| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nan Hu, Rui Guo, Xuefeng Han, Baocheng Zhu, Jun Re. Cardiac-specific overexpression of metallothionein rescues nicotine-induced cardiac contractile dysfunction and interstitial fibrosis. Toxicology letters. vol 202. issue 1. 2011-04-18. PMID:21238558. |
taken together, our findings suggest the antioxidant metallothionein may reconcile short-term nicotine exposure-induced myocardial contractile dysfunction and fibrosis possibly through inhibition of ros accumulation and apoptosis. |
2011-04-18 |
2023-08-12 |
mouse |
| Catherine Lombard, Don Farthing, Jingping Sun, Marc W Fariss, Robert J McKalli. Reference moist smokeless tobacco-induced apoptosis in human monocytes/macrophages cell line MM6. International immunopharmacology. vol 10. issue 9. 2010-12-23. PMID:20601189. |
our findings suggest that ste-induced osmotic stress, but not exposure to nicotine, plays an important role in ste-induced apoptosis of mm6 cells. |
2010-12-23 |
2023-08-12 |
human |
| Eva Martínez-García, Marta Irigoyen, Oscar González-Moreno, Leticia Corrales, Alvaro Teijeira, Elizabeth Salvo, Ana Rouzau. Repetitive nicotine exposure leads to a more malignant and metastasis-prone phenotype of SCLC: a molecular insight into the importance of quitting smoking during treatment. Toxicological sciences : an official journal of the Society of Toxicology. vol 116. issue 2. 2010-10-28. PMID:20457658. |
nicotine, a major component in cigarette smoke, has been found to promote tumor growth and angiogenesis, as well as protect cancer cells from apoptosis. |
2010-10-28 |
2023-08-12 |
mouse |
| Ingrid U Schraufstatter, Richard G DiScipio, Sophia K Khaldoyanid. Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells. Journal of stem cells. vol 4. issue 4. 2010-10-19. PMID:20720594. |
while high concentrations of nicotine (10(5)m) induced hmsc apoptosis, physiological concentrations (10(7)m) did not interfere with cell survival. |
2010-10-19 |
2023-08-12 |
human |
| Tianjie Shen, Wei Le, Allison Yee, Opal Kamdar, Peter H Hwang, Daya Upadhya. Nicotine induces resistance to chemotherapy in nasal epithelial cancer. American journal of rhinology & allergy. vol 24. issue 2. 2010-09-07. PMID:20338106. |
however, the effects of nicotine, a tobacco carcinogen that inhibits apoptosis, have not been studied before in nasal epithelial carcinoma (nc). |
2010-09-07 |
2023-08-12 |
human |
| Tianjie Shen, Wei Le, Allison Yee, Opal Kamdar, Peter H Hwang, Daya Upadhya. Nicotine induces resistance to chemotherapy in nasal epithelial cancer. American journal of rhinology & allergy. vol 24. issue 2. 2010-09-07. PMID:20338106. |
in this study, we sought to determine the effects of nicotine on chemotherapy-induced apoptosis in human nc. |
2010-09-07 |
2023-08-12 |
human |
| Narong Simakajornboon, Teeradej Kuptanon, Piyawat Jirapongsuwa. The effect of prenatal nicotine exposure on PDGFR-mediated anti-apoptotic mechanism in the caudal brainstem of developing rat. Neuroscience letters. vol 478. issue 1. 2010-08-26. PMID:20447445. |
we speculate that prenatal nicotine exposure affects apoptosis in the cb of developing animals and may increase the vulnerability of neural cells in the respiratory control area, a process that may underlie the association between maternal smoking and sids. |
2010-08-26 |
2023-08-12 |
rat |
| L Renea Arias, Carla A Perry, Liju Yan. Real-time electrical impedance detection of cellular activities of oral cancer cells. Biosensors & bioelectronics. vol 25. issue 10. 2010-08-19. PMID:20304624. |
the inhibition of cisplatin-induced apoptosis by the carcinogen, nicotine, at concentrations from 0.1 microm to 10 microm was monitored. |
2010-08-19 |
2023-08-12 |
Not clear |
| L Renea Arias, Carla A Perry, Liju Yan. Real-time electrical impedance detection of cellular activities of oral cancer cells. Biosensors & bioelectronics. vol 25. issue 10. 2010-08-19. PMID:20304624. |
the most significant inhibitory effect of nicotine on cisplatin-induced apoptosis was observed at concentrations of 0.5-1 microm. |
2010-08-19 |
2023-08-12 |
Not clear |
| Xiang Zhou, Yanhui Sheng, Rong Yang, Xiangqing Kon. Nicotine promotes cardiomyocyte apoptosis via oxidative stress and altered apoptosis-related gene expression. Cardiology. vol 115. issue 4. 2010-07-21. PMID:20339300. |
nicotine promotes cardiomyocyte apoptosis via oxidative stress and altered apoptosis-related gene expression. |
2010-07-21 |
2023-08-12 |
Not clear |
