| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shengzhi Mu, Bei Kang, Weihui Zeng, Yaowen Sun, Fan Yan. MicroRNA-143-3p inhibits hyperplastic scar formation by targeting connective tissue growth factor CTGF/CCN2 via the Akt/mTOR pathway. Molecular and cellular biochemistry. vol 416. issue 1-2. 2017-02-06. PMID:27075467. |
in conclusion, we found that mir-143-3p inhibits hypertrophic scarring by regulating the proliferation and apoptosis of human hsfs, inhibiting ecm production-associated protein expression by targeting ctgf, and restraining the akt/mtor pathway. |
2017-02-06 |
2023-08-13 |
human |
| Qi Xu, Xiang Wu, Yu Li, Hui Kong, Yu Jin, Weiping Xie, Hong Wan. Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-03. PMID:27718461. |
pulmonary vascular medial hypertrophy in hypoxic pulmonary arterial hypertension (hph) is caused in part by decreased apoptosis in pulmonary artery smooth muscle cells (pasmcs). |
2017-02-03 |
2023-08-13 |
rat |
| Satish K Raut, Gurinder B Singh, Bhawna Rastogi, Uma Nahar Saikia, Anupam Mittal, Nilambra Dogra, Sandeep Singh, Rishikesh Prasad, Madhu Khulla. miR-30c and miR-181a synergistically modulate p53-p21 pathway in diabetes induced cardiac hypertrophy. Molecular and cellular biochemistry. vol 417. issue 1-2. 2017-02-02. PMID:27221738. |
p53-p21 pathway mediates cardiomyocyte hypertrophy and apoptosis and is upregulated in diabetic cardiomyopathy (dbcm). |
2017-02-02 |
2023-08-13 |
rat |
| Satish K Raut, Gurinder B Singh, Bhawna Rastogi, Uma Nahar Saikia, Anupam Mittal, Nilambra Dogra, Sandeep Singh, Rishikesh Prasad, Madhu Khulla. miR-30c and miR-181a synergistically modulate p53-p21 pathway in diabetes induced cardiac hypertrophy. Molecular and cellular biochemistry. vol 417. issue 1-2. 2017-02-02. PMID:27221738. |
we investigated role of micrornas in regulating p53-p21 pathway in high glucose (hg)-induced cardiomyocyte hypertrophy and apoptosis. |
2017-02-02 |
2023-08-13 |
rat |
| Satish K Raut, Gurinder B Singh, Bhawna Rastogi, Uma Nahar Saikia, Anupam Mittal, Nilambra Dogra, Sandeep Singh, Rishikesh Prasad, Madhu Khulla. miR-30c and miR-181a synergistically modulate p53-p21 pathway in diabetes induced cardiac hypertrophy. Molecular and cellular biochemistry. vol 417. issue 1-2. 2017-02-02. PMID:27221738. |
effect of micrornas over-expression and inhibition on hg-induced cardiomyocyte hypertrophy and apoptosis was examined. |
2017-02-02 |
2023-08-13 |
rat |
| Satish K Raut, Gurinder B Singh, Bhawna Rastogi, Uma Nahar Saikia, Anupam Mittal, Nilambra Dogra, Sandeep Singh, Rishikesh Prasad, Madhu Khulla. miR-30c and miR-181a synergistically modulate p53-p21 pathway in diabetes induced cardiac hypertrophy. Molecular and cellular biochemistry. vol 417. issue 1-2. 2017-02-02. PMID:27221738. |
concurrent over-expression of these micrornas resulted in greater decrease in cardiomyocyte hypertrophy and apoptosis, suggesting a synergistic effect of these micrornas. |
2017-02-02 |
2023-08-13 |
rat |
| Yao Wu, Hongying Chen, Ruli Li, Xiaoxiao Wang, He Li, Juanjuan Xin, Zhiqiang Liu, Sisi Wu, Wei Jiang, Ling Zh. Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway. Toxicology letters. vol 264. 2017-02-02. PMID:27836799. |
furthermore, an autophagy inhibitor, 3-ma, was used to block the cucurbitacin-i-stirred autophagy, and then the hypertrophy and apoptosis induced by 0.3μm cucurbitacin-i were significantly attenuated. |
