| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Doina Chioran, Adrian Sitaru, Ioana Macasoi, Iulia Pinzaru, Cristian Andrei Sarau, Cristina Dehelean, Stefania Dinu, Camelia Szuhanek, Irina Nicoleta Zetu, Andra Cristine Serafin, Mircea Rivis, Marioara Poenaru, Razvan Drago. Nicotine Exerts Cytotoxic Effects in a Panel of Healthy Cell Lines and Strong Irritating Potential on Blood Vessels. International journal of environmental research and public health. vol 19. issue 14. 2022-07-27. PMID:35886732. |
in conclusion, nicotine has an extremely strong toxicological profile, as demonstrated by the drastic reduction of cell viability and the induction of morphological changes and nuclear alterations associated with cellular apoptosis. |
2022-07-27 |
2023-08-14 |
Not clear |
| Jing Chen, Yaxia Yao, Yijia Wang, Xiaotong Wang, Xia Peng, Tianli Li, Ying Liu, Juan D. Autophagy triggered by the ROS/ERK signaling pathway protects mouse embryonic palatal cells from apoptosis induced by nicotine. Environmental science and pollution research international. 2022-06-23. PMID:35739442. |
autophagy triggered by the ros/erk signaling pathway protects mouse embryonic palatal cells from apoptosis induced by nicotine. |
2022-06-23 |
2023-08-14 |
mouse |
| Jing Chen, Yaxia Yao, Yijia Wang, Xiaotong Wang, Xia Peng, Tianli Li, Ying Liu, Juan D. Autophagy triggered by the ROS/ERK signaling pathway protects mouse embryonic palatal cells from apoptosis induced by nicotine. Environmental science and pollution research international. 2022-06-23. PMID:35739442. |
first, we found that nicotine promoted mepcs proliferation and inhibited their apoptosis from 0 to 12 h. |
2022-06-23 |
2023-08-14 |
mouse |
| Zhuoying Liu, Yixuan Zhang, Ji Youn Youn, Yabing Zhang, Ayako Makino, Jason X-J Yuan, Hua Ca. Flavored and Nicotine-Containing E-Cigarettes Induce Impaired Angiogenesis and Diabetic Wound Healing via Increased Endothelial Oxidative Stress and Reduced NO Bioavailability. Antioxidants (Basel, Switzerland). vol 11. issue 5. 2022-05-28. PMID:35624768. |
endothelial cell apoptosis evaluated by caspase 3 activity was markedly increased by exposure to e-cse prepared from flavored and nicotine containing e-cigarettes. |
2022-05-28 |
2023-08-13 |
mouse |
| Zhila Khodabandeh, Mohammad Valilo, Kobra Velaei, Abbas Pirpour Tazehkan. The potential role of nicotine in breast cancer initiation, development, angiogenesis, invasion, metastasis, and resistance to therapy. Breast cancer (Tokyo, Japan). 2022-05-18. PMID:35583594. |
current study aims to review the mechanistic function of nicotine in the initiation, development, angiogenesis, invasion, metastasis, and apoptosis of breast cancer with the main focus on nicotine acetylcholine receptors (nachrs) and nachr-mediated signaling pathways as well as on its potential for the development of an effective treatment against breast cancer. |
2022-05-18 |
2023-08-13 |
Not clear |
| A Alzu'bi, M S Al Zoubi, G T Abdelhady, B Al-Trad, S Omari, M I Abualarjah, W El-Huneidi, D R Alzu'bi, J M Bani-Issa, G J Clowr. Reduced placental size and increased apoptosis are associated with prenatal nicotine exposure in rats. European review for medical and pharmacological sciences. vol 26. issue 5. 2022-03-18. PMID:35302204. |
reduced placental size and increased apoptosis are associated with prenatal nicotine exposure in rats. |
2022-03-18 |
2023-08-13 |
rat |
| Wen-Cheng Lo, Chi-Sheng Chiou, Feng-Chou Tsai, Chun-Hao Chan, Samantha Mao, Yue-Hua Deng, Chia-Yu Wu, Bou-Yue Peng, Win-Ping Den. Platelet-Derived Biomaterials Inhibit Nicotine-Induced Intervertebral Disc Degeneration Through Regulating IGF-1/AKT/IRS-1 Signaling Axis. Cell transplantation. vol 30. 2021-11-17. PMID:34586895. |
