| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaohui Huang, Zhixiang Cheng, Qiao Su, Xiaonan Zhu, Qin Wang, Ruzhu Chen, Xuelan Wan. Neuroprotection by nicotine against colchicine-induced apoptosis is mediated by PI3-kinase--Akt pathways. The International journal of neuroscience. vol 122. issue 6. 2012-09-13. PMID:22248034. |
neuroprotection by nicotine against colchicine-induced apoptosis is mediated by pi3-kinase--akt pathways. |
2012-09-13 |
2023-08-12 |
Not clear |
| Fang Zeng, Yun Cheng Li, Gang Chen, Yong Kui Zhang, Ye Kai Wang, Shi Quan Zhou, Li Na Ma, Ji Hang Zhou, Yan Yan Huang, Wang Yu Zhu, Xiao Guang Li. Nicotine inhibits cisplatin-induced apoptosis in NCI-H446 cells. Medical oncology (Northwood, London, England). vol 29. issue 1. 2012-08-23. PMID:21267677. |
nicotine inhibits cisplatin-induced apoptosis in nci-h446 cells. |
2012-08-23 |
2023-08-12 |
Not clear |
| Fang Zeng, Yun Cheng Li, Gang Chen, Yong Kui Zhang, Ye Kai Wang, Shi Quan Zhou, Li Na Ma, Ji Hang Zhou, Yan Yan Huang, Wang Yu Zhu, Xiao Guang Li. Nicotine inhibits cisplatin-induced apoptosis in NCI-H446 cells. Medical oncology (Northwood, London, England). vol 29. issue 1. 2012-08-23. PMID:21267677. |
nicotine is not only a major component in tobacco but is also a survival agonist that inhibits apoptosis induced by certain agents including chemotherapeutic drugs. |
2012-08-23 |
2023-08-12 |
Not clear |
| Fang Zeng, Yun Cheng Li, Gang Chen, Yong Kui Zhang, Ye Kai Wang, Shi Quan Zhou, Li Na Ma, Ji Hang Zhou, Yan Yan Huang, Wang Yu Zhu, Xiao Guang Li. Nicotine inhibits cisplatin-induced apoptosis in NCI-H446 cells. Medical oncology (Northwood, London, England). vol 29. issue 1. 2012-08-23. PMID:21267677. |
here, we first showed that nicotine inhibits cisplatin-induced apoptosis in nci-h446 cells. |
2012-08-23 |
2023-08-12 |
Not clear |
| Fang Zeng, Yun Cheng Li, Gang Chen, Yong Kui Zhang, Ye Kai Wang, Shi Quan Zhou, Li Na Ma, Ji Hang Zhou, Yan Yan Huang, Wang Yu Zhu, Xiao Guang Li. Nicotine inhibits cisplatin-induced apoptosis in NCI-H446 cells. Medical oncology (Northwood, London, England). vol 29. issue 1. 2012-08-23. PMID:21267677. |
first, we observed that nicotine induced no significant apoptosis when used alone and promoted cell proliferation at a low concentration or for a short time, but the opposite was observed at a high concentration or for a long time. |
2012-08-23 |
2023-08-12 |
Not clear |
| Fang Zeng, Yun Cheng Li, Gang Chen, Yong Kui Zhang, Ye Kai Wang, Shi Quan Zhou, Li Na Ma, Ji Hang Zhou, Yan Yan Huang, Wang Yu Zhu, Xiao Guang Li. Nicotine inhibits cisplatin-induced apoptosis in NCI-H446 cells. Medical oncology (Northwood, London, England). vol 29. issue 1. 2012-08-23. PMID:21267677. |
furthermore, nicotine inhibited apoptosis induced by cisplatin and caused a concentration-dependent increase in both xiap and survivin mrna or protein. |
2012-08-23 |
2023-08-12 |
Not clear |
| Anja Röthig, Rolf Schreckenberg, Kerstin Weber, Charlotte Conzelmann, Rui Manuel da Costa Rebelo, Klaus-Dieter Schlüte. Effects of nicotine on PTHrP and PTHrP receptor expression in rat coronary endothelial cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 29. issue 3-4. 2012-08-09. PMID:22508055. |
the study was aimed to investigate whether nicotine affects endothelial expression of pthrp and pthrp receptor, a peptide system involved in endothelial protection against apoptosis. |
