| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinjin Xu, Haobo Li, Michael G Irwin, Zhong-Yuan Xia, Xiaowen Mao, Shaoqing Lei, Gordon T Wong, Victor Hung, Chi Wai Cheung, Xiangming Fang, Alexander S Clanachan, Zhengyuan Xi. Propofol ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction via heme oxygenase-1/signal transducer and activator of transcription 3 signaling pathway in rats. Critical care medicine. vol 42. issue 8. 2016-04-12. PMID:24810525. |
we hypothesized that propofol, an anesthetic with antioxidant capacity, may attenuate hyperglycemia-induced oxidative stress in cardiomyocytes via enhancing heme oxygenase-1 activation and ameliorate hyperglycemia-induced cardiac hypertrophy and apoptosis via heme oxygenase-1/signal transducer and activator of transcription 3 signaling and improve cardiac function in diabetes. |
2016-04-12 |
2023-08-13 |
rat |
| Y Jing, X Zhou, X Han, J Jing, K von der Mark, J Wang, B de Crombrugghe, R J Hinton, J Q Fen. Chondrocytes Directly Transform into Bone Cells in Mandibular Condyle Growth. Journal of dental research. vol 94. issue 12. 2016-04-12. PMID:26341973. |
for decades, it has been widely accepted that hypertrophic chondrocytes undergo apoptosis prior to endochondral bone formation. |
2016-04-12 |
2023-08-13 |
mouse |
| Joaquim Fernández-Solà, Francesc Borrisser-Pairó, Emilia Antúnez, Ester Tobía. Myostatin and insulin-like growth factor-1 in hypertensive heart disease: a prospective study in human heart donors. Journal of hypertension. vol 33. issue 4. 2016-04-11. PMID:25915890. |
the physiopathological mechanisms implicated in hypertensive heart disease are multi-factorial, including myocyte hypertrophy, apoptosis and myocardial remodelling. |
2016-04-11 |
2023-08-13 |
human |
| Jihan Xia, Yuanyuan Zhang, Leilei Xin, Siyuan Kong, Yaoxing Chen, Shulin Yang, Kui L. Global Transcriptomic Profiling of Cardiac Hypertrophy and Fatty Heart Induced by Long-Term High-Energy Diet in Bama Miniature Pigs. PloS one. vol 10. issue 7. 2016-04-11. PMID:26161779. |
kegg analysis indicated that the observed heart disorder involved the signal transduction-related mapk, cytokine, and ppar signaling pathways, energy metabolism-related fatty acid and oxidative phosphorylation signaling pathways, heart function signaling-related focal adhesion, axon guidance, hypertrophic cardiomyopathy and actin cytoskeleton signaling pathways, inflammation and apoptosis pathways, and others. |
2016-04-11 |
2023-08-13 |
human |
| Hui Wang, Yimu Lai, Bryan J Mathis, Wenjuan Wang, Siying Li, Chen Qu, Bin Li, Lei Shao, Haibo Song, Joseph S Janicki, Sao-Cong Sun, Xing Li Wang, Dongqi Tang, Taixing Cu. Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2. Journal of molecular and cellular cardiology. vol 84. 2016-04-07. PMID:25935309. |
knockout of cyld improved survival rate and alleviated cardiac hypertrophy, fibrosis, apoptosis, oxidative stress, and dysfunction in mice that were subjected to sustained pressure overload induced by transverse aortic constriction. |
2016-04-07 |
2023-08-13 |
mouse |
| José Antônio Silva, Eduardo Tadeu Santana, Martha Trindade Manchini, Ednei Luis Antônio, Danilo Sales Bocalini, José Eduardo Krieger, Paulo José Ferreira Tucci, Andrey Jorge Serr. Exercise training can prevent cardiac hypertrophy induced by sympathetic hyperactivity with modulation of kallikrein-kinin pathway and angiogenesis. PloS one. vol 9. issue 3. 2016-03-31. PMID:24614810. |
