| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Indrani Sinha-Hikim, Theodore C Friedman, Mark Falz, Victor Chalfant, Mohammad Kamrul Hasan, Jorge Espinoza-Derout, Desean L Lee, Carl Sims, Peter Tran, Sushil K Mahata, Amiya P Sinha-Hiki. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell and tissue research. vol 368. issue 1. 2017-05-15. PMID:27917437. |
nicotine when combined with hfd led to a massive increase in cm apoptosis that was fully prevented by mecamylamine treatment. |
2017-05-15 |
2023-08-13 |
mouse |
| Indrani Sinha-Hikim, Theodore C Friedman, Mark Falz, Victor Chalfant, Mohammad Kamrul Hasan, Jorge Espinoza-Derout, Desean L Lee, Carl Sims, Peter Tran, Sushil K Mahata, Amiya P Sinha-Hiki. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell and tissue research. vol 368. issue 1. 2017-05-15. PMID:27917437. |
we conclude that nicotine, when combined with hfd, triggers cm apoptosis through the generation of oxidative stress and inactivation of ampk together with the activation of caspase-2-mediated intrinsic apoptotic signaling independently of fgf21 and sirt1. |
2017-05-15 |
2023-08-13 |
mouse |
| K S Nathiga Nambi, S Abdul Majeed, G Taju, Sridhar Sivasubbu, V Sarath Babu, A S Sahul Hamee. Effects of nicotine on zebrafish: A comparative response between a newly established gill cell line and whole gills. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 195. 2017-03-30. PMID:28257922. |
in addition, the production of ros and the resulting oxidative stress resulted in increased expression of apoptosis related genes p53 and cas3.collectively, our result suggests that nicotine has the potential to induce reactive oxygen species (ros) production, oxidative stress and apoptosis in drg cell line and zebrafish. |
2017-03-30 |
2023-08-13 |
cat |
| Xin Ge, Ying-Feng Liu, Yong Wong, Li-Zheng Wu, Ling Tan, Fen Liu, Xiao-Jing Wan. Impact of nicotine on the interplay between human periodontal ligament cells and CD4+ T cells. Human & experimental toxicology. vol 35. issue 9. 2017-02-13. PMID:26553320. |
in monoculture of pdl cells, nicotine dramatically repressed cell viability and increased apoptosis. |
2017-02-13 |
2023-08-13 |
human |
| Arunnjah Vivekanandarajah, Yik Lung Chan, Hui Chen, Rita Machaalan. Prenatal cigarette smoke exposure effects on apoptotic and nicotinic acetylcholine receptor expression in the infant mouse brainstem. Neurotoxicology. vol 53. 2016-12-19. PMID:26746805. |
nicotine, the major neurotoxic component of cigarette smoke, induces its actions by binding to nicotinic acetylcholine receptors (nachr), with one downstream effect being increased apoptosis. |
2016-12-19 |
2023-08-13 |
mouse |
| Juan Camilo Jurado-Coronel, Marco Avila-Rodriguez, Francisco Capani, Janneth Gonzalez, Valentina Echeverria Moran, George E Barret. Targeting the Nicotinic Acetylcholine Receptors (nAChRs) in Astrocytes as a Potential Therapeutic Target in Parkinson's Disease. Current pharmaceutical design. vol 22. issue 10. 2016-12-13. PMID:26972289. |
astrocytes are an important component in the immune response associated with pd, and that nicotine might be able to inhibit the inflammation-related apoptosis of these cells, being this a potential strategy for pd treatment. |
2016-12-13 |
2023-08-13 |
Not clear |
| H T Akkoyun, A Karadeni. Investigation of the protective effect of ellagic acid for preventing kidney injury in rats exposed to nicotine during the fetal period. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 91. issue 2. 2016-11-09. PMID:26529089. |