2012-08-09 |
2023-08-12 |
rat |
| Alessio Cardinale, Candida Nastrucci, Alfredo Cesario, Patrizia Russ. Nicotine: specific role in angiogenesis, proliferation and apoptosis. Critical reviews in toxicology. vol 42. issue 1. 2012-05-14. PMID:22050423. |
nicotine: specific role in angiogenesis, proliferation and apoptosis. |
2012-05-14 |
2023-08-12 |
Not clear |
| Alessio Cardinale, Candida Nastrucci, Alfredo Cesario, Patrizia Russ. Nicotine: specific role in angiogenesis, proliferation and apoptosis. Critical reviews in toxicology. vol 42. issue 1. 2012-05-14. PMID:22050423. |
nicotine, with its specific binding to nachr, deregulates essential biological processes like regulation of cell proliferation, apoptosis, migration, invasion, angiogenesis, inflammation and cell-mediated immunity in a wide variety of cells including foetal (regulation of development), embryonic and adult stem cells, adult tissues as well as cancer cells. |
2012-05-14 |
2023-08-12 |
Not clear |
| S W Kang, H J Park, J Y Ban, J H Chung, G S Chun, J O Ch. Effects of nicotine on apoptosis in human gingival fibroblasts. Archives of oral biology. vol 56. issue 10. 2012-02-24. PMID:21497792. |
effects of nicotine on apoptosis in human gingival fibroblasts. |
2012-02-24 |
2023-08-12 |
human |
| Wenfeng Yu, Naguib Mechawar, Slavica Krantic, Rémi Quirio. α7 Nicotinic receptor activation reduces β-amyloid-induced apoptosis by inhibiting caspase-independent death through phosphatidylinositol 3-kinase signaling. Journal of neurochemistry. vol 119. issue 4. 2011-12-23. PMID:21884524. |
nicotine has been shown to decrease aβ neurotoxicity via inhibition of caspase-dependent apoptosis, but it is unknown if its neuroprotection is mediated through caspase-independent pathways. |
2011-12-23 |
2023-08-12 |
rat |
| Angela Alama, Cristina Bruzzo, Zita Cavalieri, Alessandra Forlani, Yuri Utkin, Ida Casciano, Massimo Roman. Inhibition of the nicotinic acetylcholine receptors by cobra venom α-neurotoxins: is there a perspective in lung cancer treatment? PloS one. vol 6. issue 6. 2011-11-02. PMID:21695184. |
nicotine exerts its oncogenic effects through the binding to nicotinic acetylcholine receptors (nachrs) and the activation of downstream pathways that block apoptosis and promote neo-angiogenesis. |
2011-11-02 |
2023-08-12 |
mouse |
| Masanori Hijioka, Hideaki Matsushita, Akinori Hisatsune, Yoichiro Isohama, Hiroshi Katsuk. Therapeutic effect of nicotine in a mouse model of intracerebral hemorrhage. The Journal of pharmacology and experimental therapeutics. vol 338. issue 3. 2011-10-31. PMID:21610140. |
daily intraperitoneal administration of nicotine (2 mg/kg), starting from 3 h after the induction of ich, inhibited apoptosis and decreased the number of remaining striatal neurons at 3 days after the insult. |
2011-10-31 |
2023-08-12 |
mouse |
| Li-li Wang, Jian-li Zhao, Wayne-Bond Lau, Yan-qing Zhang, Zhong-dong Qiao, Ya-jing Wan. Estradiol pretreatment attenuated nicotine-induced endothelial cell apoptosis via estradiol functional membrane receptor. International immunopharmacology. vol 11. issue 6. 2011-10-03. PMID:21262190. |
our study provides evidence that nicotine enhances endothelial cell apoptosis, but estrogen exerts anti-apoptotic effect through its functional membrane estrogen receptor. |
2011-10-03 |
2023-08-12 |
human |
