| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aiko Ito, Yoshiki Ohnuki, Kenji Suita, Misao Ishikawa, Yasumasa Mototani, Kouichi Shiozawa, Naoya Kawamura, Yuka Yagisawa, Megumi Nariyama, Daisuke Umeki, Yoshiki Nakamura, Satoshi Okumur. Role of β-adrenergic signaling in masseter muscle. PloS one. vol 14. issue 4. 2020-01-07. PMID:30986276. |
in masseter muscle, however, chronic β1-ar stimulation did not induce muscle hypertrophy, but did induce fibrosis and apoptosis concomitantly with increased levels of p44/42 mapk (erk1/2) (thr-202/tyr-204), calmodulin kinase ii (thr-286) and mammalian target of rapamycin (mtor) (ser-2481) phosphorylation. |
2020-01-07 |
2023-08-13 |
mouse |
| Li Quanzheng, Wei Gongchang, Tao Ta. Corrigendum to "Leukocyte immunoglobulin-like receptor B4 (LILRB4) negatively mediates the pathological cardiac hypertrophy by suppressing fibrosis, inflammation and apoptosis via the activation of NF-κB signaling" [BIOCHEM BIOPH RES CO volume 509 (issue 1) (29 January 2019) pages 16-23]. Biochemical and biophysical research communications. vol 521. issue 2. 2020-01-07. PMID:31703839. |
corrigendum to "leukocyte immunoglobulin-like receptor b4 (lilrb4) negatively mediates the pathological cardiac hypertrophy by suppressing fibrosis, inflammation and apoptosis via the activation of nf-κb signaling" [biochem bioph res co volume 509 (issue 1) (29 january 2019) pages 16-23]. |
2020-01-07 |
2023-08-13 |
Not clear |
| Xinxin Jin, Xiaomin Kang, Liting Zhao, Mao Xu, Tianping Xie, Huixia Li, Fang Li, Zhuang Qian, Zhengmin Ma, Ying Zhang, Wei Yang, Zhuanmin Zhang, Xin Gao, Qian Chen, Hongzhi Sun, Shufang W. Cartilage Ablation of Sirt1 Causes Inhibition of Growth Plate Chondrogenesis by Hyperactivation of mTORC1 Signaling. Endocrinology. vol 160. issue 12. 2019-12-23. PMID:31599935. |
compared with control mice, cko mice exhibited growth retardation associated with inhibited chondrocyte proliferation and hypertrophy, as well as activated apoptosis. |
2019-12-23 |
2023-08-13 |
mouse |
| Jinjun Pu, Shun Zhu, Dandan Zhou, Lidong Zhao, Ming Yin, Zejian Wang, Jiang Hon. Propofol Alleviates Apoptosis Induced by Chronic High Glucose Exposure via Regulation of HIF-1 Oxidative medicine and cellular longevity. vol 2019. 2019-12-20. PMID:31093315. |
propofol alleviates apoptosis induced by chronic high glucose exposure via regulation of hif-1 the sedative anesthetic, propofol, is a cardioprotective agent for hyperglycemia-induced myocardial hypertrophy and dysfunction in rats. |
2019-12-20 |
2023-08-13 |
rat |
| Yun-Fei Xiao, Zhi-Xiong Zeng, Xiao-Hui Guan, Ling-Fang Wang, Chan-Juan Wang, Huidong Shi, Weinian Shou, Ke-Yu Deng, Hong-Bo Xi. FKBP12.6 protects heart from AngII-induced hypertrophy through inhibiting Ca Journal of cellular and molecular medicine. vol 22. issue 7. 2019-12-13. PMID:29682889. |
studies showed that overexpression of fkbp12.6 attenuated thoracic aortic constriction (tac)-induced cardiac hypertrophy in mice, whereas the adenovirus-mediated overexpression of fkbp12.6 induced hypertrophy and apoptosis in cultured neonatal cardiomyocytes, indicating that the role of fkbp12.6 in cardiac hypertrophy is still controversial. |
2019-12-13 |
2023-08-13 |
mouse |
| Julie Chao, Lee Cha. The Role of Adrenomedullin in Cardiovascular and Renal Function. Drug news & perspectives. vol 15. issue 8. 2019-11-20. PMID:12677190. |
adrenomedullin gene transfer also protects against cardiac and renal damages including: 1) myocardial infarction, ventricular arrhythmias and apoptosis in ischemic myocardium; 2) cardiac hypertrophy and fibrosis; 3) glomerulosclerosis, tubular disruption, protein cast accumulation in lumen, renal cell proliferation and fibrosis in the kidney; 4) neointimal hyperplasia in blood vessels induced by balloon angioplasty; 5) streptozotocin-diabeticinduced cardiac and renal glycogen accumulation, and body weight loss; and 6) cerebral ischemia-induced infarction and locomotor deficits. |
