| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nuan P Cheah, Jeroen L A Pennings, Jolanda P Vermeulen, Frederik J van Schooten, Antoon Opperhuize. In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 27. issue 3. 2013-09-18. PMID:23416264. |
formaldehyde gave the strongest response; a total of 66 genes were more than 1.5-fold differentially expressed mostly involved in apoptosis and dna damage related processes, followed by acetaldehyde (57 genes), hydroquinone (55 genes) and nicotine (8 genes). |
2013-09-18 |
2023-08-12 |
human |
| José G Treviño, Smitha Pillai, Sateesh Kunigal, Sandeep Singh, William J Fulp, Barbara A Centeno, Srikumar P Chellappa. Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma. Neoplasia (New York, N.Y.). vol 14. issue 12. 2013-07-10. PMID:23308043. |
nicotine could also confer resistance to apoptosis induced by gemcitabine in pancreatic cancer cells in vitro and depletion of src or id1 rendered the cells sensitive to gemcitabine. |
2013-07-10 |
2023-08-12 |
mouse |
| Paola Ambrosi, Andrea Becchett. Targeting neuronal nicotinic receptors in cancer: new ligands and potential side-effects. Recent patents on anti-cancer drug discovery. vol 8. issue 1. 2013-06-03. PMID:22537644. |
many cellular effects of nicotine and the tobacco-derived carcinogenic n-nitrosamines are probably caused by nachr activation, which regulates cell proliferation, migration, apoptosis and neoangiogenesis. |
2013-06-03 |
2023-08-12 |
Not clear |
| Megan E Culbreth, Joshua A Harrill, Theresa M Freudenrich, William R Mundy, Timothy J Shafe. Comparison of chemical-induced changes in proliferation and apoptosis in human and mouse neuroprogenitor cells. Neurotoxicology. vol 33. issue 6. 2013-05-28. PMID:22634143. |
cells were exposed to 0.001-100 μm concentrations of 11 chemicals (cadmium, chlorpyrifos oxon, dexamethasone, dieldrin, ketamine, lead, maneb, methylmercury, nicotine, trans-retinoic acid, and trimethyltin) reported in the literature to affect proliferation and/or apoptosis, and 5 chemicals (dimethyl pthalate, glyphosate, omeprazole, saccharin, and d-sorbitol) with no reports of effects on either endpoint. |
2013-05-28 |
2023-08-12 |
mouse |
| Graham W Warren, Michelle A Romano, Mahesh R Kudrimoti, Marcus E Randall, Ronald C McGarry, Anurag K Singh, Vivek M Rangneka. Nicotinic modulation of therapeutic response in vitro and in vivo. International journal of cancer. vol 131. issue 11. 2013-03-08. PMID:22447412. |
nicotine, a systemically available component of tobacco, is associated with tumor promotion and decreased apoptosis in cell culture; however, the role of nicotine on response to radiotherapy (rt) or chemoradiotherapy (crt) in vivo has not been evaluated. |
2013-03-08 |
2023-08-12 |
mouse |
| William P Petros, Islam R Younis, James N Ford, Scott A Wee. Effects of tobacco smoking and nicotine on cancer treatment. Pharmacotherapy. vol 32. issue 10. 2013-02-27. PMID:23033231. |
data that identify nicotine's effect on cancer cell apoptosis, tumor angiogenesis, invasion, and metastasis are emerging. |
2013-02-27 |
2023-08-12 |
Not clear |
| Jennifer E Bruin, Amanda K Woynillowicz, Bart P Hettinga, Mark A Tarnopolsky, Katherine M Morrison, Hertzel C Gerstein, Alison C Hollowa. Maternal antioxidants prevent β-cell apoptosis and promote formation of dual hormone-expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure. Journal of diabetes. vol 4. issue 3. 2013-02-01. PMID:22385833. |
maternal antioxidants prevent β-cell apoptosis and promote formation of dual hormone-expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure. |
2013-02-01 |
2023-08-12 |
Not clear |
| Jennifer E Bruin, Amanda K Woynillowicz, Bart P Hettinga, Mark A Tarnopolsky, Katherine M Morrison, Hertzel C Gerstein, Alison C Hollowa. Maternal antioxidants prevent β-cell apoptosis and promote formation of dual hormone-expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure. Journal of diabetes. vol 4. issue 3. 2013-02-01. PMID:22385833. |
fetal and neonatal nicotine exposure causes β-cell oxidative stress and apoptosis in neonates, leading to adult-onset dysglycemia. |
2013-02-01 |
2023-08-12 |
Not clear |
| Theodore C Friedman, Indrani Sinha-Hikim, Meher Parveen, Sonia M Najjar, Yanjun Liu, Michael Mangubat, Chang-Sung Shin, Alexei Lyzlov, Rasheed Ivey, Magda Shaheen, Samuel W French, Amiya P Sinha-Hiki. Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice. Endocrinology. vol 153. issue 12. 2013-01-31. PMID:23093702. |
the additive effects of nicotine on the severity of hfd-induced hepatic steatosis was associated with significantly greater oxidative stress, increased hepatic triglyceride levels, higher incidence of hepatocellular apoptosis, inactivation (dephosphorylation) of amp-activated protein kinase, and activation of its downstream target acetyl-coenzyme a-carboxylase. |
2013-01-31 |
2023-08-12 |
mouse |
