| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chong Huang, Xiong Guo, Huishou Zhao, Rui An, Kun Lian, Xiaomeng Zhang, Jinglong Zhang, Feng Yan, Huaning Xie, Shan Wang, Ling Ta. Nicotine induces H9C2 cell apoptosis via Akt protein degradation. Molecular medicine reports. vol 16. issue 5. 2018-06-08. PMID:28849146. |
however, the effect of nicotine, a key ingredient in smoking products, on cardiomyocyte apoptosis remains controversial. |
2018-06-08 |
2023-08-13 |
Not clear |
| Chong Huang, Xiong Guo, Huishou Zhao, Rui An, Kun Lian, Xiaomeng Zhang, Jinglong Zhang, Feng Yan, Huaning Xie, Shan Wang, Ling Ta. Nicotine induces H9C2 cell apoptosis via Akt protein degradation. Molecular medicine reports. vol 16. issue 5. 2018-06-08. PMID:28849146. |
the present study aims to clarify the role of nicotine on cardiomyocyte cell apoptosis and to investigate the underlying mechanism. |
2018-06-08 |
2023-08-13 |
Not clear |
| Chong Huang, Xiong Guo, Huishou Zhao, Rui An, Kun Lian, Xiaomeng Zhang, Jinglong Zhang, Feng Yan, Huaning Xie, Shan Wang, Ling Ta. Nicotine induces H9C2 cell apoptosis via Akt protein degradation. Molecular medicine reports. vol 16. issue 5. 2018-06-08. PMID:28849146. |
the results demonstrated that nicotine induced apoptosis in h9c2 cells compared with control cells (p<0.05). |
2018-06-08 |
2023-08-13 |
Not clear |
| Chong Huang, Xiong Guo, Huishou Zhao, Rui An, Kun Lian, Xiaomeng Zhang, Jinglong Zhang, Feng Yan, Huaning Xie, Shan Wang, Ling Ta. Nicotine induces H9C2 cell apoptosis via Akt protein degradation. Molecular medicine reports. vol 16. issue 5. 2018-06-08. PMID:28849146. |
in conclusion, the current study demonstrated that nicotine induced h9c2 cell apoptosis via akt protein degradation, which may be mediated by ttc3. |
2018-06-08 |
2023-08-13 |
Not clear |
| Mateusz Wątroba, Ilona Dudek, Marta Skoda, Aleksandra Stangret, Przemysław Rzodkiewicz, Dariusz Szukiewic. Sirtuins, epigenetics and longevity. Ageing research reviews. vol 40. 2018-05-15. PMID:28789901. |
sirtuins, a family of nicotine adenine dinucleotide (nad+)-dependent enzymes, are involved in the cell metabolism and can regulate many cellular functions including dna repair, inflammatory response, cell cycle or apoptosis. |
2018-05-15 |
2023-08-13 |
human |
| Haroun Nacerai, Tufo Gregory, Berdja Sihem, Akkal Salah, Aouichat-Bouguerra Souhil. GREEN TEA BEVERAGE AND EPIGALLOCATECIHIN GALLATE ATTENUATE NICOTINE CARDIOCYTOTOXICITY IN RAT. Acta poloniae pharmaceutica. vol 74. issue 1. 2018-03-16. PMID:29474782. |
it was suggested that green tea beverage can protect against nicotine toxicity by attenuating oxidative stress, endoplasmic reticulum stress and apoptosis. |
2018-03-16 |
2023-08-13 |
rat |
| Mohammad Kamrul Hasan, Theodore C Friedman, Carl Sims, Desean L Lee, Jorge Espinoza-Derout, Adaku Ume, Victor Chalfant, Martin L Lee, Indrani Sinha-Hikim, Kabirullah Lutfy, Yanjun Liu, Sushil K Mahata, Amiya P Sinha-Hiki. α7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling. Endocrinology. vol 159. issue 2. 2018-02-15. PMID:29272360. |
we recently demonstrated that nicotine, when combined with a high-fat diet (hfd), triggers oxidative stress, activates hepatocyte apoptosis, and exacerbates hfd-induced hepatic steatosis in male mice. |
2018-02-15 |
2023-08-13 |
mouse |
| Mohammad Kamrul Hasan, Theodore C Friedman, Carl Sims, Desean L Lee, Jorge Espinoza-Derout, Adaku Ume, Victor Chalfant, Martin L Lee, Indrani Sinha-Hikim, Kabirullah Lutfy, Yanjun Liu, Sushil K Mahata, Amiya P Sinha-Hiki. α7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling. Endocrinology. vol 159. issue 2. 2018-02-15. PMID:29272360. |
pnu treatment was effective in attenuating nicotine plus hfd-induced increase in hepatic triglyceride levels, hepatocyte apoptosis, and hepatic steatosis. |
2018-02-15 |
2023-08-13 |
mouse |
