| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W L Heusch, R Maneckje. Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis. vol 19. issue 4. 1998-06-04. PMID:9600337. |
the present study provides evidence that nicotine (a) activates the mitogen-activated protein (map) kinase signalling pathway in lung cancer cells, specifically extracellular signal-regulated kinase (erk2), resulting in increased expression of the bcl-2 protein and inhibition of apoptosis in these cells; and (b) blocks the inhibition of protein kinase c (pkc) and erk2 activity in lung cancer cells by anti-cancer agents, such as therapeutic opioid drugs, and thus can adversely affect cancer therapy. |
1998-06-04 |
2023-08-12 |
human |
| W L Heusch, R Maneckje. Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis. vol 19. issue 4. 1998-06-04. PMID:9600337. |
nicotine appears to have no effect on the activities of c-jun nh2-terminal protein kinase (jnk) and p38 map kinases, which have also been shown to be involved in apoptosis. |
1998-06-04 |
2023-08-12 |
human |
| W L Heusch, R Maneckje. Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis. vol 19. issue 4. 1998-06-04. PMID:9600337. |
while exposure to nicotine can result in the activation of the two major signalling pathways (map kinase and pkc) that are known to inhibit apoptosis, nicotine regulation of map (erk2) kinase activity is not dependent on pkc. |
1998-06-04 |
2023-08-12 |
human |
| T A Slotkin, E C McCook, F J Seidle. Cryptic brain cell injury caused by fetal nicotine exposure is associated with persistent elevations of c-fos protooncogene expression. Brain research. vol 750. issue 1-2. 1997-06-17. PMID:9098543. |
in the current study, pregnant rats were given nicotine by implanted minipump infusion either from gestational days 4-12 or 4-21 and fetal and neonatal brain regions were examined for expression of the mrna encoding c-fos, a nuclear transcription factor that becomes chronically elevated when cell injury or apoptosis are occurring. |
1997-06-17 |
2023-08-12 |
rat |
| T A Slotkin, E C McCook, F J Seidle. Cryptic brain cell injury caused by fetal nicotine exposure is associated with persistent elevations of c-fos protooncogene expression. Brain research. vol 750. issue 1-2. 1997-06-17. PMID:9098543. |
given that chronic elevations of c-fos are known to be associated with cell injury and to evoke apoptosis in otherwise healthy cells, these results suggest that prenatal nicotine exposure evokes delayed neurotoxicity by altering the program of neural cell differentiation, and that elevated c-fos expression provides an early marker of the eventual deficits. |
1997-06-17 |
2023-08-12 |
rat |
| K Aoshiba, A Nagai, S Yasui, K Konn. Nicotine prolongs neutrophil survival by suppressing apoptosis. The Journal of laboratory and clinical medicine. vol 127. issue 2. 1996-07-05. PMID:8636647. |
nicotine prolongs neutrophil survival by suppressing apoptosis. |
1996-07-05 |
2023-08-12 |
Not clear |
| R Maneckjee, J D Minn. Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 5. issue 10. 1995-03-14. PMID:7848904. |
opioids induce while nicotine suppresses apoptosis in human lung cancer cells. |
1995-03-14 |
2023-08-12 |
human |
| R Maneckjee, J D Minn. Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 5. issue 10. 1995-03-14. PMID:7848904. |
unexpectedly, the combination of hexamethonium and opioids or hexamethonium and nicotine stimulated apoptosis. |
1995-03-14 |
2023-08-12 |
human |
| R Maneckjee, J D Minn. Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 5. issue 10. 1995-03-14. PMID:7848904. |
these results indicate that engagement of opioid receptors in human lung cancer cells induces apoptosis, while engagement of nicotine receptors suppresses apoptosis, which in some cases appear to be working through a pkc pathway. |
1995-03-14 |
2023-08-12 |
human |
| S C Wright, J Zhong, H Zheng, J W Larric. Nicotine inhibition of apoptosis suggests a role in tumor promotion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 7. issue 11. 1993-10-12. PMID:8370474. |
nicotine inhibition of apoptosis suggests a role in tumor promotion. |
1993-10-12 |
2023-08-12 |
Not clear |
| S C Wright, J Zhong, H Zheng, J W Larric. Nicotine inhibition of apoptosis suggests a role in tumor promotion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 7. issue 11. 1993-10-12. PMID:8370474. |
the purpose of this study was to determine the effects of nicotine on the process of apoptosis. |
1993-10-12 |
2023-08-12 |
Not clear |
| S C Wright, J Zhong, H Zheng, J W Larric. Nicotine inhibition of apoptosis suggests a role in tumor promotion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 7. issue 11. 1993-10-12. PMID:8370474. |
the results demonstrate that nicotine inhibits apoptosis induced by diverse stimuli including tumor necrosis factor (tnf), uv light, chemotherapeutic drugs, and calcium ionophore. |
1993-10-12 |
2023-08-12 |
Not clear |
| S C Wright, J Zhong, H Zheng, J W Larric. Nicotine inhibition of apoptosis suggests a role in tumor promotion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 7. issue 11. 1993-10-12. PMID:8370474. |
the major nicotine metabolite, cotinine, also inhibited apoptosis, whereas n-nitrosodiethylamine, a carcinogen found in tobacco, was without effect. |
1993-10-12 |
2023-08-12 |
Not clear |