| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Khyati Girdhar, Shilpa Thakur, Pankaj Gaur, Abhinav Choubey, Surbhi Dogra, Budheswar Dehury, Sunil Kumar, Bidisha Biswas, Durgesh Kumar Dwivedi, Subrata Ghosh, Prosenjit Monda. Design, synthesis, and biological evaluation of a small molecule oral agonist of the glucagon-like-peptide-1 receptor. The Journal of biological chemistry. 2022-04-04. PMID:35378127. |
mechanistically, this protection was associated with decreased thioredoxin-interacting protein (txnip) expression, a potent inducer of diabetic β-cell apoptosis and dysfunction. |
2022-04-04 |
2023-08-13 |
mouse |
| Qian Wang, Wenying Chen, Boyang Zhang, Zilu Gao, Qipeng Zhang, Huiqiong Deng, Lingyun Han, Xiao Li She. Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication. Chemico-biological interactions. 2022-02-06. PMID:35123991. |
results indicated that a 24 h-treatment with 64 and 256 μm pfoa could remarkably induce mitochondrial-mediated apoptosis via initiating the vicious cycle between endoplasmic reticulum stress and oxidative stress, thereby increasing the level of calcium ion and decreasing the level of ΔΨm, simultaneously elevating the protein expressions of cyclophilin d (cypd), bcl-2 homologous antagonist/killer (bak), bcl-2-associated x protein (bax), bcl-2-like protein 11 (bim), cytochrome c (cyt-c), 78 kda glucose-regulated protein (grp78), ccaat/enhancer-binding protein (c/ebp) homologous protein (chop), and thioredoxin-interacting protein (txnip), while inhibiting the protein expression of tumor necrosis factor receptor-associated protein 1 (trap1), lon protease 1 (lonp1), pro-caspase-9, b-cell lymphoma-2 (bcl-2), and sigma 1-type opioid receptor (sig-1r) (p < 0.05). |
2022-02-06 |
2023-08-13 |
human |
| Jianjun Jiang, Huijuan Ouyang, Qun Zhou, Sihui Tang, Pu Fang, Guofang Xie, Jin Yang, Gengyun Su. LPS induces pulmonary microvascular endothelial cell barrier dysfunction by upregulating ceramide production. Cellular signalling. 2022-01-22. PMID:35065241. |
however, regarding apoptosis-dependent delayed barrier dysfunction, the ceramide-induced de novo synthesis pathway in paracellular cells induced the apoptosis of pmvecs, in which txnip overexpression inhibited trx activity and subsequently activated ask1 in the context of lps-induced pmvec apoptosis, acting upstream of the ceramide-induced activation of p38 mapk and jnk. |
2022-01-22 |
2023-08-13 |
rat |
| Rongrong Bai, Yue Lang, Jie Shao, Yu Deng, Reyisha Refuhati, Li Cu. The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets. ASN neuro. vol 13. 2021-11-30. PMID:34053242. |
reactive oxygen species (ros)/nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), ros/thioredoxin-interacting protein (txnip) and purinergic receptor-7 (p2x7r) signalling pathways can activate the nlrp3 inflammasome; activation of the nlrp3 inflammasome can aggravate cerebrovascular diseases by mediating apoptosis and pyroptosis. |
2021-11-30 |
2023-08-13 |
Not clear |
| Yu-Syuan Chen, Shao-Ju Weng, Shu-Hsien Chang, Rou-Ying Li, Guang-Tzuu Shane, Jui-Pao Hsu, Sheng-Wen Yeh, Ai-Ching Chang, Meng-Ju Le. Evaluating the antidiabetic effects of R-verapamil in type 1 and type 2 diabetes mellitus mouse models. PloS one. vol 16. issue 8. 2021-11-24. PMID:34358247. |
verapamil (50% s-verapamil and 50% r-verapamil) can treat dm by downregulating thioredoxin-interacting protein (txnip), which induces islet β-cell apoptosis. |
2021-11-24 |
2023-08-13 |
mouse |
| Yu-Syuan Chen, Shao-Ju Weng, Shu-Hsien Chang, Rou-Ying Li, Guang-Tzuu Shane, Jui-Pao Hsu, Sheng-Wen Yeh, Ai-Ching Chang, Meng-Ju Le. Evaluating the antidiabetic effects of R-verapamil in type 1 and type 2 diabetes mellitus mouse models. PloS one. vol 16. issue 8. 2021-11-24. PMID:34358247. |
