| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanfei Jia, Haiji Sun, Hongqiao Wu, Huilin Zhang, Xiuping Zhang, Dongjie Xiao, Xiaoli Ma, Yunshan Wan. Nicotine Inhibits Cisplatin-Induced Apoptosis via Regulating α5-nAChR/AKT Signaling in Human Gastric Cancer Cells. PloS one. vol 11. issue 2. 2016-08-01. PMID:26909550. |
nicotine inhibits cisplatin-induced apoptosis via regulating α5-nachr/akt signaling in human gastric cancer cells. |
2016-08-01 |
2023-08-13 |
human |
| Yanfei Jia, Haiji Sun, Hongqiao Wu, Huilin Zhang, Xiuping Zhang, Dongjie Xiao, Xiaoli Ma, Yunshan Wan. Nicotine Inhibits Cisplatin-Induced Apoptosis via Regulating α5-nAChR/AKT Signaling in Human Gastric Cancer Cells. PloS one. vol 11. issue 2. 2016-08-01. PMID:26909550. |
nicotine, the major component in tobacco, is a survival agonist that inhibits apoptosis induced by certain chemotherapeutic agents, but the precise mechanisms involved remain largely unknown. |
2016-08-01 |
2023-08-13 |
human |
| Yanfei Jia, Haiji Sun, Hongqiao Wu, Huilin Zhang, Xiuping Zhang, Dongjie Xiao, Xiaoli Ma, Yunshan Wan. Nicotine Inhibits Cisplatin-Induced Apoptosis via Regulating α5-nAChR/AKT Signaling in Human Gastric Cancer Cells. PloS one. vol 11. issue 2. 2016-08-01. PMID:26909550. |
in view of the results, we proceeded to investigate whether nicotine inhibits cisplatin-induced apoptosis via regulating α5-nachr in gastric cancer cell. |
2016-08-01 |
2023-08-13 |
human |
| Yanfei Jia, Haiji Sun, Hongqiao Wu, Huilin Zhang, Xiuping Zhang, Dongjie Xiao, Xiaoli Ma, Yunshan Wan. Nicotine Inhibits Cisplatin-Induced Apoptosis via Regulating α5-nAChR/AKT Signaling in Human Gastric Cancer Cells. PloS one. vol 11. issue 2. 2016-08-01. PMID:26909550. |
furthermore, nicotine inhibited apoptosis induced by cisplatin. |
2016-08-01 |
2023-08-13 |
human |
| Rafał Czyżykowski, Joanna Połowinczak-Przybyłek, Piotr Potemsk. Nicotine-induced resistance of non-small cell lung cancer to treatment--possible mechanisms. Postepy higieny i medycyny doswiadczalnej (Online). vol 70. 2016-06-24. PMID:26943316. |
the best known mechanisms by which nicotine impacts cancer biology involve suppression of apoptosis induced by certain drugs or radiation, promotion of proliferation, angiogenesis, invasion and migration of cancer cells. |
2016-06-24 |
2023-08-13 |
Not clear |
| Marjolaine A Pelissier-Rota, Ludovic Pelosi, Patrick Meresse, Muriel R Jacquier-Sarli. Nicotine-induced cellular stresses and autophagy in human cancer colon cells: A supportive effect on cell homeostasis via up-regulation of Cox-2 and PGE(2) production. The international journal of biochemistry & cell biology. vol 65. 2016-05-12. PMID:26100595. |
in this context, we suggest that this key mediator participates in the cytoprotective effects of nicotine against apoptosis by stimulating autophagy in colon cancer cells. |
2016-05-12 |
2023-08-13 |
human |
| Yu-Hsiang Lee, Ruei-Siang Chen, Nen-Chung Chang, Kueir-Rarn Lee, Chien-Tsai Huang, Yu-Ching Huang, Feng-Ming H. Synergistic Impact of Nicotine and Shear Stress Induces Cytoskeleton Collapse and Apoptosis in Endothelial Cells. Annals of biomedical engineering. vol 43. issue 9. 2016-04-25. PMID:25631203. |
synergistic impact of nicotine and shear stress induces cytoskeleton collapse and apoptosis in endothelial cells. |
2016-04-25 |
2023-08-13 |
human |
