| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Hakki, H Friedman, S Pros. Nicotine modulation of apoptosis in human coronary artery endothelial cells. International immunopharmacology. vol 2. issue 10. 2003-04-30. PMID:12400870. |
nicotine modulation of apoptosis in human coronary artery endothelial cells. |
2003-04-30 |
2023-08-12 |
human |
| A Hakki, H Friedman, S Pros. Nicotine modulation of apoptosis in human coronary artery endothelial cells. International immunopharmacology. vol 2. issue 10. 2003-04-30. PMID:12400870. |
it has been recently reported that nicotine, the addictive component of tobacco, is an important modulator at the level of immune cell apoptosis or programmed cell death. |
2003-04-30 |
2023-08-12 |
human |
| A Hakki, H Friedman, S Pros. Nicotine modulation of apoptosis in human coronary artery endothelial cells. International immunopharmacology. vol 2. issue 10. 2003-04-30. PMID:12400870. |
the present study examined the effects and the mechanisms of action of nicotine on apoptosis in human coronary artery endothelial cells (hcaecs). |
2003-04-30 |
2023-08-12 |
human |
| A Hakki, H Friedman, S Pros. Nicotine modulation of apoptosis in human coronary artery endothelial cells. International immunopharmacology. vol 2. issue 10. 2003-04-30. PMID:12400870. |
cultured hcaecs were treated with nicotine at a concentration that correlates with the tissue level of smokers (1 microg/ml), concurrently with tumor necrosis factor-alpha (tnf-alpha) and dexamethasone to induce apoptosis. |
2003-04-30 |
2023-08-12 |
human |
| A Hakki, H Friedman, S Pros. Nicotine modulation of apoptosis in human coronary artery endothelial cells. International immunopharmacology. vol 2. issue 10. 2003-04-30. PMID:12400870. |
the data showed that nicotine significantly inhibited apoptosis in hcaecs, as verified by the decreased expression level of active caspases compared to cells treated with the apoptosis inducers alone. |
2003-04-30 |
2023-08-12 |
human |
| A Hakki, H Friedman, S Pros. Nicotine modulation of apoptosis in human coronary artery endothelial cells. International immunopharmacology. vol 2. issue 10. 2003-04-30. PMID:12400870. |
this action of nicotine on apoptosis in human coronary artery endothelial cells suggests that nicotine may have an impact on cardiovascular pathology and atherogenesis. |
2003-04-30 |
2023-08-12 |
human |
| Kip A West, John Brognard, Amy S Clark, Ilona R Linnoila, Xiaowei Yang, Sandra M Swain, Curtis Harris, Steven Belinsky, Phillip A Denni. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. The Journal of clinical investigation. vol 111. issue 1. 2003-03-03. PMID:12511591. |
treatment with nicotine or nnk attenuated apoptosis caused by etoposide, ultraviolet irradiation, or hydrogen peroxide and partially induced a transformed phenotype manifest as loss of contact inhibition and loss of dependence on exogenous growth factors or adherence to ecm. |
2003-03-03 |
2023-08-12 |
mouse |
| Kip A West, John Brognard, Amy S Clark, Ilona R Linnoila, Xiaowei Yang, Sandra M Swain, Curtis Harris, Steven Belinsky, Phillip A Denni. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. The Journal of clinical investigation. vol 111. issue 1. 2003-03-03. PMID:12511591. |
redundant akt activation by nicotine and nnk could contribute to tobacco-related carcinogenesis by regulating two processes critical for tumorigenesis, cell growth and apoptosis. |
2003-03-03 |
2023-08-12 |
mouse |
| Jun Suzuki, Evelyn Bayna, Erminia Dalle Molle, Wilbur Y W Le. Nicotine inhibits cardiac apoptosis induced by lipopolysaccharide in rats. Journal of the American College of Cardiology. vol 41. issue 3. 2003-02-25. PMID:12575980. |
nicotine inhibits cardiac apoptosis induced by lipopolysaccharide in rats. |
2003-02-25 |
2023-08-12 |
rat |
| Jun Suzuki, Evelyn Bayna, Erminia Dalle Molle, Wilbur Y W Le. Nicotine inhibits cardiac apoptosis induced by lipopolysaccharide in rats. Journal of the American College of Cardiology. vol 41. issue 3. 2003-02-25. PMID:12575980. |
it was hypothesized that nicotine, which inhibits apoptosis in several cells, inhibits cardiac apoptosis induced by lipopolysaccharide (lps). |
