| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Hakki, K Pennypacker, S Eidizadeh, H Friedman, S Pros. Nicotine inhibition of apoptosis in murine immune cells. Experimental biology and medicine (Maywood, N.J.). vol 226. issue 10. 2001-12-21. PMID:11682702. |
this study examined the effects and the mechanisms of action of nicotine on dexamethasone (dex)-induced apoptosis in murine immune cells by examining the expression of levels of the 17-kda active caspase-3, a marker of apoptosis. |
2001-12-21 |
2023-08-12 |
mouse |
| A Hakki, K Pennypacker, S Eidizadeh, H Friedman, S Pros. Nicotine inhibition of apoptosis in murine immune cells. Experimental biology and medicine (Maywood, N.J.). vol 226. issue 10. 2001-12-21. PMID:11682702. |
thymocytes and splenocytes from adult balb/c female mice were incubated with concentrations of nicotine correlating to those found in the blood and tissue of smokers (0.01 microg/ml [0.022 microm] and 1 microg/ml [2.2 microm]), concurrently with 100 nm dex, to induce apoptosis. |
2001-12-21 |
2023-08-12 |
mouse |
| A Hakki, K Pennypacker, S Eidizadeh, H Friedman, S Pros. Nicotine inhibition of apoptosis in murine immune cells. Experimental biology and medicine (Maywood, N.J.). vol 226. issue 10. 2001-12-21. PMID:11682702. |
these data support that nicotine is an important immunomodulator at the level of immune cell apoptosis, a process thought to be a contributory mechanism of autoimmunity, cardiovascular disease, and carcinogenesis. |
2001-12-21 |
2023-08-12 |
mouse |
| N Sugano, T Minegishi, K Kawamoto, K It. Nicotine inhibits UV-induced activation of the apoptotic pathway. Toxicology letters. vol 125. issue 1-3. 2001-12-20. PMID:11701223. |
in the study presented here, we examined the effects of nicotine on the process of apoptosis. |
2001-12-20 |
2023-08-12 |
human |
| N Sugano, T Minegishi, K Kawamoto, K It. Nicotine inhibits UV-induced activation of the apoptotic pathway. Toxicology letters. vol 125. issue 1-3. 2001-12-20. PMID:11701223. |
preincubation of human cells with nicotine completely inhibited ultraviolet light (uv)-induced apoptosis. |
2001-12-20 |
2023-08-12 |
human |
| N Sugano, T Minegishi, K Kawamoto, K It. Nicotine inhibits UV-induced activation of the apoptotic pathway. Toxicology letters. vol 125. issue 1-3. 2001-12-20. PMID:11701223. |
the inhibition of apoptosis by nicotine was correlated with the prevention of cytochrome c release and caspase activation, which are essential components of the uv-induced apoptotic pathway. |
2001-12-20 |
2023-08-12 |
human |
| N Sugano, T Minegishi, K Kawamoto, K It. Nicotine inhibits UV-induced activation of the apoptotic pathway. Toxicology letters. vol 125. issue 1-3. 2001-12-20. PMID:11701223. |
thus, our results suggest that the inhibition of apoptosis by nicotine contributes to the increased incidence of cancer in smokers. |
2001-12-20 |
2023-08-12 |
human |
| P K Tithof, M Elgayyar, H M Schuller, M Barnhill, R Andrew. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a nicotine derivative, induces apoptosis of endothelial cells. American journal of physiology. Heart and circulatory physiology. vol 281. issue 5. 2001-12-05. PMID:11668055. |
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a nicotine derivative, induces apoptosis of endothelial cells. |
2001-12-05 |
2023-08-12 |
Not clear |
| M A Mariggiò, L Guida, A Laforgia, R Santacroce, E Curci, P Montemurro, R Fumarul. Nicotine effects on polymorphonuclear cell apoptosis and lipopolysaccharide-induced monocyte functions. A possible role in periodontal disease? Journal of periodontal research. vol 36. issue 1. 2001-04-26. PMID:11246702. |
nicotine effects on polymorphonuclear cell apoptosis and lipopolysaccharide-induced monocyte functions. |
2001-04-26 |
2023-08-12 |
Not clear |
| M A Mariggiò, L Guida, A Laforgia, R Santacroce, E Curci, P Montemurro, R Fumarul. Nicotine effects on polymorphonuclear cell apoptosis and lipopolysaccharide-induced monocyte functions. A possible role in periodontal disease? Journal of periodontal research. vol 36. issue 1. 2001-04-26. PMID:11246702. |
to learn more about the effects of nicotine on the periodontal environment, we studied its ability to modulate the apoptosis of two phagocytic lines, pmn and mononuclear cells, which are continuously recruited from gingival vessels to prevent or control plaque extension. |
