| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mina Gholami, Daniel J Klionsky, Majid Motaghineja. Preventive Effects of Crocin, a Key Carotenoid Component in Saffron, Against Nicotine-Triggered Neurodegeneration in Rat Hippocampus: Possible Role of Autophagy and Apoptosis. International journal of preventive medicine. vol 15. 2024-11-14. PMID:39539579. |
nicotine is a behavioral stimulant that in high doses, through the neuro-inflammatory and oxidative stress pathway, can induce apoptosis and autophagy leading to cell death. |
2024-11-14 |
2024-11-17 |
rat |
| Jitender Kumar Bhardwaj, Anshu Siwach, Som Nath Sachdev. Nicotine as a female reproductive toxicant-A review. Journal of applied toxicology : JAT. 2024-09-26. PMID:39323358. |
it's been demonstrated that nicotine might cause oxidative stress, apoptosis, hormonal imbalance, abnormalities in chromosomal segregation, impact oocyte development, and disruption in ovarian morphology and functions. |
2024-09-26 |
2024-09-28 |
Not clear |
| Xufeng Li, Hao Xiao, Zhixin Wu, Hui Wang, Liaobin Che. The Increased Apoptosis of Mesenchymal Stem Cells Mediated Osteopenia Due to Prenatal Nicotine Exposure in Female Offspring Rats via IGF1 Pathway. Environmental toxicology. 2024-08-29. PMID:39207236. |
the increased apoptosis of mesenchymal stem cells mediated osteopenia due to prenatal nicotine exposure in female offspring rats via igf1 pathway. |
2024-08-29 |
2024-09-04 |
rat |
| Si-Yuan Zhou, Jia-Min Du, Wen-Jing Li, Qi-Yun Liu, Qun-Ye Zhang, Guo-Hai Su, Ying L. The roles and regulatory mechanisms of cigarette smoke constituents in vascular remodeling. International immunopharmacology. vol 140. 2024-07-31. PMID:39083928. |
in this review, we overview the progression of major components of cigarette smoke (cs), such as nicotine and acrolein, involved in vascular remodeling in terms of ecs injury, vsmcs proliferation, migration, apoptosis, and ecm disruption. |
2024-07-31 |
2024-08-03 |
Not clear |
| Veno Kononenko, Ahmad Joukhan, Tadeja Bele, Igor Križaj, Slavko Kralj, Tom Turk, Damjana Drobn. Gelatin nanoparticles loaded with 3-alkylpyridinium salt APS7, an analog of marine toxin, are a promising support in human lung cancer therapy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-21. PMID:38906020. |
by nicotine), cancer cells begin to proliferate and become more resistant to chemotherapy-induced apoptosis. |
2024-06-21 |
2024-06-24 |
human |
| Khaja Shameem Mohammed Abdul, Kimin Han, Alyssa B Guerrero, Cekia N Wilson, Amogh Kulkarni, Nicole H Purcel. Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes. Journal of molecular and cellular cardiology. 2024-06-08. PMID:38851627. |
in cardiomyocytes, nicotine significantly increased nadph oxidase 4 (nox4), which coincided with increased reactive oxygen species (ros) and increased cardiomyocyte apoptosis which were dependent on phlpp1 expression. |
2024-06-08 |
2024-06-11 |
Not clear |
| Xiaofeng Zhou, Yingting He, Hongyan Quan, Jinghao Yang, Shuo Li, Yao Jiang, Jiaqi Li, Xiaolong Yua. Exposure to nicotine regulates prostaglandin E2 secretion and autophagy of granulosa cells to retard follicular maturation in mammals. Ecotoxicology and environmental safety. vol 277. 2024-04-23. PMID:38653025. |
in this study, we notably found that nicotine was likely to specifically raise the expression of histone deacetylase 3 (hdac3) to promote the apoptosis and autophagy of granulosa cells (gcs) and block follicular maturation. |
2024-04-23 |
2024-04-26 |
Not clear |
