| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Ivey, M Desai, K Green, I Sinha-Hikim, T C Friedman, A P Sinha-Hiki. Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 46. issue 8. 2015-03-03. PMID:24830635. |
addition of nicotine to hfd further resulted in an increase in the incidence of hepatocellular apoptosis and was associated with activation of caspase 2, induction of inducible nitric oxide synthase (inos), and perturbation of the bax/bcl-2 ratio. |
2015-03-03 |
2023-08-13 |
mouse |
| R Ivey, M Desai, K Green, I Sinha-Hikim, T C Friedman, A P Sinha-Hiki. Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 46. issue 8. 2015-03-03. PMID:24830635. |
together, our data indicate the involvement of caspase 2 and inos-mediated apoptotic signaling in nicotine plus hfd-induced hepatocellular apoptosis. |
2015-03-03 |
2023-08-13 |
mouse |
| Prasun Guha, Gargi Bandyopadhyaya, Swamy K Polumuri, Saranya Chumsri, Padmaja Gade, Dhananjaya V Kalvakolanu, Hafiz Ahme. Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, α9 nicotinic acetylcholine receptor and STAT3. Breast cancer research and treatment. vol 145. issue 1. 2014-12-22. PMID:24668500. |
nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, α9 nicotinic acetylcholine receptor and stat3. |
2014-12-22 |
2023-08-12 |
Not clear |
| Chunmei Lin, Jung-Min Yon, Jin Tae Hong, Jong Kwon Lee, Jayoung Jeong, In-Jeoung Baek, Beom Jun Lee, Young Won Yun, Sang-Yoon Na. 4-O-methylhonokiol inhibits serious embryo anomalies caused by nicotine via modulations of oxidative stress, apoptosis, and inflammation. Birth defects research. Part B, Developmental and reproductive toxicology. vol 101. issue 2. 2014-12-04. PMID:24692394. |
4-o-methylhonokiol inhibits serious embryo anomalies caused by nicotine via modulations of oxidative stress, apoptosis, and inflammation. |
2014-12-04 |
2023-08-13 |
mouse |
| Mao Qiang Xue, Xiao Xing Liu, Yan Ling Zhang, Feng Guang Ga. Nicotine exerts neuroprotective effects against β-amyloid-induced neurotoxicity in SH-SY5Y cells through the Erk1/2-p38-JNK-dependent signaling pathway. International journal of molecular medicine. vol 33. issue 4. 2014-10-21. PMID:24481039. |
the aim of the present study was to assess the neuroprotective effects of nicotine against toxicity induced by β-amyloid (aβ) in relation to cell apoptosis, and to elucidate the role of the activation of the erk1/2-p38-jnk pathway and the modulation of anti-apoptotic proteins in the nicotine-induced neuroprotective effects. |
2014-10-21 |
2023-08-12 |
mouse |
| Mao Qiang Xue, Xiao Xing Liu, Yan Ling Zhang, Feng Guang Ga. Nicotine exerts neuroprotective effects against β-amyloid-induced neurotoxicity in SH-SY5Y cells through the Erk1/2-p38-JNK-dependent signaling pathway. International journal of molecular medicine. vol 33. issue 4. 2014-10-21. PMID:24481039. |
the effects of nicotine on cell apoptosis were determined by flow cytmetry and microscopic observation. |
2014-10-21 |
2023-08-12 |
mouse |
| Mao Qiang Xue, Xiao Xing Liu, Yan Ling Zhang, Feng Guang Ga. Nicotine exerts neuroprotective effects against β-amyloid-induced neurotoxicity in SH-SY5Y cells through the Erk1/2-p38-JNK-dependent signaling pathway. International journal of molecular medicine. vol 33. issue 4. 2014-10-21. PMID:24481039. |
our results demonstrated that nicotine protected the sh-sy5y cells against aβ25-35-induced toxicity by inhibiting apoptosis and upregulating the expression of anti-apoptotic proteins. |
2014-10-21 |
2023-08-12 |
mouse |
| Mao Qiang Xue, Xiao Xing Liu, Yan Ling Zhang, Feng Guang Ga. Nicotine exerts neuroprotective effects against β-amyloid-induced neurotoxicity in SH-SY5Y cells through the Erk1/2-p38-JNK-dependent signaling pathway. International journal of molecular medicine. vol 33. issue 4. 2014-10-21. PMID:24481039. |
these findings suggest that nicotine prevents aβ25-35-induced neurotoxicity through the inhibition of neuronal apoptosis, and may thus prove to be a potential preventive or therapeutic agent for ad. |
2014-10-21 |
2023-08-12 |
mouse |
| Lu Wang, Xuelian Li, Yuhong Zhou, Hui Shi, Chaoqian Xu, Hua He, Shuxuan Wang, Xuehui Xiong, Yong Zhang, Zhimin Du, Ruixue Zhang, Yanjie Lu, Baofeng Yang, Hongli Sha. Downregulation of miR-133 via MAPK/ERK signaling pathway involved in nicotine-induced cardiomyocyte apoptosis. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 2. 2014-09-04. PMID:24190542. |
this study aimed to investigate whether nicotine can induce cardiomyocyte apoptosis and to explore the mechanisms involved. |
2014-09-04 |
2023-08-12 |
Not clear |
| Lu Wang, Xuelian Li, Yuhong Zhou, Hui Shi, Chaoqian Xu, Hua He, Shuxuan Wang, Xuehui Xiong, Yong Zhang, Zhimin Du, Ruixue Zhang, Yanjie Lu, Baofeng Yang, Hongli Sha. Downregulation of miR-133 via MAPK/ERK signaling pathway involved in nicotine-induced cardiomyocyte apoptosis. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 2. 2014-09-04. PMID:24190542. |
