| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X-Y Li, T Li, X-J Li, J-N Wang, Z Che. TSG-6 Induces Apoptosis of Human Hypertrophic Scar Fibroblasts via Activation of the Fas/FasL Signalling Pathway. Folia biologica. vol 64. issue 5-6. 2019-07-29. PMID:30938674. |
it is concluded that increased expression of tsg-6 may induce apoptosis of human hypertrophic scar fibroblasts via activation of the fas/fasl signalling pathway. |
2019-07-29 |
2023-08-13 |
human |
| Wei Wu, Xingxing Liu, Longfei Ha. Apoptosis of cardiomyocytes in diabetic cardiomyopathy involves overexpression of glycogen synthase kinase-3β. Bioscience reports. vol 39. issue 1. 2019-07-26. PMID:30237226. |
dm-induced cardiomyocyte injuries, which were presented as capillary basement membrane thickening, interstitial fibrosis, cardiomyocyte hypertrophy and necrosis in he staining and increased apoptosis detected by tunel assay. |
2019-07-26 |
2023-08-13 |
rat |
| Xia Lu, Sheng Luan, Ping Dai, Kun Luo, Baolong Chen, Baoxiang Cao, Li Sun, Yunjun Yan, Jie Kon. Insights into the molecular basis of immunosuppression and increasing pathogen infection severity of ammonia toxicity by transcriptome analysis in pacific white shrimp Litopenaeus vannamei. Fish & shellfish immunology. vol 88. 2019-07-25. PMID:30885745. |
a total of 13 pathways were obtained mainly involving in this process, which mainly led to the following changes: (1) increasing the immunosuppression, anemia, endocrine dysfunction, neurotoxic effect and neuroinvasion, atherosclerosis and thrombogenesis, blood-brain barrier penetration, thyroid disorder, necrosis, inflammation, and circadian disturbance; (2) reducing the ability of vascular remodeling, angiogenesis, cell survival, migration, apoptosis, and lymph transferred to blood stream; (3) leading to cell hypertrophy, cellular shape changes, and mesangial matrix expansion. |
2019-07-25 |
2023-08-13 |
Not clear |
| Elise L Kessler, Mathilde R Rivaud, Marc A Vos, Toon A B van Vee. Sex-specific influence on cardiac structural remodeling and therapy in cardiovascular disease. Biology of sex differences. vol 10. issue 1. 2019-07-22. PMID:30717770. |
these discrepancies are probably influenced by underlying genetic and molecular differences in structural remodeling pathways involved in hypertrophy, inflammation, fibrosis, and apoptosis. |
2019-07-22 |
2023-08-13 |
Not clear |
| Munetada Ishikawa, Takenobu Ishii, Taiki Morikawa, Yuki Iijima, Kenji Sueish. The Effects of Fluvastatin on Indian Hedgehog Pathway in Endochondral Ossification. Cartilage. 2019-07-22. PMID:31327238. |
this led to the promotion of cell proliferation, increase of the hypertrophic chondrocyte layer, inhibition of apoptosis, and decrease in mineralization. |
2019-07-22 |
2023-08-13 |
mouse |
| Kun Yang, Xiaosheng H. [Research progress on miR-21 in heart diseases]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 48. issue 2. 2019-07-18. PMID:31309761. |
pathological processes such as myocardial apoptosis, cardiac hypertrophy, myocardial fibrosis, and cardiac electrical remodeling are involved in the development and progression of most cardiac diseases. |
2019-07-18 |
2023-08-13 |
Not clear |
| Kun Yang, Xiaosheng H. [Research progress on miR-21 in heart diseases]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 48. issue 2. 2019-07-18. PMID:31309761. |
microrna-21 (mir-21) has been found to play an important role in heart diseases as a novel type of endogenous regulators, which can inhibit cardiomyocyte apoptosis, improve hypertension and cardiac hypertrophy, promote myocardial fibrosis and atrial electrical remodeling. |
