| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chi Zhou, Jin Huang, Qing Li, Chenao Zhan, Xizhen Xu, Xu Zhang, Ding Ai, Yi Zhu, Zheng Wen, Dao Wen Wan. CYP2J2-derived EETs attenuated ethanol-induced myocardial dysfunction through inducing autophagy and reducing apoptosis. Free radical biology & medicine. vol 117. 2019-05-08. PMID:29427791. |
the results showed that chronic ethanol intake led to cardiac dilation, contractile dysfunction, cardiomyocyte hypertrophy, oxidative stress, and cardiomyocyte apoptosis, while cyp2j2 overexpression ameliorated these effects. |
2019-05-08 |
2023-08-13 |
mouse |
| Brian B Graham, Rahul Kumar, Claudia Mickael, Biruk Kassa, Dan Koyanagi, Linda Sanders, Li Zhang, Mario Perez, Daniel Hernandez-Saavedra, Carolyn Valencia, Kandice Dixon, Julie Harral, Zoe Loomis, David Irwin, Travis Nemkov, Angelo D'Alessandro, Kurt R Stenmark, Rubin M Tude. Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension. American journal of respiratory cell and molecular biology. vol 59. issue 4. 2019-04-15. PMID:29851508. |
by stereology, there was significant rv hypertrophy and increased total vascular length in the rv free wall in close proportion, with evidence of vessel proliferation but no evidence of endothelial cell apoptosis. |
2019-04-15 |
2023-08-13 |
mouse |
| Chuan Cao, Wenping Wang, Lele Lu, Liang Wang, XiaoSong Chen, Rui Guo, Shirong Li, Junzi Jian. Inactivation of Beclin-1-dependent autophagy promotes ursolic acid-induced apoptosis in hypertrophic scar fibroblasts. Experimental dermatology. vol 27. issue 1. 2019-04-08. PMID:28767174. |
inactivation of beclin-1-dependent autophagy promotes ursolic acid-induced apoptosis in hypertrophic scar fibroblasts. |
2019-04-08 |
2023-08-13 |
Not clear |
| Chuan Cao, Wenping Wang, Lele Lu, Liang Wang, XiaoSong Chen, Rui Guo, Shirong Li, Junzi Jian. Inactivation of Beclin-1-dependent autophagy promotes ursolic acid-induced apoptosis in hypertrophic scar fibroblasts. Experimental dermatology. vol 27. issue 1. 2019-04-08. PMID:28767174. |
thus, promoting hypertrophic scar fibroblast (hsfb) apoptosis is an effective strategy for hs therapy. |
2019-04-08 |
2023-08-13 |
Not clear |
| Jieyi Zuo, Zhiying Chen, Xinchao Zhong, Wanli Lan, Yizhen Kuang, Dong Huan. FBP1 is highly expressed in human hypertrophic scars and increases fibroblast proliferation, apoptosis, and collagen expression. Connective tissue research. vol 59. issue 2. 2019-04-04. PMID:28362515. |
fbp1 is highly expressed in human hypertrophic scars and increases fibroblast proliferation, apoptosis, and collagen expression. |
2019-04-04 |
2023-08-13 |
human |
| Kah Yong Goh, Li He, Jiajia Song, Miki Jinno, Aaron J Rogers, Palaniappan Sethu, Ganesh V Halade, Namakkal Soorappan Rajasekaran, Xiaoguang Liu, Sumanth D Prabhu, Victor Darley-Usmar, Adam R Wende, Lufang Zho. Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice. Redox biology. vol 21. 2019-04-01. PMID:30641298. |
mitoq attenuated pressure overload-induced apoptosis, hypertrophic remodeling, fibrosis and lv dysfunction. |
2019-04-01 |
2023-08-13 |
mouse |
| Deguo Wang, Yong Wu, Yueyun Chen, Ancai Wang, Kun Lv, Xiang Kong, Yang He, Nengwei H. Focal selective chemo-ablation of spinal cardiac afferent nerve by resiniferatoxin protects the heart from pressure overload-induced hypertrophy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-03-25. PMID:30399572. |