interestingly, exercise blunted hypertrophy, myocardial dysfunction, fibrosis, apoptosis and capillary decreases. |
2016-03-31 |
2023-08-12 |
rat |
| Indrajeetsinh Rana, Elena Velkoska, Sheila K Patel, Louise M Burrell, Fadi J Charcha. MicroRNAs mediate the cardioprotective effect of angiotensin-converting enzyme inhibition in acute kidney injury. American journal of physiology. Renal physiology. vol 309. issue 11. 2016-03-30. PMID:26400542. |
using a subtotal nephrectomy rat model of kidney injury, we investigated changes in cardiac micrornas that are known to have direct target genes involved in the regulation of apoptosis, fibrosis, and hypertrophy. |
2016-03-30 |
2023-08-13 |
rat |
| Indrajeetsinh Rana, Elena Velkoska, Sheila K Patel, Louise M Burrell, Fadi J Charcha. MicroRNAs mediate the cardioprotective effect of angiotensin-converting enzyme inhibition in acute kidney injury. American journal of physiology. Renal physiology. vol 309. issue 11. 2016-03-30. PMID:26400542. |
there was altered expression of caspase-9, b cell lymphoma-2, transforming growth factor-β, fibronectin 1, collagen type 1a1, and forkhead box protein o3, which are all known to be involved in the regulation of apoptosis, fibrosis, and hypertrophy in cardiac cells while being targets for the above micrornas. |
2016-03-30 |
2023-08-13 |
rat |
| Mateusz Kudelko, Rakesh Sharma, Kathryn S E Cheah, Danny Cha. Comparison of proteomic datasets from hypertrophic chondrocytes in response to ER stress. Data in brief. vol 7. 2016-03-25. PMID:27014728. |
furthermore our established 13del mouse model in which the activation of er stress did not lead to apoptosis of the hypertrophic cells allowed us to address the natural consequences of er stress in vivo. |
2016-03-25 |
2023-08-13 |
mouse |
| Lili Zhou, Youhua Li. Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease. Nature reviews. Nephrology. vol 11. issue 9. 2016-03-22. PMID:26055352. |
podocytes are vulnerable to a variety of injuries and in response they undergo a series of changes ranging from hypertrophy, autophagy, dedifferentiation, mesenchymal transition and detachment to apoptosis, depending on the nature and extent of the insult. |
2016-03-22 |
2023-08-13 |
mouse |
| Tomohiro Yokota, Yibin Wan. p38 MAP kinases in the heart. Gene. vol 575. issue 2 Pt 2. 2016-03-17. PMID:26390817. |
in this review, we will focus on the structure and molecular biology of p38s, and their specific roles in heart, especially regarding myocyte proliferation, apoptosis, and hypertrophic responses. |
2016-03-17 |
2023-08-13 |
Not clear |
| W Liu, X Wang, Z Mei, J Gong, X Gao, Y Zhao, J Ma, F Xie, L Qia. Chronic stress promotes the progression of pressure overload-induced cardiac dysfunction through inducing more apoptosis and fibrosis. Physiological research. vol 64. issue 3. 2016-03-07. PMID:25536317. |
compared with the aac rats, there is a significant increase in cardiac hypertrophy, injury, apoptosis and fibrosis of the aac + stress rats. |
2016-03-07 |
2023-08-13 |
rat |
| W Liu, X Wang, Z Mei, J Gong, X Gao, Y Zhao, J Ma, F Xie, L Qia. Chronic stress promotes the progression of pressure overload-induced cardiac dysfunction through inducing more apoptosis and fibrosis. Physiological research. vol 64. issue 3. 2016-03-07. PMID:25536317. |
the higher concentration ne induced more cardiomyocytes hypertrophy and apoptosis, cardiac fibroblasts proliferation and collagen expression. |
