| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takashi Nishioka, Jinjin Guo, Daisuke Yamamoto, Lihua Chen, Petra Huppi, Chang Yan Che. Nicotine, through upregulating pro-survival signaling, cooperates with NNK to promote transformation. Journal of cellular biochemistry. vol 109. issue 1. 2010-03-02. PMID:19911375. |
here, by concurrent treatment of nicotine and nnk, we investigate the effect of the cooperation of these two compounds on cell growth and apoptosis in various different lung epithelial (rle) or cancer (lkr) cells. |
2010-03-02 |
2023-08-12 |
Not clear |
| Takashi Nishioka, Jinjin Guo, Daisuke Yamamoto, Lihua Chen, Petra Huppi, Chang Yan Che. Nicotine, through upregulating pro-survival signaling, cooperates with NNK to promote transformation. Journal of cellular biochemistry. vol 109. issue 1. 2010-03-02. PMID:19911375. |
we demonstrated that short-term nicotine exposure moderately activated mitogenic signaling pathways (such as pkc, erk, and akt) and a mediocre protection against cisplatin-mediated apoptosis. |
2010-03-02 |
2023-08-12 |
Not clear |
| Takashi Nishioka, Jinjin Guo, Daisuke Yamamoto, Lihua Chen, Petra Huppi, Chang Yan Che. Nicotine, through upregulating pro-survival signaling, cooperates with NNK to promote transformation. Journal of cellular biochemistry. vol 109. issue 1. 2010-03-02. PMID:19911375. |
interestingly, a week after the exposure to nicotine or nicotine plus nnk, bcl-2 expression was augmented, accompanied with the increased resistance to cisplatin-induced apoptosis. |
2010-03-02 |
2023-08-12 |
Not clear |
| Jinfeng Zhao, Meiguo Xin, Ton Wang, Yangde Zhang, Xingming Den. Nicotine enhances the antiapoptotic function of Mcl-1 through phosphorylation. Molecular cancer research : MCR. vol 7. issue 12. 2010-02-19. PMID:19903766. |
nicotine, a major component in tobacco smoke, functions as a survival agonist that inhibits apoptosis following various stresses. |
2010-02-19 |
2023-08-12 |
human |
| Silvia C S Oloris, Ashley A Frazer-Abel, Cristan M Jubala, Susan P Fosmire, Karen M Helm, Sally R Robinson, Derek M Korpela, Megan M Duckett, Shairaz Baksh, Jaime F Modian. Nicotine-mediated signals modulate cell death and survival of T lymphocytes. Toxicology and applied pharmacology. vol 242. issue 3. 2010-02-18. PMID:19896492. |
the data show that nicotine induces paradoxical effects that might alternatively enforce survival or trigger apoptosis, suggesting that depending on timing and context, nicotine might act both as a survival factor or as an inducer of apoptosis in normal or transformed lymphocytes, and possibly other non-neuronal cells. |
2010-02-18 |
2023-08-12 |
human |
| Laura Paleari, Alfredo Cesario, Massimo Fini, Patrizia Russ. alpha7-Nicotinic receptor antagonists at the beginning of a clinical era for NSCLC and Mesothelioma? Drug discovery today. vol 14. issue 17-18. 2009-11-17. PMID:19616116. |
the background and rationale of this approach are based on the experimental observations that: (a) nsclc and mpm cells express nachrs and (b) the activation of these receptors by agonists, namely nicotine, inhibits apoptosis, whereas receptor antagonists have a pro-apoptotic effect. |
2009-11-17 |
2023-08-12 |
human |
| Yong Wang, Xin Ge, Xiao Fang Xu, Xiao Jing Wan. Acetylcholinesterase inhibitor is a potentially useful therapeutic agent for nicotine-induced periodontal disease. Medical hypotheses. vol 73. issue 4. 2009-11-16. PMID:19625132. |
we hypothesize that there is a non-neuronal cholinergic system in periodontal tissue that is activated by excess nicotine, which increases expression of ache, thus increasing apoptosis of periodontal cells. |
2009-11-16 |
2023-08-12 |
Not clear |
| Andreia Oliveira-da-Silva, Fernanda B Vieira, Fabiana Cristina-Rodrigues, Cláudio C Filgueiras, Alex C Manhães, Yael Abreu-Villaç. Increased apoptosis and reduced neuronal and glial densities in the hippocampus due to nicotine and ethanol exposure in adolescent mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 27. issue 6. 2009-11-13. PMID:19576279. |
increased apoptosis and reduced neuronal and glial densities in the hippocampus due to nicotine and ethanol exposure in adolescent mice. |
2009-11-13 |
2023-08-12 |
mouse |
| Frederik B Thunnisse. Acetylcholine receptor pathway and lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. vol 4. issue 8. 2009-10-06. PMID:19633471. |
the reduced treatment efficacy may well be explained by the pluriform effect of nicotine on tumor cell proliferation, apoptosis, epithelialmesenchymal transition, proinvasive, and angiogenic effects, which are reenforced by an autocrine/paracrine loop. |
2009-10-06 |
2023-08-12 |
Not clear |
| Xiaohui Duan, Yebo Zhou, Xu Teng, Chaoshu Tang, Yongfen Q. Endoplasmic reticulum stress-mediated apoptosis is activated in vascular calcification. Biochemical and biophysical research communications. vol 387. issue 4. 2009-08-26. PMID:19622343. |