our findings therefore revealed that inhibition of the erk1/2-srf-mir-133 signaling pathway to increase caspases-9 and -3 is a novel mechanism for nicotine to induce cardiomyocyte apoptosis and these tobacco smokers. |
2014-09-04 |
2023-08-12 |
Not clear |
| Xiaoli Ma, Yanfei Jia, Shanshan Zu, Ruisheng Li, Ying Jia, Yun Zhao, Dongjie Xiao, Ningning Dang, Yunshan Wan. α5 Nicotinic acetylcholine receptor mediates nicotine-induced HIF-1α and VEGF expression in non-small cell lung cancer. Toxicology and applied pharmacology. vol 278. issue 2. 2014-08-05. PMID:24793809. |
by binding to nicotinic acetylcholine receptors (nachrs), nicotine induces the proliferation and apoptosis of non-small cell lung cancer (nsclc). |
2014-08-05 |
2023-08-13 |
Not clear |
| Jing Tang, Zhijie Li, Lan Lu, Chi Hin Ch. β-Adrenergic system, a backstage manipulator regulating tumour progression and drug target in cancer therapy. Seminars in cancer biology. vol 23. issue 6 Pt B. 2014-07-18. PMID:24012659. |
in this review, we summarize recent advancements about the influence of stress hormones, nicotine and β-adrenoceptors on cancer cell proliferation, apoptosis, invasion and metastasis, and also tumour vasculature normalization. |
2014-07-18 |
2023-08-12 |
Not clear |
| Simona Dinicola, Veronica Morini, Pierpaolo Coluccia, Sara Proietti, Fabrizio D'Anselmi, Alessia Pasqualato, Maria Grazia Masiello, Alessandro Palombo, Giorgio De Toma, Mariano Bizzarri, Alessandra Cucin. Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs. Toxicology in vitro : an international journal published in association with BIBRA. vol 27. issue 8. 2014-07-08. PMID:24095863. |
furthermore, nicotine increases cell proliferation and inhibits apoptosis through α7-nicotinic acetylcholine receptor (α7-nachr) activation in human colon carcinoma cells. |
2014-07-08 |
2023-08-12 |
human |
| Simona Dinicola, Veronica Morini, Pierpaolo Coluccia, Sara Proietti, Fabrizio D'Anselmi, Alessia Pasqualato, Maria Grazia Masiello, Alessandro Palombo, Giorgio De Toma, Mariano Bizzarri, Alessandra Cucin. Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs. Toxicology in vitro : an international journal published in association with BIBRA. vol 27. issue 8. 2014-07-08. PMID:24095863. |
an open issue is whether nicotine interfere with colorectal cancer pharmacological treatment, by inhibiting drug-mediated apoptosis. |
2014-07-08 |
2023-08-12 |
human |
| Simona Dinicola, Veronica Morini, Pierpaolo Coluccia, Sara Proietti, Fabrizio D'Anselmi, Alessia Pasqualato, Maria Grazia Masiello, Alessandro Palombo, Giorgio De Toma, Mariano Bizzarri, Alessandra Cucin. Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs. Toxicology in vitro : an international journal published in association with BIBRA. vol 27. issue 8. 2014-07-08. PMID:24095863. |
nicotine interfered with colorectal cancer pharmacological treatment in vitro by inhibiting apoptosis induced by chemotherapeutic drugs. |
2014-07-08 |
2023-08-12 |
human |
| Denise C Zysset-Burri, Caroline L Bellac, Stephen L Leib, Matthias Wittwe. Vitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis. BMC infectious diseases. vol 13. 2014-06-23. PMID:23977941. |
the aim of this study in a pneumococcal meningitis model was to investigate the effect of vitamin b6 on hippocampal apoptosis by histomorphology, by transcriptomics and by measurement of cellular nicotine amide adenine dinucleotide content. |
2014-06-23 |
2023-08-12 |
Not clear |
| Shingo Kasamatsu, Yasuo Watanabe, Tomohiro Sawa, Takaaki Akaike, Hideshi Ihar. Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons. The Biochemical journal. vol 459. issue 2. 2014-05-27. PMID:24499461. |
nicotine induced ho-1 (haem oxygenase 1) expression in cgns and showed cytoprotective effects against apoptosis. |
2014-05-27 |
2023-08-12 |
rat |
| Min Zhang, Yan-hua Zhao, Xiao-fei Tang, Min Ho. [Effect of nicotine on the proliferation and cell apoptosis of oral squamous cell carcinoma SCC15 cells]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. vol 47. issue 4. 2014-01-07. PMID:22800703. |
[effect of nicotine on the proliferation and cell apoptosis of oral squamous cell carcinoma scc15 cells]. |
2014-01-07 |
2023-08-12 |
Not clear |
| Min Zhang, Yan-hua Zhao, Xiao-fei Tang, Min Ho. [Effect of nicotine on the proliferation and cell apoptosis of oral squamous cell carcinoma SCC15 cells]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. vol 47. issue 4. 2014-01-07. PMID:22800703. |
to investigate the role of nicotine on the proliferation and cell apoptosis in scc15 oral squamous cell carcinoma cells. |
2014-01-07 |
2023-08-12 |
Not clear |
| Shu-Qiang Wu, Ya-Er Lv, Bai-Hua Lin, Li-Min Luo, Shi-Liang Lv, Ai-Hong Bi, Yong-Shi Ji. Silencing of periostin inhibits nicotine-mediated tumor cell growth and epithelial-mesenchymal transition in lung cancer cells. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23314871. |
nicotine has been found to induce the proliferation of lung cancer cells through tumor invasion and to confer resistance to apoptosis. |
2014-01-03 |
2023-08-12 |
Not clear |