| Xiaofeng Zhou, Yingting He, Hongyan Quan, Jinghao Yang, Shuo Li, Yao Jiang, Jiaqi Li, Xiaolong Yua. Exposure to nicotine regulates prostaglandin E2 secretion and autophagy of granulosa cells to retard follicular maturation in mammals. Ecotoxicology and environmental safety. vol 277. 2024-04-23. PMID:38653025. |
moreover, prostaglandin e2 (pge2) inhibited the apoptosis of gcs and facilitated follicular maturation, and nicotine appeared to inhibit pge2 secretion by freezing the expression of cyclooxygenase 1 (cox1), which was the rate-limiting and essential enzyme for pge2 synthesis. |
2024-04-23 |
2024-04-26 |
Not clear |
| Hind Al Khashali, Ban Darweesh, Ravel Ray, Ben Haddad, Caroline Wozniak, Robert Ranzenberger, Stuti Goel, Jeneen Khalil, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Regulation of Vascular Endothelial Growth Factor Signaling by Nicotine in a Manner Dependent on Acetylcholine-and/or β-Adrenergic-Receptors in Human Lung Cancer Cells. Cancers. vol 15. issue 23. 2023-12-09. PMID:38067204. |
the addition of anti-vegf antibodies to a549 and h1299 cells decreased cell viability and increased apoptosis; blocked the activities of pi3k, akt, and nfκb in the absence or presence of nicotine; and resulted in increased p53 activation in a549 cells. |
2023-12-09 |
2023-12-17 |
human |
| Ünal Öztekin, Mehmet Caniklioğlu, Şükrü Ateş, Züleyha Doğanyiğit, Emin Kaymak, Fatih Fırat, Ayşe Yeşim Göçmen, Fatih Ataç, Rukset Attar, Seher Yılma. The effect of Cornus mas extract on nıcotıne-ınduced oxıdatıve stress and ıntratestıcular damage ın male rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015512. |
we have shown that nicotine increases testicular damage, causes apoptosis of testicular cells and adversely affects spermatogenesis by increasing inflammation. |
2023-11-28 |
2023-11-29 |
rat |
| Hu Jin, Longmeng Cao, Dachao Tang, Xiaochun Da. Endogenous ligand of the APJ receptor Apelin-13 inhibits cell apoptosis and oxidative stress of cardiomyocytes. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015520. |
to establish an h9c2 cell model of nicotine-induced apoptosis, h9c2 cells were divided into the control group, nicotine group, and apelin-13+nicotine group. |
2023-11-28 |
2023-11-29 |
Not clear |
| Hu Jin, Longmeng Cao, Dachao Tang, Xiaochun Da. Endogenous ligand of the APJ receptor Apelin-13 inhibits cell apoptosis and oxidative stress of cardiomyocytes. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015520. |
the results revealed that the expression of b-cell lymphoma-2 (bcl-2) was remarkably down-regulated (p<0.01), while the apoptosis rate and the expressions of apoptosis-related proteins (bcl-2-associated x protein (bax) and cysteinyl aspartate specific proteinase-3 (caspase-3)) were significantly up-regulated (p<0.01) in the nicotine group. |
2023-11-28 |
2023-11-29 |
Not clear |
| Ravel Ray, Stuti Goel, Hind Al Khashali, Ban Darweesh, Ben Haddad, Caroline Wozniak, Robert Ranzenberger, Jeneen Khalil, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Regulation of Soluble E-Cadherin Signaling in Non-Small-Cell Lung Cancer Cells by Nicotine, BDNF, and β-Adrenergic Receptor Ligands. Biomedicines. vol 11. issue 9. 2023-09-28. PMID:37760996. |
in investigating the function of se-cad, we found that immunodepletion of se-cad from the media of a549 cells untreated or treated with bdnf, nicotine, or epinephrine reduced activation of egfr and igf-1r, decreased pi3k and erk1/2 activities, increased p53 activation, decreased cell viability, and increased apoptosis, while no effects were found using h1299 cells under all conditions tested. |
2023-09-28 |
2023-10-07 |
Not clear |
| Muhammed Mehdi Üremiş, Elif Gürel, Meral Aslan, Elif Taşlıder. Dexpanthenol protects against nicotine-induced kidney injury by reducing oxidative stress and apoptosis through activation of the AKT/Nrf2/HO-1 pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-22. PMID:37606756. |
