra Barbosa-da-Silva, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mell. Differential effects of angiotensin receptor blockers on pancreatic islet remodelling and glucose homeostasis in diet-induced obese mice. Molecular and cellular endocrinology. vol 439. 2017-09-25. PMID:27780713. |
high-fat diet yielded overweight, insulin resistance, islet apoptosis and hypertrophy. |
2017-09-25 |
2023-08-13 |
mouse |
| Q Li, Q Yu, R Na, B Li. Etanercept protects rat cardiomyocytes against hypertrophy by regulating inflammatory cytokines secretion and cell apoptosis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 50. issue 6. 2017-09-25. PMID:28513772. |
etanercept protects rat cardiomyocytes against hypertrophy by regulating inflammatory cytokines secretion and cell apoptosis. |
2017-09-25 |
2023-08-13 |
rat |
| Q Li, Q Yu, R Na, B Li. Etanercept protects rat cardiomyocytes against hypertrophy by regulating inflammatory cytokines secretion and cell apoptosis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 50. issue 6. 2017-09-25. PMID:28513772. |
etanercept may protect rat cardiomyocytes from hypertrophy by inhibiting inflammatory cytokines secretion and cell apoptosis. |
2017-09-25 |
2023-08-13 |
rat |
| Xi-Qiao Wang, Fei Song, Ying-Kai Li. Hypertrophic scar regression is linked to the occurrence of endothelial dysfunction. PloS one. vol 12. issue 5. 2017-09-15. PMID:28472181. |
furthermore, we assessed cell viability, total collagen production, and cell apoptosis in hypertrophic scar-derived fibroblasts cultured with ec-conditioned medium. |
2017-09-15 |
2023-08-13 |
Not clear |
| C M Ha. [Wound healing is still a game of " blind men and an elephant"]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 32. issue 10. 2017-09-08. PMID:27765087. |
in this issue, three papers involve in wound healing, one about autologous adipose-derived mesenchymal stem cells injected into wound or scar of rabbit ear, one about severe hypoxia and hypoalbuminemia inducing human hypertrophic scar derived fibroblast apoptosis in vitro, and another about the dysfunction of protein kinase b/mammalian target of rapamycin signaling pathway contributing to the pathophysiological characteristics of diabetic skin and non-healing wound. |
2017-09-08 |
2023-08-13 |
human |
| Shilpa Rani, Pradeep Kumar Sreenivasaiah, Jin Ock Kim, Mi Young Lee, Wan Seok Kang, Yong Sook Kim, Youngkeun Ahn, Woo Jin Park, Chunghee Cho, Do Han Ki. Tauroursodeoxycholic acid (TUDCA) attenuates pressure overload-induced cardiac remodeling by reducing endoplasmic reticulum stress. PloS one. vol 12. issue 4. 2017-09-07. PMID:28426781. |
microarray analysis followed by gene ontology (go) and pathway analysis demonstrated that extracellular matrix genes responsible for hypertrophy and fibrosis, and mitochondrial genes responsible for apoptosis and fatty acid metabolism were significantly altered in the veh-tac group, but the alterations were normalized in the tudca-tac group, suggesting potential of tudca in treatment of heart diseases related to pressure-overload. |
2017-09-07 |
2023-08-13 |
mouse |
| Xin Cheng, Jian-Long Chen, Zheng-Lai Ma, Zhao-Long Zhang, Shun Lv, Dong-Mei Mai, Jia-Jia Liu, Manli Chuai, Kenneth Ka Ho Lee, Chao Wan, Xuesong Yan. Biphasic influence of dexamethasone exposure on embryonic vertebrate skeleton development. Toxicology and applied pharmacology. vol 281. issue 1. 2017-09-04. PMID:25286332. |
secondly, histological analysis of chick embryo phalanxes exhibited dex exposure inhibited the proliferation of chondrocytes, increased apoptosis of chondrocytes and osteocytes, and led to atypical arranged hypertrophic chondrocytes. |
2017-09-04 |
2023-08-13 |
chicken |
| Gordon A Begg, Arun V Holden, Gregory Y H Lip, Sven Plein, Muzahir H Tayebje. Assessment of atrial fibrosis for the rhythm control of atrial fibrillation. International journal of cardiology. vol 220. 2017-08-28. PMID:27389440. |
fibrosis causes an increase in volume of dysfunctional extracellular matrix, and is associated with cellular alterations such as hypertrophy, apoptosis and membrane dysfunction within the atrial myocardium. |
2017-08-28 |
2023-08-13 |
Not clear |
| Beth A Rose, Tomohiro Yokota, Vishnu Chintalgattu, Shuxun Ren, Luisa Iruela-Arispe, Aarif Y Khakoo, Susumu Minamisawa, Yibin Wan. Cardiac myocyte p38α kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart. The Journal of biological chemistry. vol 292. issue 31. 2017-08-25. PMID:28637870. |
for example, constitutive p38 mapk activation in cardiomyocytes induces pathological features, including myocyte hypertrophy, apoptosis, contractile dysfunction, and fetal gene expression. |
2017-08-25 |
2023-08-13 |
Not clear |
