| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Bordel, M W Laschke, M D Menger, B Vollma. Nicotine does not affect vascularization but inhibits growth of freely transplanted ovarian follicles by inducing granulosa cell apoptosis. Human reproduction (Oxford, England). vol 21. issue 3. 2006-05-09. PMID:16311296. |
nicotine does not affect vascularization but inhibits growth of freely transplanted ovarian follicles by inducing granulosa cell apoptosis. |
2006-05-09 |
2023-08-12 |
Not clear |
| Tao Zhang, Heng Lu, Xuan Shang, Yihao Tian, Congyi Zheng, Shiwen Wang, Hanhua Cheng, Rongjia Zho. Nicotine prevents the apoptosis induced by menadione in human lung cancer cells. Biochemical and biophysical research communications. vol 342. issue 3. 2006-04-19. PMID:16598845. |
nicotine prevents the apoptosis induced by menadione in human lung cancer cells. |
2006-04-19 |
2023-08-12 |
human |
| Tao Zhang, Heng Lu, Xuan Shang, Yihao Tian, Congyi Zheng, Shiwen Wang, Hanhua Cheng, Rongjia Zho. Nicotine prevents the apoptosis induced by menadione in human lung cancer cells. Biochemical and biophysical research communications. vol 342. issue 3. 2006-04-19. PMID:16598845. |
in the present study, we designed a nicotine-apoptosis system, by pre-treatment of nicotine making lung cancer cell a549 to be in a physiological nicotine environment, and observed that nicotine promoted cell proliferation and prevented the menadione-induced apoptosis, and exerts its role of anti-apoptosis by shift of apoptotic stage induced by menadione from late apoptotic stage to early apoptotic stage, in which nf-kappab was up-regulated. |
2006-04-19 |
2023-08-12 |
human |
| Tao Zhang, Heng Lu, Xuan Shang, Yihao Tian, Congyi Zheng, Shiwen Wang, Hanhua Cheng, Rongjia Zho. Nicotine prevents the apoptosis induced by menadione in human lung cancer cells. Biochemical and biophysical research communications. vol 342. issue 3. 2006-04-19. PMID:16598845. |
interference analysis of nf-kappab in a549 cells showed that knock down of nf-kappab resulted in apoptosis promotion and counteracted the protective effect of nicotine. |
2006-04-19 |
2023-08-12 |
human |
| Rezan Demiralay, Nesrin Gürsan, Havva Erde. The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of pulmonary cells. Toxicology. vol 219. issue 1-3. 2006-03-09. PMID:16377052. |
this study was conducted to investigate the frequency of apoptosis in the pulmonary epithelial cells of rats after intratraperitoneal nicotine injection, in order to examine the role of inflammatory markers [myeloperoxidase (mpo) and tumor necrosis factor-alpha (tnf-alpha)] in nicotine-induced lung damage, and to determine the protective effects of three known antioxidant agents [n-acetylcysteine (nac), erdosteine, and vitamin e] on the lung toxicity of nicotine in the lungs. |
2006-03-09 |
2023-08-12 |
rat |
| A C Holloway, G E Lim, J J Petrik, W G Foster, K M Morrison, H C Gerstei. Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes. Diabetologia. vol 48. issue 12. 2006-02-16. PMID:16270195. |
fetal and neonatal exposure to nicotine in wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes. |
2006-02-16 |
2023-08-12 |
rat |
| Yousef Tizabi, Kebreten F Manaye, Robert E Taylo. Nicotine blocks ethanol-induced apoptosis in primary cultures of rat cerebral cortical and cerebellar granule cells. Neurotoxicity research. vol 7. issue 4. 2005-11-15. PMID:16237857. |
nicotine blocks ethanol-induced apoptosis in primary cultures of rat cerebral cortical and cerebellar granule cells. |
2005-11-15 |
2023-08-12 |
rat |
| Yousef Tizabi, Kebreten F Manaye, Robert E Taylo. Nicotine blocks ethanol-induced apoptosis in primary cultures of rat cerebral cortical and cerebellar granule cells. Neurotoxicity research. vol 7. issue 4. 2005-11-15. PMID:16237857. |
in this study we sought to determine whether ethanol induces formation of caspase 3 (reflective of apoptosis) in these cells and whether these effects may be blocked by nicotine pretreatment. |
2005-11-15 |
2023-08-12 |
rat |
| Yousef Tizabi, Kebreten F Manaye, Robert E Taylo. Nicotine blocks ethanol-induced apoptosis in primary cultures of rat cerebral cortical and cerebellar granule cells. Neurotoxicity research. vol 7. issue 4. 2005-11-15. PMID:16237857. |
these results suggest that at least some of the neurotoxic effects of ethanol may be mediated by apoptosis and that pretreatment with nicotine can prevent these effects of ethanol. |
2005-11-15 |
2023-08-12 |
rat |
| Gabriella Argentin, Rosadele Cicchett. Genotoxic and antiapoptotic effect of nicotine on human gingival fibroblasts. Toxicological sciences : an official journal of the Society of Toxicology. vol 79. issue 1. 2005-08-09. PMID:14718647. |
