| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriella Argentin, Rosadele Cicchett. Evidence for the role of nitric oxide in antiapoptotic and genotoxic effect of nicotine on human gingival fibroblasts. Apoptosis : an international journal on programmed cell death. vol 11. issue 11. 2007-09-19. PMID:16927020. |
our previous study revealed in human gingival fibroblasts (hgfs) a concomitant antiapoptotic and genotoxic effect of nicotine, manifested by the attenuation of staurosporine (stp)-induced apoptosis and the increase of micronucleus frequency. |
2007-09-19 |
2023-08-12 |
human |
| Gabriella Argentin, Rosadele Cicchett. Evidence for the role of nitric oxide in antiapoptotic and genotoxic effect of nicotine on human gingival fibroblasts. Apoptosis : an international journal on programmed cell death. vol 11. issue 11. 2007-09-19. PMID:16927020. |
in vitro treatment with sodium nitroprusside as no donor showed that no produced similar effects as those observed with nicotine: it caused dna damage and partially prevented apoptosis induced by staurosporine. |
2007-09-19 |
2023-08-12 |
human |
| Robert L Copeland, Jharna R Das, Yasmine M Kanaan, Robert E Taylor, Yousef Tizab. Antiapoptotic effects of nicotine in its protection against salsolinol-induced cytotoxicity. Neurotoxicity research. vol 12. issue 1. 2007-09-18. PMID:17513200. |
sh-sy5y cells were exposed to 0.4 or 0.7 mm salsolinol with and without pretreatment in combination of 0.1 mm nicotine and 0.1 mm mecamylamine and were exposed for 24 and 48 h. various parameters including cell cycle perturbations (reflected in propidium iodide dna staining); cell cycle regulator retinoblastoma protein (reflected in the western blot), apoptosis (reflected in annexin v/propidium iodide staining followed by flow cytometry) were analyzed. |
2007-09-18 |
2023-08-12 |
human |
| Robert L Copeland, Jharna R Das, Yasmine M Kanaan, Robert E Taylor, Yousef Tizab. Antiapoptotic effects of nicotine in its protection against salsolinol-induced cytotoxicity. Neurotoxicity research. vol 12. issue 1. 2007-09-18. PMID:17513200. |
the results suggest that apoptosis is a major mechanism for salsolinol-induced toxicity and that antiapoptotic effects of nicotine, mediated by nicotinic receptors, may play a primary role in its neuroprotective effects. |
2007-09-18 |
2023-08-12 |
human |
| Alessia Grozio, Alessia Catassi, Zita Cavalieri, Laura Paleari, Alfredo Cesario, Patrizia Russ. Nicotine, lung and cancer. Anti-cancer agents in medicinal chemistry. vol 7. issue 4. 2007-08-09. PMID:17630920. |
this is supported by the findings that nicotine can prevent apoptosis induced by various agents - such as chemotherapeutic in nsclc, conferring a survival advantage as well. |
2007-08-09 |
2023-08-12 |
human |
| David Chi-Leung Lam, Luc Girard, Ruben Ramirez, Wing-Shun Chau, Wai-sing Suen, Shelley Sheridan, Vicky P C Tin, Lap-ping Chung, Maria P Wong, Jerry W Shay, Adi F Gazdar, Wah-kit Lam, John D Minn. Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer research. vol 67. issue 10. 2007-07-03. PMID:17510389. |
nicotine and its derivatives, by binding to nicotinic acetylcholine receptors (nachr) on bronchial epithelial cells, can regulate cellular proliferation and apoptosis via activating the akt pathway. |
2007-07-03 |
2023-08-12 |
human |
| N H Kleinsasser, A W Sassen, M P Semmler, R Staudenmaier, U A Harréus, E Richte. [Does nicotine add to the carcinogenic strain of tobacco smoke?]. HNO. vol 54. issue 5. 2007-05-30. PMID:16170509. |
however, more recently data have accumulated which suggest that nicotine may add to the cancer risk by stimulating cellular growth via non-neuronal acetylcholine receptors, by suppressing apoptosis, and by inducing angiogenesis not only in atheromatous plaques but also in tumors. |
2007-05-30 |
2023-08-12 |
human |
| Yanfei Zhou, Xinbin Gu, Ebrahim Ashayeri, Renshu Zhang, Rajagopalan Sridha. Nicotine decreases the cytotoxicity of doxorubicin towards MCF-7 and KB-3.1 human cancer cells in culture. Journal of the National Medical Association. vol 99. issue 4. 2007-05-22. PMID:17444420. |
inhibition of apoptosis and necrosis in cancer cells by nicotine can diminish the effectiveness of doxorubicin in cancer therapy. |
2007-05-22 |
2023-08-12 |
human |
| Selim Kurtoglu, Tamer Gunes, Esad Koklu, Osman Bastug, Ozlem Canoz, Mustafa Kula, Funda Bastug, Isin Gune. Influence of maternal nicotine exposure on neonatal rat bone: protective effect of pentoxifylline. Experimental biology and medicine (Maywood, N.J.). vol 232. issue 3. 2007-04-16. PMID:17327473. |
in conclusion, maternal nicotine exposure resulted in decreased birth weight, pregnancy weight gain, and bone lengthening, and increased apoptosis. |
