| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruinan Xing, Xiaoli Cheng, Yanping Qi, Xiaoxiang Tian, Chenghui Yan, Dan Liu, Yaling Ha. Low-dose nicotine promotes autophagy of cardiomyocytes by upregulating HO-1 expression. Biochemical and biophysical research communications. vol 522. issue 4. 2020-08-31. PMID:31813548. |
furthermore, low-dose nicotine improved the inhibited autophagy and increased apoptosis induced by palmitic acid (pa) in nmcms and these effects were reversed by knocking down ho-1. |
2020-08-31 |
2023-08-13 |
mouse |
| Ruinan Xing, Xiaoli Cheng, Yanping Qi, Xiaoxiang Tian, Chenghui Yan, Dan Liu, Yaling Ha. Low-dose nicotine promotes autophagy of cardiomyocytes by upregulating HO-1 expression. Biochemical and biophysical research communications. vol 522. issue 4. 2020-08-31. PMID:31813548. |
in conclusion, our data suggested that low-dose nicotine promoted autophagy and inhibited apoptosis of cardiomyocytes by upregulating ho-1. |
2020-08-31 |
2023-08-13 |
mouse |
| Shugo Suzuki, Samuel M Cohen, Lora L Arnold, Karen L Pennington, Hiroyuki Kato, Taku Naiki, Aya Naiki-Ito, Yoriko Yamashita, Satoru Takahash. Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo. Toxicology. vol 429. 2020-08-17. PMID:31678612. |
cytotoxicity detected by scanning electron microscopy and apoptosis in the bladder urothelium were induced by nicotine but not cotinine. |
2020-08-17 |
2023-08-13 |
human |
| Qichen Yang, Vishal Jhanji, Sze Qin Tan, Kwok Ping Chan, Di Cao, Wai Kit Chu, Mingzhi Zhang, Chi Pui Pang, Tsz Kin N. Continuous exposure of nicotine and cotinine retards human primary pterygium cell proliferation and migration. Journal of cellular biochemistry. vol 120. issue 3. 2020-04-06. PMID:30260034. |
continuous exposure to the mixture of 0.15 μm nicotine and 2 μm cotinine retarded pterygium cell proliferation by 16.04% (p = 0.009) and hindered their migration by 11.93% ( p = 0.039), without affecting cell apoptosis. |
2020-04-06 |
2023-08-13 |
human |
| H Zhaleh, A Amer Ridha, K Amin. Low concentrations of methamphetamine can suppress inflammation in trophoblast JEG-3 cell line induced by nicotine. Bratislavske lekarske listy. vol 121. issue 3. 2020-03-09. PMID:32115981. |
nicotine at high concentrations induces apoptosis in trophoblastic cells through induction of cell cytotoxicity and reactive oxygen species (ros). |
2020-03-09 |
2023-08-13 |
Not clear |
| E L Durham, C Balog, R N Howie, M A Boyce, J R Arand, G Warren, A C LaRue, J J Cra. Effects of nicotine exposure on murine mandibular development. PloS one. vol 14. issue 6. 2020-02-19. PMID:31194840. |
histological investigation of molars revealed an increase in proliferation and a decrease in apoptosis with nicotine exposure. |
2020-02-19 |
2023-08-13 |
mouse |
| Alessia Santoro, Carlo Tomino, Giulia Prinzi, Palma Lamonaca, Vittorio Cardaci, Massimo Fini, Patrizia Russ. Tobacco Smoking: Risk to Develop Addiction, Chronic Obstructive Pulmonary Disease, and Lung Cancer. Recent patents on anti-cancer drug discovery. vol 14. issue 1. 2019-12-06. PMID:30605063. |
nicotine, through the non-neuronal α7nicotinic receptor, induces cell proliferation, neo-angiogenesis, epithelial to mesenchymal transition, and inhibits drug-induced apoptosis. |
2019-12-06 |
2023-08-13 |
Not clear |
| Amiya P Sinha-Hikim, Indrani Sinha-Hikim, Theodore C Friedma. Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease: Cellular and Mechanistic Insights. Frontiers in endocrinology. vol 8. 2019-11-20. PMID:28239368. |
emerging evidence now suggests that nicotine exacerbates hepatic steatosis triggered by hfd, through increased oxidative stress and hepatocellular apoptosis, decreased phosphorylation (inactivation) of adenosine-5-monophosphate-activated protein kinase and, in turn, up-regulation of sterol response-element binding protein 1-c, fatty acid synthase, and activation of acetyl-coenzyme a-carboxylase, leading to increased hepatic lipogenesis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Chunxiao Wang, Wenwen Niu, Hui Chen, Ni Shi, Dian He, Min Zhang, Lihua Ge, Zhenchuan Tian, Moci Qi, Tong Chen, Xiaofei Tan. Nicotine suppresses apoptosis by regulating α7nAChR/Prx1 axis in oral precancerous lesions. Oncotarget. vol 8. issue 43. 2019-11-20. PMID:29088845. |
nicotine suppresses apoptosis by regulating α7nachr/prx1 axis in oral precancerous lesions. |
2019-11-20 |
2023-08-13 |
Not clear |
| Chunxiao Wang, Wenwen Niu, Hui Chen, Ni Shi, Dian He, Min Zhang, Lihua Ge, Zhenchuan Tian, Moci Qi, Tong Chen, Xiaofei Tan. Nicotine suppresses apoptosis by regulating α7nAChR/Prx1 axis in oral precancerous lesions. Oncotarget. vol 8. issue 43. 2019-11-20. PMID:29088845. |
