All Relations between apoptosis and txnip

Publication Sentence Publish Date Extraction Date Species
Shan Song, Duojun Qiu, Yuhan Wang, Jinying Wei, Haijiang Wu, Ming Wu, Shuai Wang, Xinbo Zhou, Yonghong Shi, Huijun Dua. TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy. Experimental cell research. vol 388. issue 2. 2020-11-09. PMID:31982382. all these data indicate that txnip deficiency may mitigate apoptosis of podocytes by inhibiting p38 mapk or mtor signaling pathway in dn, underlining txnip as a putative target for therapy. 2020-11-09 2023-08-13 mouse
P S Lalit, Y Thangal, Y Fayi, S D Takhellamba. Potentials of Gene Therapy for Diabetic Retinopathy: The Use of Nucleic Acid Constructs Containing a TXNIP Promoter. Open access journal of ophthalmology. vol 3. issue 2. 2020-10-01. PMID:31106306. txnip's actions involve binding to and inhibition of anti-oxidant and thiol-reducing capacities of thioredoxins (trx) causing cellular oxidative stress and apoptosis. 2020-10-01 2023-08-13 Not clear
P S Lalit, Y Thangal, Y Fayi, S D Takhellamba. Potentials of Gene Therapy for Diabetic Retinopathy: The Use of Nucleic Acid Constructs Containing a TXNIP Promoter. Open access journal of ophthalmology. vol 3. issue 2. 2020-10-01. PMID:31106306. several studies provided evidence that knockdown of txnip by sirna or chemical blockade ameliorates early abnormalities of dr including endothelial dysfunction, pericyte apoptosis, müller cell gliosis and neurodegeneration. 2020-10-01 2023-08-13 Not clear
Jinghui Zhai, Lina Tao, Yueming Zhang, Huan Gao, Xiaoyu Qu, Yanqing Song, Sixi Zhan. Salvianolic Acid B Attenuates Apoptosis of HUVEC Cells Treated with High Glucose or High Fat via Sirt1 Activation. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-10-01. PMID:31118974. we also found that sab reversed hg- or pa-induced oxidative stress, apoptosis cell cytokines production, and expression of thioredoxin-interacting protein (txnip). 2020-10-01 2023-08-13 human
Dawit Zewdu Wondafrash, Asmelash Tesfay Nire'a, Gebrehiwot Gebremedihn Tafere, Desilu Mahari Desta, Demoze Asmerom Berhe, Kaleab Alemayehu Zewdi. Thioredoxin-Interacting Protein as a Novel Potential Therapeutic Target in Diabetes Mellitus and Its Underlying Complications. Diabetes, metabolic syndrome and obesity : targets and therapy. vol 13. 2020-09-28. PMID:32021350. numerous studies illustrated that elevated txnip levels were found to induce β-cell apoptosis; whereas txnip deficiency protects against type i and type ii diabetes by promoting β-cell survival. 2020-09-28 2023-08-13 Not clear
Lingjuan Cui, Xiaoyan Jiang, Chengjun Zhang, Danxia Li, Shengqiang Yu, Fengchun Wan, Yue Ma, Wei Guo, Zhengfei Sha. Ketamine induces endoplasmic reticulum stress in rats and SV-HUC-1 human uroepithelial cells by activating NLRP3/TXNIP aix. Bioscience reports. vol 39. issue 10. 2020-09-15. PMID:31652453. furthermore, knocking down txnip reversed the effects of ketamine on apoptosis and nlrp3 inflammatory body in sv-huc-1 cells. 2020-09-15 2023-08-13 human
Takhellambam S Devi, Thangal Yumnamcha, Fayi Yao, Mallika Somayajulu, Renu A Kowluru, Lalit P Sing. TXNIP mediates high glucose-induced mitophagic flux and lysosome enlargement in human retinal pigment epithelial cells. Biology open. vol 8. issue 4. 2020-02-25. PMID:31023645. thioredoxin-interacting protein (txnip) plays a critical role in oxidative stress, inflammation, apoptosis and the pathogenesis of diabetic retinopathy (dr). 2020-02-25 2023-08-13 human