2007-04-16 |
2023-08-12 |
rat |
| P Russo, A Catassi, A Cesario, D Serven. Development of novel therapeutic strategies for lung cancer: targeting the cholinergic system. Current medicinal chemistry. vol 13. issue 29. 2007-02-28. PMID:17168719. |
furthermore apoptosis mechanisms are under the control of the cholinergic system (nicotine antiapoptotic via induction of nf-kappab complexes and phosphorylation of bad at s112, curare proapoptotic via g0-g1 arrest p21waf-1-dependent, but p53-independent) [16]. |
2007-02-28 |
2023-08-12 |
human |
| Angelo O Rosa, Javier Egea, Luís Gandía, Manuela G López, Antonio G Garcí. Neuroprotection by nicotine in hippocampal slices subjected to oxygen-glucose deprivation: involvement of the alpha7 nAChR subtype. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192628. |
nicotine (nic) is neuroprotective against glutamate and hypoxia-induced neurotoxicity, preventing neuronal death and apoptosis in primary neuronal cultures. |
2007-02-23 |
2023-08-12 |
mouse |
| Qiang Liu, Jie Zhang, Hua Zhu, Chuan Qin, Qi Chen, Baolu Zha. Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 1. 2007-02-05. PMID:17135361. |
nicotine also inhibits apoptosis and cell cycle progression in this mouse line. |
2007-02-05 |
2023-08-12 |
mouse |
| Andrew M Smith, Daniel R Zeve, Douglas P Dohrman, Wei-Jung A Che. The interactive effect of alcohol and nicotine on NGF-treated pheochromocytoma cells. Alcohol (Fayetteville, N.Y.). vol 39. issue 2. 2006-12-28. PMID:17134658. |
pc12 cells were exposed to alcohol (100 mm), nicotine (10 microm), or both alcohol and nicotine for 24, 48, 72, or 96 h. caspase-3 activity and dna fragmentation, markers for apoptotic cell death, were measured to determine the role of apoptosis in mediating decreases in pc12 cell numbers. |
2006-12-28 |
2023-08-12 |
Not clear |
| Andrew M Smith, Daniel R Zeve, Douglas P Dohrman, Wei-Jung A Che. The interactive effect of alcohol and nicotine on NGF-treated pheochromocytoma cells. Alcohol (Fayetteville, N.Y.). vol 39. issue 2. 2006-12-28. PMID:17134658. |
neither alcohol nor nicotine exposure appeared to alter caspase-3 activity or dna fragmentation levels, suggesting that the reduction in pc12 cell numbers following alcohol and/or nicotine exposure may possibly be due to factors other than apoptosis, such as interference with proliferation rates. |
2006-12-28 |
2023-08-12 |
Not clear |
| Piyali Dasgupta, Rebecca Kinkade, Bharat Joshi, Christina Decook, Eric Haura, Srikumar Chellappa. Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 16. 2006-06-23. PMID:16601104. |
nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating xiap and survivin. |
2006-06-23 |
2023-08-12 |
human |
| Piyali Dasgupta, Rebecca Kinkade, Bharat Joshi, Christina Decook, Eric Haura, Srikumar Chellappa. Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 16. 2006-06-23. PMID:16601104. |
although nicotine is not carcinogenic, it can induce cell proliferation and angiogenesis and suppress apoptosis induced by certain agents. |
2006-06-23 |
2023-08-12 |
human |
| Piyali Dasgupta, Rebecca Kinkade, Bharat Joshi, Christina Decook, Eric Haura, Srikumar Chellappa. Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 16. 2006-06-23. PMID:16601104. |
here we show that nicotine inhibits apoptosis induced by the drugs gemcitabine, cisplatin, and taxol, which are used to treat nsclcs. |
2006-06-23 |
2023-08-12 |
human |
| Piyali Dasgupta, Rebecca Kinkade, Bharat Joshi, Christina Decook, Eric Haura, Srikumar Chellappa. Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 16. 2006-06-23. PMID:16601104. |
moreover, ablation of e2f1 levels caused abrogation of the protective effects of nicotine against cisplatin-induced apoptosis in a549 cells whereas ablation of signal transducer and activator of transcription 3 levels had no effect. |
2006-06-23 |
2023-08-12 |
human |
| R Bordel, M W Laschke, M D Menger, B Vollma. Nicotine does not affect vascularization but inhibits growth of freely transplanted ovarian follicles by inducing granulosa cell apoptosis. Human reproduction (Oxford, England). vol 21. issue 3. 2006-05-09. PMID:16311296. |
nicotine does not affect vascularization but inhibits growth of freely transplanted ovarian follicles by inducing granulosa cell apoptosis. |
2006-05-09 |
2023-08-12 |
Not clear |
| Tao Zhang, Heng Lu, Xuan Shang, Yihao Tian, Congyi Zheng, Shiwen Wang, Hanhua Cheng, Rongjia Zho. Nicotine prevents the apoptosis induced by menadione in human lung cancer cells. Biochemical and biophysical research communications. vol 342. issue 3. 2006-04-19. PMID:16598845. |
nicotine prevents the apoptosis induced by menadione in human lung cancer cells. |
2006-04-19 |
2023-08-12 |
human |