2019-07-18 |
2023-08-13 |
Not clear |
| Rocío Fuente, Helena Gil-Peña, Débora Claramunt-Taberner, Olaya Hernández-Frías, Ángela Fernández-Iglesias, Francisco Hermida-Prado, Gonzalo Anes-González, Isabel Rubio-Aliaga, Jose Manuel Lopez, Fernando Santo. Marked alterations in the structure, dynamics and maturation of growth plate likely explain growth retardation and bone deformities of young Hyp mice. Bone. vol 116. 2019-07-16. PMID:30096468. |
hyp mice exhibited reduced proliferation and apoptosis rates of chondrocytes as well as severe disturbance in the process of chondrocyte hypertrophy disclosed by abnormal expression of proteins likely involved in cell enlargement, irregular chondro-osseous junction and disordered bone trabecular pattern and vascular invasion in the primary spongiosa. |
2019-07-16 |
2023-08-13 |
mouse |
| Rocío Fuente, Helena Gil-Peña, Débora Claramunt-Taberner, Olaya Hernández-Frías, Ángela Fernández-Iglesias, Francisco Hermida-Prado, Gonzalo Anes-González, Isabel Rubio-Aliaga, Jose Manuel Lopez, Fernando Santo. Marked alterations in the structure, dynamics and maturation of growth plate likely explain growth retardation and bone deformities of young Hyp mice. Bone. vol 116. 2019-07-16. PMID:30096468. |
it was also observed aberrant trabecular organization at primary spongiosa and atypical growth plate organization with abnormal proliferation and hypertrophy of chondrocytes and diminished apoptosis and vascular invasion processes. |
2019-07-16 |
2023-08-13 |
mouse |
| Martín Alcalá, María Calderon-Dominguez, Eduviges Bustos, Pilar Ramos, Núria Casals, Dolors Serra, Marta Viana, Laura Herrer. Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice. Scientific reports. vol 7. issue 1. 2019-07-03. PMID:29167565. |
the hypertrophic bat from obese mice showed no signs of fibrosis nor apoptosis, but higher levels of inflammation, er stress, ros generation and antioxidant enzyme activity than the lean counterparts. |
2019-07-03 |
2023-08-13 |
mouse |
| Cristina Campos-Carraro, Patrick Turck, Bruna Gazzi de Lima-Seolin, Angela Maria Vicente Tavares, Denise Dos Santos Lacerda, Giana Blume Corssac, Rayane Brinck Teixeira, Alexandre Hickmann, Susana Llesuy, Alex Sander da Rosa Araujo, Adriane Belló-Klei. Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats. Journal of cardiovascular pharmacology. vol 72. issue 5. 2019-06-18. PMID:30212415. |
there is an increase in oxidative stress and apoptosis signaling during the transition from hypertrophy to right ventricular (rv) failure caused by pulmonary arterial hypertension (pah) induced by monocrotaline (mct). |
2019-06-18 |
2023-08-13 |
rat |
| Cristina Campos-Carraro, Patrick Turck, Bruna Gazzi de Lima-Seolin, Angela Maria Vicente Tavares, Denise Dos Santos Lacerda, Giana Blume Corssac, Rayane Brinck Teixeira, Alexandre Hickmann, Susana Llesuy, Alex Sander da Rosa Araujo, Adriane Belló-Klei. Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats. Journal of cardiovascular pharmacology. vol 72. issue 5. 2019-06-18. PMID:30212415. |
copaiba oil reduced rv hypertrophy (24%), improved rv systolic function, and reduced rv end-diastolic pressure, increased total sulfhydryl levels and enos protein expression, reduced lipid and protein oxidation, and the expression of proteins involved in apoptosis signaling in the rv of mct + copaiba oil as compared to mct group. |
2019-06-18 |
2023-08-13 |
rat |
| Jihong Shi, Houan Xiao, Jun Li, Julei Zhang, Yan Li, Jian Zhang, Xujie Wang, Xiaozhi Bai, Ke Tao, Dahai Hu, Hao Gua. Wild-type p53-modulated autophagy and autophagic fibroblast apoptosis inhibit hypertrophic scar formation. Laboratory investigation; a journal of technical methods and pathology. vol 98. issue 11. 2019-06-13. PMID:30089855. |