2019-11-20 |
2023-08-12 |
mouse |
| Gennady T. Sukhikh, Ludmila V. Vank. Interrelationships between Immune and Reproductive Systems in Human. Russian journal of immunology : RJI : official journal of Russian Society of Immunology. vol 4. issue 4. 2019-11-20. PMID:12687144. |
the study of the participation of the apoptosis process in the mechanisms of intrauterine development of the fetus and hypertrophic changes of the endometrium is interesting. |
2019-11-20 |
2023-08-12 |
human |
| Joaquim Fernández-Solà, Ana Planavila Port. New Treatment Strategies for Alcohol-Induced Heart Damage. International journal of molecular sciences. vol 17. issue 10. 2019-11-20. PMID:27690014. |
new potential therapeutic targets aim to control oxidative damage, myocyte hypertrophy, interstitial fibrosis and persistent apoptosis in addition, stem-cell therapy may improve myocyte regeneration. |
2019-11-20 |
2023-08-13 |
human |
| Walter E Knight, Si Chen, Yishuai Zhang, Masayoshi Oikawa, Meiping Wu, Qian Zhou, Clint L Miller, Yujun Cai, Deanne M Mickelsen, Christine Moravec, Eric M Small, Junichi Abe, Chen Ya. PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 45. 2019-11-20. PMID:27791092. |
in vivo, cardiac remodeling and dysfunction induced by transverse aortic constriction, including myocardial hypertrophy, apoptosis, cardiac fibrosis, and loss of contractile function, were significantly attenuated in pde1c-knockout mice relative to wild-type mice. |
2019-11-20 |
2023-08-13 |
mouse |
| N V Medvedev, N K Gorshunov. [Apoptosis and interstitial fibrosis in development of myocardial remodelling in elderly patients with arterial hypertension]. Advances in gerontology = Uspekhi gerontologii. vol 26. issue 2. 2019-11-20. PMID:28976159. |
structural reorganization of a myocardium from concentric to eccentric hypertrophy and concentric remodelling of left ventricle was characterized by strengthening of cellular apoptosis and interstitial myocardial fibrosis in extracellular matrix expressiveness, prevalence of collagen synthesis over collagen degradation, progressing of myocardium dysfunction. |
2019-11-20 |
2023-08-13 |
Not clear |
| Jia Zhou, Yixuan Zhao, Vera Simonenko, John J Xu, Kai Liu, Deling Wang, Jingli Shi, Tianyi Zhong, Lixia Zhang, Lun Zeng, Bin Huang, Shenggao Tang, Alan Y Lu, A James Mixson, Yangbai Sun, Patrick Y Lu, Qingfeng L. Simultaneous silencing of TGF-β1 and COX-2 reduces human skin hypertrophic scar through activation of fibroblast apoptosis. Oncotarget. vol 8. issue 46. 2019-11-20. PMID:29113333. |
simultaneous silencing of tgf-β1 and cox-2 reduces human skin hypertrophic scar through activation of fibroblast apoptosis. |
2019-11-20 |
2023-08-13 |
mouse |
| Bohao Liu, Benjamin W Lee, Koki Nakanishi, Aranzazu Villasante, Rebecca Williamson, Jordan Metz, Jinho Kim, Mariko Kanai, Lynn Bi, Kristy Brown, Gilbert Di Paolo, Shunichi Homma, Peter A Sims, Veli K Topkara, Gordana Vunjak-Novakovi. Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells. Nature biomedical engineering. vol 2. issue 5. 2019-11-20. PMID:30271672. |
here, we show that an engineered hydrogel patch capable of slowly releasing evs secreted from cardiomyocytes derived from induced pluripotent stem (ips) cells reduced arrhythmic burden, promoted ejection-fraction recovery, decreased cardiomyocyte apoptosis 24 hours after infarction, and reduced infarct size and cell hypertrophy 4 weeks post-infarction when implanted onto infarcted rat hearts. |
2019-11-20 |
2023-08-13 |
rat |
| Yu A Dyleva, O V Gruzdeva, O E Akbasheva, E G Uchasova, O L Barbaras. [The physiologic and pathophysiologic role of stimulating growth factor ST2.] Klinicheskaia laboratornaia diagnostika. vol 62. issue 10. 2019-11-20. PMID:30821940. |
the experimental models were used to demonstrate decreasing of myocardium fibrosis, prevention of development of hypertrophy of cardiomyocytes, decreasing of apoptosis and amelioration of functional capacity of myocardium at interaction of il-33 and st2l. |
