| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiankun Cao, Wenxin He, Yichuan Pang, Yu Cao, An Qi. Redox-dependent and independent effects of thioredoxin interacting protein. Biological chemistry. vol 401. issue 11. 2021-06-15. PMID:32845855. |
regulation of txnip expression and/or activity not only plays an important role in redox regulation but also exerts redox-independent physiological effects that exhibit direct pathophysiological consequences including elevated inflammatory response, aberrant glucose metabolism, cellular senescence and apoptosis, cellular immunity, and tumorigenesis. |
2021-06-15 |
2023-08-13 |
Not clear |
| Naila Qayyum, Muhammad Haseeb, Moon Suk Kim, Sangdun Cho. Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook. International journal of molecular sciences. vol 22. issue 5. 2021-04-27. PMID:33803178. |
txnip increases reactive oxygen species production and oxidative stress and thereby contributes to apoptosis. |
2021-04-27 |
2023-08-13 |
Not clear |
| Lingfeng Jiang, Wenkai Zhou, Bo Lu, Qichang Ya. ITCH regulates oxidative stress induced by high glucose through thioredoxin interacting protein in cultured human lens epithelial cells. Molecular medicine reports. vol 22. issue 5. 2021-04-26. PMID:32901881. |
it was found that txnip was highly expressed in cultured hlecs in high‑glucose environment, and the antioxidative function of trx was restricted and suppressed, thus promoting apoptosis. |
2021-04-26 |
2023-08-13 |
human |
| Lingfeng Jiang, Wenkai Zhou, Bo Lu, Qichang Ya. ITCH regulates oxidative stress induced by high glucose through thioredoxin interacting protein in cultured human lens epithelial cells. Molecular medicine reports. vol 22. issue 5. 2021-04-26. PMID:32901881. |
the overexpression of itch increased the expression of trx and decreased oxidative stress and apoptosis by decreasing txnip in cultured hlecs, while downregulation of itch significantly decreased the expression of trx and enhanced oxidative stress and apoptosis. |
2021-04-26 |
2023-08-13 |
human |
| Xinna Du, Xuan Shen, Li Dai, Fangjie Bi, Hu Zhang, Chunfeng L. PSMD12 promotes breast cancer growth via inhibiting the expression of pro-apoptotic genes. Biochemical and biophysical research communications. vol 526. issue 2. 2021-04-20. PMID:32222279. |
flow cytometry showed that cell apoptosis increased in the psmd12 knockdown, and rna-seq indicated that the apoptosis pathway was activated, and the txnip, gadd45a, gadd45b, rhob, and cdkn1a pro-apoptotic genes were highly expressed, a result that was validated by rt-qpcr and western blot. |
2021-04-20 |
2023-08-13 |
mouse |
| Lian Chen, E Xiang, Changyong Li, Bing Han, Quan Zhang, Wei Rao, Cuihong Xiao, Dongcheng W. Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Nephrocyte Injury and Proteinuria in a Diabetic Nephropathy Rat Model. Journal of diabetes research. vol 2020. 2021-03-18. PMID:32405507. |
most importantly, uc-mscs suppressed upregulation of thioredoxin-interacting protein (txnip), downregulation of thioredoxin 1 (trx1), and activation of apoptosis signal-regulating kinase 1 (ask1) and p38 mapk in the kidney of dn rats. |
2021-03-18 |
2023-08-13 |
rat |
| Meina Ma, Rui Li, Wenbo Sun, Qi Wang, Hong Yu, Hongmei Y. Sevoflurane preconditioning inhibits cardiomyocyte injury induced by oxygen‑glucose deprivation by modulating TXNIP. International journal of molecular medicine. vol 46. issue 2. 2021-03-08. PMID:32626926. |
the thioredoxin interaction protein (txnip) has been reported to be closely related to cell oxidative stress, apoptosis and inflammation. |
2021-03-08 |
2023-08-13 |
Not clear |
| Haocheng Ao, Haichun Li, Xiujuan Zhao, Bingqian Liu, Lin L. TXNIP positively regulates the autophagy and apoptosis in the rat müller cell of diabetic retinopathy. Life sciences. vol 267. 2021-03-02. PMID:33412212. |
txnip positively regulates the autophagy and apoptosis in the rat müller cell of diabetic retinopathy. |
2021-03-02 |
2023-08-13 |
rat |
| Haocheng Ao, Haichun Li, Xiujuan Zhao, Bingqian Liu, Lin L. TXNIP positively regulates the autophagy and apoptosis in the rat müller cell of diabetic retinopathy. Life sciences. vol 267. 2021-03-02. PMID:33412212. |
the present study evaluated the expression of thioredoxin interacting protein (txnip) and investigated the role of txnip in autophagy and apoptosis of dr. |
2021-03-02 |
2023-08-13 |
rat |
| Hesheng Ou, Hongli Teng, Yuwang Qin, Xuelan Luo, Peng Yang, Wenyu Zhang, Wei Chen, Dongning Lv, Huamin Tan. Extracellular vesicles derived from microRNA-150-5p-overexpressing mesenchymal stem cells protect rat hearts against ischemia/reperfusion. Aging. vol 12. issue 13. 2021-03-01. PMID:32657760. |
rat models of ischemia/reperfusion (i/r) were established to explore the expression profile of thioredoxin-interacting protein (txnip), which was then knocked-down to investigate its effects on myocardial remodeling, followed by detection on myocardial infarction size (mis), myocardial collagen volume fraction (cvf) and cardiomyocyte apoptosis. |
2021-03-01 |
2023-08-13 |
