| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sergio Raez-Villanueva, Amrita Debnath, Daniel B Hardy, Alison C Hollowa. Prenatal nicotine exposure leads to decreased histone H3 lysine 9 (H3K9) methylation and increased Journal of developmental origins of health and disease. 2021-05-28. PMID:34047687. |
prenatal nicotine exposure leads to decreased histone h3 lysine 9 (h3k9) methylation and increased prenatal exposure to nicotine, tobacco's major addictive constituent, has been shown to reduce birth weight and increases apoptosis, oxidative stress, and mitochondrial dysfunction in the postnatal pancreas. |
2021-05-28 |
2023-08-13 |
rat |
| Ahmad Alhowai. Molecular insights into the benefits of nicotine on memory and cognition (Review). Molecular medicine reports. vol 23. issue 6. 2021-05-10. PMID:33786606. |
in terms of its mechanism of action, nicotine slows the progression of pd by inhibiting sirtuin 6, a stress‑responsive protein deacetylase, thereby decreasing neuronal apoptosis and improving neuronal survival. |
2021-05-10 |
2023-08-13 |
Not clear |
| Krista Gonzales, Victoria Feng, Priyanka Bikkina, Marie Angelica Landicho, Michael J Haas, Arshag D Mooradia. The effect of nicotine and dextrose on endoplasmic reticulum stress in human coronary artery endothelial cells. Toxicology research. vol 10. issue 2. 2021-04-24. PMID:33884179. |
nicotine at concentrations commonly achieved in nicotine-replacement therapy (nrt) significantly increased er stress in hcaec and aggravated dextrose-induced er stress and cell apoptosis. |
2021-04-24 |
2023-08-13 |
human |
| Manuela Gallo, Maria E Street, Fabiola Guerra, Vassilios Fanos, Maria Antonietta Marciali. A review of current knowledge on Pollution, Cigarette Smoking and COVID-19 diffusion and their relationship with inflammation. Acta bio-medica : Atenei Parmensis. vol 91. issue 4. 2021-02-11. PMID:33525222. |
as to smoking, nicotine activation of nicotinic receptors leads to enhanced protease activation, apoptosis and inflammatory signaling through the same pathways (renin-angiotensin system (ras) and angiotensin-converting enzyme 2 (ace2)) used by the virus increasing the inflammatory/destructive action of the virus itself. |
2021-02-11 |
2023-08-13 |
human |
| Shugo Suzuki, Samuel M Cohen, Lora L Arnold, Karen L Pennington, Min Gi, Hiroyuki Kato, Taku Naiki, Aya Naiki-Ito, Hideki Wanibuchi, Satoru Takahash. Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin. Toxicology letters. vol 336. 2020-12-31. PMID:33176187. |
however, despite reduction of cell proliferation (labeling index), apocynin did not affect the incidence of simple hyperplasia, apoptosis, or ros generation in the kidney pelvis urothelium, in addition to 8-ohdg positivity induced by nicotine being lower. |
2020-12-31 |
2023-08-13 |
human |
| Cai-Mei Zheng, Yu-Hsuan Lee, I-Jen Chiu, Yu-Jhe Chiu, Li-Chin Sung, Yung-Ho Hsu, Hui-Wen Chi. Nicotine Causes Nephrotoxicity through the Induction of NLRP6 Inflammasome and Alpha7 Nicotinic Acetylcholine Receptor. Toxics. vol 8. issue 4. 2020-12-26. PMID:33114531. |
nicotine caused mild apoptosis and necrosis but triggered significant autophagy in human kidney cells. |
2020-12-26 |
2023-08-13 |
human |