Dian Jiao, Yi Huan, Jia Zheng, Ming Wei, Guoxu Zheng, Donghui Han, Jieheng Wu, Wenjin Xi, Feilong Wei, An-Gang Yang, Weijun Qin, He Wang, Weihong We. UHRF1 promotes renal cell carcinoma progression through epigenetic regulation of TXNIP. Oncogene. vol 38. issue 28. 2020-02-14. PMID:31043707. in addition, after uhrf1 and txnip were simultaneously downregulated, cell viability and cell invasion increased, whereas cell apoptosis decreased compared with uhrf1 single downregulated cells. 2020-02-14 2023-08-13 Not clear
Jung-Hwa Han, Suji Kim, Sujin Kim, Heejung Lee, So-Young Park, Chang-Hoon Wo. FMK, an Inhibitor of p90RSK, Inhibits High Glucose-Induced TXNIP Expression via Regulation of ChREBP in Pancreatic β Cells. International journal of molecular sciences. vol 20. issue 18. 2020-01-30. PMID:31505737. txnip (thioredoxin-interacting protein) is a key mediator of diabetic β-cell apoptosis and dysfunction in diabetes, and thus, its regulation represents a therapeutic target. 2020-01-30 2023-08-13 Not clear
Qiong Pan, Ke Guo, Yaqian Li, Qiuyun T. [Role of TXNIP-mediated oxidative stress in delaying Alzheimer's disease by estrogen]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 12. 2020-01-27. PMID:31969500. to study the functional mechanism of thioredoxin-interacting protein (txnip) in delaying alzheimer's disease (ad) by estrogen.
 methods: after estradiol (e2) treatment in aβ-induced ad cell model, reactive oxygen species (ros), txnip, and apoptosis levels were detected. 2020-01-27 2023-08-13 rat
Qiong Pan, Ke Guo, Yaqian Li, Qiuyun T. [Role of TXNIP-mediated oxidative stress in delaying Alzheimer's disease by estrogen]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 12. 2020-01-27. PMID:31969500. after lentiviral infection with txnip overexpression, the effect of e2 on ros and apoptosis were observed. 2020-01-27 2023-08-13 rat
Qiong Pan, Ke Guo, Yaqian Li, Qiuyun T. [Role of TXNIP-mediated oxidative stress in delaying Alzheimer's disease by estrogen]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 12. 2020-01-27. PMID:31969500. after overexpressing txnip, the effect of e2 on the learning and memory ability of ad rat model was observed.
 results: ros, txnip and apoptosis levels were enhanced in ad cell model, while e2 treatment reduced ros, txnip and apoptosis levels in ad cell model. 2020-01-27 2023-08-13 rat
Qiong Pan, Ke Guo, Yaqian Li, Qiuyun T. [Role of TXNIP-mediated oxidative stress in delaying Alzheimer's disease by estrogen]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 12. 2020-01-27. PMID:31969500. after enhancing txnip, e2 treatment reduced ros and apoptosis levels in ad cell model. 2020-01-27 2023-08-13 rat
Jin Wang, Yanjin Feng, Haiyan Huo, Xumei Zhang, Jiping Yue, Wenting Zhang, Zi Yan, Xiangying Jia. NLRP3 inflammasome mediates angiotensin II-induced islet β cell apoptosis. Acta biochimica et biophysica Sinica. vol 51. issue 5. 2019-12-20. PMID:30939192. the results showed that ang ii was able to reduce ins-1 cell viability and promote apoptosis and at the same time up-regulate the expressions of txnip and nlrp3 components. 2019-12-20 2023-08-13 rat