in the type 1 dm study, 100 mg/kg/day r-verapamil and racemic verapamil lowered bg, downregulated txnip expression, and reduced β-cell apoptosis. |
2021-11-24 |
2023-08-13 |
mouse |
| Shuai Wang, Shanshan Du, Yong Lv, Wenzhan Wang, Fengyan Zhan. Elevated microRNA-20b-3p and reduced thioredoxin-interacting protein ameliorate diabetic retinopathy progression by suppressing the NLRP3 inflammasomes. IUBMB life. vol 72. issue 7. 2021-11-12. PMID:32150340. |
afterward, the expression of mir-20b-3p and txnip, visual function, inflammatory factors, microvascular injury, vascular permeability, cell apoptosis, and angiogenesis in rats' retinal tissues were assessed. |
2021-11-12 |
2023-08-13 |
human |
| Shuai Wang, Shanshan Du, Yong Lv, Wenzhan Wang, Fengyan Zhan. Elevated microRNA-20b-3p and reduced thioredoxin-interacting protein ameliorate diabetic retinopathy progression by suppressing the NLRP3 inflammasomes. IUBMB life. vol 72. issue 7. 2021-11-12. PMID:32150340. |
elevated mir-20b-3p and inhibited txnip promoted the visual function, and restricted the inflammatory reaction, microvascular injury, vascular permeability, cell apoptosis, and angiogenesis in dr rats, thereby decelerating the development of dr. |
2021-11-12 |
2023-08-13 |
human |
| Yining Shi, Yongmei Jin, Fangfang Liu, Jianjun Jiang, Jiyu Cao, Youjin Lu, Jin Yan. Ceramide induces the apoptosis of non‑small cell lung cancer cells through the Txnip/Trx1 complex. International journal of molecular medicine. vol 47. issue 5. 2021-11-10. PMID:33760130. |
hoechst 33258 staining and flow cytometry were used to detect cell apoptosis, and the positional association between txnip and trx1 upregulated by ceramide was observed by immunofluorescence confocal microscopy. |
2021-11-10 |
2023-08-13 |
Not clear |
| Mina Noura, Hidemasa Matsuo, Asami Koyama, Souichi Adachi, Hiroshi Masutan. TXNIP induces growth arrest and enhances ABT263-induced apoptosis in mixed-lineage leukemia-rearranged acute myeloid leukemia cells. FEBS open bio. vol 10. issue 8. 2021-11-04. PMID:32511893. |
txnip induces growth arrest and enhances abt263-induced apoptosis in mixed-lineage leukemia-rearranged acute myeloid leukemia cells. |
2021-11-04 |
2023-08-13 |
Not clear |
| Yi Song, Feng Guo, Yanyan Zhao, Lin Zhao, Xunjie Fan, Yuanyuan Zhang, Yanling Liu, Guijun Qi. Verapamil ameliorates proximal tubular epithelial cells apoptosis and fibrosis in diabetic kidney. European journal of pharmacology. vol 911. 2021-11-01. PMID:34627808. |
after 16 weeks, mice were analyzed for blood glucose, blood pressure, and functional parameters followed by sacrifice and evaluation of renal tubular injury, alterations in txnip, apoptosis and fibrosis markers. |
2021-11-01 |
2023-08-13 |
mouse |
| Meng Zhang, Guanhua Hu, Nan Shao, Yunpeng Qin, Qian Chen, Yan Wang, Peng Zhou, Biao Ca. Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer's disease: flavonoids and phenols. Inflammopharmacology. vol 29. issue 5. 2021-10-14. PMID:34350508. |
txnip separates from the txnip-thioredoxin complex, and the txnip-nlrp3 complex assembles asc and pro-caspase-1 to form the nlrp3 inflammasome, which triggers ad inflammation and apoptosis. |
2021-10-14 |
2023-08-13 |
Not clear |
| Qiong Pan, Ke Guo, Min Xue, Qiuyun T. Estradiol exerts a neuroprotective effect on SH-SY5Y cells through the miR-106b-5p/TXNIP axis. Journal of biochemical and molecular toxicology. vol 35. issue 9. 2021-09-29. PMID:34318539. |
in the present study, we verified the neuroprotective role of estradiol against amyloid-beta 42 in sh-sy5y cells through inhibiting txnip expression, promoting cell viability and dna synthesis ability, inhibiting cell apoptosis, and affecting caspase and bax/bcl-2 apoptotic signaling. |