2017-02-02 |
2023-08-13 |
Not clear |
| Yao Wu, Hongying Chen, Ruli Li, Xiaoxiao Wang, He Li, Juanjuan Xin, Zhiqiang Liu, Sisi Wu, Wei Jiang, Ling Zh. Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway. Toxicology letters. vol 264. 2017-02-02. PMID:27836799. |
interestingly, only the erk inhibitor u0126, but not the jnk inhibitor sp600125 and p38 mapk inhibitor sb203580, weakened the induction of 0.3μm cucurbitacin-i in hypertrophy, autophagy and apoptosis. |
2017-02-02 |
2023-08-13 |
Not clear |
| Yao Wu, Hongying Chen, Ruli Li, Xiaoxiao Wang, He Li, Juanjuan Xin, Zhiqiang Liu, Sisi Wu, Wei Jiang, Ling Zh. Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway. Toxicology letters. vol 264. 2017-02-02. PMID:27836799. |
our findings suggest that cucurbitacin-i can increase the autophagy levels of h9c2 cells, most likely, through the activation of an erk-autophagy dependent pathway, which results in the hypertrophy and apoptosis of cardiomyocytes. |
2017-02-02 |
2023-08-13 |
Not clear |
| Chien-Yao Fu, Wei-Wen Kuo, Tsung-Jung Ho, Su-Ying Wen, Ling-Chun Lin, Yan-Shen Tseng, Hui-Chuan Hung, Vijaya Padma Viswanadha, Jaw-Ji Yang, Chih-Yang Huan. ZAKβ antagonizes and ameliorates the cardiac hypertrophic and apoptotic effects induced by ZAKα. Cell biochemistry and function. vol 34. issue 8. 2017-01-31. PMID:27859413. |
zakβ, an isoform of zakα, is dramatically expressed during cardiac hypertrophy and apoptosis. |
2017-01-31 |
2023-08-13 |
Not clear |
| Chien-Yao Fu, Wei-Wen Kuo, Tsung-Jung Ho, Su-Ying Wen, Ling-Chun Lin, Yan-Shen Tseng, Hui-Chuan Hung, Vijaya Padma Viswanadha, Jaw-Ji Yang, Chih-Yang Huan. ZAKβ antagonizes and ameliorates the cardiac hypertrophic and apoptotic effects induced by ZAKα. Cell biochemistry and function. vol 34. issue 8. 2017-01-31. PMID:27859413. |
these findings reveal an inherent regulatory role of zakβ to antagonize zakα and to subsequently downregulate the cardiac hypertrophy and apoptosis induced by zakα. |
2017-01-31 |
2023-08-13 |
Not clear |
| Ling Gao, Jia-Tian Cao, Yan Liang, Yi-Chao Zhao, Xian-Hua Lin, Xiao-Cui Li, Ya-Jing Tan, Jing-Yi Li, Cheng-Liang Zhou, Hai-Yan Xu, Jian-Zhong Sheng, He-Feng Huan. Calcitriol attenuates cardiac remodeling and dysfunction in a murine model of polycystic ovary syndrome. Endocrine. vol 52. issue 2. 2017-01-26. PMID:26578366. |
pcos mice progressively developed cardiac abnormalities including cardiac hypertrophy, interstitial fibrosis, myocardial apoptosis, and cardiac dysfunction. |
2017-01-26 |
2023-08-13 |
mouse |
| Marek Jankowski, Tom L Broderick, Jolanta Gutkowsk. Oxytocin and cardioprotection in diabetes and obesity. BMC endocrine disorders. vol 16. issue 1. 2017-01-18. PMID:27268060. |
ot treatment reduces cardiac apoptosis, fibrosis, and hypertrophy. |
2017-01-18 |
2023-08-13 |
mouse |
| Chi Zhang, Fan Wang, Yingxia Zhang, Yimin Kang, Haisheng Wang, Mingming Si, Liping Su, Xue Xin, Feng Xue, Fei Hao, Lechu Yu, Jinzhong Xu, Yanlong Liu, Mingming Xu. Celecoxib prevents pressure overload-induced cardiac hypertrophy and dysfunction by inhibiting inflammation, apoptosis and oxidative stress. Journal of cellular and molecular medicine. vol 20. issue 1. 2017-01-10. PMID:26512452. |
celecoxib prevents pressure overload-induced cardiac hypertrophy and dysfunction by inhibiting inflammation, apoptosis and oxidative stress. |
2017-01-10 |
2023-08-13 |
rat |
