| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiang Liu, Baolu Zha. Nicotine attenuates beta-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures. British journal of pharmacology. vol 141. issue 4. 2004-10-14. PMID:14757701. |
nicotine effectively inhibits apoptosis in hippocampal cultures caused by a beta(25-35) or a beta(1-40) treatment and increase of caspase activity induced by a beta(25-35) or a beta(1-40). |
2004-10-14 |
2023-08-12 |
Not clear |
| Pallab Maity, Kaushik Biswas, Somenath Roy, Ranajit K Banerjee, Uday Bandyopadhya. Smoking and the pathogenesis of gastroduodenal ulcer--recent mechanistic update. Molecular and cellular biochemistry. vol 253. issue 1-2. 2004-09-16. PMID:14619984. |
roi generation and roi-mediated gastric mucosal cell apoptosis are also considered to be important mechanism for aggravation of ulcer by cigarette smoke or nicotine. |
2004-09-16 |
2023-08-12 |
rat |
| Delphine Gimonet, Regis Grailhe, Paul Coninx, Frank Antonicelli, Bernard Haye, Françoise Liautaud-Roge. Functional role of nicotinic acetylcholine receptors in apoptosis in HL-60 cell line. European journal of pharmacology. vol 482. issue 1-3. 2004-08-16. PMID:14660001. |
we found that bleomycin-induced apoptosis was significantly enhanced by nicotine and was blocked by nicotinic acetylcholine receptor antagonists, including alpha-bungarotoxin, a competitive antagonist of alpha 7 nicotinic receptor. |
2004-08-16 |
2023-08-12 |
Not clear |
| Delphine Gimonet, Regis Grailhe, Paul Coninx, Frank Antonicelli, Bernard Haye, Françoise Liautaud-Roge. Functional role of nicotinic acetylcholine receptors in apoptosis in HL-60 cell line. European journal of pharmacology. vol 482. issue 1-3. 2004-08-16. PMID:14660001. |
in addition to these results, the detectable presence of alpha 7-mrna supports a key role of alpha 7-nicotinic acetylcholine receptors in the modulation of the induced apoptosis by nicotine. |
2004-08-16 |
2023-08-12 |
Not clear |
| Zhaohui Jin, Fengqin Gao, Tammy Flagg, Xingming Den. Nicotine induces multi-site phosphorylation of Bad in association with suppression of apoptosis. The Journal of biological chemistry. vol 279. issue 22. 2004-07-29. PMID:15037618. |
nicotine induces multi-site phosphorylation of bad in association with suppression of apoptosis. |
2004-07-29 |
2023-08-12 |
human |
| John J Wielgus, L Corbin Downey, Katelyn W Ewald, Melissa E Hatley, Kathleen C Wilson, Ruth Hill Yeildin. Exposure to low concentrations of nicotine during cranial nerve development inhibits apoptosis and causes cellular hypertrophy in the ventral oculomotor nuclei of the chick embryo. Brain research. vol 1000. issue 1-2. 2004-06-22. PMID:15053960. |
exposure to low concentrations of nicotine during cranial nerve development inhibits apoptosis and causes cellular hypertrophy in the ventral oculomotor nuclei of the chick embryo. |
2004-06-22 |
2023-08-12 |
chicken |
| John J Wielgus, L Corbin Downey, Katelyn W Ewald, Melissa E Hatley, Kathleen C Wilson, Ruth Hill Yeildin. Exposure to low concentrations of nicotine during cranial nerve development inhibits apoptosis and causes cellular hypertrophy in the ventral oculomotor nuclei of the chick embryo. Brain research. vol 1000. issue 1-2. 2004-06-22. PMID:15053960. |
as determined by dna fragment-labeling assay during the normal period of cell death, vomn apoptosis occurs maximally on e11 during a normal period of declining cell density, and a dose-response study demonstrated 78% e11 vomn apoptotic suppression at approximately 0.30 microm cumulative yolk nicotine with an inhibition threshold between 0.10 and 0.20 microm. |