nicotine also caused greater apoptosis in group n compared to group c. ellagic acid treatment produced histological kidney structure that was closer to normal and it exerted an anti-apoptotic effect in the n + ea group compared to the n group. |
2016-11-09 |
2023-08-13 |
rat |
| Dongsheng Nie, Dong Zhang, Jingbo Dai, Meixing Zhang, Xianglong Zhao, Wangjie Xu, Zhong Chen, Lianyun Wang, Zhaoxia Wang, Zhongdong Qia. Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation. Biology of reproduction. vol 94. issue 2. 2016-11-04. PMID:26607717. |
nicotine induced murine spermatozoa apoptosis via up-regulation of deubiquitinated rip1 by trim27 promoter hypomethylation. |
2016-11-04 |
2023-08-13 |
mouse |
| Dongsheng Nie, Dong Zhang, Jingbo Dai, Meixing Zhang, Xianglong Zhao, Wangjie Xu, Zhong Chen, Lianyun Wang, Zhaoxia Wang, Zhongdong Qia. Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation. Biology of reproduction. vol 94. issue 2. 2016-11-04. PMID:26607717. |
nicotine significantly promoted apoptosis in stages i, vii, viii, and xi spermatogonia, stages i, vii, viii, x, and xi spermatocytes, and stages i-v, vii, and viii elongating spermatids. |
2016-11-04 |
2023-08-13 |
mouse |
| Dongsheng Nie, Dong Zhang, Jingbo Dai, Meixing Zhang, Xianglong Zhao, Wangjie Xu, Zhong Chen, Lianyun Wang, Zhaoxia Wang, Zhongdong Qia. Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation. Biology of reproduction. vol 94. issue 2. 2016-11-04. PMID:26607717. |
out of the 86 genes related to apoptosis, tnf (tumor necrosis factor alpha) was screened to be the most significant varied transcript, and the onto-pathway analysis indicated that the tnf apoptotic pathway was especially activated by nicotine exposure. |
2016-11-04 |
2023-08-13 |
mouse |
| Dongsheng Nie, Dong Zhang, Jingbo Dai, Meixing Zhang, Xianglong Zhao, Wangjie Xu, Zhong Chen, Lianyun Wang, Zhaoxia Wang, Zhongdong Qia. Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation. Biology of reproduction. vol 94. issue 2. 2016-11-04. PMID:26607717. |
in summary, our study suggests that nicotine may induce murine spermatozoal apoptosis via the tnf apoptotic pathway through up-regulation of deubiquitinated rip1 by trim27 promoter hypomethylation. |
2016-11-04 |
2023-08-13 |
mouse |
| Guohua Song, Tanseli Nesil, Junran Cao, Zhongli Yang, Sulie L Chang, Ming D L. Nicotine mediates expression of genes related to antioxidant capacity and oxidative stress response in HIV-1 transgenic rat brain. Journal of neurovirology. vol 22. issue 1. 2016-10-14. PMID:26306689. |
together, we conclude that chronic nicotine treatment has a dual effect on the antioxidant defense system and oxidative-stress-induced apoptosis signaling in hiv-1tg rats. |
2016-10-14 |
2023-08-13 |
rat |
| De-Qi Jiang, Mei-Dan Wei, Ke-Wan Wang, Yan-Xian Lan, Ning Zhu, Yong Wan. Nicotine contributes to the neural stem cells fate against toxicity of microglial-derived factors induced by Aβ via the Wnt/β-catenin pathway. The International journal of neuroscience. vol 126. issue 3. 2016-10-05. PMID:26001208. |
however, addition of 10 μmol/l nicotine before microglias treated with aβ was beneficial to protect the nscs against neurotoxicity of microglial-derived factors induced by aβ, which partially rescued proliferation, differentiation and inhibited apoptosis of nscs via activation of wnt/β-catenin pathway. |
