| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' A Piek, R A de Boer, H H W Sillj\\xc3\\xa. The fibrosis-cell death axis in heart failure. Heart failure reviews. vol 21. issue 2. 2016-12-13. PMID:26883434.' |
whereas pathological and physiological (exercise, pregnancy) overload both stimulate cardiomyocyte growth (hypertrophy), only pathological remodeling is characterized by increased deposition of extracellular matrix proteins, termed fibrosis, and loss of cardiomyocytes by necrosis, apoptosis and/or phagocytosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yu-Lan Yeh, Hsiang-I Tsai, Shiu-Min Cheng, Peiying Pai, Tsung-Jung Ho, Ray-Jade Chen, Chao-Hung Lai, Pei-Jane Huang, V Vijaya Padma, Chih-Yang Huan. Mechanism of Taiwan Mingjian Oolong Tea to Inhibit Isoproterenol-Induced Hypertrophy and Apoptosis in Cardiomyoblasts. The American journal of Chinese medicine. vol 44. issue 1. 2016-12-13. PMID:26916915. |
mechanism of taiwan mingjian oolong tea to inhibit isoproterenol-induced hypertrophy and apoptosis in cardiomyoblasts. |
2016-12-13 |
2023-08-13 |
Not clear |
| Radhakrishnan Rajesh Kumar, Madhusudhanan Narasimhan, Gobinath Shanmugam, Jennifer Hong, Asokan Devarajan, Sethu Palaniappan, Jianhua Zhang, Ganesh V Halade, Victor M Darley-Usmar, John R Hoidal, Namakkal S Rajasekara. Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress. Journal of translational medicine. vol 14. 2016-11-07. PMID:27048381. |
anomalies in myocardial structure involving myocyte growth, hypertrophy, differentiation, apoptosis, necrosis etc. |
2016-11-07 |
2023-08-13 |
Not clear |
| Brijesh Sutariya, Dimple Jhonsa, Madhusudan N Sara. TGF-β: the connecting link between nephropathy and fibrosis. Immunopharmacology and immunotoxicology. vol 38. issue 1. 2016-11-02. PMID:26849902. |
besides ecm protein synthesis, tgf-β is involved in hypertrophy, proliferation, and apoptosis in renal cells. |
2016-11-02 |
2023-08-13 |
Not clear |
| Anita Thakur, Md Jahangir Alam, M R Ajayakumar, Saroj Ghaskadbi, Manish Sharma, Shyamal K Goswam. Norepinephrine-induced apoptotic and hypertrophic responses in H9c2 cardiac myoblasts are characterized by different repertoire of reactive oxygen species generation. Redox biology. vol 5. 2016-11-01. PMID:26070033. |
we demonstrate through our experiments that h9c2 cardiac myoblasts treated with 2 µm ne (hypertrophic dose) generate dcfh-da positive ros only for 2h; while those treated with 100 µm ne (apoptotic dose) sustains generation for 48 h, followed by apoptosis. |
2016-11-01 |
2023-08-13 |
Not clear |
| Ouyang Chen, Zhouheng Ye, Zhiyong Cao, Anatol Manaenko, Ke Ning, Xiao Zhai, Rongjia Zhang, Ting Zhang, Xiao Chen, Wenwu Liu, Xuejun Su. Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions. Free radical biology & medicine. vol 90. 2016-10-21. PMID:26585905. |
moreover, treatment with 10mg/kg ms for 3 days significantly reduced myocyte apoptosis, improved cardiac function and inhibited myocardial remodeling (reduced anterior wall thickness, attenuated myocyte hypertrophy, and decreased myocardial collagen). |
2016-10-21 |
2023-08-13 |
rat |
| Heike Wanka, Doreen Staar, Philipp Lutze, Barbara Peters, Johanna Hildebrandt, Tim Beck, Inga Bäumgen, Alexander Albers, Thomas Krieg, Katrin Zimmermann, Jaroslaw Sczodrok, Simon Schäfer, Sigrid Hoffmann, Jörg Peter. Anti-necrotic and cardioprotective effects of a cytosolic renin isoform under ischemia-related conditions. Journal of molecular medicine (Berlin, Germany). vol 94. issue 1. 2016-10-19. PMID:26256830. |