rat |
| Min Liu, Chunyan Liu, Shenli Shen, Jianhui Liu, Fei Yi. Geniposide inhibits glucolipotoxicity and cooperates with Txnip knockdown to potentiate cell adaption to endoplasmic reticulum stress in pancreatic beta cells. Cell biology international. vol 44. issue 7. 2021-02-03. PMID:32215982. |
our previous data demonstrated that geniposide improved glucose-stimulated insulin secretion by accelerating txnip degradation and prevented the early-stage apoptosis of pancreatic β cells induced by palmitate, but the underlying mechanisms are still unclear. |
2021-02-03 |
2023-08-13 |
rat |
| Min Liu, Chunyan Liu, Shenli Shen, Jianhui Liu, Fei Yi. Geniposide inhibits glucolipotoxicity and cooperates with Txnip knockdown to potentiate cell adaption to endoplasmic reticulum stress in pancreatic beta cells. Cell biology international. vol 44. issue 7. 2021-02-03. PMID:32215982. |
the objective of this study is to identify the role of txnip in geniposide preventing the apoptosis of pancreatic β cells induced by high glucose and palmitate (hg/pa). |
2021-02-03 |
2023-08-13 |
rat |
| Qiong Pan, Ke Guo, Min Xue, Qiuyun T. Estrogen protects neuroblastoma cell from amyloid-β 42 (Aβ42)-induced apoptosis via TXNIP/TRX axis and AMPK signaling. Neurochemistry international. vol 135. 2021-01-25. PMID:31931042. |
consistently, in the hippocampus in female ad mice, apoptosis and txnip expression were enhanced while trx expression was suppressed. |
2021-01-25 |
2023-08-13 |
mouse |
| Qiong Pan, Ke Guo, Min Xue, Qiuyun T. Estrogen protects neuroblastoma cell from amyloid-β 42 (Aβ42)-induced apoptosis via TXNIP/TRX axis and AMPK signaling. Neurochemistry international. vol 135. 2021-01-25. PMID:31931042. |
in aβ42-stimulated sh-sy5y cells, the administration of estradiol significantly rescued aβ42-suppressed cell viability and protein level of trx while inhibited aβ42-induced increases in ros production, cell apoptosis, ΔΨm, and the protein levels of perk, ireα, and txnip, further confirming the potential role of estrogen in ad progression and the involvement of txnip/trx axis. |
2021-01-25 |
2023-08-13 |
mouse |
| Yiting Chen, Jieling Ning, Wenjie Cao, Shuanglian Wang, Tao Du, Jiahui Jiang, Xueping Feng, Bin Zhan. Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers. Frontiers in oncology. vol 10. 2020-11-17. PMID:33194655. |
thioredoxin-interacting protein (txnip) is a thioredoxin-binding protein that can mediate oxidative stress, inhibit cell proliferation, and induce apoptosis by inhibiting the function of the thioredoxin system. |
2020-11-17 |
2023-08-13 |
Not clear |
| Yiting Chen, Jieling Ning, Wenjie Cao, Shuanglian Wang, Tao Du, Jiahui Jiang, Xueping Feng, Bin Zhan. Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers. Frontiers in oncology. vol 10. 2020-11-17. PMID:33194655. |
txnip can also prevent the occurrence of bladder cancer by inhibiting the activation of erk, which inhibits apoptosis in bladder cancer cells. |
2020-11-17 |
2023-08-13 |
Not clear |
| Yiting Chen, Jieling Ning, Wenjie Cao, Shuanglian Wang, Tao Du, Jiahui Jiang, Xueping Feng, Bin Zhan. Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers. Frontiers in oncology. vol 10. 2020-11-17. PMID:33194655. |
in addition, we also summarize emerging insights on txnip expression and its functional role in different kinds of cancers, as well as clarify its participation in metabolic reprogramming and oxidative stress in cancer cells, wherein it acts as a putative tumor suppressor gene to inhibit the proliferation, invasion, and migration of different tumor cells as well as promote apoptosis in these cells. |
2020-11-17 |
2023-08-13 |
Not clear |
| Shan Song, Duojun Qiu, Yuhan Wang, Jinying Wei, Haijiang Wu, Ming Wu, Shuai Wang, Xinbo Zhou, Yonghong Shi, Huijun Dua. TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy. Experimental cell research. vol 388. issue 2. 2020-11-09. PMID:31982382. |
txnip deficiency mitigates podocyte apoptosis via restraining the activation of mtor or p38 mapk signaling in diabetic nephropathy. |
2020-11-09 |
2023-08-13 |
mouse |
| Shan Song, Duojun Qiu, Yuhan Wang, Jinying Wei, Haijiang Wu, Ming Wu, Shuai Wang, Xinbo Zhou, Yonghong Shi, Huijun Dua. TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy. Experimental cell research. vol 388. issue 2. 2020-11-09. PMID:31982382. |
in this study, we investigated the potential function of txnip on apoptosis of podocytes and its potential mechanism in vivo and in vitro in diabetic nephropathy (dn). |
2020-11-09 |
2023-08-13 |
mouse |
| Shan Song, Duojun Qiu, Yuhan Wang, Jinying Wei, Haijiang Wu, Ming Wu, Shuai Wang, Xinbo Zhou, Yonghong Shi, Huijun Dua. TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy. Experimental cell research. vol 388. issue 2. 2020-11-09. PMID:31982382. |
txnip silencing attenuated hg-induced apoptosis and obliterated the activation of signaling pathways of mammalian target of rapamycin (mtor) and p38 mitogen-activated protein kinase (mapk) in conditionally immortalized mouse podocytes. |
2020-11-09 |
2023-08-13 |
mouse |