| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenjing Xu, Cheng Wang, Minglu Liang, Long Chen, Qin Fu, Fengxiao Zhang, Yan Wang, Dan Huang, Kai Huan. A20 prevents obesity-induced development of cardiac dysfunction. Journal of molecular medicine (Berlin, Germany). vol 96. issue 2. 2019-10-14. PMID:29143862. |
cardiac-specific supplementation with a20 via recombinant adeno-associated virus subtype 9 (raav9) could reverse myocardial dysfunction, hypertrophy and fibrosis in mice exposed to 24 weeks of hfd, along with reduced cardiac apoptosis and inflammation. |
2019-10-14 |
2023-08-13 |
mouse |
| Yun Liu, Huan-Jia Shen, Xin-Qiu-Yue Wang, Hai-Qi Liu, Ling-Yun Zheng, Jian-Dong Lu. EndophilinA2 protects against angiotensin II-induced cardiac hypertrophy by inhibiting angiotensin II type 1 receptor trafficking in neonatal rat cardiomyocytes. Journal of cellular biochemistry. vol 119. issue 10. 2019-10-09. PMID:29923351. |
moreover, endoa2 inhibited apoptosis induced by excessive endoplasmic reticulum stress (ers), which accounted for the beneficial effects of endoa2 on cardiac hypertrophy. |
2019-10-09 |
2023-08-13 |
rat |
| Quanzheng Li, Gongchang Wei, Tao Ta. Leukocyte immunoglobulin-like receptor B4 (LILRB4) negatively mediates the pathological cardiac hypertrophy by suppressing fibrosis, inflammation and apoptosis via the activation of NF-κB signaling. Biochemical and biophysical research communications. vol 509. issue 1. 2019-10-07. PMID:30581005. |
leukocyte immunoglobulin-like receptor b4 (lilrb4) negatively mediates the pathological cardiac hypertrophy by suppressing fibrosis, inflammation and apoptosis via the activation of nf-κb signaling. |
2019-10-07 |
2023-08-13 |
mouse |
| Quanzheng Li, Gongchang Wei, Tao Ta. Leukocyte immunoglobulin-like receptor B4 (LILRB4) negatively mediates the pathological cardiac hypertrophy by suppressing fibrosis, inflammation and apoptosis via the activation of NF-κB signaling. Biochemical and biophysical research communications. vol 509. issue 1. 2019-10-07. PMID:30581005. |
lilrb4-knockout mice developed cardiac hypertrophy and heart failure by promoting cardiac dysfunction, fibrosis, inflammation and apoptosis. |
2019-10-07 |
2023-08-13 |
mouse |
| Meilu Dai, Baiyan Sui, Yang Xue, Xin Liu, Jiao Su. Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes. Biomaterials. vol 180. 2019-09-30. PMID:30031224. |
cartilage repair in degenerative osteoarthritis mediated by squid type ii collagen via immunomodulating activation of m2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes. |
2019-09-30 |
2023-08-13 |
rat |
| Meilu Dai, Baiyan Sui, Yang Xue, Xin Liu, Jiao Su. Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes. Biomaterials. vol 180. 2019-09-30. PMID:30031224. |
in addition, glycine in scii activates glycine receptors on inflammatory chondrocytes to decrease intracellular calcium concentration, leading to effective inhibition of chondrocyte apoptosis and hypertrophy. |
2019-09-30 |
2023-08-13 |
rat |
| Bharath Kumar Velmurugan, Ruey-Lin Chang, Shibu Marthandam Asokan, Chih-Fen Chang, Cecilia-Hsuan Day, Yueh-Min Lin, Yuan-Chuan Lin, Wei-Wen Kuo, Chih-Yang Huan. A minireview of E4BP4/NFIL3 in heart failure. Journal of cellular physiology. vol 233. issue 11. 2019-09-25. PMID:29856483. |
deeper insights into the molecular mechanisms involved in etiopathology of hf indicate the significant role of calcium signaling, autocrine signaling pathways, and insulin-like growth factor-1 signaling that regulates the physiologic functions of heart growth and development such as contraction, metabolism, hypertrophy, cytokine signaling, and apoptosis. |
2019-09-25 |
2023-08-13 |
Not clear |