we prepared two rat models of calcification, vitamin d(3) plus nicotine (vdn) and rapid calcification (rc), to investigate whether ers-mediated apoptosis is activated in vc. |
2009-08-26 |
2023-08-12 |
rat |
| John W Martin, Shaymaa S Mousa, Olfat Shaker, Shaker A Mous. The multiple faces of nicotine and its implications in tissue and wound repair. Experimental dermatology. vol 18. issue 6. 2009-08-25. PMID:19492997. |
while its beneficial effects are still under investigation, important findings regarding nicotine's acceleration of atherosclerosis, tumor angiogenesis, cell proliferation e and resistance to apoptosis put its systemic use into question. |
2009-08-25 |
2023-08-12 |
Not clear |
| Baolu Zha. Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease. Neurochemical research. vol 34. issue 4. 2009-06-03. PMID:19125328. |
the author reviews the studies on the protecting effects of natural antioxidants on neurons in neurodegenerative diseases, especially summarized the results about protective effect of green tea polyphenols on neurons against apoptosis of cellular and animal pd models, and of genestine and nicotine on neurons against a beta-induced apoptosis of hippocampal neuronal and transgenic mouse ad models. |
2009-06-03 |
2023-08-12 |
mouse |
| Zhe Zhang, Yuan Zhou, Yi-You Zou, Li Wang, Zhi-Chun Yang, Ren Guo, Dai Li, Jun Peng, Yuan-Jian L. Detrimental effects of nicotine on the acute gastric mucosal injury induced by ethanol: role of asymmetric dimethylarginine. Canadian journal of physiology and pharmacology. vol 86. issue 12. 2009-03-31. PMID:19088804. |
the concentration of adma in the culture medium and the ratio of cell apoptosis were measured, and the effect of nicotine or adma alone on cell apoptosis was also examined. |
2009-03-31 |
2023-08-12 |
human |
| Zhe Zhang, Yuan Zhou, Yi-You Zou, Li Wang, Zhi-Chun Yang, Ren Guo, Dai Li, Jun Peng, Yuan-Jian L. Detrimental effects of nicotine on the acute gastric mucosal injury induced by ethanol: role of asymmetric dimethylarginine. Canadian journal of physiology and pharmacology. vol 86. issue 12. 2009-03-31. PMID:19088804. |
similarly, ethanol was able to induce epithelial cell apoptosis that was exacerbated by nicotine. |
2009-03-31 |
2023-08-12 |
human |
| Zhe Zhang, Yuan Zhou, Yi-You Zou, Li Wang, Zhi-Chun Yang, Ren Guo, Dai Li, Jun Peng, Yuan-Jian L. Detrimental effects of nicotine on the acute gastric mucosal injury induced by ethanol: role of asymmetric dimethylarginine. Canadian journal of physiology and pharmacology. vol 86. issue 12. 2009-03-31. PMID:19088804. |
incubation of epithelial cells with nicotine alone did not induce cell apoptosis, but administration of adma alone did induce cell apoptosis. |
2009-03-31 |
2023-08-12 |
human |
| Jingmei Zhang, Opal Kamdar, Wei Le, Glenn D Rosen, Daya Upadhya. Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer. American journal of respiratory cell and molecular biology. vol 40. issue 2. 2009-02-03. PMID:18676776. |
tobacco carcinogens have been studied widely; however, little is known about the agents that inhibit apoptosis, such as nicotine. |
2009-02-03 |
2023-08-12 |
Not clear |
| Jingmei Zhang, Opal Kamdar, Wei Le, Glenn D Rosen, Daya Upadhya. Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer. American journal of respiratory cell and molecular biology. vol 40. issue 2. 2009-02-03. PMID:18676776. |
we found that nicotine prevented chemotherapy-induced apoptosis, improved cell survival, and caused modest increases in dna synthesis. |
2009-02-03 |
2023-08-12 |
Not clear |
| Jingmei Zhang, Opal Kamdar, Wei Le, Glenn D Rosen, Daya Upadhya. Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer. American journal of respiratory cell and molecular biology. vol 40. issue 2. 2009-02-03. PMID:18676776. |
inhibition of mitogen-activated protein kinase (mapk) and akt prevented the antiapoptotic effects of nicotine and decreased chemotherapy-induced apoptosis. |
2009-02-03 |
2023-08-12 |
Not clear |
| Jingmei Zhang, Opal Kamdar, Wei Le, Glenn D Rosen, Daya Upadhya. Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer. American journal of respiratory cell and molecular biology. vol 40. issue 2. 2009-02-03. PMID:18676776. |
small interfering rna mapk kinase-1 blocked antiapoptotic effects of nicotine, whereas small interfering rna mapk kinase-2 blocked chemotherapy-induced apoptosis. |
2009-02-03 |
2023-08-12 |
Not clear |
| Jingmei Zhang, Opal Kamdar, Wei Le, Glenn D Rosen, Daya Upadhya. Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer. American journal of respiratory cell and molecular biology. vol 40. issue 2. 2009-02-03. PMID:18676776. |
nicotine up-regulated akt-mediated antiapoptotic x-linked inhibitor of apoptosis protein and phosphorylated proapoptotic bcl2-antagonist of cell death. |
2009-02-03 |
2023-08-12 |
Not clear |