| Kamrul M Hasan, Theodore C Friedman, Meher Parveen, Jorge Espinoza-Derout, Francisco Bautista, Mohammad M Razipour, Xuesi M Shao, Maria C Jordan, Kenneth P Roos, Sushil K Mahata, Amiya P Sinha-Hiki. Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice. PloS one. vol 15. issue 10. 2020-11-30. PMID:33002059. |
the detrimental effects of e-cigarettes (2.4% nicotine) on cardiac structure and function was accompanied by increased oxidative stress, plasma free fatty acid levels, cm apoptosis, and inactivation of amp-activated protein kinase and activation of its downstream target, acetyl-coa-carboxylase. |
2020-11-30 |
2023-08-13 |
mouse |
| Xin Li, Bei Zhou, Xinjia Han, Huishu Li. Effect of nicotine on placental inflammation and apoptosis in preeclampsia-like model. Life sciences. vol 261. 2020-11-18. PMID:32835699. |
effect of nicotine on placental inflammation and apoptosis in preeclampsia-like model. |
2020-11-18 |
2023-08-13 |
Not clear |
| Xin Li, Bei Zhou, Xinjia Han, Huishu Li. Effect of nicotine on placental inflammation and apoptosis in preeclampsia-like model. Life sciences. vol 261. 2020-11-18. PMID:32835699. |
whether the beneficial effects of nicotine are related to inhibition of placental inflammation and apoptosis in the pe-like model were investigated. |
2020-11-18 |
2023-08-13 |
Not clear |
| Shi Chen, Shiyi Tan, Shang Yang, Gang Chen, Li Zhu, Zhiqian Sun, Haibin Li, Sanqiao Ya. Nicotine induces apoptosis through exacerbation of blocked alveolar macrophage autophagic degradation in silicosis. Toxicology letters. vol 334. 2020-11-04. PMID:33010382. |
nicotine induces apoptosis through exacerbation of blocked alveolar macrophage autophagic degradation in silicosis. |
2020-11-04 |
2023-08-13 |
human |
| Shi Chen, Shiyi Tan, Shang Yang, Gang Chen, Li Zhu, Zhiqian Sun, Haibin Li, Sanqiao Ya. Nicotine induces apoptosis through exacerbation of blocked alveolar macrophage autophagic degradation in silicosis. Toxicology letters. vol 334. 2020-11-04. PMID:33010382. |
however, the effects of nicotine on am autophagy and apoptosis in silicosis are unknown. |
2020-11-04 |
2023-08-13 |
human |
| Shi Chen, Shiyi Tan, Shang Yang, Gang Chen, Li Zhu, Zhiqian Sun, Haibin Li, Sanqiao Ya. Nicotine induces apoptosis through exacerbation of blocked alveolar macrophage autophagic degradation in silicosis. Toxicology letters. vol 334. 2020-11-04. PMID:33010382. |
these results suggest that nicotine may induce apoptosis by blocking am autophagic degradation in human silicosis. |
2020-11-04 |
2023-08-13 |
human |
| Sawsan M Elsonbaty, Amel F M Ismai. Nicotine encourages oxidative stress and impairment of rats' brain mitigated by Spirulina platensis lipopolysaccharides and low-dose ionizing radiation. Archives of biochemistry and biophysics. vol 689. 2020-10-09. PMID:32343976. |
rats treated with nicotine for two months showed alterations in the oxidative stress markers (malondialdehyde (mda), reduced glutathione (gsh) and oxidized glutathione disulfide (gssg)), antioxidant enzymes (superoxide dismutase (sod), catalase (cat), glutathione enzymes (gpx and gst)) as well as several pro-inflammatory markers (tumor necrosis factor-alpha (tnf-α), interleukin-17 (il-17), and nuclear factor-kappa b (nf-κb)), and induced apoptosis through caspase-3 activity. |
2020-10-09 |
2023-08-13 |
rat |
| Ylenia Duca, Antonio Aversa, Rosita Angela Condorelli, Aldo Eugenio Calogero, Sandro La Vigner. Substance Abuse and Male Hypogonadism. Journal of clinical medicine. vol 8. issue 5. 2020-10-01. PMID:31121993. |