2016-03-07 |
2023-08-13 |
rat |
| W Liu, X Wang, Z Mei, J Gong, X Gao, Y Zhao, J Ma, F Xie, L Qia. Chronic stress promotes the progression of pressure overload-induced cardiac dysfunction through inducing more apoptosis and fibrosis. Physiological research. vol 64. issue 3. 2016-03-07. PMID:25536317. |
these results revealed that high level of ne-induced cardiomyocytes hypertrophy and apoptosis, cardiac fibroblasts proliferation and collagen expression further contributes to the effect of chronic stress on acceleration of pressure overload-induced cardiac dysfunction. |
2016-03-07 |
2023-08-13 |
rat |
| Hirohisa Kawahata, Daisuke Sotobayashi, Motokuni Aoki, Hideo Shimizu, Hironori Nakagami, Toshio Ogihara, Ryuichi Morishit. Continuous infusion of angiotensin II modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse. Hypertension research : official journal of the Japanese Society of Hypertension. vol 38. issue 6. 2016-03-03. PMID:25693858. |
continuous infusion of angiotensin ii modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse. |
2016-03-03 |
2023-08-13 |
mouse |
| Hirohisa Kawahata, Daisuke Sotobayashi, Motokuni Aoki, Hideo Shimizu, Hironori Nakagami, Toshio Ogihara, Ryuichi Morishit. Continuous infusion of angiotensin II modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse. Hypertension research : official journal of the Japanese Society of Hypertension. vol 38. issue 6. 2016-03-03. PMID:25693858. |
overall, the present study demonstrated that ang ii promoted hypertrophic differentiation of chondrocytes and reduced apoptosis of hypertrophic chondrocytes independently of high blood pressure. |
2016-03-03 |
2023-08-13 |
mouse |
| Jianquan Chen, Nilsson Holguin, Yu Shi, Matthew J Silva, Fanxin Lon. mTORC2 signaling promotes skeletal growth and bone formation in mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 30. issue 2. 2016-02-22. PMID:25196701. |
subsequently, the embryonic skeletal elements are shortened due to a delay in chondrocyte hypertrophy, with no change in proliferation, apoptosis, cell size, or matrix production. |
2016-02-22 |
2023-08-13 |
mouse |
| W Li, J F Fei, Q Yang, B L Li, C Lin, Q Yue, Q G Men. Acute toxic effects of sonodynamic therapy on hypertrophic scar fibroblasts of rabbit ears. Genetics and molecular research : GMR. vol 14. issue 2. 2016-02-18. PMID:25966193. |
furthermore, annexin v/pi double staining showed necrosis and apoptosis of the hypertrophic scar fibroblasts. |
2016-02-18 |
2023-08-13 |
rabbit |
| Sarita Nehra, Varun Bhardwaj, Namita Kalra, Lilly Ganju, Anju Bansal, Shweta Saxena, Deepika Saraswa. Nanocurcumin protects cardiomyoblasts H9c2 from hypoxia-induced hypertrophy and apoptosis by improving oxidative balance. Journal of physiology and biochemistry. vol 71. issue 2. 2016-02-17. PMID:25846484. |
nanocurcumin protects cardiomyoblasts h9c2 from hypoxia-induced hypertrophy and apoptosis by improving oxidative balance. |
2016-02-17 |
2023-08-13 |
Not clear |
| Sarita Nehra, Varun Bhardwaj, Namita Kalra, Lilly Ganju, Anju Bansal, Shweta Saxena, Deepika Saraswa. Nanocurcumin protects cardiomyoblasts H9c2 from hypoxia-induced hypertrophy and apoptosis by improving oxidative balance. Journal of physiology and biochemistry. vol 71. issue 2. 2016-02-17. PMID:25846484. |
nanocurcumin, in ameliorating hypoxia-induced hypertrophy and apoptosis in h9c2 cardiomyoblasts and compared it to curcumin. |
2016-02-17 |
2023-08-13 |
Not clear |