in the present study, we investigate the effects of nicotine in oral precancerous lesions focusing on apoptosis and nachr/prx1 signaling. |
2019-11-20 |
2023-08-13 |
Not clear |
| Chunxiao Wang, Wenwen Niu, Hui Chen, Ni Shi, Dian He, Min Zhang, Lihua Ge, Zhenchuan Tian, Moci Qi, Tong Chen, Xiaofei Tan. Nicotine suppresses apoptosis by regulating α7nAChR/Prx1 axis in oral precancerous lesions. Oncotarget. vol 8. issue 43. 2019-11-20. PMID:29088845. |
we detected expression of prx1, α3nachr, α7nachr, phosphorylation of mitogen-activated protein kinases (mapk) and apoptosis in dysplastic oral keratinocyte (dok) cells as well as in 4-nitroquinoline 1-oxide (4nqo) or 4nqo + nicotine - induced oral precancerous lesions in prx1 wild-type (prx1 |
2019-11-20 |
2023-08-13 |
Not clear |
| Han-Xiao Liu, Sha Liu, Wen Qu, Hui-Yi Yan, Xiao Wen, Ting Chen, Li-Fang Hou, Jie Pin. α7 nAChR mediated Fas demethylation contributes to prenatal nicotine exposure-induced programmed thymocyte apoptosis in mice. Oncotarget. vol 8. issue 55. 2019-11-20. PMID:29212186. |
α7 nachr mediated fas demethylation contributes to prenatal nicotine exposure-induced programmed thymocyte apoptosis in mice. |
2019-11-20 |
2023-08-13 |
mouse |
| Han-Xiao Liu, Sha Liu, Wen Qu, Hui-Yi Yan, Xiao Wen, Ting Chen, Li-Fang Hou, Jie Pin. α7 nAChR mediated Fas demethylation contributes to prenatal nicotine exposure-induced programmed thymocyte apoptosis in mice. Oncotarget. vol 8. issue 55. 2019-11-20. PMID:29212186. |
this study aimed to investigate the effects of prenatal nicotine exposure (pne) on thymocyte apoptosis and postnatal immune impairments |
2019-11-20 |
2023-08-13 |
mouse |
| Tao Li, Jun Zhang, Jiahui Zhang, Nannan Zhang, Yang Zeng, Shengnan Tang, Zehua Tao, Xiying Qu, Jue Jia, Wei Zhu, Xiaochun Sun, Huabiao Che. Nicotine-enhanced stemness and epithelial-mesenchymal transition of human umbilical cord mesenchymal stem cells promote tumor formation and growth in nude mice. Oncotarget. vol 9. issue 1. 2019-11-20. PMID:29416638. |
we found that nicotine has a toxic effect on huc-mscs and changes the morphology, inhibits proliferation and promotes apoptosis of huc-mscs in a dose-dependent manner. |
2019-11-20 |
2023-08-13 |
mouse |
| S Syam Das, S S Nair, M Indir. Atorvastatin modulates drug transporters and ameliorates nicotine-induced testicular toxicity. Andrologia. vol 50. issue 6. 2019-07-23. PMID:29740849. |
nicotine administration activated apoptosis and downregulated slcob1, which transport atorvastatin. |
2019-07-23 |
2023-08-13 |
rat |
| Xiaofang Cao, Chunling Han, Jinsuo Wen, Xiaokun Guo, Kejian Zhan. Nicotine increases apoptosis in HUVECs cultured in high glucose/high fat via Akt ubiquitination and degradation. Clinical and experimental pharmacology & physiology. vol 45. issue 2. 2019-05-23. PMID:28963785. |
nicotine increases apoptosis in huvecs cultured in high glucose/high fat via akt ubiquitination and degradation. |
2019-05-23 |
2023-08-13 |
human |
| Xiaofang Cao, Chunling Han, Jinsuo Wen, Xiaokun Guo, Kejian Zhan. Nicotine increases apoptosis in HUVECs cultured in high glucose/high fat via Akt ubiquitination and degradation. Clinical and experimental pharmacology & physiology. vol 45. issue 2. 2019-05-23. PMID:28963785. |
compared to the hg/hf incubated group, nicotine incubation significantly decreased cell survival and increased apoptosis. |
2019-05-23 |
2023-08-13 |
human |
| Xiaofang Cao, Chunling Han, Jinsuo Wen, Xiaokun Guo, Kejian Zhan. Nicotine increases apoptosis in HUVECs cultured in high glucose/high fat via Akt ubiquitination and degradation. Clinical and experimental pharmacology & physiology. vol 45. issue 2. 2019-05-23. PMID:28963785. |
moreover, nicotine induced akt degradation via ups, and akt overexpression blocked nicotine-induced apoptosis in huvecs cultured in hg/hf media. |
2019-05-23 |
2023-08-13 |
human |
| Xiaofang Cao, Chunling Han, Jinsuo Wen, Xiaokun Guo, Kejian Zhan. Nicotine increases apoptosis in HUVECs cultured in high glucose/high fat via Akt ubiquitination and degradation. Clinical and experimental pharmacology & physiology. vol 45. issue 2. 2019-05-23. PMID:28963785. |
furthermore, the ttc3 and mul1 shrna adenovirus dramatically decreased the akt ubiquitination and apoptosis induced by nicotine. |
2019-05-23 |
2023-08-13 |
human |
| Xi Xiao, Xueliang Shang, Baohui Zhai, Hui Zhang, Tao Zhan. Nicotine alleviates chronic stress-induced anxiety and depressive-like behavior and hippocampal neuropathology via regulating autophagy signaling. Neurochemistry international. vol 114. 2019-05-08. PMID:29339018. |
in addition, concomitant treatment with nicotine (10 μm) significantly attenuated the loss of pc12 cell viability (p < .01) and apoptosis compared to that of corticosterone treatment alone. |
2019-05-08 |
2023-08-13 |
mouse |