histologic analysis, real-time reverse transcription-polymerase chain reaction, and western blots showed that rtx prevented tac-induced cardiac hypertrophy, cardiac fibrosis, and cardiac apoptosis and reduced the expression of apoptotic proteins and myocardial mrnas. |
2019-03-25 |
2023-08-13 |
rat |
| Chen Chen, Lei-Xin Zou, Qiu-Yue Lin, Xiao Yan, Hai-Lian Bi, Xin Xie, Shuai Wang, Qing-Shan Wang, Yun-Long Zhang, Hui-Hua L. Resveratrol as a new inhibitor of immunoproteasome prevents PTEN degradation and attenuates cardiac hypertrophy after pressure overload. Redox biology. vol 20. 2019-03-21. PMID:30412827. |
our results showed that administration of res significantly suppressed pressure overload-induced cardiac hypertrophy, fibrosis and apoptosis and improved in vivo heart function in mice. |
2019-03-21 |
2023-08-13 |
mouse |
| Prathapan A, Salin Raj P, Priya Rani M, Raghu K . Apoptosis in angiotensin II-stimulated hypertrophic cardiac cells -modulation by phenolics rich extract of Boerhavia diffusa L. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-18. PMID:30372810. |
apoptosis in angiotensin ii-stimulated hypertrophic cardiac cells -modulation by phenolics rich extract of boerhavia diffusa l. herein, we investigated the effects of b. diffusa (bde), a well-known cardiotonic edible medicinal plant against apoptosis in angiotensin ii (ang ii)-stimulated hypertrophic cardiac cells (h9c2). |
2019-03-18 |
2023-08-13 |
Not clear |
| Prathapan A, Salin Raj P, Priya Rani M, Raghu K . Apoptosis in angiotensin II-stimulated hypertrophic cardiac cells -modulation by phenolics rich extract of Boerhavia diffusa L. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-18. PMID:30372810. |
the cells were analyzed for viability, markers of hypertrophy, apoptosis, and the expression of various proteins related to apoptosis. |
2019-03-18 |
2023-08-13 |
Not clear |
| Ibrahim Muhammed, Suruthi Sankar, Sakthivel Govindara. Ameliorative Effect of Epigallocatechin Gallate on Cardiac Hypertrophy and Fibrosis in Aged Rats. Journal of cardiovascular pharmacology. vol 71. issue 2. 2019-03-14. PMID:29419571. |
the objective of the present study is to evaluate the effect of epigallocatechin gallate (egcg) on aging-mediated cardiac hypertrophy, fibrosis, and apoptosis. |
2019-03-14 |
2023-08-13 |
rat |
| Ibrahim Muhammed, Suruthi Sankar, Sakthivel Govindara. Ameliorative Effect of Epigallocatechin Gallate on Cardiac Hypertrophy and Fibrosis in Aged Rats. Journal of cardiovascular pharmacology. vol 71. issue 2. 2019-03-14. PMID:29419571. |
taken together, it is evident that egcg may potentially inhibit aging-induced cardiac hypertrophy, fibrosis, and apoptosis, thereby preserving cardiac function. |
2019-03-14 |
2023-08-13 |
rat |
| Ibrahim Muhammed, Suruthi Sankar, Sakthivel Govindara. Ameliorative Effect of Epigallocatechin Gallate on Cardiac Hypertrophy and Fibrosis in Aged Rats. Journal of cardiovascular pharmacology. vol 71. issue 2. 2019-03-14. PMID:29419571. |
hence, the present study suggests that egcg can be useful to fight against aging-induced cardiac hypertrophy, fibrosis, and apoptosis. |
2019-03-14 |
2023-08-13 |
rat |
| Wendi Yang, Bing Hui Wang, Ian Wang, Li Huang, Feby Savira, Andrew Kompa, Beat M Jucker, Robert N Willette, Darren Kelly, Henry Krum, Zhiliang Li, Qian F. Inhibition of Apoptosis Signal-Regulating Kinase 1 Attenuates Myocyte Hypertrophy and Fibroblast Collagen Synthesis. Heart, lung & circulation. vol 28. issue 3. 2019-03-11. PMID:29277546. |
inhibition of apoptosis signal-regulating kinase 1 attenuates myocyte hypertrophy and fibroblast collagen synthesis. |