2004-06-22 |
2023-08-12 |
chicken |
| John J Wielgus, L Corbin Downey, Katelyn W Ewald, Melissa E Hatley, Kathleen C Wilson, Ruth Hill Yeildin. Exposure to low concentrations of nicotine during cranial nerve development inhibits apoptosis and causes cellular hypertrophy in the ventral oculomotor nuclei of the chick embryo. Brain research. vol 1000. issue 1-2. 2004-06-22. PMID:15053960. |
these results suggest that plasma nicotine concentrations resulting from tobacco use or nicotine replacement therapy (nrt) are sufficient to inhibit motoneuron apoptosis and enhance neuronal growth. |
2004-06-22 |
2023-08-12 |
chicken |
| M V Hejmadi, F Dajas-Bailador, S M Barns, B Jones, S Wonnacot. Neuroprotection by nicotine against hypoxia-induced apoptosis in cortical cultures involves activation of multiple nicotinic acetylcholine receptor subtypes. Molecular and cellular neurosciences. vol 24. issue 3. 2004-05-05. PMID:14664825. |
neuroprotection by nicotine against hypoxia-induced apoptosis in cortical cultures involves activation of multiple nicotinic acetylcholine receptor subtypes. |
2004-05-05 |
2023-08-12 |
rat |
| M V Hejmadi, F Dajas-Bailador, S M Barns, B Jones, S Wonnacot. Neuroprotection by nicotine against hypoxia-induced apoptosis in cortical cultures involves activation of multiple nicotinic acetylcholine receptor subtypes. Molecular and cellular neurosciences. vol 24. issue 3. 2004-05-05. PMID:14664825. |
the presence of nicotine (10 microm) during the hypoxic insult protected a subpopulation of susceptible neurones against dna damage and apoptosis induced by oxygen deprivation. |
2004-05-05 |
2023-08-12 |
rat |
| Mario B Marrero, Roger L Papke, Balwinder S Bhatti, Seán Shaw, Merouane Bencheri. The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. The Journal of pharmacology and experimental therapeutics. vol 309. issue 1. 2004-05-04. PMID:14722323. |
nicotine interaction with the alpha7 nachr inhibits abeta (1-42) interaction with the same receptor, and the abeta (1-42)-induced apoptosis is prevented through nicotine-induced activation of jak2. |
2004-05-04 |
2023-08-12 |
Not clear |
| Sonya Trombino, Alfredo Cesario, Stefano Margaritora, PierLuigi Granone, Giovanni Motta, Carla Falugi, Patrizia Russ. Alpha7-nicotinic acetylcholine receptors affect growth regulation of human mesothelioma cells: role of mitogen-activated protein kinase pathway. Cancer research. vol 64. issue 1. 2004-04-01. PMID:14729617. |
thus, these data demonstrate that: (a) human mesothelioma cells and human biopsies of mesothelioma as well as of normal pleural mesothelial cells express functionally alpha-7 nicotinic acethlycholine receptors, evaluated by alpha-bungarotoxin-fitc binding, receptor binding assay, western blot, and reverse transcription-pcr; (b) choline acetyltransferase immunostaining is present in mesothelioma cells; (c) mesothelioma cell growth is modulated by the cholinergic system in which agonists (i.e., nicotine) has a proliferative effect, and antagonists (i.e., curare) has an inhibitory effect, evaluated by cell cloning, dna synthesis and cell cycle; (d) nicotine induces ca(+2) influx, evaluated by [(45)ca(2+)] uptake, and consequently activation of mitogen-activated protein kinase pathway (extracellular signal-regulated kinase and p90(rsk) phosphorylation), evaluated by western blot; and (e) apoptosis mechanisms in mesothelioma cells are under the control of the cholinergic system (nicotine antiapoptotic via induction of nuclear factor-kappab complexes and phosphorylation of bad at ser(112); curare proapoptotic via g(0)-g(1) arrest p21(waf-1) dependent but p53 independent). |