| Xiang Zhou, Yanhui Sheng, Rong Yang, Xiangqing Kon. Nicotine promotes cardiomyocyte apoptosis via oxidative stress and altered apoptosis-related gene expression. Cardiology. vol 115. issue 4. 2010-07-21. PMID:20339300. |
to investigate the effect of nicotine on cardiomyocyte apoptosis in vitro and explore the potential mechanisms involved. |
2010-07-21 |
2023-08-12 |
Not clear |
| R Wickströ. Effects of nicotine during pregnancy: human and experimental evidence. Current neuropharmacology. vol 5. issue 3. 2010-06-11. PMID:19305804. |
it is concluded that as findings indicate that functional nachrs are present very early in neuronal development, and that activation at this stage leads to apoptosis and mitotic abnormalities, a total abstinence from all forms of nicotine should be advised to pregnant women for the entirety of gestation. |
2010-06-11 |
2023-08-12 |
human |
| X L Cheng, H Zhang, D Guo, Z D Qia. Upregulation of Fas and FasL expression in nicotine-induced apoptosis of endothelial cells. Methods and findings in experimental and clinical pharmacology. vol 32. issue 1. 2010-06-08. PMID:20383341. |
there is controversy over reports about the effect of nicotine on apoptosis. |
2010-06-08 |
2023-08-12 |
human |
| X L Cheng, H Zhang, D Guo, Z D Qia. Upregulation of Fas and FasL expression in nicotine-induced apoptosis of endothelial cells. Methods and findings in experimental and clinical pharmacology. vol 32. issue 1. 2010-06-08. PMID:20383341. |
the effect of nicotine on apoptosis of human umbilical vein endothelial cells (huvecs) and the expressions of fas/fas ligand (fasl) and caspase-3 were evaluated in this study. |
2010-06-08 |
2023-08-12 |
human |
| X L Cheng, H Zhang, D Guo, Z D Qia. Upregulation of Fas and FasL expression in nicotine-induced apoptosis of endothelial cells. Methods and findings in experimental and clinical pharmacology. vol 32. issue 1. 2010-06-08. PMID:20383341. |
annexin v fluorescein isothiocyanate and propidium iodide double staining demonstrated that nicotine (0.2 microm, 0.5 microm and 1 microm) could induce apoptosis of huvecs; reverse transcription (rt)-pcr and western blotting analysis demonstrated that levels of fas and fasl expression were increased in nicotine-treated huvecs. |
2010-06-08 |
2023-08-12 |
human |
| X L Cheng, H Zhang, D Guo, Z D Qia. Upregulation of Fas and FasL expression in nicotine-induced apoptosis of endothelial cells. Methods and findings in experimental and clinical pharmacology. vol 32. issue 1. 2010-06-08. PMID:20383341. |
these data indicate that nicotine induces the apoptosis of huvecs, and that the fas/fasl pathway may play an important role. |
2010-06-08 |
2023-08-12 |
human |
| Vivian Yvonne Shin, Hong Chuan Jin, Enders Kai On Ng, Joseph Jao Yiu Sung, Kent Man Chu, Chi Hin Ch. Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth. Cancer letters. vol 292. issue 2. 2010-05-04. PMID:20061081. |
cells treated with nicotine dose- and time-dependently induced cell proliferation, invasion and suppressed apoptosis. |
2010-05-04 |
2023-08-12 |
human |
| Claude Sadis, Gwen Teske, Geurt Stokman, Carole Kubjak, Nike Claessen, Fabrice Moore, Patrizia Loi, Bilo Diallo, Luc Barvais, Michel Goldman, Sandrine Florquin, Alain Le Moin. Nicotine protects kidney from renal ischemia/reperfusion injury through the cholinergic anti-inflammatory pathway. PloS one. vol 2. issue 5. 2010-04-29. PMID:17520028. |
reduced tubular damage in nicotine pre-treated mice was associated with a decrease in tubular cell apoptosis and proliferative response as attested by the reduction of caspase-3 and ki67 positive cells, respectively. |
2010-04-29 |
2023-08-12 |
mouse |
| Akinori Akaike, Yuki Takada-Takatori, Toshiaki Kume, Yasuhiko Izum. Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19714494. |
nicotine as well as other nicotinic receptor agonists protected cortical neurons against glutamate neurotoxicity via alpha4 and alpha7 nachrs at least partly by inhibiting the process of apoptosis in near-pure neuronal cultures obtained from the cerebral cortex of fetal rats. |
2010-04-21 |
2023-08-12 |
rat |
| Isaac Túnez, René Drucker-Colín, Pedro Montilla, José Peña, Ignacio Jimena, Francisco Javier Medina, Inmaculada Tasse. Protective effect of nicotine on oxidative and cell damage in rats with depression induced by olfactory bulbectomy. European journal of pharmacology. vol 627. issue 1-3. 2010-04-05. PMID:19887066. |
in conclusions: i) obx induces oxidative stress and cell death by apoptosis; and ii) nicotine presents antidepressant and antioxidant effect. |
2010-04-05 |
2023-08-12 |
rat |