| Alessandra Cucina, Simona Dinicola, Pierpaolo Coluccia, Sara Proietti, Fabrizio D'Anselmi, Alessia Pasqualato, Mariano Bizzarr. Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways. The Journal of surgical research. vol 178. issue 1. 2013-01-10. PMID:22520577. |
nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways. |
2013-01-10 |
2023-08-12 |
human |
| Alessandra Cucina, Simona Dinicola, Pierpaolo Coluccia, Sara Proietti, Fabrizio D'Anselmi, Alessia Pasqualato, Mariano Bizzarr. Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways. The Journal of surgical research. vol 178. issue 1. 2013-01-10. PMID:22520577. |
nicotine, one of the major components of cigarette smoking, can stimulate cell proliferation and suppress apoptosis both in normal cells and in several human cancer cell lines derived from various organs. |
2013-01-10 |
2023-08-12 |
human |
| Alessandra Cucina, Simona Dinicola, Pierpaolo Coluccia, Sara Proietti, Fabrizio D'Anselmi, Alessia Pasqualato, Mariano Bizzarr. Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways. The Journal of surgical research. vol 178. issue 1. 2013-01-10. PMID:22520577. |
however, although nicotine appears to have a role in stimulating cell proliferation of colon cancer cells, there is no information on its role in inhibiting apoptosis in these cells. |
2013-01-10 |
2023-08-12 |
human |
| Wen-Yan Cui, Ju Wang, Jinxue Wei, Junran Cao, Sulie L Chang, Jun Gu, Ming D L. Modulation of innate immune-related pathways in nicotine-treated SH-SY5Y cells. Amino acids. vol 43. issue 3. 2012-12-21. PMID:22187147. |
interestingly, most of the differentially expressed genes in these pathways leading to nuclear factor κb (nf-κb) activation and those important inhibitors of pathways leading to apoptosis, including flip and bcl-2, were up-regulated by nicotine. |
2012-12-21 |
2023-08-12 |
Not clear |
| Xue-Jiao Yang, Hui-Yuan Lu, Zi-Yin Li, Qian Bian, Liang-Lin Qiu, Zhong Li, Qizhan Liu, Jianmin Li, Xinru Wang, Shou-Lin Wan. Cytochrome P450 2A13 mediates aflatoxin B1-induced cytotoxicity and apoptosis in human bronchial epithelial cells. Toxicology. vol 300. issue 3. 2012-10-05. PMID:22743290. |
finally, treatment with nicotine, a competitor of afb(1), and 8-methoxypsoralen (8-mop), an inhibitor of cyp enzyme, further confirm the critical role of cyp2a13 in afb(1)-induced cytotoxicity and apoptosis. |
2012-10-05 |
2023-08-12 |
human |
| Nam-Yong Do, Sung-Chul Li. A low level of nicotine-induced chemoresistance in a KB cell line. Molecular medicine reports. vol 1. issue 1. 2012-10-02. PMID:21479378. |
nicotine induced bad phosphorylation in association with the suppression of apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Zong-Zhuang Li, Qiu-Yan Da. Pathogenesis of abdominal aortic aneurysms: role of nicotine and nicotinic acetylcholine receptors. Mediators of inflammation. vol 2012. 2012-09-20. PMID:22529515. |
in this paper, we will mainly discuss the pathogenesis of aaas involving inflammation, proteolysis, smooth muscle cell apoptosis and angiogenesis, and the roles of nicotine and nachrs. |
2012-09-20 |
2023-08-12 |
Not clear |
| Xinpeng Zheng, Chun Xia, Zhongyi Chen, Jiagu Huang, Fengguang Gao, Guideng Li, Bing Zhan. Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis. Biochemical and biophysical research communications. vol 423. issue 3. 2012-09-20. PMID:22713471. |
requirement of the phosphatidylinositol 3-kinase/akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis. |
2012-09-20 |
2023-08-12 |
rat |
| Xinpeng Zheng, Chun Xia, Zhongyi Chen, Jiagu Huang, Fengguang Gao, Guideng Li, Bing Zhan. Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis. Biochemical and biophysical research communications. vol 423. issue 3. 2012-09-20. PMID:22713471. |
nicotine is able to confer resistance to apoptosis and promote cell survival in some cell lines, but its regulatory mechanism is ambiguous. |
2012-09-20 |
2023-08-12 |
rat |
| Xinpeng Zheng, Chun Xia, Zhongyi Chen, Jiagu Huang, Fengguang Gao, Guideng Li, Bing Zhan. Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis. Biochemical and biophysical research communications. vol 423. issue 3. 2012-09-20. PMID:22713471. |
we aimed to investigate the effect of nicotine on il-1β-induced chondrocyte apoptosis and the mechanism underlying how nicotine antagonizes il-1β-induced apoptosis of rat chondrocytes. |
2012-09-20 |
2023-08-12 |
rat |
| Xinpeng Zheng, Chun Xia, Zhongyi Chen, Jiagu Huang, Fengguang Gao, Guideng Li, Bing Zhan. Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis. Biochemical and biophysical research communications. vol 423. issue 3. 2012-09-20. PMID:22713471. |
the results showed that nicotine neutralized the effect of il-1β on chondrocytes by activating pi3k/akt signaling pathways, including the pi3k/akt/bcl-2 pathway, to block il-1β-induced cell apoptosis and the pi3k/akt/p70s6k (p70s6 kinase)/s6 pathway for promoting protein synthesis, modulating its downstream effectors such as timp-1 and mmp-13. |
2012-09-20 |
2023-08-12 |
rat |