2003-02-25 |
2023-08-12 |
rat |
| Haiqiang Mai, W Stratford May, Fengqin Gao, Zhaohui Jin, Xingming Den. A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis. The Journal of biological chemistry. vol 278. issue 3. 2003-02-14. PMID:12421819. |
a functional role for nicotine in bcl2 phosphorylation and suppression of apoptosis. |
2003-02-14 |
2023-08-12 |
Not clear |
| Haiqiang Mai, W Stratford May, Fengqin Gao, Zhaohui Jin, Xingming Den. A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis. The Journal of biological chemistry. vol 278. issue 3. 2003-02-14. PMID:12421819. |
nicotine is not only a major component in tobacco but is also a survival agonist that inhibits apoptosis induced by diverse stimuli including chemotherapeutic drugs. |
2003-02-14 |
2023-08-12 |
Not clear |
| Haiqiang Mai, W Stratford May, Fengqin Gao, Zhaohui Jin, Xingming Den. A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis. The Journal of biological chemistry. vol 278. issue 3. 2003-02-14. PMID:12421819. |
however, the intracellular mechanism(s) involved in nicotine suppression of apoptosis is unclear. |
2003-02-14 |
2023-08-12 |
Not clear |
| Haiqiang Mai, W Stratford May, Fengqin Gao, Zhaohui Jin, Xingming Den. A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis. The Journal of biological chemistry. vol 278. issue 3. 2003-02-14. PMID:12421819. |
furthermore, et-18-och3, a specific phospholipase c (plc) inhibitor, blocks nicotine-stimulated bcl2 phosphorylation and promotes apoptosis, suggesting that plc may be involved in nicotine activation of bcl2 kinases. |
2003-02-14 |
2023-08-12 |
Not clear |
| M Soor. Hormone mediation of immune responses in the progression of diabetes, rheumatoid arthritis and periodontal diseases. Current drug targets. Immune, endocrine and metabolic disorders. vol 2. issue 1. 2003-01-28. PMID:12477294. |
nicotine has well documented effects on the immune response, cell adhesion proteins and apoptosis which affect the severity of disease presentation and response to treatment. |
2003-01-28 |
2023-08-12 |
Not clear |
| Mi-Hyeon Jang, Min-Chul Shin, Sae-Bin Jung, Taeck-Hyun Lee, Geon-Ho Bahn, Yunhee Kim Kwon, Ee-Hwa Kim, Chang-Ju Ki. Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus. Neuroreport. vol 13. issue 12. 2002-10-23. PMID:12218695. |
alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus. |
2002-10-23 |
2023-08-12 |
rat |
| Mi-Hyeon Jang, Min-Chul Shin, Sae-Bin Jung, Taeck-Hyun Lee, Geon-Ho Bahn, Yunhee Kim Kwon, Ee-Hwa Kim, Chang-Ju Ki. Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus. Neuroreport. vol 13. issue 12. 2002-10-23. PMID:12218695. |
in the present study, the effects of alcohol and nicotine on cell proliferation and apoptosis in the dentate gyrus of young rats were investigated. |
2002-10-23 |
2023-08-12 |
rat |
| Yu-Ping Wu, Kazuko Kita, Nobuo Suzuk. Involvement of human heat shock protein 90 alpha in nicotine-induced apoptosis. International journal of cancer. vol 100. issue 1. 2002-07-29. PMID:12115584. |
there have been conflicting reports of the apoptotic effects of nicotine on human cells and those studies reporting nicotine-induced apoptosis have not unequivocally clarified the molecular mechanisms underlying the effect. |
2002-07-29 |
2023-08-12 |
human |
| Yu-Ping Wu, Kazuko Kita, Nobuo Suzuk. Involvement of human heat shock protein 90 alpha in nicotine-induced apoptosis. International journal of cancer. vol 100. issue 1. 2002-07-29. PMID:12115584. |
however, we found here that human rsa cells, established from embryonic fibroblastic cells doubly infected with rous sarcoma virus and simian virus 40, underwent apoptosis when cultured with medium containing 0.06-0.6 microm nicotine. |
2002-07-29 |
2023-08-12 |
human |
| Yu-Ping Wu, Kazuko Kita, Nobuo Suzuk. Involvement of human heat shock protein 90 alpha in nicotine-induced apoptosis. International journal of cancer. vol 100. issue 1. 2002-07-29. PMID:12115584. |
thus, it was suggested that nicotine induces apoptosis, possibly via hsp90 alpha expression, in human cells tested. |
2002-07-29 |
2023-08-12 |
human |