nicotine has been shown to induce kidney damage through the mechanisms of oxidative stress and apoptosis. |
2023-08-22 |
2023-09-07 |
rat |
| Wafaa A Hewedy, Shaymaa A Abdulmalek, Doaa A Ghareeb, Esraa S Habib. AMPK-mediated autophagy is involved in the protective effect of canagliflozin in the vitamin D3 plus nicotine calcification model in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023-07-31. PMID:37522915. |
a mutual interplay between inflammation, oxidative stress, apoptosis, and autophagy is implicated in its development. herein, we aimed to evaluate the potential protective effects of canagliflozin in a vitamin d3 plus nicotine (vdn) model of vc, and to explore potential mechanisms. |
2023-07-31 |
2023-08-14 |
rat |
| Rita Chaaya, Joel R Steele, Brian G Oliver, Hui Chen, Rita Machaalan. Effects of e-vapour and high-fat diet on the immunohistochemical staining of nicotinic acetylcholine receptors, apoptosis, microglia and astrocytes in the adult male mouse hippocampus. Journal of chemical neuroanatomy. 2023-06-21. PMID:37343645. |
this study, using a mouse model, investigated the effects of exposure to e-vapour (± nicotine) and hfd (43% fat) consumption, on the expression of nicotinic acetylcholine receptor (nachr) subunits α3, α4, α7 and β2, apoptosis markers caspase-3 and tunel, microglial marker iba-1, and astrocyte marker gfap, in hippocampal subregions of dentate gyrus (dg) and cornu ammonis (ca) 1-3. |
2023-06-21 |
2023-08-14 |
mouse |
| Rita Chaaya, Joel R Steele, Brian G Oliver, Hui Chen, Rita Machaalan. Effects of e-vapour and high-fat diet on the immunohistochemical staining of nicotinic acetylcholine receptors, apoptosis, microglia and astrocytes in the adult male mouse hippocampus. Journal of chemical neuroanatomy. 2023-06-21. PMID:37343645. |
these findings highlight that e-vapour itself alters nachrs, particularly in the ca2 subregion, associated with a decrease in neuroinflammatory response (iba-1) across the whole hippocampus, and the addition of nicotine increases cell apoptosis across the whole hippocampus. |
2023-06-21 |
2023-08-14 |
mouse |
| Rita Chaaya, Joel R Steele, Brian G Oliver, Hui Chen, Rita Machaalan. Effects of e-vapour and high-fat diet on the immunohistochemical staining of nicotinic acetylcholine receptors, apoptosis, microglia and astrocytes in the adult male mouse hippocampus. Journal of chemical neuroanatomy. 2023-06-21. PMID:37343645. |
hfd alone was not detrimental in our model, but in the presence of nicotine-free e-vapour, it differentially affected apoptosis, while the addition of nicotine increased nachr subunits. |
2023-06-21 |
2023-08-14 |
mouse |
| Qiao-Ran Sun, Dan-Ya Wu, Jing-Jing Zhang, Lin-Hui Wu, Xia Zhang, Jilong Zhou, Yi-Liang Mia. Nicotine exposure disrupts placental development via the Notch signaling pathway. Reproduction (Cambridge, England). 2023-06-13. PMID:37310899. |
in this study, we found that nicotine significantly elevated reactive oxygen species, dna damage and cell apoptosis levels with the decrease of blastocyst formation during early embryonic development. |
2023-06-13 |
2023-08-14 |
Not clear |
| Xin Xiao, Juan Xu, Xiaoan Sheng, Chao Wang, Juanjuan Dong, Xianfeng Sh. Tobacco nicotine promotes TRAIL resistance in lung cancer through SNHG5. Experimental and therapeutic medicine. vol 25. issue 3. 2023-02-27. PMID:36845946. |
therefore, nicotine promoted trail resistance in lung cancer through snhg5/x-linked inhibitor of apoptosis protein. |
2023-02-27 |
2023-08-14 |
Not clear |