| Peiying Pai, Ching Jung Lai, Ching-Yuang Lin, Yi-Fan Liou, Chih-Yang Huang, Shin-Da Le. Effect of superoxide anion scavenger on rat hearts with chronic intermittent hypoxia. Journal of applied physiology (Bethesda, Md. : 1985). vol 120. issue 8. 2016-12-27. PMID:26769958. |
the superoxide anion scavenger decreased hypoxia-induced myocardial architecture abnormalities, left ventricular hypertrophy, and tunel-positive apoptosis. |
2016-12-27 |
2023-08-13 |
rat |
| Ji Luo, Wei-dong Zhang, Yi-meng D. Early administration of nifedipine protects against angiotensin II-induced cardiomyocyte hypertrophy through regulating CaMKII-SERCA2a pathway and apoptosis in rat cardiomyocytes. Cell biochemistry and function. vol 34. issue 3. 2016-12-15. PMID:26968727. |
early administration of nifedipine protects against angiotensin ii-induced cardiomyocyte hypertrophy through regulating camkii-serca2a pathway and apoptosis in rat cardiomyocytes. |
2016-12-15 |
2023-08-13 |
rat |
| Ji Luo, Wei-dong Zhang, Yi-meng D. Early administration of nifedipine protects against angiotensin II-induced cardiomyocyte hypertrophy through regulating CaMKII-SERCA2a pathway and apoptosis in rat cardiomyocytes. Cell biochemistry and function. vol 34. issue 3. 2016-12-15. PMID:26968727. |
we investigated the effects of early- and late-stage nifedipine administration on calcium homeostasis, camkii (ca(2+) /calmodulin-dependent protein kinase ii) activity and apoptosis of cardiomyocytes under hypertrophic stimulation with angiotensin ii (angii). |
2016-12-15 |
2023-08-13 |
rat |
| Ji Luo, Wei-dong Zhang, Yi-meng D. Early administration of nifedipine protects against angiotensin II-induced cardiomyocyte hypertrophy through regulating CaMKII-SERCA2a pathway and apoptosis in rat cardiomyocytes. Cell biochemistry and function. vol 34. issue 3. 2016-12-15. PMID:26968727. |
these results indicate that the timing of ccb administration affects the calcium concentration and apoptosis of hypertrophic cardiomyocytes through the camkii-serca2a signalling pathway, thereby influencing the drug's protective activity against cardiomyocyte hypertrophy. |
2016-12-15 |
2023-08-13 |
rat |
| Guixian Song, Xiaorong Li, Yahui Shen, Lingmei Qian, Xiangqing Kong, Minglong Chen, Kejiang Cao, Fengxiang Zhan. Transplantation of iPSc Restores Cardiac Function by Promoting Angiogenesis and Ameliorating Cardiac Remodeling in a Post-infarcted Swine Model. Cell biochemistry and biophysics. vol 71. issue 3. 2016-12-13. PMID:25388842. |
terminal deoxynucleotidyl nick end labeling, histology, and immunofluorescence were used to examine the effect of transplanted ips cells on apoptosis, fibrosis, and hypertrophy. |
2016-12-13 |
2023-08-13 |
Not clear |
| Roberto D V S Morais, Ralph G Thomé, Hélio B Santos, Nilo Bazzoli, Elizete Rizz. Relationship between bcl-2, bax, beclin-1, and cathepsin-D proteins during postovulatory follicular regression in fish ovary. Theriogenology. vol 85. issue 6. 2016-12-13. PMID:26719039. |
similar events of pof regression were detected by histology, terminal transferase-mediated dutp nick-end labeling (tunel), and electron microscopy in the three species: follicular cells hypertrophy, progressive disintegration of the basement membrane, gradual closing of the follicular lumen, theca thickening, and formation of large autophagic vacuoles preceding apoptosis of the follicular cells. |
2016-12-13 |
2023-08-13 |
Not clear |