| Dwipayan Bhattacharya, Mohammed Majrashi, Sindhu Ramesh, Manoj Govindarajulu, Jenna Bloemer, Ayaka Fujihashi, Bailee-Ryan Crump, Harrison Hightower, Subhrajit Bhattacharya, Timothy Moore, Vishnu Suppiramaniam, Muralikrishnan Dhanasekara. Assessment of the cerebellar neurotoxic effects of nicotine in prenatal alcohol exposure in rats. Life sciences. vol 194. 2018-02-13. PMID:29225110. |
in this study, we evaluated the behavioral changes, biochemical markers of oxidative stress and apoptosis, mitochondrial functions and the molecular mechanisms associated with nicotine in prenatal alcohol exposure on the cerebellum. |
2018-02-13 |
2023-08-13 |
human |
| Istvan Arany, Anthony Carter, Samuel Hall, Tibor Fulop, Mehul Dixi. Coenzyme Q10 protects renal proximal tubule cells against nicotine-induced apoptosis through induction of p66 Apoptosis : an international journal on programmed cell death. vol 22. issue 2. 2018-02-09. PMID:27770269. |
coenzyme q10 protects renal proximal tubule cells against nicotine-induced apoptosis through induction of p66 chronic nicotine exposure (via smoking, e-cigarettes) increases oxidative stress in the kidney that sensitizes it to additional injury in experimental models and in the renal patient. |
2018-02-09 |
2023-08-13 |
Not clear |
| Manish Bodas, Colin Van Westphal, Rhett Carpenter-Thompson, Dillip K Mohanty, Neeraj Vi. Nicotine exposure induces bronchial epithelial cell apoptosis and senescence via ROS mediated autophagy-impairment. Free radical biology & medicine. vol 97. 2018-01-04. PMID:27394171. |
nicotine exposure induces bronchial epithelial cell apoptosis and senescence via ros mediated autophagy-impairment. |
2018-01-04 |
2023-08-13 |
mouse |
| Manish Bodas, Colin Van Westphal, Rhett Carpenter-Thompson, Dillip K Mohanty, Neeraj Vi. Nicotine exposure induces bronchial epithelial cell apoptosis and senescence via ROS mediated autophagy-impairment. Free radical biology & medicine. vol 97. 2018-01-04. PMID:27394171. |
overall, our data shows that nicotine, a common component of wps, e-cigarette vapor and cigarette smoke, induces bronchial epithelial cell apoptosis and senescence via ros mediated autophagy-impairment as a potential mechanism for copd-emphysema pathogenesis. |
2018-01-04 |
2023-08-13 |
mouse |
| Xiu Liu, Chao-Nan Wang, Chen-Yang Qiu, Wei Song, Lin-Fang Wang, Bao Li. Adipocytes promote nicotine-induced injury of endothelial cells via the NF-κB pathway. Experimental cell research. vol 359. issue 1. 2017-10-16. PMID:28733145. |
our results showed that nicotine dose-dependently induces the apoptosis of huvecs and adipocytes and is associated with increased ikkβ and nf-κb p65 expression and with ikbα degradation. |
2017-10-16 |
2023-08-13 |
Not clear |
| Michael R Kanost, Estela L Arrese, Xiaolong Cao, Yun-Ru Chen, Sanjay Chellapilla, Marian R Goldsmith, Ewald Grosse-Wilde, David G Heckel, Nicolae Herndon, Haobo Jiang, Alexie Papanicolaou, Jiaxin Qu, Jose L Soulages, Heiko Vogel, James Walters, Robert M Waterhouse, Seung-Joon Ahn, Francisca C Almeida, Chunju An, Peshtewani Aqrawi, Anne Bretschneider, William B Bryant, Sascha Bucks, Hsu Chao, Germain Chevignon, Jayne M Christen, David F Clarke, Neal T Dittmer, Laura C F Ferguson, Spyridoula Garavelou, Karl H J Gordon, Ramesh T Gunaratna, Yi Han, Frank Hauser, Yan He, Hanna Heidel-Fischer, Ariana Hirsh, Yingxia Hu, Hongbo Jiang, Divya Kalra, Christian Klinner, Christopher König, Christie Kovar, Ashley R Kroll, Suyog S Kuwar, Sandy L Lee, Rüdiger Lehman, Kai Li, Zhaofei Li, Hanquan Liang, Shanna Lovelace, Zhiqiang Lu, Jennifer H Mansfield, Kyle J McCulloch, Tittu Mathew, Brian Morton, Donna M Muzny, David Neunemann, Fiona Ongeri, Yannick Pauchet, Ling-Ling Pu, Ioannis Pyrousis, Xiang-Jun Rao, Amanda Redding, Charles Roesel, Alejandro Sanchez-Gracia, Sarah Schaack, Aditi Shukla, Guillaume Tetreau, Yang Wang, Guang-Hua Xiong, Walther Traut, Tom K Walsh, Kim C Worley, Di Wu, Wenbi Wu, Yuan-Qing Wu, Xiufeng Zhang, Zhen Zou, Hannah Zucker, Adriana D Briscoe, Thorsten Burmester, Rollie J Clem, René Feyereisen, Cornelis J P Grimmelikhuijzen, Stavros J Hamodrakas, Bill S Hansson, Elisabeth Huguet, Lars S Jermiin, Que Lan, Herman K Lehman, Marce Lorenzen, Hans Merzendorfer, Ioannis Michalopoulos, David B Morton, Subbaratnam Muthukrishnan, John G Oakeshott, Will Palmer, Yoonseong Park, A Lorena Passarelli, Julio Rozas, Lawrence M Schwartz, Wendy Smith, Agnes Southgate, Andreas Vilcinskas, Richard Vogt, Ping Wang, John Werren, Xiao-Qiang Yu, Jing-Jiang Zhou, Susan J Brown, Steven E Scherer, Stephen Richards, Gary W Blissar. Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, Manduca sexta. Insect biochemistry and molecular biology. vol 76. 2017-09-01. PMID:27522922. |