2019-11-20 |
2023-08-13 |
Not clear |
| Yongqiang Xiao, Dayuan Xu, Hongyuan Song, Futing Shu, Pei Wei, Xiaolan Yang, Chenjian Zhong, Xiaohong Wang, Werner Eg Müller, YongJun Zheng, Shichu Xiao, Zhaofan Xi. Cuprous oxide nanoparticles reduces hypertrophic scarring by inducing fibroblast apoptosis. International journal of nanomedicine. vol 14. 2019-11-13. PMID:31534333. |
cuprous oxide nanoparticles reduces hypertrophic scarring by inducing fibroblast apoptosis. |
2019-11-13 |
2023-08-13 |
Not clear |
| Yongqiang Xiao, Dayuan Xu, Hongyuan Song, Futing Shu, Pei Wei, Xiaolan Yang, Chenjian Zhong, Xiaohong Wang, Werner Eg Müller, YongJun Zheng, Shichu Xiao, Zhaofan Xi. Cuprous oxide nanoparticles reduces hypertrophic scarring by inducing fibroblast apoptosis. International journal of nanomedicine. vol 14. 2019-11-13. PMID:31534333. |
less apoptosis and excessive growth of fibroblasts contribute to the progression of hypertrophic scar formation. |
2019-11-13 |
2023-08-13 |
Not clear |
| Zhijun Huang, Jingxian Shu, Weihong Jiang, Mengqing Jiang, Yao Lu, Haijiang Dai, Nana Xu, Hong Yuan, Jingjing Ca. Regulator of G Protein Signaling 6 Facilities Cardiac Hypertrophy by Activating Apoptosis Signal-Regulating Kinase 1-P38/c-JUN N-Terminal Kinase 1/2 Signaling. Journal of the American Heart Association. vol 7. issue 19. 2019-11-12. PMID:30371330. |
regulator of g protein signaling 6 facilities cardiac hypertrophy by activating apoptosis signal-regulating kinase 1-p38/c-jun n-terminal kinase 1/2 signaling. |
2019-11-12 |
2023-08-13 |
mouse |
| Zhijun Huang, Jingxian Shu, Weihong Jiang, Mengqing Jiang, Yao Lu, Haijiang Dai, Nana Xu, Hong Yuan, Jingjing Ca. Regulator of G Protein Signaling 6 Facilities Cardiac Hypertrophy by Activating Apoptosis Signal-Regulating Kinase 1-P38/c-JUN N-Terminal Kinase 1/2 Signaling. Journal of the American Heart Association. vol 7. issue 19. 2019-11-12. PMID:30371330. |
according to the mechanistic studies, rgs 6 mediated cardiac hypertrophy by directly interacting with apoptosis signal-regulating kinase 1, which further activates the p38-c- jun n-terminal kinase 1/2 signaling pathway. |
2019-11-12 |
2023-08-13 |
mouse |
| Lei-Lei Ma, Xin Ma, Fei-Juan Kong, Jun-Jie Guo, Hong-Tao Shi, Jian-Bing Zhu, Yun-Zeng Zou, Jun-Bo G. Mammalian target of rapamycin inhibition attenuates myocardial ischaemia-reperfusion injury in hypertrophic heart. Journal of cellular and molecular medicine. vol 22. issue 3. 2019-10-21. PMID:29314656. |
most importantly, we found that mi/r-induced myocardial injury was markedly reduced by rapamycin treatment manifested by the inhibition of myocardial apoptosis, the reduction of myocardial infarct size and the improvement of cardiac function in hypertrophic heart. |
2019-10-21 |
2023-08-13 |
mouse |
| Shengban You, Jianchang Qian, Chuchu Sun, Hailing Zhang, Shiju Ye, Taiwei Chen, Zheng Xu, Jingying Wang, Weijian Huang, Guang Lian. An Aza resveratrol-chalcone derivative 6b protects mice against diabetic cardiomyopathy by alleviating inflammation and oxidative stress. Journal of cellular and molecular medicine. vol 22. issue 3. 2019-10-15. PMID:29327811. |
in h9c2 myocardial cells, 6b potently decreased high glucose (hg)-induced cell fibrosis, hypertrophy and apoptosis, alleviating inflammatory response and oxidant stress. |
2019-10-15 |
2023-08-13 |
mouse |
| Shengban You, Jianchang Qian, Chuchu Sun, Hailing Zhang, Shiju Ye, Taiwei Chen, Zheng Xu, Jingying Wang, Weijian Huang, Guang Lian. An Aza resveratrol-chalcone derivative 6b protects mice against diabetic cardiomyopathy by alleviating inflammation and oxidative stress. Journal of cellular and molecular medicine. vol 22. issue 3. 2019-10-15. PMID:29327811. |
in stz-induced type 1 diabetic mice (stz-dm1), orally administration with 6b for 16 weeks significantly attenuated cardiac hypertrophy, apoptosis and fibrosis. |
2019-10-15 |
2023-08-13 |
mouse |