| Yu-Hsiang Lee, Ruei-Siang Chen, Nen-Chung Chang, Kueir-Rarn Lee, Chien-Tsai Huang, Yu-Ching Huang, Feng-Ming H. Synergistic Impact of Nicotine and Shear Stress Induces Cytoskeleton Collapse and Apoptosis in Endothelial Cells. Annals of biomedical engineering. vol 43. issue 9. 2016-04-25. PMID:25631203. |
our results showed that cells sheared by 12 dynes cm(-2) lss with nicotine excessively elongated and aligned with the flow direction, and exhibited significant apoptosis as compared to the groups with nicotine or lss alone. |
2016-04-25 |
2023-08-13 |
human |
| Yuan Liu, Xiaoning Zeng, Yujian Hui, Chenlei Zhu, Jie Wu, Devin H Taylor, Juan Ji, Weimin Fan, Zuhu Huang, Jun H. Activation of α7 nicotinic acetylcholine receptors protects astrocytes against oxidative stress-induced apoptosis: implications for Parkinson's disease. Neuropharmacology. vol 91. 2015-09-28. PMID:25486621. |
in the present study, we showed that nicotine exerts a protective effect on h2o2-induced astrocyte apoptosis and glial cell-derived neurotrophic factor (gdnf) downregulation, and this effect was abolished by an α7-nachr-selective antagonist. |
2015-09-28 |
2023-08-13 |
Not clear |
| Yuan Liu, Xiaoning Zeng, Yujian Hui, Chenlei Zhu, Jie Wu, Devin H Taylor, Juan Ji, Weimin Fan, Zuhu Huang, Jun H. Activation of α7 nicotinic acetylcholine receptors protects astrocytes against oxidative stress-induced apoptosis: implications for Parkinson's disease. Neuropharmacology. vol 91. 2015-09-28. PMID:25486621. |
taken together these findings demonstrate, for the first time, that nicotine suppresses h2o2-induced astrocyte apoptosis via the mitochondrial pathway through the stimulation of α7-nachrs. |
2015-09-28 |
2023-08-13 |
Not clear |
| Filippo Zanetti, Marta Giacomello, Yves Donati, Stephanie Carnesecchi, Maud Frieden, Constance Barazzone-Argiroff. Nicotine mediates oxidative stress and apoptosis through cross talk between NOX1 and Bcl-2 in lung epithelial cells. Free radical biology & medicine. vol 76. 2015-08-25. PMID:25151121. |
nicotine mediates oxidative stress and apoptosis through cross talk between nox1 and bcl-2 in lung epithelial cells. |
2015-08-25 |
2023-08-13 |
human |
| Filippo Zanetti, Marta Giacomello, Yves Donati, Stephanie Carnesecchi, Maud Frieden, Constance Barazzone-Argiroff. Nicotine mediates oxidative stress and apoptosis through cross talk between NOX1 and Bcl-2 in lung epithelial cells. Free radical biology & medicine. vol 76. 2015-08-25. PMID:25151121. |
we found that chronic exposure to nicotine (48h) induced nox1-dependent oxidative stress and apoptosis in primary pulmonary cells. |
2015-08-25 |
2023-08-13 |
human |
| Filippo Zanetti, Marta Giacomello, Yves Donati, Stephanie Carnesecchi, Maud Frieden, Constance Barazzone-Argiroff. Nicotine mediates oxidative stress and apoptosis through cross talk between NOX1 and Bcl-2 in lung epithelial cells. Free radical biology & medicine. vol 76. 2015-08-25. PMID:25151121. |
in murine (mle-12) and human (beas-2b) lung epithelial cell lines, nicotine acted as a sensitizer to cell death and synergistically enhanced apoptosis when cells were concomitantly exposed to hyperoxia. |
2015-08-25 |
2023-08-13 |
human |