| Ryan Grant, Ephraim Ansa-Addo, Dan Stratton, Samuel Antwi-Baffour, Samireh Jorfi, Sharad Kholia, Lizelle Krige, Sigrun Lange, Jameel Ina. A filtration-based protocol to isolate human plasma membrane-derived vesicles and exosomes from blood plasma. Journal of immunological methods. vol 371. issue 1-2. 2011-09-27. PMID:21741384. |
nicotine, as for calpeptin was shown to dose-dependently (from 10 up to 50 μm) reduce levels of early apoptosis in thp-1 monocytes and to decrease the level of pmv release. |
2011-09-27 |
2023-08-12 |
human |
| Muzafar A Macha, Ajay Matta, Shyam Singh Chauhan, K W Michael Siu, Ranju Ralha. Guggulsterone targets smokeless tobacco induced PI3K/Akt pathway in head and neck cancer cells. PloS one. vol 6. issue 2. 2011-09-01. PMID:21383988. |
we hypothesized gs can abrogate the effects of st and nicotine on apoptosis in hnscc cells, in part by activation of pi3k/akt pathway and its downstream targets, bax and bad. |
2011-09-01 |
2023-08-12 |
Not clear |
| Virender K Rehan, Reiko Sakurai, John S Torda. Thirdhand smoke: a new dimension to the effects of cigarette smoke on the developing lung. American journal of physiology. Lung cellular and molecular physiology. vol 301. issue 1. 2011-08-31. PMID:21478255. |
fetal rat lung explants were exposed to nicotine, 1-(n-methyl-n-nitrosamino)-1-(3-pyridinyl)-4-butanal (nna), or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (nnk), the two main tobacco-specific n-nitrosamine constituents of ths, for 24 h. we then determined key markers for alveolar paracrine signaling [epithelial differentiation markers surfactant phospholipid and protein synthesis; mesenchymal differentiation markers peroxisome proliferator-activated receptor γ (ppar-γ), fibronectin and calponin], the bcl-2-to-bax ratio (bcl-2/bax), a marker of apoptosis and the involvement of nicotinic acetylcholine receptors (nachr)-α3 and -α7 in mediating nna's and nnk's effects on the developing lung. |
2011-08-31 |
2023-08-12 |
rat |
| David E Rothem, Lilah Rothem, Aviva Dahan, Rami Eliakim, Michael Soudr. Nicotinic modulation of gene expression in osteoblast cells, MG-63. Bone. vol 48. issue 4. 2011-07-28. PMID:21168537. |
gene ontology analysis suggested effects of nicotine on various biological and cellular processes which were associated with survival, proliferation, differentiation and apoptosis processes within the cell. |
2011-07-28 |
2023-08-12 |
human |
| Makoto Osanai, Gang-Hong Le. Nicotine-mediated suppression of the retinoic acid metabolizing enzyme CYP26A1 limits the oncogenic potential of breast cancer. Cancer science. vol 102. issue 6. 2011-07-20. PMID:21371177. |
here, we present evidence that nicotine significantly suppresses constitutive expression of cyp26a1, and that cells treated with nicotine exhibit enhanced sensitivity to apoptosis. |
2011-07-20 |
2023-08-12 |
Not clear |
| Nan Hu, Rui Guo, Xuefeng Han, Baocheng Zhu, Jun Re. Cardiac-specific overexpression of metallothionein rescues nicotine-induced cardiac contractile dysfunction and interstitial fibrosis. Toxicology letters. vol 202. issue 1. 2011-04-18. PMID:21238558. |
biochemical and histological findings depicted overt accumulation of reactive oxygen species (ros), apoptosis and myocardial fibrosis without any change in myocardial cross-sectional area following nicotine treatment, which was mitigated by metallothionein. |
2011-04-18 |
2023-08-12 |
mouse |