since nicotine has been demonstrated to adversely impact various physiological processes, such as sympathetic nervous system, leading to impaired vasculature and cellular apoptosis, we aimed to investigate whether nicotine could induce ivd degeneration. |
2021-11-17 |
2023-08-13 |
mouse |
| Yuan Liu, Shi Xu, Haijun Zhang, Kaoliang Qian, Jiachen Huang, Xianger Gu, Yan Li, Yi Fan, Jun H. Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis. Cell death & disease. vol 12. issue 5. 2021-10-14. PMID:33953172. |
next, we observed that α7-nachrs deficiency did not affect cartilage degradation in oa development but reversed the beneficial effects of nicotine on mechanical allodynia, cartilage degradation, and an mia-induced switch from autophagy to apoptosis. |
2021-10-14 |
2023-08-13 |
mouse |
| Yuan Liu, Shi Xu, Haijun Zhang, Kaoliang Qian, Jiachen Huang, Xianger Gu, Yan Li, Yi Fan, Jun H. Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis. Cell death & disease. vol 12. issue 5. 2021-10-14. PMID:33953172. |
thus, our findings not only confirmed that nicotine alleviated mia-induced pain behavior and cartilage degradation via stimulating the α7-nachrs/mtor signal pathway but found the potential role of α7-nachrs in mediating the balance between apoptosis and autophagy. |
2021-10-14 |
2023-08-13 |
mouse |
| Xinjia Zhou, Yuan Gao, Yue Hu, Xiulan M. Melatonin protects cochlear hair cells from nicotine-induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress. Basic & clinical pharmacology & toxicology. vol 129. issue 4. 2021-09-15. PMID:34254721. |
functional investigations showed that nicotine (10 μm) stimulation dramatically promoted apoptosis, inflammatory response, oxidative stress and endoplasmic reticulum stress in hei-oc1 cells. |
2021-09-15 |
2023-08-13 |
Not clear |
| Xinjia Zhou, Yuan Gao, Yue Hu, Xiulan M. Melatonin protects cochlear hair cells from nicotine-induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress. Basic & clinical pharmacology & toxicology. vol 129. issue 4. 2021-09-15. PMID:34254721. |
collectively, we demonstrated that nicotine induced apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress of cochlear hair cells in an in vitro cell model. |
2021-09-15 |
2023-08-13 |
Not clear |
| Lilan Wang, Yao Wang, Jianwen Chen, Xue-Min Yang, Xing-Tao Jiang, Peiqing Liu, Min L. Comparison of biological and transcriptomic effects of conventional cigarette and electronic cigarette smoke exposure at toxicological dose in BEAS-2B cells. Ecotoxicology and environmental safety. vol 222. 2021-08-19. PMID:34229167. |
we found that acute exposure of beas-2b cells to csc at ic50 leaded to morphological change, inflammatory cytokines production and cell apoptosis, while ecsc did not exert such cell effects in equivalent nicotine level. |
2021-08-19 |
2023-08-13 |
human |
| Xinjia Han, Ning Zhou, Huiping Hu, Xin Li, Huishu Li. Nicotine Alleviates Cortical Neuronal Injury by Suppressing Neuroinflammation and Upregulating Neuronal PI3K-AKT Signaling in an Eclampsia-Like Seizure Model. Neurotoxicity research. vol 38. issue 3. 2021-07-09. PMID:32767216. |
wortmannin also blocked the anti-neuronal apoptosis action of nicotine. |
2021-07-09 |
2023-08-13 |
Not clear |
| Ting-Ting Meng, Wei Wang, Fan-Liang Meng, Shu-Ya Wang, Hui-Hui Wu, Jia-Min Chen, Yan Zheng, Guang-Xin Wang, Mao-Xiu Zhang, Ying Li, Guo-Hai S. Nicotine Causes Mitochondrial Dynamics Imbalance and Apoptosis Through ROS Mediated Mitophagy Impairment in Cardiomyocytes. Frontiers in physiology. vol 12. 2021-06-29. PMID:34177609. |