Jin Wang, Yanjin Feng, Haiyan Huo, Xumei Zhang, Jiping Yue, Wenting Zhang, Zi Yan, Xiangying Jia. NLRP3 inflammasome mediates angiotensin II-induced islet β cell apoptosis. Acta biochimica et biophysica Sinica. vol 51. issue 5. 2019-12-20. PMID:30939192. ang ii-induced apoptosis was inhibited after administration of the nlrp3 inhibitor mcc950, and txnip silencing could reduce the nlrp3 expression and apoptosis, while both effects of ang ii on txnip-nlrp3 and its apoptosis-inducing effect were inhibited by angiotensin ii type i receptor (at1r) blocker telmisartan. 2019-12-20 2023-08-13 rat
Xuhui Hou, Songbai Yang, Jian Yi. Blocking the REDD1/TXNIP axis ameliorates LPS-induced vascular endothelial cell injury through repressing oxidative stress and apoptosis. American journal of physiology. Cell physiology. vol 316. issue 1. 2019-11-14. PMID:30485138. most important, depletion of redd1 protected huvecs against inflammation-mediated apoptosis and oxidative damage partly through thioredoxin-interacting protein (txnip). 2019-11-14 2023-08-13 human
Yurika Katsu-Jiménez, Carmela Vázquez-Calvo, Camilla Maffezzini, Maria Halldin, Xiaoxiao Peng, Christoph Freyer, Anna Wredenberg, Alfredo Giménez-Cassina, Anna Wedell, Elias S J Arné. Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate. Diabetes. vol 68. issue 4. 2019-09-17. PMID:30755400. txnip expression is induced by glucose and promotes β-cell apoptosis in the pancreas, and deletion of its gene in mouse models protects against diabetes. 2019-09-17 2023-08-13 mouse
Susanne Schuster, Casey D Johnson, Marie Hennebelle, Theresa Holtmann, Ameer Y Taha, Irina A Kirpich, Akiko Eguchi, Christopher E Ramsden, Bettina G Papouchado, Craig J McClain, Ariel E Feldstei. Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice. Journal of lipid research. vol 59. issue 9. 2019-09-09. PMID:30084831. oxidative stress increased thioredoxin-interacting protein (txnip) in the liver and stimulated the activation of mitochondrial apoptosis signal-regulating kinase 1 (ask1) leading to apoptosis. 2019-09-09 2023-08-13 mouse
Paul L Feingold, Deborah R Surman, Kate Brown, Yuan Xu, Lucas A McDuffie, Vivek Shukla, Emily S Reardon, Daniel R Crooks, Jane B Trepel, Sunmin Lee, Min-Jung Lee, Shaojian Gao, Sichuan Xi, Kaitlin C McLoughlin, Laurence P Diggs, David G Beer, Derek J Nancarrow, Leonard M Neckers, Jeremy L Davis, Chuong D Hoang, Jonathan M Hernandez, David S Schrump, R Taylor Riple. Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma. Molecular cancer therapeutics. vol 17. issue 9. 2019-09-03. PMID:29934340. txnip overexpression increased, whereas knockdown abrogated, dna damage and apoptosis following cisplatin treatment. 2019-09-03 2023-08-13 Not clear
Paul L Feingold, Deborah R Surman, Kate Brown, Yuan Xu, Lucas A McDuffie, Vivek Shukla, Emily S Reardon, Daniel R Crooks, Jane B Trepel, Sunmin Lee, Min-Jung Lee, Shaojian Gao, Sichuan Xi, Kaitlin C McLoughlin, Laurence P Diggs, David G Beer, Derek J Nancarrow, Leonard M Neckers, Jeremy L Davis, Chuong D Hoang, Jonathan M Hernandez, David S Schrump, R Taylor Riple. Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma. Molecular cancer therapeutics. vol 17. issue 9. 2019-09-03. PMID:29934340. an hdac inhibitor, entinostat (currently in clinical trials), upregulated txnip and synergistically increased cisplatin-mediated dna damage and apoptosis. 2019-09-03 2023-08-13 Not clear