in the heart, secretory renin promotes hypertrophy, apoptosis, necrosis, fibrosis, and cardiac failure through angiotensin generation from angiotensinogen. |
2016-10-19 |
2023-08-13 |
rat |
| C Corinaldesi, L Di Luigi, A Lenzi, C Cresciol. Phosphodiesterase type 5 inhibitors: back and forward from cardiac indications. Journal of endocrinological investigation. vol 39. issue 2. 2016-10-13. PMID:26122487. |
nowadays, fine-tuned biomolecular mechanisms of pde5i are well recognized to be beneficial onto myocardial contractility and geometry, to reduce tissue fibrosis, hypertrophy and apoptosis. |
2016-10-13 |
2023-08-13 |
Not clear |
| J Heger, R Schulz, G Eule. Molecular switches under TGFβ signalling during progression from cardiac hypertrophy to heart failure. British journal of pharmacology. vol 173. issue 1. 2016-10-13. PMID:26431212. |
during pathological remodelling processes leading to heart failure, decompensated hypertrophy, death of cardiomyocytes by apoptosis or necroptosis and fibrosis as well as a progressive dysfunction of cardiomyocytes are apparent. |
2016-10-13 |
2023-08-13 |
Not clear |
| Jonathan A Kirk, Oscar H Cingolan. Thrombospondins in the transition from myocardial infarction to heart failure. Journal of molecular and cellular cardiology. vol 90. 2016-10-11. PMID:26686988. |
in the present review, we provide basic as well as clinical evidence linking the thrombospondin proteins with the post myocardial infarction response, including inflammation, fibrotic matrix remodeling, angiogenesis, as well as myocyte hypertrophy, apoptosis, and contractile dysfunction in heart failure. |
2016-10-11 |
2023-08-13 |
Not clear |
| Mateusz Kudelko, Cecilia W L Chan, Rakesh Sharma, Qing Yao, Edward Lau, Ivan K Chu, Kathryn S E Cheah, Julian A Tanner, Danny Cha. Label-Free Quantitative Proteomics Reveals Survival Mechanisms Developed by Hypertrophic Chondrocytes under ER Stress. Journal of proteome research. vol 15. issue 1. 2016-10-06. PMID:26587667. |
er stress is triggered in hypertrophic chondrocytes (hcs) in a mouse model (13del) of metaphyseal chondrodysplasia type schmid (mcds) caused by misfolded mutant collagen x proteins, but the hcs do not undergo apoptosis; rather chondrocyte differentiation is altered, causing skeletal abnormality. |
2016-10-06 |
2023-08-13 |
mouse |
| Meng Mei, Futian Tang, Meili Lu, Xin He, Hongxin Wang, Xuwei Hou, Jin Hu, Chonghua Xu, Ronghui Ha. Astragaloside IV attenuates apoptosis of hypertrophic cardiomyocyte through inhibiting oxidative stress and calpain-1 activation. Environmental toxicology and pharmacology. vol 40. issue 3. 2016-10-05. PMID:26433482. |
astragaloside iv attenuates apoptosis of hypertrophic cardiomyocyte through inhibiting oxidative stress and calpain-1 activation. |
2016-10-05 |
2023-08-13 |
rat |
| Meng Mei, Futian Tang, Meili Lu, Xin He, Hongxin Wang, Xuwei Hou, Jin Hu, Chonghua Xu, Ronghui Ha. Astragaloside IV attenuates apoptosis of hypertrophic cardiomyocyte through inhibiting oxidative stress and calpain-1 activation. Environmental toxicology and pharmacology. vol 40. issue 3. 2016-10-05. PMID:26433482. |
calpain-1 activation and oxidative stress are two critical factors contributing to apoptosis of hypertrophic cardiomyocyte. |
2016-10-05 |
2023-08-13 |
rat |
| Meng Mei, Futian Tang, Meili Lu, Xin He, Hongxin Wang, Xuwei Hou, Jin Hu, Chonghua Xu, Ronghui Ha. Astragaloside IV attenuates apoptosis of hypertrophic cardiomyocyte through inhibiting oxidative stress and calpain-1 activation. Environmental toxicology and pharmacology. vol 40. issue 3. 2016-10-05. PMID:26433482. |