2001-04-26 |
2023-08-12 |
Not clear |
| M A Mariggiò, L Guida, A Laforgia, R Santacroce, E Curci, P Montemurro, R Fumarul. Nicotine effects on polymorphonuclear cell apoptosis and lipopolysaccharide-induced monocyte functions. A possible role in periodontal disease? Journal of periodontal research. vol 36. issue 1. 2001-04-26. PMID:11246702. |
brief exposure of pmn to nicotine concentrations ranging from 0.01 to 0.3% shortened, in a dose-dependent relationship, the lag culture time required to observe at fluorescent microscopy the morphological traces of apoptosis. |
2001-04-26 |
2023-08-12 |
Not clear |
| R Garrido, M P Mattson, B Hennig, M Tobore. Nicotine protects against arachidonic-acid-induced caspase activation, cytochrome c release and apoptosis of cultured spinal cord neurons. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238724. |
nicotine protects against arachidonic-acid-induced caspase activation, cytochrome c release and apoptosis of cultured spinal cord neurons. |
2001-04-05 |
2023-08-12 |
Not clear |
| R Garrido, M P Mattson, B Hennig, M Tobore. Nicotine protects against arachidonic-acid-induced caspase activation, cytochrome c release and apoptosis of cultured spinal cord neurons. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238724. |
in addition, because nicotine can exert a variety of neuroprotective effects, we hypothesized that it can prevent arachidonic acid induced apoptosis of spinal cord neurons. |
2001-04-05 |
2023-08-12 |
Not clear |
| O Genbacev, M T McMaster, J Lazic, S Nedeljkovic, M Cvetkovic, R Joslin, S J Fishe. Concordant in situ and in vitro data show that maternal cigarette smoking negatively regulates placental cytotrophoblast passage through the cell cycle. Reproductive toxicology (Elmsford, N.Y.). vol 14. issue 6. 2001-01-04. PMID:11099875. |
nicotine (0.23 to 6.0 microm) negatively affected the expression of a number of cell cycle regulators/markers and brdu incorporation, without discernable effects on apoptosis. |
2001-01-04 |
2023-08-12 |
Not clear |
| N Sugano, K It. Nicotine switches the form of H(2)O(2)-induced cell death from apoptosis to necrosis in U937 cells. Immunology letters. vol 72. issue 3. 2000-08-15. PMID:10880836. |
nicotine switches the form of h(2)o(2)-induced cell death from apoptosis to necrosis in u937 cells. |
2000-08-15 |
2023-08-12 |
Not clear |
| N Sugano, K It. Nicotine switches the form of H(2)O(2)-induced cell death from apoptosis to necrosis in U937 cells. Immunology letters. vol 72. issue 3. 2000-08-15. PMID:10880836. |
the present study examined the effect of nicotine on h(2)o(2)-induced apoptosis in u937 cells. |
2000-08-15 |
2023-08-12 |
Not clear |
| N Sugano, K It. Nicotine switches the form of H(2)O(2)-induced cell death from apoptosis to necrosis in U937 cells. Immunology letters. vol 72. issue 3. 2000-08-15. PMID:10880836. |
in the presence of 1 microg/ml nicotine, cell viability was not affected, but the cells were unable to undergo h(2)o(2)-induced apoptosis and instead died as a result of necrosis. |
2000-08-15 |
2023-08-12 |
Not clear |
| W L Heusch, R Maneckje. Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis. vol 19. issue 4. 1998-06-04. PMID:9600337. |
signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. |
1998-06-04 |
2023-08-12 |
human |
| W L Heusch, R Maneckje. Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis. vol 19. issue 4. 1998-06-04. PMID:9600337. |
the present study provides evidence that nicotine (a) activates the mitogen-activated protein (map) kinase signalling pathway in lung cancer cells, specifically extracellular signal-regulated kinase (erk2), resulting in increased expression of the bcl-2 protein and inhibition of apoptosis in these cells; and (b) blocks the inhibition of protein kinase c (pkc) and erk2 activity in lung cancer cells by anti-cancer agents, such as therapeutic opioid drugs, and thus can adversely affect cancer therapy. |
1998-06-04 |
2023-08-12 |
human |
| W L Heusch, R Maneckje. Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis. vol 19. issue 4. 1998-06-04. PMID:9600337. |
nicotine appears to have no effect on the activities of c-jun nh2-terminal protein kinase (jnk) and p38 map kinases, which have also been shown to be involved in apoptosis. |
1998-06-04 |
2023-08-12 |
human |