| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaofang Cao, Chunling Han, Jinsuo Wen, Xiaokun Guo, Kejian Zhan. Nicotine increases apoptosis in HUVECs cultured in high glucose/high fat via Akt ubiquitination and degradation. Clinical and experimental pharmacology & physiology. vol 45. issue 2. 2019-05-23. PMID:28963785. |
furthermore, the ttc3 and mul1 shrna adenovirus dramatically decreased the akt ubiquitination and apoptosis induced by nicotine. |
2019-05-23 |
2023-08-13 |
human |
| Xi Xiao, Xueliang Shang, Baohui Zhai, Hui Zhang, Tao Zhan. Nicotine alleviates chronic stress-induced anxiety and depressive-like behavior and hippocampal neuropathology via regulating autophagy signaling. Neurochemistry international. vol 114. 2019-05-08. PMID:29339018. |
in addition, concomitant treatment with nicotine (10 μm) significantly attenuated the loss of pc12 cell viability (p < .01) and apoptosis compared to that of corticosterone treatment alone. |
2019-05-08 |
2023-08-13 |
mouse |
| Lorella Marinucci, Stefania Balloni, Katia Fettucciari, Maria Bodo, Vincenzo N Talesa, Cinzia Antognell. Nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by H Free radical biology & medicine. vol 117. 2019-05-08. PMID:29355739. |
nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by h nicotine contained in cigarette smoke contributes to the onset of several diseases, including osteoporosis, whose emerging pathogenic mechanism is associated with osteoblasts apoptosis. |
2019-05-08 |
2023-08-13 |
human |
| Lorella Marinucci, Stefania Balloni, Katia Fettucciari, Maria Bodo, Vincenzo N Talesa, Cinzia Antognell. Nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by H Free radical biology & medicine. vol 117. 2019-05-08. PMID:29355739. |
scanty information is available on the molecular mechanisms of nicotine on osteoblasts apoptosis and, consequently, on an important aspect of the pathogenesis of smokers-related osteoporosis. |
2019-05-08 |
2023-08-13 |
human |
| Lorella Marinucci, Stefania Balloni, Katia Fettucciari, Maria Bodo, Vincenzo N Talesa, Cinzia Antognell. Nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by H Free radical biology & medicine. vol 117. 2019-05-08. PMID:29355739. |
the aim of this study was to investigate whether, and by means of which mechanism, the antiglycation defence glo1 was involved in the apoptosis induced by 0.1 and 1µm nicotine in human primary osteoblasts chronically exposed for 11 and 21 days. |
2019-05-08 |
2023-08-13 |
human |
| Shimaa M Azmy, Mai A Abd El Fattah, Sahar S Abd El-Rahman, Somia A Nada, Omar M E Abdel Salam, Mohammed F El-Yamany, Noha N Nassa. Does nicotine impact tramadol abuse? Insights from neurochemical and neurobehavioral changes in mice. Neurotoxicology. vol 67. 2019-04-08. PMID:29906478. |
increased oxidative stress by tramadol and/or nicotine sequentially augmented nuclear factor kappa b and the proinflammatory cytokine tumor necrosis factor α with the induction of apoptosis evident by the increased caspase-3 immunoreactivity. |
2019-04-08 |
2023-08-13 |
mouse |
| Xianglong Zhao, Wangjie Xu, Jiajie Wu, Dong Zhang, Abdelrahman Abou-Shakra, Ling Di, Zhaoxia Wang, Lianyun Wang, Fan Yang, Zhongdong Qia. Nicotine induced autophagy of Leydig cells rather than apoptosis is the major reason of the decrease of serum testosterone. The international journal of biochemistry & cell biology. vol 100. 2019-03-08. PMID:29753783. |
nicotine induced autophagy of leydig cells rather than apoptosis is the major reason of the decrease of serum testosterone. |
2019-03-08 |
2023-08-13 |
mouse |