the present study was designed to investigate whether the inhibitory effect of asiv on isoproterenol (iso)-induced apoptosis of hypertrophic cardiomyocyte was associated with the anti-oxidation and calpain-1 inhibition. |
2016-10-05 |
2023-08-13 |
rat |
| Meng Mei, Futian Tang, Meili Lu, Xin He, Hongxin Wang, Xuwei Hou, Jin Hu, Chonghua Xu, Ronghui Ha. Astragaloside IV attenuates apoptosis of hypertrophic cardiomyocyte through inhibiting oxidative stress and calpain-1 activation. Environmental toxicology and pharmacology. vol 40. issue 3. 2016-10-05. PMID:26433482. |
hypertrophy, apoptosis, mitochondrial oxidative stress and calpain-1 expression were measured in the heart tissue of sprague-dawley (sd) rats and h9c2 cells treated with iso alone or combination with asiv. |
2016-10-05 |
2023-08-13 |
rat |
| Celestino Sardu, Michelangela Barbieri, Maria Rosaria Rizzo, Pasquale Paolisso, Giuseppe Paolisso, Raffaele Marfell. Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes. Journal of diabetes research. vol 2016. 2016-10-05. PMID:26636106. |
crt effects are related to alterations in genes and micrornas (mirs) expression, which regulate cardiac processes involved in cardiac apoptosis, cardiac fibrosis, cardiac hypertrophy and angiogenesis, and membrane channel ionic currents. |
2016-10-05 |
2023-08-13 |
Not clear |
| Matteo Sorge, Mara Brancacci. Melusin Promotes a Protective Signal Transduction Cascade in Stressed Hearts. Frontiers in molecular biosciences. vol 3. 2016-09-27. PMID:27672636. |
in particular melusin activates akt and erk1/2 signaling, protects cardiomyocytes from apoptosis and induces a compensatory hypertrophic response in several pathological conditions. |
2016-09-27 |
2023-08-13 |
human |
| Xuhe Gong, Pengbo Wang, Qingqing Wu, Sijia Wang, Litian Yu, Guogan Wan. Human umbilical cord blood derived mesenchymal stem cells improve cardiac function in cTnT(R141W) transgenic mouse of dilated cardiomyopathy. European journal of cell biology. vol 95. issue 1. 2016-09-26. PMID:26655348. |
in conclusion, ucb-mscs preserve cardiac function after intramyocardial transplantation in a dcm mouse, and this effect may be associated with reductions in cellular apoptosis, inflammation, hypertrophy and myocardial fibrosis; in addition to; up-regulation of akt, vegf and igf-1; and enhanced angiogenesis. |
2016-09-26 |
2023-08-13 |
mouse |
| Linjie Si, Jing Xu, Chenlong Yi, Xiaohan Xu, Chao Ma, Junyi Yang, Fang Wang, Yuqing Zhang, Xiaowei Wan. Asiatic Acid Attenuates the Progression of Left Ventricular Hypertrophy and Heart Failure Induced by Pressure Overload by Inhibiting Myocardial Remodeling in Mice. Journal of cardiovascular pharmacology. vol 66. issue 6. 2016-09-22. PMID:26647013. |
cardiac structural remodeling, including cardiomyocyte apoptosis, interstitial fibrosis, and inflammation, appears to be a key event associated with the progression of left ventricular hypertrophy and heart failure. |
2016-09-22 |
2023-08-13 |
mouse |
| Yueh-Shan Weng, Hsueh-Fang Wang, Pei-Ying Pai, Gwo-Ping Jong, Chao-Hung Lai, Li-Chin Chung, Dennis Jine-Yuan Hsieh, Cecilia HsuanDay, Wei-Wen Kuo, Chih-Yang Huan. Tanshinone IIA Prevents Leu27IGF-II-Induced Cardiomyocyte Hypertrophy Mediated by Estrogen Receptor and Subsequent Akt Activation. The American journal of Chinese medicine. vol 43. issue 8. 2016-09-12. PMID:26621443. |
igf-iir plays important roles as a key regulator in myocardial pathological hypertrophy and apoptosis, which subsequently lead to heart failure. |
2016-09-12 |
2023-08-13 |
Not clear |