nicotine causes mitochondrial dynamics imbalance and apoptosis through ros mediated mitophagy impairment in cardiomyocytes. |
2021-06-29 |
2023-08-13 |
rat |
| Ting-Ting Meng, Wei Wang, Fan-Liang Meng, Shu-Ya Wang, Hui-Hui Wu, Jia-Min Chen, Yan Zheng, Guang-Xin Wang, Mao-Xiu Zhang, Ying Li, Guo-Hai S. Nicotine Causes Mitochondrial Dynamics Imbalance and Apoptosis Through ROS Mediated Mitophagy Impairment in Cardiomyocytes. Frontiers in physiology. vol 12. 2021-06-29. PMID:34177609. |
the purpose of this study was to explore the effects and potential mechanism of nicotine on mitophagy, mitochondrial dynamics, apoptosis, and the relationship between these processes in nrvms. |
2021-06-29 |
2023-08-13 |
rat |
| Ting-Ting Meng, Wei Wang, Fan-Liang Meng, Shu-Ya Wang, Hui-Hui Wu, Jia-Min Chen, Yan Zheng, Guang-Xin Wang, Mao-Xiu Zhang, Ying Li, Guo-Hai S. Nicotine Causes Mitochondrial Dynamics Imbalance and Apoptosis Through ROS Mediated Mitophagy Impairment in Cardiomyocytes. Frontiers in physiology. vol 12. 2021-06-29. PMID:34177609. |
finally, nicotine caused excessive mitochondrial fission and contributed to apoptosis, which could be alleviated by mdivi-1, an inhibitor of drp1. |
2021-06-29 |
2023-08-13 |
rat |
| Ting-Ting Meng, Wei Wang, Fan-Liang Meng, Shu-Ya Wang, Hui-Hui Wu, Jia-Min Chen, Yan Zheng, Guang-Xin Wang, Mao-Xiu Zhang, Ying Li, Guo-Hai S. Nicotine Causes Mitochondrial Dynamics Imbalance and Apoptosis Through ROS Mediated Mitophagy Impairment in Cardiomyocytes. Frontiers in physiology. vol 12. 2021-06-29. PMID:34177609. |
excessive mitochondrial fission induced by nicotine ultimately leads to apoptosis. |
2021-06-29 |
2023-08-13 |
rat |
| Ting-Ting Meng, Wei Wang, Fan-Liang Meng, Shu-Ya Wang, Hui-Hui Wu, Jia-Min Chen, Yan Zheng, Guang-Xin Wang, Mao-Xiu Zhang, Ying Li, Guo-Hai S. Nicotine Causes Mitochondrial Dynamics Imbalance and Apoptosis Through ROS Mediated Mitophagy Impairment in Cardiomyocytes. Frontiers in physiology. vol 12. 2021-06-29. PMID:34177609. |
torin1 restored the decreased ctsl enzyme activity by removing excessive ros and alleviated the effects of nicotine on mitophagic flux, mitochondrial dynamics, and apoptosis. |
2021-06-29 |
2023-08-13 |
rat |
| Miranda P Ween, Rhys Hamon, Matthew G Macowan, Leigh Thredgold, Paul N Reynolds, Sandra J Hodg. Effects of E-cigarette E-liquid components on bronchial epithelial cells: Demonstration of dysfunctional efferocytosis. Respirology (Carlton, Vic.). vol 25. issue 6. 2021-06-22. PMID:31542893. |
this study assessed the effect of e-cigarette constituents, 3 e-liquid apple flavours, nicotine, vegetable glycerine and propylene glycol, on bronchial epithelial cell viability, apoptosis and cytokine secretion and macrophage phagocytosis of apoptotic airway cells and phagocytic recognition molecules. |
2021-06-22 |
2023-08-13 |
Not clear |
| Mei-Mei Gao, Fei Hu, Xiang-Da Zeng, Hui-Ling Tang, Huan Zhang, Wei Jiang, Hua-Juan Yan, Hang Shi, Yousheng Shu, Yue-Sheng Lon. Hypothalamic proteome changes in response to nicotine and its withdrawal are potentially associated with alteration in body weight. Journal of proteomics. vol 214. 2021-06-18. PMID:31911195. |
through tmt-based proteomic analysis, this study identified differential hypothalamic protein profiles in response to nicotine treatment and its withdrawal, and 4 nicotine- and withdrawal-induced contrary proteins casp3, lcmt2, grin2d and ccnt2 are involved in several enriched go terms and kegg pathways, which are associated with cell apoptosis, neurotransmission and metabolism. |
2021-06-18 |
2023-08-13 |
mouse |