| Taylor A Johnson, Dinender K Singl. PTEN inhibitor VO-OHpic attenuates inflammatory M1 macrophages and cardiac remodeling in doxorubicin-induced cardiomyopathy. American journal of physiology. Heart and circulatory physiology. vol 315. issue 5. 2019-09-24. PMID:30095997. |
our data show a significant increase in apoptosis, hypertrophy, fibrosis, and proinflammatory m1 macrophages with doxo treatment, whereas vo treatment significantly reduced apoptosis, adverse cardiac remodeling, and proinflammatory m1 macrophages significantly ( p < 0.05) compared with the doxo-treated group. |
2019-09-24 |
2023-08-13 |
Not clear |
| Taylor A Johnson, Dinender K Singl. PTEN inhibitor VO-OHpic attenuates inflammatory M1 macrophages and cardiac remodeling in doxorubicin-induced cardiomyopathy. American journal of physiology. Heart and circulatory physiology. vol 315. issue 5. 2019-09-24. PMID:30095997. |
these novel findings on the phosphatase and tensin homolog inhibitor vo-ohpic in dic is the first report, as per the best of our knowledge, that vo-ohpic significantly decreases apoptosis, fibrosis, hypertrophy, adverse cardiac remodeling, and proinflammatory m1 macrophages and increases anti-inflammatory m2 macrophages along with significantly improved cardiac function. |
2019-09-24 |
2023-08-13 |
Not clear |
| Daebeom Park, Ho-Sung Lee, Jun Hyuk Kang, Seon-Myeong Kim, Jeong-Ryeol Gong, Kwang-Hyun Ch. Attractor landscape analysis of the cardiac signaling network reveals mechanism-based therapeutic strategies for heart failure. Journal of molecular cell biology. vol 10. issue 3. 2019-09-17. PMID:29579284. |
apoptosis and hypertrophy of cardiomyocytes are the primary causes of heart failure (hf), a global leading cause of death, and are regulated through the complicated intracellular signaling network, limiting the development of effective treatments due to its complexity. |
2019-09-17 |
2023-08-13 |
Not clear |
| Daebeom Park, Ho-Sung Lee, Jun Hyuk Kang, Seon-Myeong Kim, Jeong-Ryeol Gong, Kwang-Hyun Ch. Attractor landscape analysis of the cardiac signaling network reveals mechanism-based therapeutic strategies for heart failure. Journal of molecular cell biology. vol 10. issue 3. 2019-09-17. PMID:29579284. |
attractor landscape analysis of the network model identifies distinct sets of control nodes that effectively suppress apoptosis and hypertrophy of cardiomyocytes under ischemic or pressure overload-induced hf, the two major types of hf. |
2019-09-17 |
2023-08-13 |
Not clear |
| Cristina Carresi, Vincenzo Musolino, Micaela Gliozzi, Jessica Maiuolo, Rocco Mollace, Saverio Nucera, Alessia Maretta, Domenico Sergi, Saverio Muscoli, Santo Gratteri, Ernesto Palma, Francesca Bosco, Caterina Giancotta, Carolina Muscoli, Fabiola Marino, Iolanda Aquila, Daniele Torella, Franco Romeo, Vincenzo Mollac. Anti-oxidant effect of bergamot polyphenolic fraction counteracts doxorubicin-induced cardiomyopathy: Role of autophagy and c-kit Journal of molecular and cellular cardiology. vol 119. 2019-09-16. PMID:29654879. |
the cardioprotective effect of bpf on doxo acute toxicity was also associated with a significant antioxidant effect coupled with protective autophagy restoration, and attenuation of cardiomyocyte apoptosis and reactive hypertrophy. |
2019-09-16 |
2023-08-13 |
rat |
| Zhengwei Ma, Qingqing Wei, Ming Zhang, Jian-Kang Chen, Zheng Don. Dicer deficiency in proximal tubules exacerbates renal injury and tubulointerstitial fibrosis and upregulates Smad2/3. American journal of physiology. Renal physiology. vol 315. issue 6. 2019-09-16. PMID:30280598. |
renal hypertrophy, renal tubular apoptosis, kidney inflammation, and tubulointerstitial fibrosis were examined. |
2019-09-16 |
2023-08-13 |
mouse |
| Tzlil Bejerano, Sharon Etzion, Sigal Elyagon, Yoram Etzion, Smadar Cohe. Nanoparticle Delivery of miRNA-21 Mimic to Cardiac Macrophages Improves Myocardial Remodeling after Myocardial Infarction. Nano letters. vol 18. issue 9. 2019-09-12. PMID:30141949. |