| Xianglong Zhao, Wangjie Xu, Jiajie Wu, Dong Zhang, Abdelrahman Abou-Shakra, Ling Di, Zhaoxia Wang, Lianyun Wang, Fan Yang, Zhongdong Qia. Nicotine induced autophagy of Leydig cells rather than apoptosis is the major reason of the decrease of serum testosterone. The international journal of biochemistry & cell biology. vol 100. 2019-03-08. PMID:29753783. |
a new report has shown that nicotine exposure can decrease serum testosterone by apoptosis in leydig cells; however, in our previous studies, we have almost never observed apoptosis there. |
2019-03-08 |
2023-08-13 |
mouse |
| Xianglong Zhao, Wangjie Xu, Jiajie Wu, Dong Zhang, Abdelrahman Abou-Shakra, Ling Di, Zhaoxia Wang, Lianyun Wang, Fan Yang, Zhongdong Qia. Nicotine induced autophagy of Leydig cells rather than apoptosis is the major reason of the decrease of serum testosterone. The international journal of biochemistry & cell biology. vol 100. 2019-03-08. PMID:29753783. |
likewise, chemical and immune-histological staining demonstrated that autophagy of the leydig cells increased after nicotine treatment rather than apoptosis. |
2019-03-08 |
2023-08-13 |
mouse |
| Wamidh H Talib, Lina T Al Kur. Parthenolide inhibits tumor-promoting effects of nicotine in lung cancer by inducing P53 - dependent apoptosis and inhibiting VEGF expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-22. PMID:30257366. |
parthenolide inhibits tumor-promoting effects of nicotine in lung cancer by inducing p53 - dependent apoptosis and inhibiting vegf expression. |
2019-01-22 |
2023-08-13 |
Not clear |
| Wamidh H Talib, Lina T Al Kur. Parthenolide inhibits tumor-promoting effects of nicotine in lung cancer by inducing P53 - dependent apoptosis and inhibiting VEGF expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-22. PMID:30257366. |
enhanced proliferation, angiogenesis induction, and resistance to apoptosis were reported as direct results associated with exposure to nicotine (the active ingredient of cigarettes). |
2019-01-22 |
2023-08-13 |
Not clear |
| Shugo Suzuki, Samuel M Cohen, Lora L Arnold, Hiroyuki Kato, Satoshi Fuji, Karen L Pennington, Yuko Nagayasu, Aya Naiki-Ito, Yoriko Yamashita, Satoru Takahash. Orally administered nicotine effects on rat urinary bladder proliferation and carcinogenesis. Toxicology. vol 398-399. 2018-12-28. PMID:29501575. |
ki67 and pstat3 labeling indices and expression of nicotinic acetylcholine receptor alpha 7 (nachrα7) in non-tumor bladder urothelial lesions were significantly increased by nicotine, but the tunel assay for apoptosis showed no increase. |
2018-12-28 |
2023-08-13 |
mouse |
| João Pedro Gomes, Abdulla Watad, Yehuda Shoenfel. Nicotine and autoimmunity: The lotus' flower in tobacco. Pharmacological research. vol 128. 2018-12-14. PMID:29051105. |
nicotine, the major component of cigarettes, has demonstrated conflicting impact on the immune system: some authors suggest that increases pro-inflammatory cytokines and provokes cellular apoptosis of neutrophils, releasing intracellular components that act as auto-antigens; others claimed that nicotine has a protective and anti-inflammatory effects, especially by binding to α7 subunit of nicotinic acetylcholine receptors. |
2018-12-14 |
2023-08-13 |
Not clear |
| Yu-Wei Chang, Kamaleshwar P Sing. Duration-dependent effects of nicotine exposure on growth and AKT activation in human kidney epithelial cells. Molecular and cellular biochemistry. vol 448. issue 1-2. 2018-10-31. PMID:29396723. |
analysis of cell cycle and expression of marker genes related to proliferation and apoptosis further confirmed the effects of nicotine. |
2018-10-31 |