2021-09-29 |
2023-08-13 |
Not clear |
| Qiong Pan, Ke Guo, Min Xue, Qiuyun T. Estradiol exerts a neuroprotective effect on SH-SY5Y cells through the miR-106b-5p/TXNIP axis. Journal of biochemical and molecular toxicology. vol 35. issue 9. 2021-09-29. PMID:34318539. |
within sh-sy5y cells, mir-106b-5p inhibition repressed cell viability and dna synthesis ability and promoted cell apoptosis through caspase and bax/bcl-2 apoptotic signaling, while mir-106b-5p overexpression or txnip knockdown exerted the opposite effects on sh-sy5y cells; txnip knockdown remarkably attenuated the roles of mir-106b-5p inhibition. |
2021-09-29 |
2023-08-13 |
Not clear |
| Qiong Pan, Ke Guo, Min Xue, Qiuyun T. Estradiol exerts a neuroprotective effect on SH-SY5Y cells through the miR-106b-5p/TXNIP axis. Journal of biochemical and molecular toxicology. vol 35. issue 9. 2021-09-29. PMID:34318539. |
mir-106b-5p exerts a neuroprotective effect on sh-sy5y cells by promoting cell proliferation and inhibiting cell apoptosis through targeting txnip. |
2021-09-29 |
2023-08-13 |
Not clear |
| Alireza Malayeri, Mehrnoosh Zakerkish, Farrokh Ramesh, Hamid Galehdari, Ali Asghar Hemmati, Kambiz A Angal. The Effect of Verapamil on TXNIP Gene Expression, GLP1R mRNA, FBS, HbA1c, and Lipid Profile in T2DM Patients Receiving Metformin and Sitagliptin. Diabetes therapy : research, treatment and education of diabetes and related disorders. vol 12. issue 10. 2021-09-29. PMID:34480721. |
thioredoxin interacting protein (txnip) inhibits thioredoxin, which is part of the intracellular antioxidant system, thereby accelerating oxidative stress and apoptosis of pancreatic beta cells. |
2021-09-29 |
2023-08-13 |
Not clear |
| Xiang Zhang, Song Zhao, Qingqing Yuan, Lin Zhu, Fan Li, Hui Wang, Dezhi Kong, Jun Ha. TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression. Cell death & disease. vol 12. issue 7. 2021-09-20. PMID:34162834. |
then, dna methyltransferase (dnmt) inhibitor 5-aza has been reported to benefit schwann cell in dpn, and here 5-aza treatment reduced txnip protein expression, improved autophagy and inhibited apoptosis in high glucose-treated rsc96 cells and the sciatic nerves of diabetic mice. |
2021-09-20 |
2023-08-13 |
mouse |
| Xiang Zhang, Song Zhao, Qingqing Yuan, Lin Zhu, Fan Li, Hui Wang, Dezhi Kong, Jun Ha. TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression. Cell death & disease. vol 12. issue 7. 2021-09-20. PMID:34162834. |
taken together, pi3k/akt pathway inhibition mediated high glucose-induced dnmt1 and dnmt3a overexpression, leading to cell autophagy inhibition and apoptosis via txnip protein upregulation in schwann cells of dpn. |
2021-09-20 |
2023-08-13 |
mouse |
| Ming Xie, Ruiyan Xie, Sen Xie, Yiyi Wu, Wei Wang, Xiang Li, Yuanyu Xu, Bo Liu, Yu Zhou, Tao Wang, Lei Gao, Tiejun Pa. Thioredoxin interacting protein (TXNIP) acts as a tumor suppressor in human prostate cancer. Cell biology international. vol 44. issue 10. 2021-08-10. PMID:32639616. |
additionally, overexpression of txnip could remarkably block cell cycle in the g0/g1 phase and promoted cell apoptosis. |
2021-08-10 |
2023-08-13 |
human |
| Yamin Rao, Jing Chen, Yaoxing Guo, Tianhai Ji, Ping Xi. Rivaroxaban ameliorates angiotensin II-induced cardiac remodeling by attenuating TXNIP/Trx2 interaction in KKAy mice. Thrombosis research. vol 193. 2021-06-17. PMID:32521334. |
rivaroxaban inhibited the expression of thioredoxin binding protein (txnip) as well as the activation of apoptosis stimulating kinase 1 (ask1). |
2021-06-17 |
2023-08-13 |
mouse |