| Manindra Nath Tiwari, Swati Agarwal, Priyanka Bhatnagar, Naveen Kumar Singhal, Shashi Kant Tiwari, Pradeep Kumar, Lalit Kumar Singh Chauhan, Devendra Kumar Patel, Rajnish Kumar Chaturvedi, Mahendra Pratap Singh, Kailash Chand Gupt. Nicotine-encapsulated poly(lactic-co-glycolic) acid nanoparticles improve neuroprotective efficacy against MPTP-induced parkinsonism. Free radical biology & medicine. vol 65. 2015-08-07. PMID:23933227. |
the selected indicators of oxidative stress, dopaminergic neurodegeneration and apoptosis, were measured in both in vitro and rodent models of parkinsonism in the presence or absence of "nanotized" or bulk nicotine. |
2015-08-07 |
2023-08-12 |
mouse |
| Manindra Nath Tiwari, Swati Agarwal, Priyanka Bhatnagar, Naveen Kumar Singhal, Shashi Kant Tiwari, Pradeep Kumar, Lalit Kumar Singh Chauhan, Devendra Kumar Patel, Rajnish Kumar Chaturvedi, Mahendra Pratap Singh, Kailash Chand Gupt. Nicotine-encapsulated poly(lactic-co-glycolic) acid nanoparticles improve neuroprotective efficacy against MPTP-induced parkinsonism. Free radical biology & medicine. vol 65. 2015-08-07. PMID:23933227. |
the results obtained from this study demonstrate that nanotization of nicotine improves neuroprotective efficacy by enhancing its bioavailability and subsequent modulation in the indicators of oxidative stress and apoptosis. |
2015-08-07 |
2023-08-12 |
mouse |
| Seyedeh Nazanin Seyed Saadat, Fahimeh Mohammadghasemi, Sina Khajeh Jahromi, Mohammad Amin Homafar, Mostafa Haghir. Melatonin protects uterus and oviduct exposed to nicotine in mice. Interdisciplinary toxicology. vol 7. issue 1. 2015-06-03. PMID:26038675. |
co-administration of melatonin-nicotine in group d ameliorated the histology of the uterus and oviduct, increased eralpha numbers and reduced apoptosis in the uterus and oviduct compared with the nicotine group b (p<0.05). |
2015-06-03 |
2023-08-13 |
mouse |
| Seyedeh Nazanin Seyed Saadat, Fahimeh Mohammadghasemi, Sina Khajeh Jahromi, Mohammad Amin Homafar, Mostafa Haghir. Melatonin protects uterus and oviduct exposed to nicotine in mice. Interdisciplinary toxicology. vol 7. issue 1. 2015-06-03. PMID:26038675. |
this study indicates that nicotine impairs the histology of the uterus and oviduct and co-administration of melatonin-nicotine ameliorates these findings, partly through alteration in eralpha numbers and reduction of apoptosis. |
2015-06-03 |
2023-08-13 |
mouse |
| Yue Zhao, Wei Zhou, Liyan Xue, Weimin Zhang, Qimin Zha. Nicotine activates YAP1 through nAChRs mediated signaling in esophageal squamous cell cancer (ESCC). PloS one. vol 9. issue 3. 2015-05-29. PMID:24621512. |
in addition, we find nicotine signaling also inhibits the interaction of yap1 with p63, which contributes to the inhibitory effect of nicotine on apoptosis. |
2015-05-29 |
2023-08-12 |
Not clear |
| R Ivey, M Desai, K Green, I Sinha-Hikim, T C Friedman, A P Sinha-Hiki. Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 46. issue 8. 2015-03-03. PMID:24830635. |
additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. |
2015-03-03 |
2023-08-13 |
mouse |
| R Ivey, M Desai, K Green, I Sinha-Hikim, T C Friedman, A P Sinha-Hiki. Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 46. issue 8. 2015-03-03. PMID:24830635. |
we recently demonstrated that combined treatment with nicotine and a high-fat diet (hfd) triggers greater oxidative stress, activates hepatocellular apoptosis, and exacerbates hfd-induced hepatic steatosis. |
2015-03-03 |
2023-08-13 |
mouse |