2016-10-05 |
2023-08-13 |
Not clear |
| Alex I Chernyavsky, Igor B Shchepotin, Sergei A Grand. Mechanisms of growth-promoting and tumor-protecting effects of epithelial nicotinic acetylcholine receptors. International immunopharmacology. vol 29. issue 1. 2016-09-14. PMID:26071223. |
although the role of nicotine as a carcinogen is debatable, it is widely accepted that it contributes to cancer by promoting growth and survival of mutated cell clones and protecting them from the chemo- and radiotherapy-induced apoptosis. |
2016-09-14 |
2023-08-13 |
Not clear |
| Alex I Chernyavsky, Igor B Shchepotin, Sergei A Grand. Mechanisms of growth-promoting and tumor-protecting effects of epithelial nicotinic acetylcholine receptors. International immunopharmacology. vol 29. issue 1. 2016-09-14. PMID:26071223. |
nicotine also can permeate cells and activate mitochondrial (mt)-nachrs coupled to inhibition of the mitochondrial permeability transition pore (mptp) opening, thus preventing apoptosis. |
2016-09-14 |
2023-08-13 |
Not clear |
| Abd El-Fattah B M El-Beltagy, Amoura M Abou-El-Naga, Dalia M Sabr. Neurotoxicological effects of nicotine on the embryonic development of cerebellar cortex of chick embryo during various stages of incubation. Tissue & cell. vol 47. issue 5. 2016-09-13. PMID:26235253. |
moreover, the flow cytometric analysis confirmed that the percentage of apoptosis in control group was significantly higher compared with that of nicotine treated group. |
2016-09-13 |
2023-08-13 |
chicken |
| Yunqi Gu, Wangjie Xu, Dongsheng Nie, Dong Zhang, Jingbo Dai, Xianglong Zhao, Meixing Zhang, Zhaoxia Wang, Zhong Chen, Zhongdong Qia. Nicotine induces Nme2-mediated apoptosis in mouse testes. Biochemical and biophysical research communications. vol 472. issue 4. 2016-08-08. PMID:26972251. |
nicotine induces nme2-mediated apoptosis in mouse testes. |
2016-08-08 |
2023-08-13 |
mouse |
| Yunqi Gu, Wangjie Xu, Dongsheng Nie, Dong Zhang, Jingbo Dai, Xianglong Zhao, Meixing Zhang, Zhaoxia Wang, Zhong Chen, Zhongdong Qia. Nicotine induces Nme2-mediated apoptosis in mouse testes. Biochemical and biophysical research communications. vol 472. issue 4. 2016-08-08. PMID:26972251. |
to evaluate the effects of nicotine exposure on apoptosis during spermatogenesis, we first constructed a nicotine-treated mouse model and detected germ cell apoptosis activity in the testes using the tunel method. |
2016-08-08 |
2023-08-13 |
mouse |
| Yunqi Gu, Wangjie Xu, Dongsheng Nie, Dong Zhang, Jingbo Dai, Xianglong Zhao, Meixing Zhang, Zhaoxia Wang, Zhong Chen, Zhongdong Qia. Nicotine induces Nme2-mediated apoptosis in mouse testes. Biochemical and biophysical research communications. vol 472. issue 4. 2016-08-08. PMID:26972251. |
further, we investigated a highly expressed gene, nme2, in mouse testes after nicotine treatment from our previous results, which has close correlation with the apoptosis activity predicted by bioinformatics. |
2016-08-08 |
2023-08-13 |
mouse |
| Chang Seong Kim, Joon Seok Choi, Soo Yeon Joo, Eun Hui Bae, Seong Kwon Ma, JongUn Lee, Soo Wan Ki. Nicotine-Induced Apoptosis in Human Renal Proximal Tubular Epithelial Cells. PloS one. vol 11. issue 3. 2016-08-05. PMID:27028622. |
this study investigated nicotine's effects on renal tubular epithelial cell apoptosis in vitro and it explored the mechanisms underlying its effects. |
2016-08-05 |
2023-08-13 |
human |