2019-03-11 |
2023-08-13 |
Not clear |
| Yogesh Bulani, Krishnamoorthy Srinivasan, Shyam Sunder Sharm. Attenuation of type-1 diabetes-induced cardiovascular dysfunctions by direct thrombin inhibitor in rats: a mechanistic study. Molecular and cellular biochemistry. vol 451. issue 1-2. 2019-03-08. PMID:29971544. |
further, it also protected heart against structural changes induced by diabetes as shown by reduction in fibrosis, hypertrophy and apoptosis. |
2019-03-08 |
2023-08-13 |
rat |
| Yihui Yu, Zuoying Hu, Bing Li, Zhimei Wang, Shaoliang Che. Ivabradine improved left ventricular function and pressure overload-induced cardiomyocyte apoptosis in a transverse aortic constriction mouse model. Molecular and cellular biochemistry. vol 450. issue 1-2. 2019-03-06. PMID:29790114. |
hematoxylin-eosin (h&e), masson's trichome staining, and tunel assays were conducted to evaluate cardiac hypertrophy, fibrosis, and apoptosis, respectively. |
2019-03-06 |
2023-08-13 |
mouse |
| Yihui Yu, Zuoying Hu, Bing Li, Zhimei Wang, Shaoliang Che. Ivabradine improved left ventricular function and pressure overload-induced cardiomyocyte apoptosis in a transverse aortic constriction mouse model. Molecular and cellular biochemistry. vol 450. issue 1-2. 2019-03-06. PMID:29790114. |
cardiac hypertrophy, fibrosis, and apoptosis induced by tac were notably suppressed after either rapamycin or ivabradine treatment (p < 0.05). |
2019-03-06 |
2023-08-13 |
mouse |
| Yihui Yu, Zuoying Hu, Bing Li, Zhimei Wang, Shaoliang Che. Ivabradine improved left ventricular function and pressure overload-induced cardiomyocyte apoptosis in a transverse aortic constriction mouse model. Molecular and cellular biochemistry. vol 450. issue 1-2. 2019-03-06. PMID:29790114. |
ivabradine improved cardiac hypertrophy and fibrosis as well as reduced cardiomyocyte apoptosis via the pi3k/akt/mtor/p70s6k pathway in tac model mice. |
2019-03-06 |
2023-08-13 |
mouse |
| Zhi-Feng Xiao, Guo-Yi Su, Yu Hou, Shu-Dong Chen, Ding-Kun Li. Cartilage degradation in osteoarthritis: A process of osteochondral remodeling resembles the endochondral ossification in growth plate? Medical hypotheses. vol 121. 2019-03-05. PMID:30396477. |
many factors such as mechanics, inflammation and immunological abnormality could drive the joint tissues metabolic and disturb the steady state of cartilage and bone, which further devoted to a serial pathological manifestations, consisting of hypertrophy and apoptosis of articular chondrocytes, degradation of cartilage matrix, angiogenesis and calcification of hyaline cartilage, replication of tidemark, formation of osteophytes, degeneration of ligaments and, in the knee, the menisci, hypertrophy of the joint capsule and remodeling of subchondral bone along with increased permeability of the osteochondral interface. |
2019-03-05 |
2023-08-13 |
Not clear |
| Karl Toischer, Wuqiang Zhu, Mark Hünlich, Belal A Mohamed, Sara Khadjeh, Sean P Reuter, Katrin Schäfer, Deepak Ramanujam, Stefan Engelhardt, Loren J Field, Gerd Hasenfus. Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload. The Journal of clinical investigation. vol 127. issue 12. 2019-02-26. PMID:29083322. |
following tac, cyclin d2 expression attenuated cardiomyocyte hypertrophy, reduced cardiomyocyte apoptosis, fibrosis, calcium/calmodulin-dependent protein kinase iiδ phosphorylation, brain natriuretic peptide expression, and sustained capillarization. |
2019-02-26 |
2023-08-13 |
mouse |