following intravenous administration, the mirna-21 nps were targeted to cardiac macrophages at the infarct zone, elicited their phenotype switch from pro-inflammatory to reparative, promoted angiogenesis, and reduced hypertrophy, fibrosis and cell apoptosis in the remote myocardium. |
2019-09-12 |
2023-08-13 |
Not clear |
| Hao Li, Youyang Shi, Xuliang Wang, Ping Li, Songyue Zhang, Tingting Wu, Yaoyao Yan, Yi Zhan, Yue Ren, Xing Rong, Tianhe Xia, Maoping Chu, Rongzhou W. Piceatannol alleviates inflammation and oxidative stress via modulation of the Nrf2/HO-1 and NF-κB pathways in diabetic cardiomyopathy. Chemico-biological interactions. vol 310. 2019-09-09. PMID:31323227. |
in vivo, oral administration of pic suppressed stz-induced inflammation, oxidative stress hypertrophy, fibrosis(myocardial collagen volume fraction in 5 mg/kg and 10 mg/kg pic group was decreased 25.83% and 55.61% compared with the dm group), and apoptosis(caspase-3 level in 5 mg/kg and 10 mg/kg pic group was decreased 13.21% and 33.91% compared with the dm group), thereby relieving cardiac dysfunction and improving both fibrosis and pathological changes in cardiac tissues of diabetic rats. |
2019-09-09 |
2023-08-13 |
rat |
| Xiaolu Ye, Zhiying Pang, Ningwen Zh. Dihydromyricetin attenuates hypertrophic scar formation by targeting activin receptor-like kinase 5. European journal of pharmacology. vol 852. 2019-09-03. PMID:30807748. |
furthermore, both in vitro and in vivo study both demonstrated that dihydromyricetin inhibited the proliferation, activation, contractile and migration abilities of hypertrophic scar-derived fibroblasts (hsfs) but did not affect hsfs apoptosis. |
2019-09-03 |
2023-08-13 |
mouse |
| Xubin Yang, Xiaoshan Li, Qiongyan Lin, Quanfu X. Up-regulation of microRNA-203 inhibits myocardial fibrosis and oxidative stress in mice with diabetic cardiomyopathy through the inhibition of PI3K/Akt signaling pathway via PIK3CA. Gene. vol 715. 2019-08-27. PMID:31336140. |
the obtained results indicated that up-regulation of mir-203 reduced myocardial hypertrophy, myocardial fibrosis, myocardial apoptosis, and levels of pik3ca, pi3k, akt, coi i, coi iii, anp, mda and ros in the myocardial tissues, by which dm-induced cardiac dysfunction and pathological changes could be ameliorated. |
2019-08-27 |
2023-08-13 |
mouse |
| Q-H Yang, M Yang, L-L Zhang, M-C Xiao, Y Zhao, D-X Ya. The mechanism of miR-23a in regulating myocardial cell apoptosis through targeting FoxO3. European review for medical and pharmacological sciences. vol 21. issue 24. 2019-08-14. PMID:29272015. |
mir-23a is related to myocardial hypertrophy and cardiac remodeling by regulating myocardial cell growth and apoptosis. |
2019-08-14 |
2023-08-13 |
Not clear |
| Paula Paccielli Freire, Geysson Javier Fernandez, Sarah Santiloni Cury, Diogo de Moraes, Jakeline Santos Oliveira, Grasieli de Oliveira, Maeli Dal-Pai-Silva, Patrícia Pintor Dos Reis, Robson Francisco Carvalh. The Pathway to Cancer Cachexia: MicroRNA-Regulated Networks in Muscle Wasting Based on Integrative Meta-Analysis. International journal of molecular sciences. vol 20. issue 8. 2019-08-13. PMID:31013615. |
we identified deregulated genes involved in the regulation of apoptosis, muscle hypertrophy, catabolism, and acute phase response. |
2019-08-13 |
2023-08-13 |
Not clear |
| X-Y Li, T Li, X-J Li, J-N Wang, Z Che. TSG-6 Induces Apoptosis of Human Hypertrophic Scar Fibroblasts via Activation of the Fas/FasL Signalling Pathway. Folia biologica. vol 64. issue 5-6. 2019-07-29. PMID:30938674. |
tsg-6 induces apoptosis of human hypertrophic scar fibroblasts via activation of the fas/fasl signalling pathway. |
2019-07-29 |
2023-08-13 |
human |