| Jessica Venugopal, Gustavo Blanc. On the Many Actions of Ouabain: Pro-Cystogenic Effects in Autosomal Dominant Polycystic Kidney Disease. Molecules (Basel, Switzerland). vol 22. issue 5. 2017-08-18. PMID:28467389. |
it is now clear that ouabain regulates multiple cell functions, including cell proliferation and hypertrophy, apoptosis, cell adhesion, cell migration, and cell metabolism in a cell and tissue type specific manner. |
2017-08-18 |
2023-08-13 |
Not clear |
| Thomas Münzel, Giovanni G Camici, Christoph Maack, Nicole R Bonetti, Valentin Fuster, Jason C Kovaci. Impact of Oxidative Stress on the Heart and Vasculature: Part 2 of a 3-Part Series. Journal of the American College of Cardiology. vol 70. issue 2. 2017-08-16. PMID:28683969. |
reactive oxygen species (ros) negatively affect myocardial calcium handling, cause arrhythmia, and contribute to cardiac remodeling by inducing hypertrophic signaling, apoptosis, and necrosis. |
2017-08-16 |
2023-08-13 |
Not clear |
| Xiao-Qing Sun, Rui Zhang, Hong-Da Zhang, Ping Yuan, Xiao-Jian Wang, Qin-Hua Zhao, Lan Wang, Rong Jiang, Harm Jan Bogaard, Zhi-Cheng Jin. Reversal of right ventricular remodeling by dichloroacetate is related to inhibition of mitochondria-dependent apoptosis. Hypertension research : official journal of the Japanese Society of Hypertension. vol 39. issue 5. 2017-08-07. PMID:26763846. |
dca treatment was also associated with restored rv mitochondrial function and a reduction in rv hypertrophy, fibrosis, capillary rarefaction and apoptosis. |
2017-08-07 |
2023-08-13 |
rat |
| Yuan Yuan, Ling Yan, Qing-Qing Wu, Heng Zhou, Ya-Ge Jin, Zhou-Yan Bian, Wei Deng, Zheng Yang, Di-Fei Shen, Xiao-Feng Zeng, Sha-Sha Wang, Hongliang Li, Qi-Zhu Tan. Mnk1 (Mitogen-Activated Protein Kinase-Interacting Kinase 1) Deficiency Aggravates Cardiac Remodeling in Mice. Hypertension (Dallas, Tex. : 1979). vol 68. issue 6. 2017-08-07. PMID:27698061. |
after 4 weeks of transverse aortic constriction, mnk1-knockout mice developed exaggerated cardiac hypertrophy, fibrosis, dysfunction, and cardiomyocyte apoptosis and showed increased erk1/2 (extracellular signal-regulated kinase 1/2) activation along with reduced sprouty2 expression. |
2017-08-07 |
2023-08-13 |
mouse |
| Sarita Nehra, Varun Bhardwaj, Santosh Kar, Deepika Saraswa. Chronic Hypobaric Hypoxia Induces Right Ventricular Hypertrophy and Apoptosis in Rats: Therapeutic Potential of Nanocurcumin in Improving Adaptation. High altitude medicine & biology. vol 17. issue 4. 2017-07-31. PMID:27626325. |
chronic hypobaric hypoxia induces right ventricular hypertrophy and apoptosis in rats: therapeutic potential of nanocurcumin in improving adaptation. |
2017-07-31 |
2023-08-13 |
rat |
| Sarita Nehra, Varun Bhardwaj, Santosh Kar, Deepika Saraswa. Chronic Hypobaric Hypoxia Induces Right Ventricular Hypertrophy and Apoptosis in Rats: Therapeutic Potential of Nanocurcumin in Improving Adaptation. High altitude medicine & biology. vol 17. issue 4. 2017-07-31. PMID:27626325. |
chronic hypobaric hypoxia induces right ventricular hypertrophy and apoptosis in rats: therapeutic potential of nanocurcumin in improving adaptation. |
2017-07-31 |
2023-08-13 |
rat |
| Mitchel Tate, David J Grieve, Rebecca H Ritchi. Are targeted therapies for diabetic cardiomyopathy on the horizon? Clinical science (London, England : 1979). vol 131. issue 10. 2017-07-27. PMID:28473471. |
post-mortem examination reveals that human diastolic dysfunction is closely associated with lv damage, including cardiomyocyte hypertrophy, apoptosis and fibrosis, with impaired coronary microvascular perfusion. |
2017-07-27 |
2023-08-13 |
human |
| Hairuo Lin, Liang Shen, Xiajun Zhang, Jiahe Xie, Huixin Hao, Yingxue Zhang, Zhenhuan Chen, Hiroshi Yamamoto, Wangjun Liao, Jianping Bin, Shiping Cao, Xiaobo Huang, Yulin Lia. HMGB1-RAGE Axis Makes No Contribution to Cardiac Remodeling Induced by Pressure-Overload. PloS one. vol 11. issue 6. 2017-07-19. PMID:27355349. |
considering that inflammation is involved in pressure overload-induced cardiac hypertrophy, we herein attempted to investigate whether hmgb1 plays a role in myocardial hypertrophy in rage knockout mice as well as in the growth and apoptosis of cardiomyocytes. |
2017-07-19 |
2023-08-13 |
mouse |
| Nadine Kirschmer, Sandra Bandleon, Viktor von Ehrlich-Treuenstätt, Sonja Hartmann, Alice Schaaf, Anna-Karina Lamprecht, Erick Miranda-Laferte, Tanja Langsenlehner, Oliver Ritter, Petra Ede. TRPC4α and TRPC4β Similarly Affect Neonatal Cardiomyocyte Survival during Chronic GPCR Stimulation. PloS one. vol 11. issue 12. 2017-07-10. PMID:27992507. |
further analyses revealed that, although hypertrophy was preserved in ad-c4α nrcs and even attenuated in ad-c4β nrcs, cardiomyocytes had an increased apoptosis rate and thus were less viable after chronic gpcr stimulation. |
2017-07-10 |
2023-08-13 |
rat |