2023-08-13 |
human |
| Dan Liang, Ke-Jing Wang, Zhi-Qun Tang, Run-He Liu, Fulei Zeng, Miao-Ying Cheng, Qi-Si Lian, Hong-Kun W. Effects of nicotine on the metabolism and gene expression profile of Sprague‑Dawley rat primary osteoblasts. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29658611. |
the present study assessed alterations in osteogenic activity by performing a cell counting kit‑8 assay to investigate proliferation, annexin v‑fluorescein isothiocyanate/propidium iodide staining to investigate apoptosis, alizarin red staining to investigate the formation of mineralized nodules, reverse transcription‑quantitative polymerase chain reaction and western blotting to investigate the mrna and protein levels of collagen i, alkaline phosphatase, bone osteocalcin, bone sialoprotein and osteopontin; and mrna microarray expression analysis, kyoto encyclopedia of genes and genomes and gene ontology analysis to investigate the whole genome expression profile of sprague‑dawley (sd) rat primary osteoblasts following treatment with different concentrations of nicotine. |
2018-09-26 |
2023-08-13 |
rat |
| Dan Liang, Ke-Jing Wang, Zhi-Qun Tang, Run-He Liu, Fulei Zeng, Miao-Ying Cheng, Qi-Si Lian, Hong-Kun W. Effects of nicotine on the metabolism and gene expression profile of Sprague‑Dawley rat primary osteoblasts. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29658611. |
the results demonstrated that nicotine inhibited proliferation, promoted early apoptosis and inhibited mineralized nodule formation in a dose‑dependent manner by regulating alkaline phosphatase activity and the expression of osteoblast metabolism‑associated genes and proteins. |
2018-09-26 |
2023-08-13 |
rat |
| Maryam Torshabi, Zeinab Rezaei Esfahrood, Mahshid Jamshidi, Abbas Mansuri Torshizi, Samira Sotoude. Efficacy of vitamins E and C for reversing the cytotoxic effects of nicotine and cotinine. European journal of oral sciences. vol 125. issue 6. 2018-08-06. PMID:29024129. |
vitamin e (separately and combined with vitamin c) was statistically significantly more effective than vitamin c (at the concentration used in this study) at improving cell viability, proliferation, and migration, and at reducing apoptosis of cells exposed to nicotine or cotinine. |
2018-08-06 |
2023-08-13 |
human |
| Alex Battaglia, Thanh Nguye. Transmucosal Delivery of Nicotine in Combination with Tincture of Benzoin Inhibits Apoptosis. Drugs in R&D. vol 17. issue 4. 2018-06-29. PMID:29058303. |
transmucosal delivery of nicotine in combination with tincture of benzoin inhibits apoptosis. |
2018-06-29 |
2023-08-13 |
Not clear |
| Ting Chen, You-E Yan, Sha Liu, Han-Xiao Liu, Hui-Yi Yan, Li-Fang Hou, Wen Qu, Jie Pin. Increased Fetal Thymocytes Apoptosis Contributes to Prenatal Nicotine Exposure-induced Th1/Th2 Imbalance in Male Offspring Mice. Scientific reports. vol 6. 2018-06-15. PMID:27976742. |
increased fetal thymocytes apoptosis contributes to prenatal nicotine exposure-induced th1/th2 imbalance in male offspring mice. |
2018-06-15 |
2023-08-13 |
mouse |
| Ting Chen, You-E Yan, Sha Liu, Han-Xiao Liu, Hui-Yi Yan, Li-Fang Hou, Wen Qu, Jie Pin. Increased Fetal Thymocytes Apoptosis Contributes to Prenatal Nicotine Exposure-induced Th1/Th2 Imbalance in Male Offspring Mice. Scientific reports. vol 6. 2018-06-15. PMID:27976742. |
this study was designed to investigate the effects of prenatal nicotine exposure (pne) on the balance of th1/th2 in offspring, and further explore the developmental origin mechanisms from the perspective of fetal thymocytes apoptosis. |
2018-06-15 |
2023-08-13 |
mouse |