wild-type p53-modulated autophagy and autophagic fibroblast apoptosis inhibit hypertrophic scar formation. |
2019-06-13 |
2023-08-13 |
rabbit |
| Bingju Yan, Jun Wan. UBIAD1 expression is associated with cardiac hypertrophy in spontaneously hypertensive rats. Molecular medicine reports. vol 19. issue 1. 2019-05-28. PMID:30483777. |
shrs exhibited increased blood pressure and cardiomyocyte apoptosis, as well as cardiac hypertrophy, compared with age‑matched wky rats. |
2019-05-28 |
2023-08-13 |
rat |
| Marie Maumus, Yves-Marie Pers, Maxime Ruiz, Christian Jorgensen, Danièle Noë. [Mesenchymal stem cells and regenerative medicine: future perspectives in osteoarthritis]. Medecine sciences : M/S. vol 34. issue 12. 2019-05-21. PMID:30623767. |
depending on the mode of administration and behavior after implantation, they can decrease local inflammation, prevent chondrocyte hypertrophy and apoptosis as well as differentiate into cartilage-forming chondrocytes. |
2019-05-21 |
2023-08-13 |
Not clear |
| Yi Zhang, Li Zhang, Qiyu Zhang, Weilong Hong, Xiaohua Li. [microRNA-222 regulates proliferation and apoptosis of fibroblasts in hypertrophic scar via matrix metalloproteinase 1]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 46. issue 6. 2019-05-20. PMID:29658663. |
[microrna-222 regulates proliferation and apoptosis of fibroblasts in hypertrophic scar via matrix metalloproteinase 1]. |
2019-05-20 |
2023-08-13 |
Not clear |
| Yi Zhang, Li Zhang, Qiyu Zhang, Weilong Hong, Xiaohua Li. [microRNA-222 regulates proliferation and apoptosis of fibroblasts in hypertrophic scar via matrix metalloproteinase 1]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 46. issue 6. 2019-05-20. PMID:29658663. |
objective: to explore the effect of microrna(mir)-222 on cell proliferation and apoptosis of fibroblasts in hypertrophic scar (hs) and the underlying mechanisms. |
2019-05-20 |
2023-08-13 |
Not clear |
| Jiahui Jiang, Cong Lan, Liangpeng Li, Dezhong Yang, Xuewei Xia, Qiao Liao, Wenbin Fu, Xiongwen Chen, Songzhu An, Wei Eric Wang, Chunyu Zen. A novel porcupine inhibitor blocks WNT pathways and attenuates cardiac hypertrophy. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 10. 2019-05-20. PMID:30076960. |
cgx1321 significantly reduced cardiomyocyte hypertrophy, cardiomyocyte apoptosis and fibrosis induced by tac injury. |
2019-05-20 |
2023-08-13 |
mouse |
| Jaemin Byun, Dominic P Del Re, Peiyong Zhai, Shohei Ikeda, Akihiro Shirakabe, Wataru Mizushima, Shigeki Miyamoto, Joan H Brown, Junichi Sadoshim. Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload. The Journal of biological chemistry. vol 294. issue 10. 2019-05-20. PMID:30635403. |
our previous work demonstrated that cardiac-specific loss of yap leads to increased cardiomyocyte (cm) apoptosis and impaired cm hypertrophy during chronic myocardial infarction (mi) in the mouse heart. |
2019-05-20 |
2023-08-13 |
mouse |
| Min Fan, Juan Song, Yijie He, Xin Shen, Jiantao Li, Linli Que, Guoqing Zhu, Quan Zhu, Xin Cai, Tuanzhu Ha, Qi Chen, Yong Xu, Chuanfu Li, Yuehua L. The TIR/BB-loop mimetic AS-1 attenuates mechanical stress-induced cardiac fibroblast activation and paracrine secretion via modulation of large tumor suppressor kinase 1. Biochimica et biophysica acta. vol 1862. issue 6. 2019-05-08. PMID:26964796. |
as-1 also ameliorated cardiomyocyte hypertrophy and apoptosis through dampening paracrine secretion of stretched cardiac fibroblasts. |
2019-05-08 |
2023-08-13 |
mouse |