annotation and analyses were carried out for gene families involved in a wide spectrum of biological processes, including apoptosis, vacuole sorting, growth and development, structures of exoskeleton, egg shells, and muscle, vision, chemosensation, ion channels, signal transduction, neuropeptide signaling, neurotransmitter synthesis and transport, nicotine tolerance, lipid metabolism, and immunity. |
2017-09-01 |
2023-08-13 |
Not clear |
| Xiqian Lan, Rivka Lederman, Judith M Eng, Seyedeh Shadafarin Marashi Shoshtari, Moin A Saleem, Ashwani Malhotra, Pravin C Singha. Nicotine Induces Podocyte Apoptosis through Increasing Oxidative Stress. PloS one. vol 11. issue 12. 2017-06-29. PMID:27907022. |
nicotine induces podocyte apoptosis through increasing oxidative stress. |
2017-06-29 |
2023-08-13 |
Not clear |
| Philippe Klee, Domenico Bosco, Audrey Guérardel, Emmanuel Somm, Audrey Toulotte, Pierre Maechler, Valérie M Schwitzgebe. Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets. Endocrinology. vol 157. issue 10. 2017-05-29. PMID:27471776. |
here, we show that nach-r activation by nicotine and choline, 2 agonists of the receptor, decreases murine and human β-cell apoptosis induced by proinflammatory cytokines known to be present in the islet environment at the onset of t1dm. |
2017-05-29 |
2023-08-13 |
human |
| Indrani Sinha-Hikim, Theodore C Friedman, Mark Falz, Victor Chalfant, Mohammad Kamrul Hasan, Jorge Espinoza-Derout, Desean L Lee, Carl Sims, Peter Tran, Sushil K Mahata, Amiya P Sinha-Hiki. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell and tissue research. vol 368. issue 1. 2017-05-15. PMID:27917437. |
nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. |
2017-05-15 |
2023-08-13 |
mouse |
| Indrani Sinha-Hikim, Theodore C Friedman, Mark Falz, Victor Chalfant, Mohammad Kamrul Hasan, Jorge Espinoza-Derout, Desean L Lee, Carl Sims, Peter Tran, Sushil K Mahata, Amiya P Sinha-Hiki. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell and tissue research. vol 368. issue 1. 2017-05-15. PMID:27917437. |
given that cm apoptosis has been implicated as a potential mechanism in the development of cardiomyopathy and heart failure, we characterize the key signaling pathways in nicotine plus high-fat diet (hfd)-induced cm apoptosis. |
2017-05-15 |
2023-08-13 |
mouse |
| Indrani Sinha-Hikim, Theodore C Friedman, Mark Falz, Victor Chalfant, Mohammad Kamrul Hasan, Jorge Espinoza-Derout, Desean L Lee, Carl Sims, Peter Tran, Sushil K Mahata, Amiya P Sinha-Hiki. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell and tissue research. vol 368. issue 1. 2017-05-15. PMID:27917437. |
nicotine when combined with hfd led to a massive increase in cm apoptosis that was fully prevented by mecamylamine treatment. |
2017-05-15 |
2023-08-13 |
mouse |
| Indrani Sinha-Hikim, Theodore C Friedman, Mark Falz, Victor Chalfant, Mohammad Kamrul Hasan, Jorge Espinoza-Derout, Desean L Lee, Carl Sims, Peter Tran, Sushil K Mahata, Amiya P Sinha-Hiki. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell and tissue research. vol 368. issue 1. 2017-05-15. PMID:27917437. |
we conclude that nicotine, when combined with hfd, triggers cm apoptosis through the generation of oxidative stress and inactivation of ampk together with the activation of caspase-2-mediated intrinsic apoptotic signaling independently of fgf21 and sirt1. |
2017-05-15 |
2023-08-13 |
mouse |