since the correlation between apoptosis and dna damage is already well documented, we investigated the response of human gingival fibroblasts (hgfs) to nicotine exposure by examining its effect on dna damage induction and apoptotic process in parallel. |
2005-08-09 |
2023-08-12 |
human |
| Gabriella Argentin, Rosadele Cicchett. Genotoxic and antiapoptotic effect of nicotine on human gingival fibroblasts. Toxicological sciences : an official journal of the Society of Toxicology. vol 79. issue 1. 2005-08-09. PMID:14718647. |
furthermore, we found that preincubation of hgfs with 1 microm nicotine strongly attenuated staurosporine (stp)-induced apoptosis. |
2005-08-09 |
2023-08-12 |
human |
| Junji Tsurutani, S Sianna Castillo, John Brognard, Courtney A Granville, Chunyu Zhang, Joell J Gills, Jacqueline Sayyah, Phillip A Denni. Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells. Carcinogenesis. vol 26. issue 7. 2005-07-29. PMID:15790591. |
despite similar induction of proliferation, only nicotine decreased apoptosis caused by serum deprivation and/or chemotherapy. |
2005-07-29 |
2023-08-12 |
Not clear |
| Khae-Hawn Kim, Kwan-Joong Joo, Heung-Jae Park, Chil-Hun Kwon, Mi-Hyeon Jang, Chang-Ju Ki. Nicotine induces apoptosis in TM3 mouse Leydig cells. Fertility and sterility. vol 83 Suppl 1. 2005-06-07. PMID:15831280. |
nicotine induces apoptosis in tm3 mouse leydig cells. |
2005-06-07 |
2023-08-12 |
mouse |
| Takahiro Utsumi, Koji Shimoke, Soichiro Kishi, Harue Sasaya, Toshihiko Ikeuchi, Hitoshi Nakayam. Protective effect of nicotine on tunicamycin-induced apoptosis of PC12h cells. Neuroscience letters. vol 370. issue 2-3. 2005-01-31. PMID:15488331. |
protective effect of nicotine on tunicamycin-induced apoptosis of pc12h cells. |
2005-01-31 |
2023-08-12 |
Not clear |
| Takahiro Utsumi, Koji Shimoke, Soichiro Kishi, Harue Sasaya, Toshihiko Ikeuchi, Hitoshi Nakayam. Protective effect of nicotine on tunicamycin-induced apoptosis of PC12h cells. Neuroscience letters. vol 370. issue 2-3. 2005-01-31. PMID:15488331. |
the present study deals with the neuroprotective effect of nicotine on the tunicamycin-induced apoptosis of pc12h cells. |
2005-01-31 |
2023-08-12 |
Not clear |
| Takahiro Utsumi, Koji Shimoke, Soichiro Kishi, Harue Sasaya, Toshihiko Ikeuchi, Hitoshi Nakayam. Protective effect of nicotine on tunicamycin-induced apoptosis of PC12h cells. Neuroscience letters. vol 370. issue 2-3. 2005-01-31. PMID:15488331. |
nicotine dose-dependently prevented the tunicamycin-induced apoptosis. |
2005-01-31 |
2023-08-12 |
Not clear |
| Takahiro Utsumi, Koji Shimoke, Soichiro Kishi, Harue Sasaya, Toshihiko Ikeuchi, Hitoshi Nakayam. Protective effect of nicotine on tunicamycin-induced apoptosis of PC12h cells. Neuroscience letters. vol 370. issue 2-3. 2005-01-31. PMID:15488331. |
hoechst 33258 staining demonstrated the protective effect of nicotine against tunicamycin-induced apoptosis. |
2005-01-31 |
2023-08-12 |
Not clear |
| Sonya Trombino, Alessandra Bisio, Alessia Catassi, Alfredo Cesario, Carla Falugi, Patrizia Russ. Role of the non-neuronal human cholinergic system in lung cancer and mesothelioma: possibility of new therapeutic strategies. Current medicinal chemistry. Anti-cancer agents. vol 4. issue 6. 2005-01-25. PMID:15579018. |
in humans, different studies have showed that many lung cancer cells expressed nachrs and that low concentrations of nicotine blocked the induction of apoptosis in these cells. |
2005-01-25 |
2023-08-12 |
human |
| Sonya Trombino, Alessandra Bisio, Alessia Catassi, Alfredo Cesario, Carla Falugi, Patrizia Russ. Role of the non-neuronal human cholinergic system in lung cancer and mesothelioma: possibility of new therapeutic strategies. Current medicinal chemistry. Anti-cancer agents. vol 4. issue 6. 2005-01-25. PMID:15579018. |
furthermore apoptosis mechanisms in mesothelioma cells are under the control of the cholinergic system (nicotine antiapoptotic via induction of nf-kappab complexes and phosphorilation of bad at serine(112), curare proapoptotic via g(0)-g(1) arrest p21(waf-1)-dependent, but p53-independent). |
2005-01-25 |
2023-08-12 |
human |
| William K K Wu, Chi Hin Ch. The pharmacological actions of nicotine on the gastrointestinal tract. Journal of pharmacological sciences. vol 94. issue 4. 2004-11-15. PMID:15107574. |
in this regard, nicotine and its metabolites are found to be mutagenic and have the ability to modulate cell proliferation, apoptosis, and angiogenesis during tumoriogenesis through specific receptors and signalling pathways. |
2004-11-15 |
2023-08-12 |
Not clear |