other substances such as nicotine, cannabis, and amphetamines alter spermatogenesis inducing oxidative stress and subsequent apoptosis in testicular tissue. |
2020-10-01 |
2023-08-13 |
Not clear |
| Anshu Jain, Shruti Agrawal, Swaran J S Flor. Arsenic and nicotine co-exposure lead to some synergistic effects on oxidative stress and apoptotic markers in young rat blood, liver, kidneys and brain. Toxicology reports. vol 2. 2020-09-30. PMID:28962476. |
male rats were exposed to a very low dose of arsenic (25 ppm in drinking water) or nicotine (0.25 mg/kg, sub-cutaneously) for a period of 5 months and post exposure various biochemical variables indicative of oxidative stress and apoptosis evaluated. |
2020-09-30 |
2023-08-13 |
rat |
| Ken Kobayashi, Yusaku Tsugami, Norihiro Suzuki, Takahiro Suzuki, Takanori Nishimur. Nicotine directly affects milk production in lactating mammary epithelial cells concurrently with inactivation of STAT5 and glucocorticoid receptor in vitro. Toxicology in vitro : an international journal published in association with BIBRA. vol 63. 2020-09-28. PMID:31783125. |
nicotine treatment also induced mec apoptosis concurrently with inactivation of akt. |
2020-09-28 |
2023-08-13 |
mouse |
| Guizhi Jia, Zhijun Meng, Caihong Liu, Xinliang Ma, Jia Gao, Jing Liu, Rui Guo, Zheyi Yan, Theodore Christopher, Bernard Lopez, Wenxia Liu, Hongliang Dai, Wayne Bond Lau, Xiangying Jiao, Jianli Zhao, Zi-Xuan Wang, Jimin Cao, Yajing Wan. Nicotine induces cardiac toxicity through blocking mitophagic clearance in young adult rat. Life sciences. vol 257. 2020-09-17. PMID:32663572. |
gene array combined with bioinformatics analysis identified cardiac apoptosis and mitophagy were the key signals responsible for nicotine induced cardiac detrimental effect. |
2020-09-17 |
2023-08-13 |
rat |
| Ruinan Xing, Xiaoli Cheng, Yanping Qi, Xiaoxiang Tian, Chenghui Yan, Dan Liu, Yaling Ha. Low-dose nicotine promotes autophagy of cardiomyocytes by upregulating HO-1 expression. Biochemical and biophysical research communications. vol 522. issue 4. 2020-08-31. PMID:31813548. |
the results indicated that low-dose nicotine promoted neonatal mouse cardiac myocytes (nmcms) autophagy and accelerated autophagic flux while inhibiting nmcms apoptosis, but high-dose nicotine inhibited autophagy and promoted apoptosis. |
2020-08-31 |
2023-08-13 |
mouse |
| Ruinan Xing, Xiaoli Cheng, Yanping Qi, Xiaoxiang Tian, Chenghui Yan, Dan Liu, Yaling Ha. Low-dose nicotine promotes autophagy of cardiomyocytes by upregulating HO-1 expression. Biochemical and biophysical research communications. vol 522. issue 4. 2020-08-31. PMID:31813548. |
moreover, low-dose nicotine upregulated heme oxygenase-1 (ho-1) expression and knocking down ho-1 abolished the effects of nicotine on the autophagy and apoptosis of nmcms. |
2020-08-31 |
2023-08-13 |
mouse |
| Ruinan Xing, Xiaoli Cheng, Yanping Qi, Xiaoxiang Tian, Chenghui Yan, Dan Liu, Yaling Ha. Low-dose nicotine promotes autophagy of cardiomyocytes by upregulating HO-1 expression. Biochemical and biophysical research communications. vol 522. issue 4. 2020-08-31. PMID:31813548. |
methyllycaconitine citrate (α7-nachr blocker, mla) inhibited ho-1 expression and the effects of nicotine on autophagy and apoptosis of nmcms. |
2020-08-31 |
2023-08-13 |
mouse |