2004-04-01 |
2023-08-12 |
human |
| Rosario Garrido, Joe E Springer, Bernhard Hennig, Michal Tobore. Apoptosis of spinal cord neurons by preventing depletion nicotine attenuates arachidonic acid-induced of neurotrophic factors. Journal of neurotrauma. vol 20. issue 11. 2004-01-16. PMID:14651807. |
apoptosis of spinal cord neurons by preventing depletion nicotine attenuates arachidonic acid-induced of neurotrophic factors. |
2004-01-16 |
2023-08-12 |
Not clear |
| Rosario Garrido, Joe E Springer, Bernhard Hennig, Michal Tobore. Apoptosis of spinal cord neurons by preventing depletion nicotine attenuates arachidonic acid-induced of neurotrophic factors. Journal of neurotrauma. vol 20. issue 11. 2004-01-16. PMID:14651807. |
in addition, nicotine, bdnf and fgf-2 fully protected against arachidonic acid-induced apoptosis of spinal cord neurons. |
2004-01-16 |
2023-08-12 |
Not clear |
| Rosario Garrido, Joe E Springer, Bernhard Hennig, Michal Tobore. Apoptosis of spinal cord neurons by preventing depletion nicotine attenuates arachidonic acid-induced of neurotrophic factors. Journal of neurotrauma. vol 20. issue 11. 2004-01-16. PMID:14651807. |
these results suggest that arachidonic acid can induce apoptosis of spinal cord neurons by depletion of neurotrophic factors and that nicotine can protect against these effects through the nachralpha7-mediated pathway. |
2004-01-16 |
2023-08-12 |
Not clear |
| Rosario Garrido, Kelley King-Pospisil, Kwang Won Son, Bernhard Hennig, Michal Tobore. Nicotine upregulates nerve growth factor expression and prevents apoptosis of cultured spinal cord neurons. Neuroscience research. vol 47. issue 3. 2004-01-05. PMID:14568117. |
nicotine upregulates nerve growth factor expression and prevents apoptosis of cultured spinal cord neurons. |
2004-01-05 |
2023-08-12 |
Not clear |
| Rosario Garrido, Kelley King-Pospisil, Kwang Won Son, Bernhard Hennig, Michal Tobore. Nicotine upregulates nerve growth factor expression and prevents apoptosis of cultured spinal cord neurons. Neuroscience research. vol 47. issue 3. 2004-01-05. PMID:14568117. |
both nicotine and exogenous ngf inhibited arachidonic acid induced apoptosis of spinal cord neurons. |
2004-01-05 |
2023-08-12 |
Not clear |
| Cara L Crowley-Weber, Katerina Dvorakova, Cheray Crowley, Harris Bernstein, Carol Bernstein, Harinder Garewal, Claire M Payn. Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis. Chemico-biological interactions. vol 145. issue 1. 2003-05-09. PMID:12606154. |
nicotine increases oxidative stress, activates nf-kappab and grp78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis. |
2003-05-09 |
2023-08-12 |
Not clear |
| A Hakki, H Friedman, S Pros. Nicotine modulation of apoptosis in human coronary artery endothelial cells. International immunopharmacology. vol 2. issue 10. 2003-04-30. PMID:12400870. |
nicotine modulation of apoptosis in human coronary artery endothelial cells. |
2003-04-30 |
2023-08-12 |
human |
| A Hakki, H Friedman, S Pros. Nicotine modulation of apoptosis in human coronary artery endothelial cells. International immunopharmacology. vol 2. issue 10. 2003-04-30. PMID:12400870. |
it has been recently reported that nicotine, the addictive component of tobacco, is an important modulator at the level of immune cell apoptosis or programmed cell death. |
2003-04-30 |
2023-08-12 |
human |